[
 {
  "term": "abdominal panniculectomy",
  "canonical": "Panniculectomy",
  "outcomes": [],
  "reason": "A panniculectomy is abdominal by definition, so the qualifier adds nothing; it is a cosmetic/functional procedure meeting no outcome."
 },
 {
  "term": "abdominal strangulated hernia",
  "canonical": "Abdominal strangulated hernia",
  "outcomes": [
   "B02"
  ],
  "reason": "Strangulation follows incarceration of bowel, so a strangulated abdominal hernia is in the large majority a closed-loop mechanical bowel obstruction."
 },
 {
  "term": "acute nephritis",
  "canonical": "Nephritis",
  "outcomes": [],
  "reason": "Acute nephritis is a lowest-level variant of Nephritis, usually glomerular, which is neither acute kidney injury by definition nor interstitial nephritis."
 },
 {
  "term": "acute sinusitis",
  "canonical": "Sinusitis",
  "outcomes": [],
  "reason": "Acute sinusitis is a lowest-level term under Sinusitis and is mostly viral, so it is not a bacterial infection."
 },
 {
  "term": "afferent loop syndrome",
  "canonical": "Afferent loop syndrome",
  "outcomes": [
   "B02"
  ],
  "reason": "Afferent loop syndrome is by definition a mechanical obstruction of the afferent limb after gastrojejunostomy."
 },
 {
  "term": "altered mental status",
  "canonical": "Mental status changes",
  "outcomes": [],
  "reason": "Altered mental status is a lowest-level term of Mental status changes, a nonspecific acute state that meets no outcome."
 },
 {
  "term": "anticoagulant-related nephropathy",
  "canonical": "Anticoagulant-related nephropathy",
  "outcomes": [
   "A17"
  ],
  "reason": "Anticoagulant-related nephropathy is defined as acute kidney injury from glomerular haemorrhage during over-anticoagulation, not a chronic nephropathy."
 },
 {
  "term": "anticoagulation drug level above therapeutic",
  "canonical": "Anticoagulation drug level above therapeutic",
  "outcomes": [
   "A11"
  ],
  "reason": "A supratherapeutic anticoagulant level reported as a serious event is an acquired drug-induced coagulopathy, the same as INR increased reported as a disorder."
 },
 {
  "term": "anticoagulation drug level increased",
  "canonical": "Anticoagulation drug level increased",
  "outcomes": [
   "A11"
  ],
  "reason": "Reported as a serious event, a raised anticoagulant level is over-anticoagulation, an acquired clotting disorder like INR increased."
 },
 {
  "term": "arteriosclerosis coronary",
  "canonical": "Arteriosclerosis coronary artery",
  "outcomes": [],
  "reason": "This is a lowest-level variant of the preferred term Arteriosclerosis coronary artery; coronary disease is a cardiometabolic outcome left out of the codebook."
 },
 {
  "term": "arthroplasty",
  "canonical": "Arthroplasty",
  "outcomes": [
   "A44"
  ],
  "reason": "In these middle-aged, mostly obese trial populations a joint replacement reported as a musculoskeletal event is done almost only for end-stage arthritis, chiefly osteoarthritis."
 },
 {
  "term": "asthma exacerbation",
  "canonical": "Asthma",
  "outcomes": [],
  "reason": "Asthma exacerbation is a lowest-level term under Asthma, and asthma is excluded from COPD."
 },
 {
  "term": "atherosclerosis generalized",
  "canonical": "Arteriosclerosis",
  "outcomes": [],
  "reason": "Generalised atherosclerosis is a lowest-level variant of Arteriosclerosis and meets no outcome."
 },
 {
  "term": "atrioventricular block third degree",
  "canonical": "Atrioventricular block complete",
  "outcomes": [],
  "reason": "Third-degree AV block is a lowest-level term of the preferred term Atrioventricular block complete."
 },
 {
  "term": "atypical migraine",
  "canonical": "Migraine",
  "outcomes": [
   "A43"
  ],
  "reason": "Atypical migraine is a lowest-level variant of Migraine, which is headache."
 },
 {
  "term": "auricular perichondritis",
  "canonical": "Auricular perichondritis",
  "outcomes": [
   "A18"
  ],
  "reason": "Auricular perichondritis is an infection of the ear cartilage caused in the large majority by Pseudomonas or Staphylococcus, while relapsing polychondritis has its own term."
 },
 {
  "term": "bacterial test positive",
  "canonical": "Bacterial test positive",
  "outcomes": [
   "A18"
  ],
  "reason": "A positive bacterial test reported as a serious event stands for a clinically significant bacterial infection in the large majority of cases."
 },
 {
  "term": "benign intracranial hypertension",
  "canonical": "Idiopathic intracranial hypertension",
  "outcomes": [],
  "reason": "MedDRA renamed Benign intracranial hypertension to the preferred term Idiopathic intracranial hypertension, and the condition is not itself headache."
 },
 {
  "term": "biliary ascites",
  "canonical": "Biliary ascites",
  "outcomes": [
   "B01"
  ],
  "reason": "Biliary ascites is a bile leak into the peritoneum, a disorder of the biliary tract, which B01 counts apart from cancer and primary biliary cholangitis."
 },
 {
  "term": "biliary dilatation",
  "canonical": "Biliary dilatation",
  "outcomes": [
   "B01"
  ],
  "reason": "Dilatation of the bile ducts is itself a biliary tract disorder, most often from stones, and counts as biliary disease."
 },
 {
  "term": "biliary fistula",
  "canonical": "Biliary fistula",
  "outcomes": [
   "B01"
  ],
  "reason": "A biliary fistula, whether cholecystoenteric from stones or a postoperative leak, is a disorder of the biliary tract."
 },
 {
  "term": "biloma",
  "canonical": "Biloma",
  "outcomes": [
   "B01"
  ],
  "reason": "A biloma is a collection of leaked bile, a disorder of the biliary tract."
 },
 {
  "term": "biloma infected",
  "canonical": "Biloma infected",
  "outcomes": [
   "A18",
   "B01"
  ],
  "reason": "An infected biloma is a bacterial infection of a bile collection, so it meets both bacterial infection and biliary disease."
 },
 {
  "term": "bleeding varicose vein",
  "canonical": "Varicose vein ruptured",
  "outcomes": [],
  "reason": "Bleeding varicose vein is a variant of the preferred term Varicose vein ruptured, a bleeding event that meets no outcome."
 },
 {
  "term": "blood alcohol increased",
  "canonical": "Blood alcohol increased",
  "outcomes": [
   "A01"
  ],
  "reason": "A raised blood alcohol reported as a serious event is alcoholic intoxication, which A01 includes."
 },
 {
  "term": "blood loss anaemia",
  "canonical": "Haemorrhagic anaemia",
  "outcomes": [
   "A28"
  ],
  "reason": "Blood loss anaemia is a lowest-level term of the preferred term Haemorrhagic anaemia, which is anaemia."
 },
 {
  "term": "brainstem compression",
  "canonical": "Brain compression",
  "outcomes": [],
  "reason": "Brainstem compression is a site-qualified variant of the preferred term Brain compression and meets no outcome."
 },
 {
  "term": "bronchitis chronic",
  "canonical": "Bronchitis chronic",
  "outcomes": [
   "A26"
  ],
  "reason": "Bronchitis chronic is itself the MedDRA preferred term in MedDRA's word order, and chronic bronchitis is COPD."
 },
 {
  "term": "bronchopulmonary aspergillosis",
  "canonical": "Bronchopulmonary aspergillosis",
  "outcomes": [
   "A21"
  ],
  "reason": "Bronchopulmonary aspergillosis (unlike the allergic form, which has its own term) is a fungal lung infection, which A21 counts as pneumonia."
 },
 {
  "term": "bullous erysipelas",
  "canonical": "Erysipelas",
  "outcomes": [
   "A18"
  ],
  "reason": "Bullous erysipelas is a form of Erysipelas, a streptococcal skin infection."
 },
 {
  "term": "bullous lung disease",
  "canonical": "Bullous lung disease",
  "outcomes": [
   "A26"
  ],
  "reason": "Bullous lung disease is in the large majority bullous emphysema, which A26 includes."
 },
 {
  "term": "cancer pain",
  "canonical": "Cancer pain",
  "outcomes": [
   "B06"
  ],
  "reason": "Cancer pain occurs only in a person with a malignant neoplasm, so each event reported under it is an event of malignancy."
 },
 {
  "term": "cancer, unknown primary",
  "canonical": "Malignant neoplasm of unknown primary site",
  "outcomes": [
   "B06"
  ],
  "reason": "This free-text form maps to the preferred term Malignant neoplasm of unknown primary site, a malignancy."
 },
 {
  "term": "cardiac arrhythmia",
  "canonical": "Arrhythmia",
  "outcomes": [],
  "reason": "Cardiac arrhythmia is a lowest-level term of the preferred term Arrhythmia."
 },
 {
  "term": "cardiopulmonary failure",
  "canonical": "Cardiopulmonary failure",
  "outcomes": [
   "A27"
  ],
  "reason": "Cardiopulmonary failure is combined cardiac and respiratory failure, so it always includes respiratory failure."
 },
 {
  "term": "cardiospasm",
  "canonical": "Achalasia",
  "outcomes": [],
  "reason": "Cardiospasm is an old name and lowest-level term for Achalasia, which meets no outcome."
 },
 {
  "term": "cellulite",
  "canonical": "Cellulitis",
  "outcomes": [
   "A18"
  ],
  "reason": "Cosmetic cellulite is never a serious event; a serious event reported as 'cellulite' is the French word for cellulitis miscoded, so it is cellulitis."
 },
 {
  "term": "cellulitis of foot",
  "canonical": "Cellulitis",
  "outcomes": [
   "A18"
  ],
  "reason": "Cellulitis of foot is a site-qualified lowest-level term of Cellulitis, a bacterial infection."
 },
 {
  "term": "cellulitis of leg",
  "canonical": "Cellulitis",
  "outcomes": [
   "A18"
  ],
  "reason": "Cellulitis of leg is a site-qualified lowest-level term of Cellulitis, a bacterial infection."
 },
 {
  "term": "cellulitis orbital",
  "canonical": "Cellulitis orbital",
  "outcomes": [
   "A18"
  ],
  "reason": "Cellulitis orbital is itself the MedDRA preferred term in MedDRA's word order, and it is bacterial in the large majority."
 },
 {
  "term": "cerebrovascular event",
  "canonical": "Cerebrovascular accident",
  "outcomes": [],
  "reason": "Cerebrovascular event is a lowest-level term of Cerebrovascular accident; stroke is a cardiometabolic outcome left out of the codebook."
 },
 {
  "term": "cervical pain",
  "canonical": "Neck pain",
  "outcomes": [],
  "reason": "Reported as a musculoskeletal event, cervical pain is a lowest-level variant of Neck pain, which is not muscle pain or joint pain."
 },
 {
  "term": "chest pain - cardiac",
  "canonical": "Chest pain - cardiac",
  "outcomes": [],
  "reason": "This is a CTCAE term whose MedDRA preferred term cannot be told with confidence, so the term is kept; it meets no outcome."
 },
 {
  "term": "chest pain exertional",
  "canonical": "Chest pain",
  "outcomes": [],
  "reason": "Exertional chest pain is a variant of the preferred term Chest pain, under which it was reported."
 },
 {
  "term": "choking",
  "canonical": "Choking",
  "outcomes": [
   "A22"
  ],
  "reason": "Choking as a serious event is in the large majority foreign-body (usually food) obstruction of the airway, which A22 counts as aspiration."
 },
 {
  "term": "chronic gastritis",
  "canonical": "Chronic gastritis",
  "outcomes": [
   "A36"
  ],
  "reason": "Chronic gastritis is itself a MedDRA preferred term, so it is kept rather than mapped to Gastritis, and it is gastritis."
 },
 {
  "term": "cirrhosis alcoholic",
  "canonical": "Cirrhosis alcoholic",
  "outcomes": [],
  "reason": "Cirrhosis alcoholic is itself a MedDRA preferred term and is organ damage, which A01 excludes; cirrhosis without failure is not A30."
 },
 {
  "term": "clostridium test positive",
  "canonical": "Clostridium test positive",
  "outcomes": [
   "A18"
  ],
  "reason": "A positive Clostridium (usually C. difficile) test reported as a serious event is a bacterial infection in the large majority."
 },
 {
  "term": "cns ventriculitis",
  "canonical": "CNS ventriculitis",
  "outcomes": [
   "A18"
  ],
  "reason": "CNS ventriculitis is itself the MedDRA preferred term and is bacterial in the large majority, mostly after neurosurgery or shunts."
 },
 {
  "term": "colon gangrene",
  "canonical": "Colon gangrene",
  "outcomes": [
   "A37"
  ],
  "reason": "Colon gangrene is the gangrenous form of colonic ischaemia, i.e. ischaemic colitis, which A37 includes; it is not infected gangrene."
 },
 {
  "term": "complicated migraine",
  "canonical": "Migraine",
  "outcomes": [
   "A43"
  ],
  "reason": "Complicated migraine is a lowest-level variant of Migraine, which is headache."
 },
 {
  "term": "conductive deafness",
  "canonical": "Conductive deafness",
  "outcomes": [],
  "reason": "Conductive deafness is itself a MedDRA preferred term among the hearing losses, so it is kept, and it meets no outcome."
 },
 {
  "term": "coronary atherosclerosis",
  "canonical": "Arteriosclerosis coronary artery",
  "outcomes": [],
  "reason": "Coronary atherosclerosis is a lowest-level term of Arteriosclerosis coronary artery and meets no outcome."
 },
 {
  "term": "coronary insufficiency",
  "canonical": "Coronary artery insufficiency",
  "outcomes": [],
  "reason": "Coronary insufficiency is a lowest-level term of Coronary artery insufficiency and meets no outcome."
 },
 {
  "term": "culture positive",
  "canonical": "Culture positive",
  "outcomes": [
   "A18"
  ],
  "reason": "A positive culture reported as a serious event stands for a clinically significant infection, which is bacterial in the large majority."
 },
 {
  "term": "culture urine positive",
  "canonical": "Culture urine positive",
  "outcomes": [
   "A18"
  ],
  "reason": "A positive urine culture reported as a serious event is in the large majority a bacterial urinary tract infection."
 },
 {
  "term": "dactylitis",
  "canonical": "Dactylitis",
  "outcomes": [
   "A44",
   "A46"
  ],
  "reason": "Dactylitis is in the large majority a manifestation of psoriatic arthritis or spondyloarthropathy, made up of tenosynovitis and synovitis."
 },
 {
  "term": "dependence on respirator",
  "canonical": "Dependence on respirator",
  "outcomes": [
   "A27"
  ],
  "reason": "Dependence on a ventilator means the person cannot breathe without one, i.e. chronic respiratory failure."
 },
 {
  "term": "dermatofibrosarcoma",
  "canonical": "Dermatofibrosarcoma protuberans",
  "outcomes": [
   "B06"
  ],
  "reason": "Dermatofibrosarcoma is in effect always dermatofibrosarcoma protuberans, the preferred term, and is a malignant sarcoma."
 },
 {
  "term": "diabetic gangrene",
  "canonical": "Diabetic gangrene",
  "outcomes": [],
  "reason": "The codebook counts only infected gangrene, and diabetic gangrene is often dry and ischaemic, so it is not bacterial in the large majority."
 },
 {
  "term": "diverticulum oesophageal",
  "canonical": "Diverticulum oesophageal",
  "outcomes": [],
  "reason": "A39 is the intestinal diverticular disease of the VA atlas, and an oesophageal (Zenker-type) pouch is a different disease."
 },
 {
  "term": "drug exposure during pregnancy",
  "canonical": "Exposure during pregnancy",
  "outcomes": [],
  "reason": "Drug exposure during pregnancy is a lowest-level term of Exposure during pregnancy and meets no outcome."
 },
 {
  "term": "ductal adenocarcinoma of pancreas",
  "canonical": "Adenocarcinoma pancreas",
  "outcomes": [
   "B06",
   "B07",
   "B11"
  ],
  "reason": "Ductal adenocarcinoma of pancreas is a variant of the preferred term Adenocarcinoma pancreas, which is pancreatic cancer."
 },
 {
  "term": "dysentery",
  "canonical": "Dysentery",
  "outcomes": [
   "A18"
  ],
  "reason": "Unqualified dysentery (bloody diarrhoea) is bacterial in the large majority, chiefly Shigella and Campylobacter, with amoebic dysentery coded separately."
 },
 {
  "term": "emphysematous cholecystitis",
  "canonical": "Emphysematous cholecystitis",
  "outcomes": [
   "A18",
   "B01"
  ],
  "reason": "Unlike plain cholecystitis, emphysematous cholecystitis is defined by gas-forming bacterial infection of the gallbladder, so it is both bacterial infection and gallbladder disease."
 },
 {
  "term": "endometrial hyperplasia with cellular atypia",
  "canonical": "Endometrial hyperplasia",
  "outcomes": [],
  "reason": "Reported under the reproductive system, it maps to Endometrial hyperplasia, a precancerous condition that B06 excludes."
 },
 {
  "term": "focal peritonitis",
  "canonical": "Peritonitis",
  "outcomes": [
   "A18"
  ],
  "reason": "Focal peritonitis is a localised variant of Peritonitis, which as a serious event is in the large majority bacterial peritoneal infection."
 },
 {
  "term": "gallbladder adenoma",
  "canonical": "Gallbladder adenoma",
  "outcomes": [],
  "reason": "A gallbladder adenoma is a benign neoplasm, not the stone or inflammatory gallbladder disease that B01 counts, which also leaves out biliary neoplasms (cancer)."
 },
 {
  "term": "gangrene",
  "canonical": "Gangrene",
  "outcomes": [],
  "reason": "The codebook counts only infected gangrene, and unqualified gangrene is often dry ischaemic necrosis."
 },
 {
  "term": "gangrenous appendicitis",
  "canonical": "Appendicitis",
  "outcomes": [],
  "reason": "Gangrenous appendicitis is a lowest-level term of Appendicitis, which A18 explicitly excludes."
 },
 {
  "term": "gastric neuroendocrine carcinoma",
  "canonical": "Gastric neuroendocrine carcinoma",
  "outcomes": [
   "B06",
   "B07"
  ],
  "reason": "A gastric neuroendocrine carcinoma is a malignant gastric cancer of unstated site, which B07 says to code there too."
 },
 {
  "term": "gastroenteritis noninfectious",
  "canonical": "Gastroenteritis noninfective",
  "outcomes": [
   "A37"
  ],
  "reason": "This is a spelling variant of Gastroenteritis noninfective, the term the codebook names under A37."
 },
 {
  "term": "gastroenteropancreatic neuroendocrine tumour disease",
  "canonical": "Gastroenteropancreatic neuroendocrine tumour disease",
  "outcomes": [
   "B06"
  ],
  "reason": "Gastroenteropancreatic neuroendocrine tumours are classed by WHO as malignant neoplasms, but their site spans organs off the B07 list."
 },
 {
  "term": "gastrointestinal stromal tumour",
  "canonical": "Gastrointestinal stromal tumour",
  "outcomes": [
   "B06"
  ],
  "reason": "GIST is a sarcoma, classed as malignant since WHO 2020, so it is a malignancy; it is not a gastric or colorectal carcinoma for B07."
 },
 {
  "term": "haemarthrosis",
  "canonical": "Haemarthrosis",
  "outcomes": [
   "A45"
  ],
  "reason": "Haemarthrosis is a bloody joint effusion that presents as a painful swollen joint, and A45 includes joint effusion and swelling."
 },
 {
  "term": "hypernatremic dehydration",
  "canonical": "Dehydration",
  "outcomes": [],
  "reason": "Hypernatraemic dehydration is a variant of the preferred term Dehydration and meets no outcome."
 },
 {
  "term": "infections and infestations - other",
  "canonical": "Infection",
  "outcomes": [],
  "reason": "This CTCAE 'other' catch-all names an unspecified infection, so it maps to Infection and is not known to be bacterial."
 },
 {
  "term": "infectious pleural effusion",
  "canonical": "Infectious pleural effusion",
  "outcomes": [
   "A18"
  ],
  "reason": "An infected pleural effusion is a parapneumonic, empyema-type infection, bacterial in the large majority, and A25 excludes empyema as an infection."
 },
 {
  "term": "insulin-requiring type 2 diabetes mellitus",
  "canonical": "Insulin-requiring type 2 diabetes mellitus",
  "outcomes": [],
  "reason": "Insulin-requiring type 2 diabetes mellitus is itself a MedDRA preferred term, so it is kept."
 },
 {
  "term": "intolerable gastrointestional side effects",
  "canonical": "Gastrointestinal disorder",
  "outcomes": [],
  "reason": "This misspelled free text maps to the nonspecific preferred term Gastrointestinal disorder and names no specific outcome."
 },
 {
  "term": "klebsiella urinary tract infection",
  "canonical": "Klebsiella urinary tract infection",
  "outcomes": [
   "A18"
  ],
  "reason": "It cannot be told with confidence that MedDRA folds this organism-specific UTI into a broader term, so the term is kept; it is bacterial."
 },
 {
  "term": "laparoscopic cholecystectomy",
  "canonical": "Cholecystectomy",
  "outcomes": [
   "B01"
  ],
  "reason": "Laparoscopic cholecystectomy is a lowest-level term of Cholecystectomy, done almost only for gallbladder disease."
 },
 {
  "term": "linguinal herniation",
  "canonical": "Inguinal hernia",
  "outcomes": [],
  "reason": "'Linguinal herniation' is a misspelling of Inguinal hernia, which is not an obstruction."
 },
 {
  "term": "lung abscess",
  "canonical": "Lung abscess",
  "outcomes": [
   "A18",
   "A19",
   "A21"
  ],
  "reason": "A lung abscess is a suppurative lung infection that is bacterial in the large majority (anaerobes, S. aureus, Klebsiella), so it is a bacterial pneumonia as well as a lung infection."
 },
 {
  "term": "malignant neoplasm of uterine adnexa",
  "canonical": "Malignant neoplasm of uterine adnexa",
  "outcomes": [
   "B06",
   "B07"
  ],
  "reason": "Adnexal malignancies are in the large majority ovarian or tubal cancers, which count as ovarian cancer in B07."
 },
 {
  "term": "medical device site joint pain",
  "canonical": "Medical device site joint pain",
  "outcomes": [
   "A45"
  ],
  "reason": "This is joint pain qualified by a device site, and A45 includes joint pain of any site or cause."
 },
 {
  "term": "meniscus lesion",
  "canonical": "Meniscus injury",
  "outcomes": [],
  "reason": "Meniscus lesion, reported as an injury, is a lowest-level term of Meniscus injury."
 },
 {
  "term": "meniscus tear",
  "canonical": "Meniscus injury",
  "outcomes": [],
  "reason": "Meniscus tear is a lowest-level term of Meniscus injury, a joint injury, which A44 excludes."
 },
 {
  "term": "mixed deafness",
  "canonical": "Mixed deafness",
  "outcomes": [],
  "reason": "Mixed deafness is itself a MedDRA preferred term, so it is kept, and it meets no outcome."
 },
 {
  "term": "monarthritis",
  "canonical": "Monarthritis",
  "outcomes": [
   "A44"
  ],
  "reason": "Monarthritis is MedDRA's own spelling of the preferred term, and it is arthritis."
 },
 {
  "term": "multiple endocrine adenomatosis type i",
  "canonical": "Multiple endocrine neoplasia Type 1",
  "outcomes": [],
  "reason": "Multiple endocrine adenomatosis type I is an old lowest-level name for Multiple endocrine neoplasia Type 1, a genetic syndrome that is not itself a malignancy."
 },
 {
  "term": "narcolepsy",
  "canonical": "Narcolepsy",
  "outcomes": [
   "A42"
  ],
  "reason": "Narcolepsy is a primary central hypersomnia, a sleep disorder in A42, not drug or illness somnolence."
 },
 {
  "term": "nasopharyngeal carcinoma",
  "canonical": "Nasopharyngeal cancer",
  "outcomes": [
   "B06"
  ],
  "reason": "Nasopharyngeal carcinoma is a lowest-level term of the preferred term Nasopharyngeal cancer."
 },
 {
  "term": "nausea & vomiting",
  "canonical": "Nausea",
  "outcomes": [
   "A34"
  ],
  "reason": "'Nausea and vomiting' is a MedDRA lowest-level term linked to the preferred term Nausea, and it is A34."
 },
 {
  "term": "nausea, vomiting, pain",
  "canonical": "Nausea",
  "outcomes": [
   "A34"
  ],
  "reason": "This free-text combination maps like 'nausea and vomiting' to Nausea, and the pain is not stated to be abdominal."
 },
 {
  "term": "nephropathy toxic",
  "canonical": "Nephropathy toxic",
  "outcomes": [
   "A17"
  ],
  "reason": "Toxic nephropathy reported as a serious event is acute nephrotoxic kidney injury in the large majority (it is in the narrow acute renal failure SMQ), unlike chronic nephropathy."
 },
 {
  "term": "neuroendocrine breast tumour",
  "canonical": "Neuroendocrine breast tumour",
  "outcomes": [
   "B06",
   "B07"
  ],
  "reason": "WHO classes neuroendocrine tumours of the breast as invasive breast carcinomas, so they are malignant breast cancer."
 },
 {
  "term": "neuroendocrine tumour",
  "canonical": "Neuroendocrine tumour",
  "outcomes": [
   "B06"
  ],
  "reason": "Neuroendocrine tumours are classed as malignant neoplasms (ICD-O behaviour /3) with metastatic potential, so they are malignancies, but of unstated site."
 },
 {
  "term": "neuroendocrine tumour of the lung",
  "canonical": "Neuroendocrine tumour of the lung",
  "outcomes": [
   "B06"
  ],
  "reason": "Lung neuroendocrine tumours, from carcinoid to small-cell carcinoma, are all malignant neoplasms."
 },
 {
  "term": "non-sustained ventricular tachycardia",
  "canonical": "Ventricular tachycardia",
  "outcomes": [],
  "reason": "Non-sustained ventricular tachycardia is a lowest-level term of Ventricular tachycardia."
 },
 {
  "term": "nosocomial infection",
  "canonical": "Nosocomial infection",
  "outcomes": [
   "A18"
  ],
  "reason": "Hospital-acquired infections (bloodstream, urinary, surgical-site, C. difficile, ventilator pneumonia) are bacterial in the large majority."
 },
 {
  "term": "obstructive sleep apnoea syndrome",
  "canonical": "Obstructive sleep apnoea syndrome",
  "outcomes": [
   "A42"
  ],
  "reason": "Obstructive sleep apnoea syndrome is itself a MedDRA preferred term (alongside Central sleep apnoea syndrome), so it is kept, and it is a sleep disorder."
 },
 {
  "term": "oesophageal achalasia",
  "canonical": "Achalasia",
  "outcomes": [],
  "reason": "Oesophageal achalasia is a lowest-level term of Achalasia."
 },
 {
  "term": "oncologic complication",
  "canonical": "Oncologic complication",
  "outcomes": [
   "B06"
  ],
  "reason": "An oncologic complication occurs only in a person with a malignancy, so each event is an event of malignant neoplasm, as with cancer pain."
 },
 {
  "term": "oophoritis",
  "canonical": "Oophoritis",
  "outcomes": [
   "A18"
  ],
  "reason": "Oophoritis is in the large majority part of pelvic inflammatory disease, an ascending bacterial infection, while autoimmune oophoritis is rare."
 },
 {
  "term": "other cancer",
  "canonical": "Neoplasm malignant",
  "outcomes": [
   "B06"
  ],
  "reason": "'Other cancer' is free text for an unspecified malignancy, which maps to Neoplasm malignant."
 },
 {
  "term": "overdose to illicit drug",
  "canonical": "Overdose",
  "outcomes": [],
  "reason": "This free text maps to Overdose; the drug is not named, so it cannot be assigned to a substance-use outcome."
 },
 {
  "term": "palsy bells",
  "canonical": "Facial paralysis",
  "outcomes": [],
  "reason": "Bell's palsy, here with its words inverted, is a lowest-level term of the preferred term Facial paralysis."
 },
 {
  "term": "pancreatic neuroendocrine tumor",
  "canonical": "Pancreatic neuroendocrine tumour",
  "outcomes": [
   "B06",
   "B07",
   "B11"
  ],
  "reason": "Pancreatic neuroendocrine tumours are classed by WHO as malignant (ICD-O /3), so they are pancreatic cancer, which B11 names."
 },
 {
  "term": "pancreatic neuroendocrine tumour",
  "canonical": "Pancreatic neuroendocrine tumour",
  "outcomes": [
   "B06",
   "B07",
   "B11"
  ],
  "reason": "Pancreatic neuroendocrine tumours are classed by WHO as malignant (ICD-O /3), so they are pancreatic cancer, which B11 names."
 },
 {
  "term": "paranoia",
  "canonical": "Paranoia",
  "outcomes": [
   "A07"
  ],
  "reason": "Paranoia severe enough to be a serious event is in the large majority paranoid psychosis, and it is in the narrow psychosis SMQ."
 },
 {
  "term": "paroxysmal atrial fibrillation",
  "canonical": "Atrial fibrillation",
  "outcomes": [],
  "reason": "Paroxysmal atrial fibrillation is a lowest-level term of Atrial fibrillation."
 },
 {
  "term": "paroxysmal atrioventricular block",
  "canonical": "Atrioventricular block",
  "outcomes": [],
  "reason": "Paroxysmal atrioventricular block is a variant of the preferred term Atrioventricular block."
 },
 {
  "term": "patellofemoral pain syndrome",
  "canonical": "Patellofemoral pain syndrome",
  "outcomes": [
   "A45"
  ],
  "reason": "Patellofemoral pain syndrome is pain arising from the patellofemoral joint of the knee, i.e. joint pain."
 },
 {
  "term": "periodontitis",
  "canonical": "Periodontitis",
  "outcomes": [
   "A18"
  ],
  "reason": "Periodontitis is an infection of the periodontium driven by plaque bacteria in essentially every case, which MedDRA files under infections."
 },
 {
  "term": "philadelphia positive chronic myeloid leukaemia",
  "canonical": "Chronic myeloid leukaemia",
  "outcomes": [
   "B06"
  ],
  "reason": "Nearly all chronic myeloid leukaemia is Philadelphia-positive, so this is a variant of Chronic myeloid leukaemia."
 },
 {
  "term": "pickwickian syndrome",
  "canonical": "Pickwickian syndrome",
  "outcomes": [
   "A27",
   "A42"
  ],
  "reason": "Pickwickian (obesity hypoventilation) syndrome is chronic hypercapnic respiratory failure by definition and is classed as a sleep-related hypoventilation disorder."
 },
 {
  "term": "pneumonia necrotising",
  "canonical": "Pneumonia necrotising",
  "outcomes": [
   "A18",
   "A19",
   "A21"
  ],
  "reason": "Necrotising pneumonia is bacterial in the large majority (S. aureus, pneumococcus, Klebsiella, anaerobes), so it is a bacterial pneumonia."
 },
 {
  "term": "pneumonitis aspiration",
  "canonical": "Pneumonia aspiration",
  "outcomes": [
   "A21",
   "A22",
   "A23"
  ],
  "reason": "Aspiration pneumonitis is a lowest-level term of the preferred term Pneumonia aspiration, which the codebook codes to A21, A22 and A23."
 },
 {
  "term": "post cholecystectomy syndrome",
  "canonical": "Postcholecystectomy syndrome",
  "outcomes": [
   "B01"
  ],
  "reason": "MedDRA writes the preferred term as Postcholecystectomy syndrome, persisting biliary-type symptoms after gallbladder removal."
 },
 {
  "term": "post lumbar puncture syndrome",
  "canonical": "Post lumbar puncture syndrome",
  "outcomes": [
   "A43"
  ],
  "reason": "Post lumbar puncture syndrome is in the large majority post-dural-puncture headache, itself a headache disorder rather than a headache from a structural lesion."
 },
 {
  "term": "postoperative thoracic procedure complication",
  "canonical": "Postoperative thoracic procedure complication",
  "outcomes": [
   "A24"
  ],
  "reason": "Complications of chest-cavity procedures are mostly respiratory and pleural (air leak, atelectasis, pneumonia, effusion) and are named as postoperative."
 },
 {
  "term": "premenopausal menorrhagia",
  "canonical": "Menorrhagia",
  "outcomes": [],
  "reason": "Premenopausal menorrhagia is a lowest-level variant of Menorrhagia."
 },
 {
  "term": "prostatic adenoma",
  "canonical": "Prostatic adenoma",
  "outcomes": [],
  "reason": "Reported under neoplasms, prostatic adenoma is kept as its own MedDRA preferred term; it is benign, so it is not B06."
 },
 {
  "term": "pruritus generalised",
  "canonical": "Pruritus",
  "outcomes": [],
  "reason": "MedDRA demoted Pruritus generalised to a lowest-level term under Pruritus."
 },
 {
  "term": "quadriceps tendon rupture",
  "canonical": "Tendon rupture",
  "outcomes": [
   "A46"
  ],
  "reason": "Quadriceps tendon rupture is a site-qualified variant of Tendon rupture, which A46 includes."
 },
 {
  "term": "quadriplegic event",
  "canonical": "Quadriplegia",
  "outcomes": [],
  "reason": "'Quadriplegic event' is free text for Quadriplegia."
 },
 {
  "term": "reactive gastropathy",
  "canonical": "Reactive gastropathy",
  "outcomes": [
   "A36"
  ],
  "reason": "Reactive gastropathy is chemical (type C) gastritis from bile or NSAIDs, a type of gastritis."
 },
 {
  "term": "reduced ability to walk",
  "canonical": "Reduced ability to walk",
  "outcomes": [],
  "reason": "The preferred term for this phrase cannot be told with confidence (gait disturbance or mobility decreased), so the term is kept; it meets no outcome."
 },
 {
  "term": "renal perivascular epithelioid cell tumour",
  "canonical": "Perivascular epithelioid cell tumour",
  "outcomes": [],
  "reason": "This is a site-qualified variant of Perivascular epithelioid cell tumour, mostly benign (angiomyolipoma) and not stated as malignant."
 },
 {
  "term": "retinal vein occlusion",
  "canonical": "Retinal vein occlusion",
  "outcomes": [
   "A12"
  ],
  "reason": "Retinal vein occlusion is thrombosis of the retinal vein, a venous thrombosis of a named site, and it is in the narrow venous thrombotic SMQ."
 },
 {
  "term": "retinopathy",
  "canonical": "Retinopathy",
  "outcomes": [
   "B04"
  ],
  "reason": "In trials of diabetes drugs, an unqualified retinopathy reported as a serious event is diabetic retinopathy in the large majority."
 },
 {
  "term": "retinopathy haemorrhagic",
  "canonical": "Retinopathy haemorrhagic",
  "outcomes": [
   "B04"
  ],
  "reason": "In these diabetic trial populations, haemorrhagic retinopathy is in the large majority diabetic retinopathy."
 },
 {
  "term": "schizophrenia simple",
  "canonical": "Schizophrenia simple",
  "outcomes": [
   "A07"
  ],
  "reason": "It cannot be told that MedDRA folded this subtype into Schizophrenia, so the term is kept; it is a psychotic disorder."
 },
 {
  "term": "schizophrenia, paranoid type",
  "canonical": "Schizophrenia, paranoid type",
  "outcomes": [
   "A07"
  ],
  "reason": "Schizophrenia, paranoid type has its own MedDRA preferred term, so it is kept, and it is a psychotic disorder."
 },
 {
  "term": "seizure like phenomena",
  "canonical": "Seizure like phenomena",
  "outcomes": [],
  "reason": "This term exists for seizure-like events where a seizure is not established (e.g. convulsive syncope or non-epileptic attacks), so it is not a seizure in the large majority."
 },
 {
  "term": "septic embolus",
  "canonical": "Septic embolus",
  "outcomes": [
   "A18",
   "A20"
  ],
  "reason": "Septic emboli travel in the blood from an infected focus (usually endocarditis), so they mean a bacteraemic bacterial infection, though usually not a venous one."
 },
 {
  "term": "septic pulmonary embolism",
  "canonical": "Septic pulmonary embolism",
  "outcomes": [
   "A12",
   "A13",
   "A18",
   "A20"
  ],
  "reason": "Septic pulmonary embolism is an embolism to the pulmonary arteries (ICD I26), usually from septic thrombophlebitis or right-sided endocarditis, with bacteraemia."
 },
 {
  "term": "serum amylase increased",
  "canonical": "Amylase increased",
  "outcomes": [],
  "reason": "Serum amylase increased is a lowest-level term of Amylase increased, which A49 excludes as raised pancreatic enzymes."
 },
 {
  "term": "shock haemorrhagic",
  "canonical": "Shock haemorrhagic",
  "outcomes": [],
  "reason": "Shock haemorrhagic is itself the MedDRA preferred term in MedDRA's word order, and A40 excludes shock."
 },
 {
  "term": "signet-ring cell carcinoma",
  "canonical": "Signet-ring cell carcinoma",
  "outcomes": [
   "B06",
   "B07"
  ],
  "reason": "Signet-ring cell carcinoma arises in the large majority in the stomach, colorectum, breast or pancreas, all obesity-associated sites."
 },
 {
  "term": "somatic delusion",
  "canonical": "Somatic delusion",
  "outcomes": [
   "A07"
  ],
  "reason": "A delusion is a psychotic symptom by definition, and somatic type is a recognised subtype of delusional disorder."
 },
 {
  "term": "stoma obstruction",
  "canonical": "Stoma obstruction",
  "outcomes": [
   "B02"
  ],
  "reason": "Stoma obstruction is in the large majority blockage of an ileostomy or colostomy, i.e. bowel obstruction at the stoma."
 },
 {
  "term": "stroke",
  "canonical": "Cerebrovascular accident",
  "outcomes": [],
  "reason": "Stroke is a lowest-level term of Cerebrovascular accident; stroke is a cardiometabolic outcome left out of the codebook."
 },
 {
  "term": "subacute pancreatitis",
  "canonical": "Pancreatitis",
  "outcomes": [
   "A49"
  ],
  "reason": "Subacute pancreatitis is a variant of Pancreatitis, not chronic pancreatitis."
 },
 {
  "term": "suspected drug-induced liver injury",
  "canonical": "Drug-induced liver injury",
  "outcomes": [],
  "reason": "'Suspected' is a qualifier on the preferred term Drug-induced liver injury, which is not hepatic failure."
 },
 {
  "term": "temporal arteritis",
  "canonical": "Giant cell arteritis",
  "outcomes": [],
  "reason": "Temporal arteritis is a lowest-level term of Giant cell arteritis, which only sometimes causes ischaemic optic neuropathy."
 },
 {
  "term": "terminal ileitis",
  "canonical": "Ileitis",
  "outcomes": [
   "A37"
  ],
  "reason": "Terminal ileitis is a site-qualified variant of Ileitis, which A37 includes."
 },
 {
  "term": "thalassaemia beta",
  "canonical": "Thalassaemia beta",
  "outcomes": [
   "A28"
  ],
  "reason": "Beta thalassaemia is a hereditary anaemia (ICD classes it among the haemolytic anaemias), and as a serious event it is an anaemia."
 },
 {
  "term": "third degree chemical burn of skin",
  "canonical": "Chemical burn of skin",
  "outcomes": [],
  "reason": "Third-degree chemical burn of skin is a severity-qualified variant of Chemical burn of skin."
 },
 {
  "term": "tick-borne fever",
  "canonical": "Tick-borne fever",
  "outcomes": [
   "A18"
  ],
  "reason": "Tick-borne febrile illnesses are bacterial in the large majority (rickettsial spotted fevers, anaplasmosis, ehrlichiosis, borrelial relapsing fever)."
 },
 {
  "term": "torn muscle",
  "canonical": "Muscle rupture",
  "outcomes": [],
  "reason": "Torn muscle is a lowest-level term of Muscle rupture, an injury that is not myalgia."
 },
 {
  "term": "transient epileptic amnesia",
  "canonical": "Transient epileptic amnesia",
  "outcomes": [
   "A08"
  ],
  "reason": "Transient epileptic amnesia is a form of temporal lobe epilepsy; its amnesic attacks are ictal, acute states like those A09 leaves out, not a neurocognitive disorder."
 },
 {
  "term": "transient global amnesia",
  "canonical": "Transient global amnesia",
  "outcomes": [],
  "reason": "Transient global amnesia is a benign, self-limiting episode that ICD files with transient ischaemic attacks, an acute transient state rather than a neurocognitive disorder."
 },
 {
  "term": "unilateral carpal tunnel syndrome",
  "canonical": "Carpal tunnel syndrome",
  "outcomes": [],
  "reason": "Unilateral carpal tunnel syndrome is a lowest-level variant of Carpal tunnel syndrome."
 },
 {
  "term": "unilateral renal artery stenosis",
  "canonical": "Renal artery stenosis",
  "outcomes": [],
  "reason": "Unilateral renal artery stenosis is a lowest-level variant of Renal artery stenosis."
 },
 {
  "term": "unstable angina",
  "canonical": "Angina unstable",
  "outcomes": [],
  "reason": "Unstable angina is a lowest-level term of the preferred term Angina unstable."
 },
 {
  "term": "upper airway resistance syndrome",
  "canonical": "Upper airway resistance syndrome",
  "outcomes": [
   "A42"
  ],
  "reason": "Upper airway resistance syndrome is a sleep-related breathing disorder, classed with obstructive sleep apnoea."
 },
 {
  "term": "upper respiratory infection",
  "canonical": "Upper respiratory tract infection",
  "outcomes": [],
  "reason": "Upper respiratory infection is a lowest-level term of Upper respiratory tract infection, which A21 excludes and which is mostly viral."
 },
 {
  "term": "uremia",
  "canonical": "Azotaemia",
  "outcomes": [],
  "reason": "Uraemia is a lowest-level term of Azotaemia in MedDRA and is not specific to acute kidney injury."
 },
 {
  "term": "urine output decreased",
  "canonical": "Urine output decreased",
  "outcomes": [
   "A17"
  ],
  "reason": "Decreased urine output is oliguria by another name, which A17 includes."
 },
 {
  "term": "vascular disorders",
  "canonical": "Vascular disorder",
  "outcomes": [],
  "reason": "This SOC-name catch-all maps to the nonspecific preferred term Vascular disorder."
 },
 {
  "term": "vasovagal syncope",
  "canonical": "Syncope",
  "outcomes": [
   "A41"
  ],
  "reason": "Vasovagal syncope is a lowest-level term of Syncope."
 }
]