[ { "local_id": "C1", "type": "empirical", "core": true, "statement": "In eyes-closed resting-state fMRI from 72 adults (OpenNeuro ds002748; 100 Schaefer parcels, 0.01-0.1 Hz band-pass, TR 2.5 s), the intrinsic timescale ACW-50 of the salience network is shorter than that of the default mode network (Hodges-Lehmann difference 0.0391 s, 95% CI 0.0057 to 0.0731) and of the control network (0.0751 s, 0.0397 to 0.1085), but the default mode network's is not the longest: it is shorter than the control network's by 0.0416 s (95% CI 0.0125 to 0.07).", "evidence": [ { "result": "R1.family_A_hierarchy_acw50.A1_DMN_gt_SN.hodges_lehmann_s", "produced_by": "code/analyze.py", "tolerance": 0.01 }, { "result": "R1.family_A_hierarchy_acw50.A1_DMN_gt_SN.ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.015 }, { "result": "R1.family_A_hierarchy_acw50.A1_DMN_gt_SN.ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.015 }, { "result": "R1.family_A_hierarchy_acw50.A3_CEN_gt_SN.hodges_lehmann_s", "produced_by": "code/analyze.py", "tolerance": 0.01 }, { "result": "R1.family_A_hierarchy_acw50.A3_CEN_gt_SN.ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.015 }, { "result": "R1.family_A_hierarchy_acw50.A3_CEN_gt_SN.ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.015 }, { "result": "R1.family_A_hierarchy_acw50.A2_DMN_gt_CEN.hodges_lehmann_s", "produced_by": "code/analyze.py", "tolerance": 0.01 }, { "result": "R1.family_A_hierarchy_acw50.A2_DMN_gt_CEN.ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.015 }, { "result": "R1.family_A_hierarchy_acw50.A2_DMN_gt_CEN.ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.015 }, { "result": "R1.family_A_hierarchy_acw50.A1_DMN_gt_SN.n", "produced_by": "code/analyze.py" } ], "depends_on": [], "falsified_if": "A re-run of the same pipeline gives a default-mode-minus-control difference whose 95% CI includes zero or is positive, or a default-mode-minus-salience or control-minus-salience CI that includes zero.", "confidence": 0.7 }, { "local_id": "C2", "type": "negative_result", "core": true, "statement": "In the same data, 51 adults with mild-to-moderate depression and 21 controls did not differ in default mode network ACW-50 (probability a depressed participant's value exceeds a control's 0.4015, 95% CI 0.2708 to 0.5378), in mean dwell time of default-mode-dominant states (0.5131, 0.3679 to 0.6536) or in the entropy of transitions among default-mode-, salience- and control-dominant states (0.549, 0.3987 to 0.6975); the design had 80% power only for differences near an AUC of 0.70.", "evidence": [ { "result": "R1.family_B_depression.B1_acw50_DMN_group.auc_depression_gt_control", "produced_by": "code/analyze.py", "tolerance": 0.03 }, { "result": "R1.family_B_depression.B1_acw50_DMN_group.auc_ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B1_acw50_DMN_group.auc_ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B2_dmn_dwell_group.auc_depression_gt_control", "produced_by": "code/analyze.py", "tolerance": 0.03 }, { "result": "R1.family_B_depression.B2_dmn_dwell_group.auc_ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B2_dmn_dwell_group.auc_ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B3_transition_entropy_group.auc_depression_gt_control", "produced_by": "code/analyze.py", "tolerance": 0.03 }, { "result": "R1.family_B_depression.B3_transition_entropy_group.auc_ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B3_transition_entropy_group.auc_ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B1_acw50_DMN_group.n_depression", "produced_by": "code/analyze.py" }, { "result": "R1.family_B_depression.B1_acw50_DMN_group.n_control", "produced_by": "code/analyze.py" } ], "depends_on": [], "falsified_if": "A re-run gives any of the three group AUC confidence intervals excluding 0.5, or a larger sample under the same pipeline finds a group difference with AUC beyond 0.70 or below 0.30.", "confidence": 0.7 }, { "local_id": "C3", "type": "negative_result", "core": false, "statement": "Within the 45 depressed participants with Ruminative Responses Scale scores, brooding was not correlated with default mode network ACW-50 (Spearman rho 0.1065, 95% CI -0.1848 to 0.3812) or with default-mode-dominant dwell time (rho -0.2063, -0.4732 to 0.0887).", "evidence": [ { "result": "R1.family_B_depression.B4_brooding_vs_acw50_DMN.rho", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B4_brooding_vs_acw50_DMN.ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.07 }, { "result": "R1.family_B_depression.B4_brooding_vs_acw50_DMN.ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.07 }, { "result": "R1.family_B_depression.B5_brooding_vs_dmn_dwell.rho", "produced_by": "code/analyze.py", "tolerance": 0.05 }, { "result": "R1.family_B_depression.B5_brooding_vs_dmn_dwell.ci95.0", "produced_by": "code/analyze.py", "tolerance": 0.07 }, { "result": "R1.family_B_depression.B5_brooding_vs_dmn_dwell.ci95.1", "produced_by": "code/analyze.py", "tolerance": 0.07 }, { "result": "R1.family_B_depression.B4_brooding_vs_acw50_DMN.n", "produced_by": "code/analyze.py" } ], "depends_on": [], "falsified_if": "A re-run gives either Spearman confidence interval excluding zero.", "confidence": 0.65 } ]