{
  "harness": "sj-harness 0.6.0",
  "job": "job:778c7ace88a7f3978f2d4ebbab877da7",
  "kind": "methods_review",
  "bundle": "sha256:eb8f71de6dd7a26acb758afdc9fad72338405cf0489a62461fa9fe09b4df6cdb",
  "claims": [
    {
      "local_id": "C1",
      "claim_id": "claim:cf22781ed6f3524b5be231efc7129faab11feb0c53acc86645de9f658879a8d7",
      "verdict": "sound",
      "significance": "known",
      "reason": "Eligibility and counts traceable; positive controls behave as expected; MH estimates reproduce."
    },
    {
      "local_id": "C2",
      "claim_id": "claim:b6e575472f620a2e50b72a6f649969ae2def61c71af18200a9afbd443d9d06cf",
      "verdict": "minor_issues",
      "significance": "moderate",
      "reason": "Recomputed MH RRs match (A18 0.878, A21 0.868); robust per registered rule and halves. On-treatment AE collection with more drug discontinuation could bias toward fewer events on drug; should be bounded or stated in the claim."
    },
    {
      "local_id": "C3",
      "claim_id": "claim:70fab88d29c1fe055fc6504ec67780a5b3a01a028dd861b6b0efce3be2058053",
      "verdict": "sound",
      "significance": "minor",
      "reason": "Discovery/replication split by seeded size-paired halves with BH in discovery; follows registered method."
    },
    {
      "local_id": "C4",
      "claim_id": "claim:bf4636e8fb9dc1ccc97cd9d033debab9fb5237048a2bcfae929d12528ead5a7f",
      "verdict": "minor_issues",
      "significance": "moderate",
      "reason": "Categories applied as registered with blind power; 'confirm' means significance in direction, not magnitude agreement, which should be stated."
    },
    {
      "local_id": "C5",
      "claim_id": "claim:7fca5e4a9907984359ec9a59ef37d973e85eb8f01eedaf148032c109d997e84d",
      "verdict": "minor_issues",
      "significance": "moderate",
      "reason": "RR 1.13 (0.92-1.38) recomputes, but compares any-cause pancreatitis RR with the atlas's drug-induced pancreatitis HR; the claim should name the definitional difference."
    },
    {
      "local_id": "C6",
      "claim_id": "claim:a38d2107c0d790a3c5624868ecdd48d7d7bb171f2df75e2eebb34d37d15f54b9",
      "verdict": "minor_issues",
      "significance": "known",
      "reason": "Death 0.87 recomputes; limited to comparisons reporting deaths in every group, and any-SAE 0.96 is sensitive to differential observation time."
    },
    {
      "local_id": "C7",
      "claim_id": "claim:e08ef7977c9117522a6df0b3f5ca9781f8f81b59754c49fd030fcd8565189231",
      "verdict": "sound",
      "significance": "minor",
      "reason": "Cancer estimates reproduce; thyroid signal correctly presented as nominal and not robust."
    },
    {
      "local_id": "C8",
      "claim_id": "claim:56c1ee2f2b437cdac68aa1a900733e4f0d6ece8eee3bd048f6de5d963855927b",
      "verdict": "minor_issues",
      "significance": "minor",
      "reason": "Ileus 1.03 (0.82-1.28) supports no detected increase, not absence; should state the excluded size. Optic neuropathy correctly called too rare."
    }
  ]
}