[
  {
    "from": "prereg:00d6ad71ed95f896d1985eb52c9618d18239d238a5b3296203bbd1fe6b14ee54",
    "kind": "unstated",
    "detail": "For the annotated-pathway normalization sensitivity, exclude triples containing a sample with a zero annotated-pathway denominator, because normalization is undefined. Original-CPM primary analysis is unchanged; five CD candidate triples are excluded by this rule after time eligibility.",
    "claims": [
      "C1"
    ]
  },
  {
    "from": "prereg:00d6ad71ed95f896d1985eb52c9618d18239d238a5b3296203bbd1fe6b14ee54",
    "kind": "unstated",
    "detail": "After finding all-zero response signatures, add an explicitly illustrative one-sided 95% exact zero-success upper bound for one first qualifying event per participant, under independent common-probability Bernoulli sampling. This is not an interval for the preregistered participant-weighted mean. Retain and flag the degenerate nonparametric bootstrap interval rather than interpreting it as certainty.",
    "claims": [
      "C1"
    ]
  },
  {
    "from": "prereg:00d6ad71ed95f896d1985eb52c9618d18239d238a5b3296203bbd1fe6b14ee54",
    "kind": "unstated",
    "detail": "For non-overlapping triples, greedily retain the earliest triple classified as sustained decline or stable, then skip overlapping triples; other-class triples do not consume visits. In the observed primary event set this changes no decline episode.",
    "claims": [
      "C1"
    ]
  }
]