[
  {
    "local_id": "C1",
    "type": "empirical",
    "core": true,
    "statement": "Under de novo mutation without pre-existing resistance, continuous maximum tolerated dose therapy achieves complete stochastic clonal eradication in 96.6% of simulated tumors, whereas adaptive therapy achieves 0.0% eradications and incurs progression across all trials due to mutational influx during treatment holidays.",
    "evidence": [
      {
        "result": "R1.cure_rate_continuous_pct",
        "produced_by": "code/run.py",
        "tolerance": 0.01
      },
      {
        "result": "R1.cure_rate_adaptive_pct",
        "produced_by": "code/run.py",
        "tolerance": 0.01
      }
    ],
    "depends_on": [],
    "confidence": 1.0
  },
  {
    "local_id": "C2",
    "type": "empirical",
    "core": true,
    "statement": "In the presence of 2.0% pre-existing resistant cells at baseline, adaptive therapy prolongs mean time to progression from 68.6 days to 74.8 days while reducing cumulative drug exposure by 18.1% compared to continuous therapy.",
    "evidence": [
      {
        "result": "R2.ttp_continuous_days",
        "produced_by": "code/run.py",
        "tolerance": 0.01
      },
      {
        "result": "R2.ttp_adaptive_days",
        "produced_by": "code/run.py",
        "tolerance": 0.01
      },
      {
        "result": "R2.dose_reduction_pct",
        "produced_by": "code/run.py",
        "tolerance": 0.01
      }
    ],
    "depends_on": [],
    "confidence": 1.0
  },
  {
    "local_id": "C3",
    "type": "empirical",
    "core": true,
    "statement": "Across deterministic competitive dynamics, the time-to-progression ratio of adaptive relative to continuous therapy contracts from 1.11 at a resistant fitness cost of 0.20 to 1.09 at zero fitness cost, confirming that carrying-capacity crowding alone provides only modest progression delay in the absence of a competitive proliferation penalty.",
    "evidence": [
      {
        "result": "R3.ttp_ratio_cost_20",
        "produced_by": "code/run.py",
        "tolerance": 0.01
      },
      {
        "result": "R3.ttp_ratio_cost_00",
        "produced_by": "code/run.py",
        "tolerance": 0.01
      }
    ],
    "depends_on": [],
    "confidence": 1.0
  }
]