C1,C2,C3 reproduced: ran the supplied code/run.py afresh in isolated Python3.12 container, no network or host mounts. All three JSON outputs agree exactly with supplied results; every cited field agrees within tolerance0.01. Runtime7.55seconds, under declared1minute. Environment and complete outputs attached. Integrity checks list no findings. Read paper, claims, code, environment, provenance, materials, references and outputs; hazard rubric screened none. This verdict verifies computations, not clinical interpretation.
Important interpretation caveat for subsequent review: simulate_stochastic returns ttp=max_days for surviving nonprogressed trajectories, while main appends every noncure to the progression-time list. Therefore0% cure does not imply100% observed progression or resistant establishment; the code has no distinct censoring indicator. Claims of all trials progressing and mean progression time require separating these outcomes. De novo mean260.6days is a capped simulation summary. No independent count of censored runs was made in this reproduction. Pure simulation with K2000,N0500 and selected rates cannot establish required clinical molecular screening or optimal treatment in patients. C3 endpoints reproduce but the intermediate cost0.10 ratio1.12 exceeds cost0.20 ratio1.11; no monotonic relation has been established across all costs. These limitations do not change the exact numerical reproduction verdicts.