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"hi": 1.45799, "lo": 0.58258, "log_rr": -0.0816152, "p": 0.727276, "placebo_affected": 38, "placebo_at_risk": 35018, "rr": 0.921627, "se": 0.234021, "strata_with_events": 7, "z": -0.348751 }, "discovery_q": 0.917541, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 1.27049, "lo": 0.354825, "log_rr": -0.398362, "p": 0.220865, "placebo_affected": 23, "placebo_at_risk": 32526, "rr": 0.671419, "se": 0.325398, "strata_with_events": 6, "z": -1.22423 } }, "Acute respiratory distress syndrome": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.46552, "lo": 0.256586, "log_rr": -0.489042, "p": 0.271269, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 0.613214, "se": 0.444524, "strata_with_events": 8, "z": -1.10015 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 1.73767, "lo": 0.268302, "log_rr": -0.381548, "p": 0.423373, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 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"Adenocarcinoma pancreas": { "all": { "glp1_affected": 23, "glp1_at_risk": 93765, "hi": 2.39186, "lo": 0.680125, "log_rr": 0.243297, "p": 0.448222, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 1.27545, "se": 0.32081, "strata_with_events": 13, "z": 0.758383 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 2.29025, "lo": 0.506572, "log_rr": 0.0742865, "p": 0.846954, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 1.07712, "se": 0.384892, "strata_with_events": 7, "z": 0.193006 }, "discovery_q": 0.943906, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 6.01448, "lo": 0.581738, "log_rr": 0.626218, "p": 0.293319, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.87052, "se": 0.595905, "strata_with_events": 6, "z": 1.05087 } }, "Alanine aminotransferase increased": { "all": { "glp1_affected": 7, "glp1_at_risk": 93765, "hi": 1.2735, "lo": 0.186679, "log_rr": -0.718295, 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0.32637, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 7.9886, "lo": 0.129767, "log_rr": 0.0180004, "p": 0.986336, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 1.01816, "se": 1.05105, "strata_with_events": 5, "z": 0.0171261 } }, "Anaphylactic reaction": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 1.49414, "lo": 0.292926, "log_rr": -0.413143, "p": 0.320257, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 0.661567, "se": 0.415666, "strata_with_events": 16, "z": -0.99393 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 1.84891, "lo": 0.214561, "log_rr": -0.462282, "p": 0.40014, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 0.629845, "se": 0.549438, "strata_with_events": 9, "z": -0.841372 }, "discovery_q": 0.772315, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 2.46456, "lo": 0.203814, "log_rr": -0.344266, "p": 0.588225, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.70874, "se": 0.635869, "strata_with_events": 7, "z": -0.541411 } }, "Angina pectoris": { "all": { "glp1_affected": 504, "glp1_at_risk": 93765, "hi": 1.00513, "lo": 0.787674, "log_rr": -0.116776, "p": 0.0604272, "placebo_affected": 537, "placebo_at_risk": 67544, "rr": 0.889784, "se": 0.0621924, "strata_with_events": 39, "z": -1.87766 }, "discovered": false, "discovery": { "glp1_affected": 336, "glp1_at_risk": 47388, "hi": 1.01203, "lo": 0.755491, "log_rr": -0.134213, "p": 0.0719278, "placebo_affected": 380, "placebo_at_risk": 35018, "rr": 0.874404, "se": 0.0745802, "strata_with_events": 18, "z": -1.79957 }, "discovery_q": 0.517062, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 168, "glp1_at_risk": 46377, "hi": 1.15452, "lo": 0.742194, "log_rr": -0.0772286, "p": 0.493236, "placebo_affected": 157, "placebo_at_risk": 32526, "rr": 0.925678, "se": 0.112714, "strata_with_events": 21, "z": -0.685171 } }, "Angina unstable": { "all": { "glp1_affected": 588, "glp1_at_risk": 93765, "hi": 0.953581, "lo": 0.763442, "log_rr": -0.158725, "p": 0.00514577, "placebo_affected": 647, "placebo_at_risk": 67544, "rr": 0.853231, "se": 0.0567326, "strata_with_events": 49, "z": -2.79776 }, "discovered": false, "discovery": { "glp1_affected": 450, "glp1_at_risk": 47388, "hi": 1.0121, "lo": 0.785589, "log_rr": -0.114648, "p": 0.0760819, "placebo_affected": 494, "placebo_at_risk": 35018, "rr": 0.89168, "se": 0.0646308, "strata_with_events": 26, "z": -1.77389 }, "discovery_q": 0.517062, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 138, "glp1_at_risk": 46377, "hi": 0.929307, "lo": 0.583219, "log_rr": -0.306254, "p": 0.00997054, "placebo_affected": 153, "placebo_at_risk": 32526, "rr": 0.7362, "se": 0.118848, "strata_with_events": 23, "z": -2.57685 } }, "Angioedema": { "all": { "glp1_affected": 25, "glp1_at_risk": 93765, "hi": 1.49239, "lo": 0.474565, "log_rr": -0.172489, "p": 0.555096, "placebo_affected": 25, "placebo_at_risk": 67544, "rr": 0.841568, "se": 0.292284, "strata_with_events": 18, "z": -0.590141 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 1.42774, "lo": 0.252244, "log_rr": -0.510632, "p": 0.248207, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 0.600116, "se": 0.442215, "strata_with_events": 5, "z": -1.15472 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 17, "glp1_at_risk": 46377, "hi": 2.39551, "lo": 0.504551, "log_rr": 0.0947561, "p": 0.811528, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 1.09939, "se": 0.397376, "strata_with_events": 13, "z": 0.238455 } }, "Angioplasty": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 1.65926, "lo": 0.354809, "log_rr": -0.2649, "p": 0.500842, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 0.767282, "se": 0.393515, 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0.351214, "log_rr": -0.519198, "p": 0.0535627, "placebo_affected": 37, "placebo_at_risk": 35018, "rr": 0.594998, "se": 0.268965, "strata_with_events": 17, "z": -1.93036 }, "discovery_q": 0.507552, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 46, "glp1_at_risk": 46377, "hi": 1.27867, "lo": 0.576266, "log_rr": -0.152682, "p": 0.452691, "placebo_affected": 46, "placebo_at_risk": 32526, "rr": 0.858403, "se": 0.203322, "strata_with_events": 16, "z": -0.750936 } }, "Anxiety": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 3.01332, "lo": 0.651049, "log_rr": 0.336936, "p": 0.388688, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 1.40065, "se": 0.390878, "strata_with_events": 13, "z": 0.861999 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 4.0665, "lo": 0.661451, "log_rr": 0.494731, "p": 0.285591, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.64006, "se": 0.463299, "strata_with_events": 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"strata_with_events": 5, "z": 1.22756 } }, "Aortic stenosis": { "all": { "glp1_affected": 59, "glp1_at_risk": 93765, "hi": 1.39495, "lo": 0.676078, "log_rr": -0.0292941, "p": 0.874032, "placebo_affected": 58, "placebo_at_risk": 67544, "rr": 0.971131, "se": 0.184776, "strata_with_events": 17, "z": -0.158539 }, "discovered": false, "discovery": { "glp1_affected": 22, "glp1_at_risk": 47388, "hi": 1.15182, "lo": 0.387046, "log_rr": -0.403933, "p": 0.146528, "placebo_affected": 32, "placebo_at_risk": 35018, "rr": 0.667689, "se": 0.278209, "strata_with_events": 8, "z": -1.4519 }, "discovery_q": 0.630071, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 37, "glp1_at_risk": 46377, "hi": 2.19628, "lo": 0.811887, "log_rr": 0.289187, "p": 0.25466, "placebo_affected": 26, "placebo_at_risk": 32526, "rr": 1.33534, "se": 0.253872, "strata_with_events": 9, "z": 1.1391 } }, "Aortic valve incompetence": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 2.08031, "lo": 0.38237, "log_rr": -0.114425, "p": 0.791164, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 0.891879, "se": 0.432121, "strata_with_events": 8, "z": -0.2648 }, "discovered": false, "discovery": { "glp1_affected": 4, "glp1_at_risk": 47388, "hi": 1.58753, "lo": 0.149311, "log_rr": -0.719775, "p": 0.23265, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.486862, "se": 0.603048, "strata_with_events": 5, "z": -1.19356 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 7.99703, "lo": 0.500694, "log_rr": 0.693654, "p": 0.326434, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.00101, "se": 0.706858, "strata_with_events": 3, "z": 0.981321 } }, "Aortic valve stenosis": { "all": { "glp1_affected": 56, "glp1_at_risk": 93765, "hi": 1.53763, "lo": 0.714656, "log_rr": 0.0471461, "p": 0.809398, "placebo_affected": 51, "placebo_at_risk": 67544, "rr": 1.04828, "se": 0.195462, "strata_with_events": 12, "z": 0.241203 }, "discovered": false, "discovery": { "glp1_affected": 40, "glp1_at_risk": 47388, "hi": 1.53617, "lo": 0.633699, "log_rr": -0.0134452, "p": 0.952537, "placebo_affected": 39, "placebo_at_risk": 35018, "rr": 0.986645, "se": 0.22589, "strata_with_events": 7, "z": -0.0595209 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 2.69515, "lo": 0.580046, "log_rr": 0.223403, "p": 0.568613, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 1.25032, "se": 0.39187, "strata_with_events": 5, "z": 0.570095 } }, "Appendicitis": { "all": { "glp1_affected": 111, "glp1_at_risk": 93765, "hi": 1.54907, "lo": 0.843898, "log_rr": 0.133966, "p": 0.387261, "placebo_affected": 73, "placebo_at_risk": 67544, "rr": 1.14335, "se": 0.154947, "strata_with_events": 52, "z": 0.864595 }, "discovered": false, "discovery": { "glp1_affected": 68, "glp1_at_risk": 47388, "hi": 1.68353, "lo": 0.778721, "log_rr": 0.135395, "p": 0.491212, "placebo_affected": 45, "placebo_at_risk": 35018, "rr": 1.14499, "se": 0.196686, "strata_with_events": 28, "z": 0.688382 }, "discovery_q": 0.804653, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 43, "glp1_at_risk": 46377, "hi": 1.86761, "lo": 0.696758, "log_rr": 0.131672, "p": 0.600636, "placebo_affected": 28, "placebo_at_risk": 32526, "rr": 1.14073, "se": 0.251529, "strata_with_events": 24, "z": 0.523486 } }, "Appendicitis perforated": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 2.02591, "lo": 0.42929, "log_rr": -0.0698006, "p": 0.860029, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 0.93258, "se": 0.395835, "strata_with_events": 12, "z": -0.176338 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 1.61578, "lo": 0.283601, "log_rr": -0.390185, "p": 0.379391, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 0.676932, "se": 0.443887, 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4.11074, "lo": 0.507813, "log_rr": 0.367981, "p": 0.490345, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 1.44481, "se": 0.533491, "strata_with_events": 6, "z": 0.689759 } }, "B-cell lymphoma": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 1.94312, "lo": 0.422414, "log_rr": -0.0987366, "p": 0.799789, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 0.905981, "se": 0.389309, "strata_with_events": 11, "z": -0.25362 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 2.73095, "lo": 0.25443, "log_rr": -0.182041, "p": 0.763672, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.833567, "se": 0.605465, "strata_with_events": 5, "z": -0.300662 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 2.60342, "lo": 0.354242, "log_rr": -0.040476, "p": 0.936598, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.960332, "se": 0.508836, "strata_with_events": 6, "z": -0.0795463 } }, "Back pain": { "all": { "glp1_affected": 104, "glp1_at_risk": 93765, "hi": 1.03911, "lo": 0.604841, "log_rr": -0.232211, "p": 0.0925605, "placebo_affected": 114, "placebo_at_risk": 67544, "rr": 0.792779, "se": 0.138053, "strata_with_events": 35, "z": -1.68204 }, "discovered": false, "discovery": { "glp1_affected": 57, "glp1_at_risk": 47388, "hi": 0.902193, "lo": 0.449489, "log_rr": -0.451286, "p": 0.011115, "placebo_affected": 77, "placebo_at_risk": 35018, "rr": 0.636809, "se": 0.177737, "strata_with_events": 20, "z": -2.53906 }, "discovery_q": 0.27584, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 47, "glp1_at_risk": 46377, "hi": 1.74218, "lo": 0.72243, "log_rr": 0.115002, "p": 0.608571, "placebo_affected": 37, "placebo_at_risk": 32526, "rr": 1.12188, "se": 0.224564, "strata_with_events": 15, "z": 0.512115 } }, "Bacteraemia": { "all": { "glp1_affected": 20, "glp1_at_risk": 93765, "hi": 1.24154, "lo": 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"strata_with_events": 17, "z": -0.625734 }, "discovered": false, "discovery": { "glp1_affected": 42, "glp1_at_risk": 47388, "hi": 1.21477, "lo": 0.535167, "log_rr": -0.215312, "p": 0.303191, "placebo_affected": 51, "placebo_at_risk": 35018, "rr": 0.80629, "se": 0.209119, "strata_with_events": 9, "z": -1.02961 }, "discovery_q": 0.739916, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 42, "glp1_at_risk": 46377, "hi": 1.62169, "lo": 0.67158, "log_rr": 0.0426738, "p": 0.849508, "placebo_affected": 39, "placebo_at_risk": 32526, "rr": 1.0436, "se": 0.2249, "strata_with_events": 8, "z": 0.189746 } }, "Benign prostatic hyperplasia": { "all": { "glp1_affected": 128, "glp1_at_risk": 93765, "hi": 1.49845, "lo": 0.895541, "log_rr": 0.147053, "p": 0.262791, "placebo_affected": 107, "placebo_at_risk": 67544, "rr": 1.15842, "se": 0.131319, "strata_with_events": 20, "z": 1.11982 }, "discovered": false, "discovery": { "glp1_affected": 83, "glp1_at_risk": 47388, "hi": 1.74178, "lo": 0.907392, "log_rr": 0.228862, "p": 0.168891, "placebo_affected": 65, "placebo_at_risk": 35018, "rr": 1.25717, "se": 0.166351, "strata_with_events": 9, "z": 1.37578 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 45, "glp1_at_risk": 46377, "hi": 1.53708, "lo": 0.662475, "log_rr": 0.00905629, "p": 0.966356, "placebo_affected": 42, "placebo_at_risk": 32526, "rr": 1.0091, "se": 0.214712, "strata_with_events": 11, "z": 0.0421787 } }, "Bile duct stone": { "all": { "glp1_affected": 56, "glp1_at_risk": 93765, "hi": 2.34439, "lo": 0.986184, "log_rr": 0.419057, "p": 0.0578297, "placebo_affected": 34, "placebo_at_risk": 67544, "rr": 1.52053, "se": 0.220906, "strata_with_events": 18, "z": 1.89699 }, "discovered": false, "discovery": { "glp1_affected": 38, "glp1_at_risk": 47388, "hi": 3.50108, "lo": 1.10827, "log_rr": 0.677935, "p": 0.0208725, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 1.96981, "se": 0.293442, "strata_with_events": 11, "z": 2.31028 }, "discovery_q": 0.32637, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 18, "glp1_at_risk": 46377, "hi": 2.02561, "lo": 0.524168, "log_rr": 0.0299647, "p": 0.930759, "placebo_affected": 16, "placebo_at_risk": 32526, "rr": 1.03042, "se": 0.344857, "strata_with_events": 7, "z": 0.0868903 } }, "Biliary colic": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 5.88104, "lo": 0.864871, "log_rr": 0.813279, "p": 0.0962938, "placebo_affected": 6, "placebo_at_risk": 67544, "rr": 2.25529, "se": 0.489016, "strata_with_events": 11, "z": 1.66309 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 9.91654, "lo": 0.603454, "log_rr": 0.894559, "p": 0.210323, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 2.44626, "se": 0.714118, "strata_with_events": 5, "z": 1.25268 }, "discovery_q": 0.709325, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 7.75274, "lo": 0.559883, "log_rr": 0.73401, "p": 0.273596, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.08342, "se": 0.670439, "strata_with_events": 6, "z": 1.09482 } }, "Bladder cancer": { "all": { "glp1_affected": 33, "glp1_at_risk": 93765, "hi": 1.04557, "lo": 0.429494, "log_rr": -0.400294, "p": 0.0777919, "placebo_affected": 46, "placebo_at_risk": 67544, "rr": 0.670123, "se": 0.22697, "strata_with_events": 16, "z": -1.76364 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 1.14454, "lo": 0.279488, "log_rr": -0.569896, "p": 0.11306, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 0.565584, "se": 0.359649, "strata_with_events": 7, "z": -1.58459 }, "discovery_q": 0.582075, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 21, "glp1_at_risk": 46377, "hi": 1.34156, "lo": 0.424248, "log_rr": -0.281803, "p": 0.337303, "placebo_affected": 25, "placebo_at_risk": 32526, "rr": 0.754422, "se": 0.293696, "strata_with_events": 9, "z": -0.959508 } }, "Bladder neoplasm": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 1.31812, "lo": 0.258679, "log_rr": -0.537981, "p": 0.195299, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.583926, "se": 0.415409, "strata_with_events": 11, "z": -1.29506 }, "discovered": false, "discovery": { "glp1_affected": 3, "glp1_at_risk": 47388, "hi": 1.91599, "lo": 0.103166, "log_rr": -0.81059, "p": 0.276791, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.444596, "se": 0.745332, "strata_with_events": 5, "z": -1.08756 }, "discovery_q": 0.724555, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 1.78995, "lo": 0.248967, "log_rr": -0.404124, "p": 0.421939, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.667561, "se": 0.503228, "strata_with_events": 6, "z": -0.803063 } }, "Bladder transitional cell carcinoma": { "all": { "glp1_affected": 41, "glp1_at_risk": 93765, "hi": 1.26136, "lo": 0.541952, "log_rr": -0.190196, "p": 0.377475, "placebo_affected": 48, "placebo_at_risk": 67544, "rr": 0.826797, "se": 0.215505, "strata_with_events": 11, "z": -0.882558 }, "discovered": false, "discovery": { "glp1_affected": 27, "glp1_at_risk": 47388, "hi": 1.40795, "lo": 0.505989, "log_rr": -0.169551, "p": 0.516049, "placebo_affected": 32, "placebo_at_risk": 35018, "rr": 0.844043, "se": 0.26107, "strata_with_events": 5, "z": -0.649447 }, "discovery_q": 0.831308, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 14, "glp1_at_risk": 46377, "hi": 1.67435, "lo": 0.374905, "log_rr": -0.232829, "p": 0.541949, "placebo_affected": 16, "placebo_at_risk": 32526, "rr": 0.792289, "se": 0.381769, "strata_with_events": 6, "z": -0.609868 } }, "Blood creatinine increased": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 3.23858, "lo": 0.567765, "log_rr": 0.304543, "p": 0.492953, "placebo_affected": 9, "placebo_at_risk": 67544, "rr": 1.35601, "se": 0.444187, "strata_with_events": 11, "z": 0.68562 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 8.48696, "lo": 0.837849, "log_rr": 0.980807, "p": 0.0968235, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 2.66661, "se": 0.590686, "strata_with_events": 6, "z": 1.66045 }, "discovery_q": 0.567738, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 2, "glp1_at_risk": 46377, "hi": 1.93955, "lo": 0.0488532, "log_rr": -1.17824, "p": 0.209629, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 0.30782, "se": 0.939147, "strata_with_events": 5, "z": -1.25459 } }, "Blood glucose increased": { "all": { "glp1_affected": 16, "glp1_at_risk": 93765, "hi": 1.37817, "lo": 0.380163, "log_rr": -0.323201, "p": 0.325261, "placebo_affected": 21, "placebo_at_risk": 67544, "rr": 0.723829, "se": 0.328555, "strata_with_events": 7, "z": -0.983704 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 1.32805, "lo": 0.260075, "log_rr": -0.531537, "p": 0.201291, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.587701, "se": 0.415951, "strata_with_events": 4, "z": -1.27788 }, "discovery_q": 0.68333, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 3.09406, "lo": 0.358494, "log_rr": 0.0518215, "p": 0.924912, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 1.05319, "se": 0.549839, "strata_with_events": 3, "z": 0.0942486 } }, "Bowen's disease": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 2.19686, "lo": 0.432352, "log_rr": -0.0257442, "p": 0.950498, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 0.974584, "se": 0.414687, "strata_with_events": 7, "z": -0.0620809 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 2.16223, "lo": 0.302947, "log_rr": -0.211529, "p": 0.673097, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 0.809346, "se": 0.501371, "strata_with_events": 4, "z": -0.421902 }, "discovery_q": 0.897462, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 6.53197, "lo": 0.331279, "log_rr": 0.385957, "p": 0.611849, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 1.47102, "se": 0.760602, "strata_with_events": 3, "z": 0.507437 } }, "Bradycardia": { "all": { "glp1_affected": 67, "glp1_at_risk": 93765, "hi": 1.40808, "lo": 0.71734, "log_rr": 0.0050115, "p": 0.976763, "placebo_affected": 65, "placebo_at_risk": 67544, "rr": 1.00502, "se": 0.172052, "strata_with_events": 18, "z": 0.0291278 }, "discovered": false, "discovery": { "glp1_affected": 32, "glp1_at_risk": 47388, "hi": 1.38861, "lo": 0.539339, "log_rr": -0.144554, "p": 0.549063, "placebo_affected": 37, "placebo_at_risk": 35018, "rr": 0.865408, "se": 0.241259, "strata_with_events": 8, "z": -0.599165 }, "discovery_q": 0.85996, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 35, "glp1_at_risk": 46377, "hi": 1.91583, "lo": 0.727857, "log_rr": 0.16625, "p": 0.500712, "placebo_affected": 28, "placebo_at_risk": 32526, "rr": 1.18087, "se": 0.246892, "strata_with_events": 10, "z": 0.673369 } }, "Brain injury": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 5.59239, "lo": 0.873867, "log_rr": 0.793289, "p": 0.0938871, "placebo_affected": 6, "placebo_at_risk": 67544, "rr": 2.21066, "se": 0.473538, "strata_with_events": 9, "z": 1.67524 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 9.02685, "lo": 0.603446, "log_rr": 0.847553, "p": 0.219414, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 2.33393, "se": 0.690141, "strata_with_events": 4, "z": 1.22809 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 7.51756, "lo": 0.586499, "log_rr": 0.741828, "p": 0.254291, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.09977, "se": 0.650733, "strata_with_events": 5, "z": 1.13999 } }, "Brain stem infarction": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 2.08069, "lo": 0.392489, "log_rr": -0.101273, "p": 0.811875, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 0.903686, "se": 0.425505, "strata_with_events": 10, "z": -0.238007 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 1.59678, "lo": 0.230205, "log_rr": -0.500397, "p": 0.311166, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 0.60629, "se": 0.494084, "strata_with_events": 5, "z": -1.01278 }, "discovery_q": 0.739916, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 40.8164, "lo": 0.426832, "log_rr": 1.42886, "p": 0.219382, "placebo_affected": 1, "placebo_at_risk": 32526, "rr": 4.17393, "se": 1.1634, "strata_with_events": 5, "z": 1.22817 } }, "Breast cancer": { "all": { "glp1_affected": 58, "glp1_at_risk": 93765, "hi": 1.76274, "lo": 0.768092, "log_rr": 0.151512, "p": 0.474642, "placebo_affected": 39, "placebo_at_risk": 67544, "rr": 1.16359, "se": 0.211921, "strata_with_events": 31, "z": 0.714947 }, "discovered": false, "discovery": { "glp1_affected": 27, "glp1_at_risk": 47388, "hi": 2.12848, "lo": 0.619974, "log_rr": 0.138665, "p": 0.659454, "placebo_affected": 19, "placebo_at_risk": 35018, "rr": 1.14874, "se": 0.31467, "strata_with_events": 14, "z": 0.440667 }, "discovery_q": 0.890462, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 31, "glp1_at_risk": 46377, "hi": 2.06328, "lo": 0.671108, "log_rr": 0.162735, "p": 0.570048, "placebo_affected": 20, "placebo_at_risk": 32526, "rr": 1.17673, "se": 0.286516, "strata_with_events": 17, "z": 0.567981 } }, "Breast cancer female": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 2.47087, "lo": 0.601204, "log_rr": 0.197875, "p": 0.583149, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.21881, "se": 0.360566, "strata_with_events": 2, "z": 0.54879 }, "discovered": false, "discovery": { "glp1_affected": 1, "glp1_at_risk": 47388, "hi": null, "lo": null, "p": null, "placebo_affected": 0, "placebo_at_risk": 35018, "rr": null, "strata_with_events": 1 }, "discovery_q": null, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 2.34875, "lo": 0.560342, "log_rr": 0.137337, "p": 0.707172, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 1.14721, "se": 0.365591, "strata_with_events": 1, "z": 0.375657 } }, "Breast cancer metastatic": { "all": { "glp1_affected": 11, "glp1_at_risk": 93765, "hi": 2.30707, "lo": 0.364609, "log_rr": -0.0864772, "p": 0.854217, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 0.917156, "se": 0.470648, "strata_with_events": 10, "z": -0.183741 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 8.0622, "lo": 0.417317, "log_rr": 0.606639, "p": 0.421931, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 1.83426, "se": 0.755395, "strata_with_events": 6, "z": 0.803075 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.87836, "lo": 0.146177, "log_rr": -0.64627, "p": 0.321116, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.523996, "se": 0.651373, "strata_with_events": 4, "z": -0.992166 } }, "Bronchial carcinoma": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 2.96787, "lo": 0.570622, "log_rr": 0.263408, "p": 0.531177, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 1.30136, "se": 0.420639, "strata_with_events": 9, "z": 0.62621 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 5.97876, "lo": 0.512431, "log_rr": 0.559812, "p": 0.371749, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 1.75034, "se": 0.626747, "strata_with_events": 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46377, "hi": 1.0642, "lo": 0.452993, "log_rr": -0.364826, "p": 0.0940575, "placebo_affected": 47, "placebo_at_risk": 32526, "rr": 0.694317, "se": 0.217888, "strata_with_events": 14, "z": -1.67437 } }, "Bronchitis chronic": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 2.35421, "lo": 0.397873, "log_rr": -0.0327087, "p": 0.942507, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 0.96782, "se": 0.453536, "strata_with_events": 8, "z": -0.0721193 }, "discovered": false, "discovery": { "glp1_affected": 4, "glp1_at_risk": 47388, "hi": 2.97927, "lo": 0.214888, "log_rr": -0.222979, "p": 0.739565, "placebo_affected": 5, "placebo_at_risk": 35018, "rr": 0.800132, "se": 0.670756, "strata_with_events": 4, "z": -0.33243 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 3.82735, "lo": 0.336983, "log_rr": 0.127225, "p": 0.837384, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.13567, 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0.395313, "strata_with_events": 13, "z": 0.241667 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 5.31118, "lo": 0.552666, "log_rr": 0.538407, "p": 0.350978, "placebo_affected": 5, "placebo_at_risk": 35018, "rr": 1.71327, "se": 0.577259, "strata_with_events": 8, "z": 0.932695 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 2.08153, "lo": 0.223689, "log_rr": -0.382199, "p": 0.501804, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.682359, "se": 0.569042, "strata_with_events": 5, "z": -0.671653 } }, "COVID-19": { "all": { "glp1_affected": 329, "glp1_at_risk": 93765, "hi": 0.972283, "lo": 0.725155, "log_rr": -0.174739, "p": 0.019508, "placebo_affected": 375, "placebo_at_risk": 67544, "rr": 0.839676, "se": 0.074813, "strata_with_events": 21, "z": -2.33568 }, "discovered": false, "discovery": { "glp1_affected": 259, "glp1_at_risk": 47388, "hi": 1.01644, "lo": 0.729308, "log_rr": -0.149676, "p": 0.0771584, "placebo_affected": 291, "placebo_at_risk": 35018, "rr": 0.860987, "se": 0.0846864, "strata_with_events": 11, "z": -1.76742 }, "discovery_q": 0.517062, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 70, "glp1_at_risk": 46377, "hi": 1.04952, "lo": 0.560866, "log_rr": -0.26497, "p": 0.0973986, "placebo_affected": 84, "placebo_at_risk": 32526, "rr": 0.767229, "se": 0.159852, "strata_with_events": 10, "z": -1.6576 } }, "COVID-19 pneumonia": { "all": { "glp1_affected": 370, "glp1_at_risk": 93765, "hi": 0.917578, "lo": 0.695281, "log_rr": -0.224728, "p": 0.00149637, "placebo_affected": 433, "placebo_at_risk": 67544, "rr": 0.798733, "se": 0.070772, "strata_with_events": 23, "z": -3.17539 }, "discovered": false, "discovery": { "glp1_affected": 276, "glp1_at_risk": 47388, "hi": 0.905443, "lo": 0.660193, "log_rr": -0.257276, "p": 0.00141016, "placebo_affected": 342, "placebo_at_risk": 35018, "rr": 0.773154, "se": 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"placebo_affected": 609, "placebo_at_risk": 67544, "rr": 0.800583, "se": 0.0596545, "strata_with_events": 30, "z": -3.72838 }, "discovered": false, "discovery": { "glp1_affected": 330, "glp1_at_risk": 47388, "hi": 0.924315, "lo": 0.693853, "log_rr": -0.222099, "p": 0.00239991, "placebo_affected": 409, "placebo_at_risk": 35018, "rr": 0.800836, "se": 0.0731627, "strata_with_events": 16, "z": -3.03568 }, "discovery_q": 0.137595, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 172, "glp1_at_risk": 46377, "hi": 0.979127, "lo": 0.653772, "log_rr": -0.223045, "p": 0.0304121, "placebo_affected": 200, "placebo_at_risk": 32526, "rr": 0.800079, "se": 0.103038, "strata_with_events": 14, "z": -2.16468 } }, "Cardiac failure acute": { "all": { "glp1_affected": 119, "glp1_at_risk": 93765, "hi": 0.998218, "lo": 0.618842, "log_rr": -0.240845, "p": 0.048315, "placebo_affected": 148, "placebo_at_risk": 67544, "rr": 0.785964, "se": 0.121972, "strata_with_events": 15, "z": 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"log_rr": -0.0203707, "p": 0.888777, "placebo_affected": 95, "placebo_at_risk": 35018, "rr": 0.979835, "se": 0.145659, "strata_with_events": 8, "z": -0.139852 }, "discovery_q": 0.969575, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 56, "glp1_at_risk": 46377, "hi": 1.49851, "lo": 0.687708, "log_rr": 0.0150395, "p": 0.939664, "placebo_affected": 50, "placebo_at_risk": 32526, "rr": 1.01515, "se": 0.198692, "strata_with_events": 9, "z": 0.0756922 } }, "Cardiac failure congestive": { "all": { "glp1_affected": 363, "glp1_at_risk": 93765, "hi": 1.00721, "lo": 0.759112, "log_rr": -0.134211, "p": 0.0628291, "placebo_affected": 400, "placebo_at_risk": 67544, "rr": 0.874405, "se": 0.0721412, "strata_with_events": 32, "z": -1.8604 }, "discovered": false, "discovery": { "glp1_affected": 237, "glp1_at_risk": 47388, "hi": 1.09664, "lo": 0.771918, "log_rr": -0.083314, "p": 0.352316, "placebo_affected": 253, "placebo_at_risk": 35018, "rr": 0.920062, "se": 0.0895747, "strata_with_events": 16, "z": -0.930107 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 126, "glp1_at_risk": 46377, "hi": 1.01161, "lo": 0.627314, "log_rr": -0.227382, "p": 0.062145, "placebo_affected": 147, "placebo_at_risk": 32526, "rr": 0.796617, "se": 0.121903, "strata_with_events": 16, "z": -1.86526 } }, "Cardio-respiratory arrest": { "all": { "glp1_affected": 69, "glp1_at_risk": 93765, "hi": 1.43268, "lo": 0.729363, "log_rr": 0.0219806, "p": 0.898447, "placebo_affected": 65, "placebo_at_risk": 67544, "rr": 1.02222, "se": 0.17223, "strata_with_events": 16, "z": 0.127623 }, "discovered": false, "discovery": { "glp1_affected": 53, "glp1_at_risk": 47388, "hi": 1.67121, "lo": 0.757554, "log_rr": 0.117943, "p": 0.558997, "placebo_affected": 46, "placebo_at_risk": 35018, "rr": 1.12518, "se": 0.201842, "strata_with_events": 10, "z": 0.584332 }, "discovery_q": 0.866048, "overlap_bound": 1.0, "replicated": false, "replication": { 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"placebo_at_risk": 67544, "rr": 1.81084, "se": 0.354581, "strata_with_events": 11, "z": 1.67463 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 3.68622, "lo": 0.65992, "log_rr": 0.444483, "p": 0.311132, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 1.55968, "se": 0.438845, "strata_with_events": 5, "z": 1.01285 }, "discovery_q": 0.739916, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 7.67529, "lo": 0.70995, "log_rr": 0.847723, "p": 0.162747, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 2.33432, "se": 0.607298, "strata_with_events": 6, "z": 1.39589 } }, "Cognitive disorder": { "all": { "glp1_affected": 8, "glp1_at_risk": 93765, "hi": 1.09105, "lo": 0.203263, "log_rr": -0.753058, "p": 0.0789698, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 0.470924, "se": 0.428679, "strata_with_events": 8, "z": -1.75669 }, "discovered": false, "discovery": { 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"placebo_affected": 8, "placebo_at_risk": 67544, "rr": 3.18774, "se": 0.406524, "strata_with_events": 5, "z": 2.85177 }, "discovered": false, "discovery": { "glp1_affected": 21, "glp1_at_risk": 47388, "hi": 7.05541, "lo": 1.27635, "log_rr": 1.0989, "p": 0.0117563, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 3.00086, "se": 0.436179, "strata_with_events": 3, "z": 2.51938 }, "discovery_q": 0.27584, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 41.1748, "lo": 0.490855, "log_rr": 1.50311, "p": 0.183448, "placebo_affected": 1, "placebo_at_risk": 32526, "rr": 4.49565, "se": 1.12998, "strata_with_events": 2, "z": 1.33021 } }, "Completed suicide": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 3.82339, "lo": 0.640678, "log_rr": 0.447955, "p": 0.32562, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 1.56511, "se": 0.455714, "strata_with_events": 8, "z": 0.982974 }, "discovered": false, "discovery": { 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"hi": 1.04421, "lo": 0.696192, "log_rr": -0.159436, "p": 0.123152, "placebo_affected": 198, "placebo_at_risk": 67544, "rr": 0.852624, "se": 0.103417, "strata_with_events": 11, "z": -1.54168 }, "discovered": false, "discovery": { "glp1_affected": 150, "glp1_at_risk": 47388, "hi": 1.05606, "lo": 0.684221, "log_rr": -0.162463, "p": 0.142291, "placebo_affected": 173, "placebo_at_risk": 35018, "rr": 0.850047, "se": 0.110722, "strata_with_events": 7, "z": -1.46731 }, "discovery_q": 0.629158, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 23, "glp1_at_risk": 46377, "hi": 1.53507, "lo": 0.493427, "log_rr": -0.138902, "p": 0.631412, "placebo_affected": 25, "placebo_at_risk": 32526, "rr": 0.870314, "se": 0.289535, "strata_with_events": 4, "z": -0.47974 } }, "Craniocerebral injury": { "all": { "glp1_affected": 28, "glp1_at_risk": 93765, "hi": 2.12773, "lo": 0.681509, "log_rr": 0.185805, "p": 0.522344, "placebo_affected": 22, "placebo_at_risk": 67544, "rr": 1.20419, 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"lo": 1.03963, "log_rr": 0.792732, "p": 0.0393022, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 2.20942, "se": 0.384633, "strata_with_events": 10, "z": 2.06101 }, "discovery_q": 0.43697, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 13, "glp1_at_risk": 46377, "hi": 1.4626, "lo": 0.320131, "log_rr": -0.379406, "p": 0.32761, "placebo_affected": 16, "placebo_at_risk": 32526, "rr": 0.684268, "se": 0.387568, "strata_with_events": 9, "z": -0.978939 } }, "Cystocele": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 2.82656, "lo": 0.51996, "log_rr": 0.192529, "p": 0.655772, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 1.21231, "se": 0.431912, "strata_with_events": 9, "z": 0.445758 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 5.73393, "lo": 0.461494, "log_rr": 0.486558, "p": 0.449081, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 1.62671, "se": 0.642789, "strata_with_events": 4, 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46377, "hi": 1.19709, "lo": 0.576025, "log_rr": -0.185857, "p": 0.319265, "placebo_affected": 62, "placebo_at_risk": 32526, "rr": 0.830392, "se": 0.186609, "strata_with_events": 8, "z": -0.995969 } }, "Decreased appetite": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 4.75335, "lo": 0.859203, "log_rr": 0.70355, "p": 0.106914, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 2.02091, "se": 0.436386, "strata_with_events": 9, "z": 1.61222 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 7.9711, "lo": 0.784465, "log_rr": 0.916534, "p": 0.121249, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 2.50061, "se": 0.591484, "strata_with_events": 4, "z": 1.54955 }, "discovery_q": 0.596143, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 5.58198, "lo": 0.425517, "log_rr": 0.432547, "p": 0.510073, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.54118, "se": 0.656643, "strata_with_events": 5, "z": 0.658725 } }, "Decubitus ulcer": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.58236, "lo": 0.281269, "log_rr": -0.404763, "p": 0.358338, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 0.667135, "se": 0.440661, "strata_with_events": 10, "z": -0.918537 }, "discovered": false, "discovery": { "glp1_affected": 4, "glp1_at_risk": 47388, "hi": 1.44353, "lo": 0.136912, "log_rr": -0.810665, "p": 0.177314, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 0.444562, "se": 0.600905, "strata_with_events": 5, "z": -1.34907 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 4.51387, "lo": 0.302202, "log_rr": 0.155247, "p": 0.821922, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.16795, "se": 0.689761, "strata_with_events": 5, "z": 0.225074 } }, "Deep vein thrombosis": { "all": { "glp1_affected": 103, "glp1_at_risk": 93765, "hi": 1.97499, "lo": 1.06038, "log_rr": 0.369598, "p": 0.0198322, "placebo_affected": 64, "placebo_at_risk": 67544, "rr": 1.44715, "se": 0.158659, "strata_with_events": 28, "z": 2.32951 }, "discovered": false, "discovery": { "glp1_affected": 59, "glp1_at_risk": 47388, "hi": 1.82711, "lo": 0.84333, "log_rr": 0.21617, "p": 0.273069, "placebo_affected": 44, "placebo_at_risk": 35018, "rr": 1.24131, "se": 0.197232, "strata_with_events": 15, "z": 1.09602 }, "discovery_q": 0.719187, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 44, "glp1_at_risk": 46377, "hi": 3.21861, "lo": 1.11423, "log_rr": 0.638557, "p": 0.0182911, "placebo_affected": 20, "placebo_at_risk": 32526, "rr": 1.89375, "se": 0.270613, "strata_with_events": 13, "z": 2.35967 } }, "Dehydration": { "all": { "glp1_affected": 160, "glp1_at_risk": 93765, "hi": 1.76321, "lo": 1.07218, "log_rr": 0.318417, "p": 0.0121012, "placebo_affected": 106, "placebo_at_risk": 67544, "rr": 1.37495, "se": 0.126901, 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"log_rr": -1.09845, "p": 0.0570402, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 0.333389, "se": 0.577217, "strata_with_events": 3, "z": -1.903 }, "discovery_q": 0.507552, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 18, "glp1_at_risk": 46377, "hi": 1.97318, "lo": 0.527131, "log_rr": 0.019671, "p": 0.953416, "placebo_affected": 17, "placebo_at_risk": 32526, "rr": 1.01987, "se": 0.336729, "strata_with_events": 6, "z": 0.058418 } }, "Dementia": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 1.4704, "lo": 0.369798, "log_rr": -0.304633, "p": 0.386977, "placebo_affected": 19, "placebo_at_risk": 67544, "rr": 0.737394, "se": 0.352131, "strata_with_events": 7, "z": -0.865113 }, "discovered": false, "discovery": { "glp1_affected": 4, "glp1_at_risk": 47388, "hi": 1.03356, "lo": 0.107593, "log_rr": -1.09819, "p": 0.0570711, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 0.333473, "se": 0.577156, "strata_with_events": 3, "z": 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4.4663, "lo": 0.41829, "log_rr": 0.312491, "p": 0.604976, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.36683, "se": 0.604129, "strata_with_events": 8, "z": 0.517258 } }, "Depression": { "all": { "glp1_affected": 56, "glp1_at_risk": 93765, "hi": 1.13238, "lo": 0.555661, "log_rr": -0.231636, "p": 0.202162, "placebo_affected": 64, "placebo_at_risk": 67544, "rr": 0.793235, "se": 0.181616, "strata_with_events": 29, "z": -1.27542 }, "discovered": false, "discovery": { "glp1_affected": 31, "glp1_at_risk": 47388, "hi": 1.61077, "lo": 0.599786, "log_rr": -0.0172343, "p": 0.945479, "placebo_affected": 29, "placebo_at_risk": 35018, "rr": 0.982913, "se": 0.252019, "strata_with_events": 12, "z": -0.0683848 }, "discovery_q": 0.995648, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 25, "glp1_at_risk": 46377, "hi": 1.0634, "lo": 0.376094, "log_rr": -0.458224, "p": 0.0839629, "placebo_affected": 35, "placebo_at_risk": 32526, "rr": 0.632406, "se": 0.265154, "strata_with_events": 17, "z": -1.72814 } }, "Device dislocation": { "all": { "glp1_affected": 11, "glp1_at_risk": 93765, "hi": 1.12447, "lo": 0.246329, "log_rr": -0.641886, "p": 0.0974993, "placebo_affected": 19, "placebo_at_risk": 67544, "rr": 0.526299, "se": 0.387355, "strata_with_events": 8, "z": -1.6571 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 1.33278, "lo": 0.216842, "log_rr": -0.620658, "p": 0.180302, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 0.537591, "se": 0.463237, "strata_with_events": 5, "z": -1.33983 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 2.00186, "lo": 0.125478, "log_rr": -0.690775, "p": 0.328249, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.501188, "se": 0.706569, "strata_with_events": 3, "z": -0.977646 } }, "Device malfunction": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 1.77582, "lo": 0.461064, "log_rr": -0.0999778, "p": 0.771336, "placebo_affected": 18, "placebo_at_risk": 67544, "rr": 0.904858, "se": 0.344006, "strata_with_events": 11, "z": -0.290628 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 1.59544, "lo": 0.286092, "log_rr": -0.392147, "p": 0.371084, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 0.675605, "se": 0.438425, "strata_with_events": 5, "z": -0.894445 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 4.70384, "lo": 0.478843, "log_rr": 0.405998, "p": 0.486076, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.5008, "se": 0.582858, "strata_with_events": 6, "z": 0.696564 } }, "Device related infection": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 1.24147, "lo": 0.358357, "log_rr": -0.404964, "p": 0.201395, "placebo_affected": 25, "placebo_at_risk": 67544, "rr": 0.667001, "se": 0.316976, "strata_with_events": 12, "z": -1.27759 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 1.82292, "lo": 0.412752, "log_rr": -0.142235, "p": 0.707388, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.867418, "se": 0.378922, "strata_with_events": 7, "z": -0.375367 }, "discovery_q": 0.916484, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.22415, "lo": 0.109887, "log_rr": -1.00303, "p": 0.102874, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.366768, "se": 0.614948, "strata_with_events": 5, "z": -1.63108 } }, "Diabetes mellitus": { "all": { "glp1_affected": 24, "glp1_at_risk": 93765, "hi": 0.784658, "lo": 0.287138, "log_rr": -0.745151, "p": 0.00366574, "placebo_affected": 46, "placebo_at_risk": 67544, "rr": 0.474663, "se": 0.256455, "strata_with_events": 12, "z": -2.90558 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 0.862037, "lo": 0.233232, "log_rr": -0.802089, "p": 0.0161669, "placebo_affected": 29, "placebo_at_risk": 35018, "rr": 0.448391, "se": 0.333492, "strata_with_events": 5, "z": -2.40513 }, "discovery_q": 0.27974, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 11, "glp1_at_risk": 46377, "hi": 1.13587, "lo": 0.235264, "log_rr": -0.659822, "p": 0.100431, "placebo_affected": 17, "placebo_at_risk": 32526, "rr": 0.516943, "se": 0.401653, "strata_with_events": 7, "z": -1.64277 } }, "Diabetes mellitus inadequate control": { "all": { "glp1_affected": 67, "glp1_at_risk": 93765, "hi": 0.773483, "lo": 0.421745, "log_rr": -0.560104, "p": 0.000294559, "placebo_affected": 113, "placebo_at_risk": 67544, "rr": 0.57115, "se": 0.154723, "strata_with_events": 17, "z": -3.62004 }, "discovered": false, "discovery": { "glp1_affected": 46, "glp1_at_risk": 47388, "hi": 0.852735, "lo": 0.410165, "log_rr": -0.52525, "p": 0.00490522, "placebo_affected": 77, "placebo_at_risk": 35018, "rr": 0.591407, "se": 0.18671, "strata_with_events": 8, "z": -2.81319 }, "discovery_q": 0.210411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 21, "glp1_at_risk": 46377, "hi": 0.910241, "lo": 0.307654, "log_rr": -0.636413, "p": 0.0214585, "placebo_affected": 36, "placebo_at_risk": 32526, "rr": 0.529187, "se": 0.276723, "strata_with_events": 9, "z": -2.29982 } }, "Diabetic foot": { "all": { "glp1_affected": 157, "glp1_at_risk": 93765, "hi": 0.98805, "lo": 0.647144, "log_rr": -0.223605, "p": 0.0383278, "placebo_affected": 187, "placebo_at_risk": 67544, "rr": 0.799631, "se": 0.107952, "strata_with_events": 15, "z": -2.07133 }, "discovered": false, "discovery": { "glp1_affected": 97, "glp1_at_risk": 47388, "hi": 1.06345, "lo": 0.624487, "log_rr": -0.204654, "p": 0.131816, "placebo_affected": 118, "placebo_at_risk": 35018, "rr": 0.814929, "se": 0.135804, "strata_with_events": 9, "z": -1.50698 }, "discovery_q": 0.622575, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 60, "glp1_at_risk": 46377, "hi": 1.09742, "lo": 0.546283, "log_rr": -0.255829, "p": 0.150551, "placebo_affected": 69, "placebo_at_risk": 32526, "rr": 0.774275, "se": 0.177957, "strata_with_events": 6, "z": -1.43759 } }, "Diabetic foot infection": { "all": { "glp1_affected": 39, "glp1_at_risk": 93765, "hi": 1.34115, "lo": 0.555181, "log_rr": -0.147466, "p": 0.51221, "placebo_affected": 42, "placebo_at_risk": 67544, "rr": 0.862892, "se": 0.225001, "strata_with_events": 14, "z": -0.655401 }, "discovered": false, "discovery": { "glp1_affected": 24, "glp1_at_risk": 47388, "hi": 2.31138, "lo": 0.678764, "log_rr": 0.225181, "p": 0.471295, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 1.25255, "se": 0.312589, "strata_with_events": 7, "z": 0.720374 }, "discovery_q": 0.799978, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 15, "glp1_at_risk": 46377, "hi": 1.10122, "lo": 0.293239, "log_rr": -0.565176, "p": 0.0940652, "placebo_affected": 24, "placebo_at_risk": 32526, "rr": 0.56826, "se": 0.337553, "strata_with_events": 7, "z": -1.67433 } }, "Diabetic gangrene": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 2.08485, "lo": 0.367044, "log_rr": -0.133789, "p": 0.762706, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 0.874775, "se": 0.443113, "strata_with_events": 7, "z": -0.301929 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 6.97622, "lo": 0.398474, "log_rr": 0.511197, "p": 0.483923, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 1.66729, "se": 0.730274, "strata_with_events": 3, "z": 0.700007 }, "discovery_q": 0.799978, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 1.79393, "lo": 0.177822, "log_rr": -0.571283, "p": 0.332619, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.5648, "se": 0.589649, "strata_with_events": 4, "z": -0.968853 } }, "Diabetic 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0.0138958, "placebo_affected": 25, "placebo_at_risk": 67544, "rr": 0.427562, "se": 0.345397, "strata_with_events": 10, "z": -2.45995 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 1.51217, "lo": 0.184238, "log_rr": -0.638988, "p": 0.234093, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 0.527826, "se": 0.537019, "strata_with_events": 5, "z": -1.18988 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 0.904022, "lo": 0.152838, "log_rr": -0.989641, "p": 0.0290737, "placebo_affected": 16, "placebo_at_risk": 32526, "rr": 0.37171, "se": 0.453447, "strata_with_events": 5, "z": -2.18249 } }, "Diabetic nephropathy": { "all": { "glp1_affected": 26, "glp1_at_risk": 93765, "hi": 1.48087, "lo": 0.498801, "log_rr": -0.151459, "p": 0.585343, "placebo_affected": 28, "placebo_at_risk": 67544, "rr": 0.859453, "se": 0.277601, "strata_with_events": 11, "z": -0.545597 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 1.43622, "lo": 0.300706, "log_rr": -0.419804, "p": 0.292607, "placebo_affected": 16, "placebo_at_risk": 35018, "rr": 0.657176, "se": 0.398894, "strata_with_events": 5, "z": -1.05242 }, "discovery_q": 0.736933, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 15, "glp1_at_risk": 46377, "hi": 2.42506, "lo": 0.518951, "log_rr": 0.114955, "p": 0.770083, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 1.12182, "se": 0.393324, "strata_with_events": 6, "z": 0.292266 } }, "Diabetic neuropathy": { "all": { "glp1_affected": 27, "glp1_at_risk": 93765, "hi": 1.5592, "lo": 0.514135, "log_rr": -0.110548, "p": 0.696097, "placebo_affected": 27, "placebo_at_risk": 67544, "rr": 0.895343, "se": 0.283026, "strata_with_events": 14, "z": -0.390594 }, "discovered": false, "discovery": { "glp1_affected": 18, "glp1_at_risk": 47388, "hi": 2.69621, "lo": 0.627807, "log_rr": 0.263162, "p": 0.479048, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 1.30104, "se": 0.371784, "strata_with_events": 8, "z": 0.707835 }, "discovery_q": 0.799978, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 1.28815, "lo": 0.208908, "log_rr": -0.656327, "p": 0.157267, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 0.518753, "se": 0.464057, "strata_with_events": 6, "z": -1.41432 } }, "Diabetic retinopathy": { "all": { "glp1_affected": 60, "glp1_at_risk": 93765, "hi": 1.61808, "lo": 0.770697, "log_rr": 0.110391, "p": 0.559609, "placebo_affected": 53, "placebo_at_risk": 67544, "rr": 1.11671, "se": 0.189213, "strata_with_events": 9, "z": 0.583423 }, "discovered": false, "discovery": { "glp1_affected": 39, "glp1_at_risk": 47388, "hi": 2.00203, "lo": 0.778045, "log_rr": 0.221595, "p": 0.358062, "placebo_affected": 31, "placebo_at_risk": 35018, "rr": 1.24807, "se": 0.241109, "strata_with_events": 4, "z": 0.919063 }, 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"lo": 1.06683, "log_rr": 0.584602, "p": 0.0275349, "placebo_affected": 21, "placebo_at_risk": 32526, "rr": 1.79428, "se": 0.265264, "strata_with_events": 14, "z": 2.20385 } }, "Diffuse large B-cell lymphoma": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 3.40588, "lo": 0.660935, "log_rr": 0.405702, "p": 0.332075, "placebo_affected": 9, "placebo_at_risk": 67544, "rr": 1.50036, "se": 0.418274, "strata_with_events": 9, "z": 0.969943 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 2.64299, "lo": 0.344389, "log_rr": -0.0470353, "p": 0.927911, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 0.954054, "se": 0.51988, "strata_with_events": 6, "z": -0.0904733 }, "discovery_q": 0.98519, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 16.8664, "lo": 0.728698, "log_rr": 1.25441, "p": 0.117563, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 3.50578, "se": 0.8015, 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0.380146, "log_rr": -0.323413, "p": 0.324816, "placebo_affected": 21, "placebo_at_risk": 67544, "rr": 0.723675, "se": 0.328468, "strata_with_events": 11, "z": -0.984609 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 1.10634, "lo": 0.188652, "log_rr": -0.783398, "p": 0.0825602, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.456851, "se": 0.451261, "strata_with_events": 6, "z": -1.73602 }, "discovery_q": 0.525939, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 3.78675, "lo": 0.495709, "log_rr": 0.314871, "p": 0.543826, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 1.37008, "se": 0.518702, "strata_with_events": 5, "z": 0.607037 } }, "Diverticulum intestinal": { "all": { "glp1_affected": 25, "glp1_at_risk": 93765, "hi": 5.06926, "lo": 1.15116, "log_rr": 0.88198, "p": 0.0196908, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 2.41568, "se": 0.378177, 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"lo": 0.145134, "log_rr": -0.830341, "p": 0.138922, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 0.4359, "se": 0.561111, "strata_with_events": 5, "z": -1.47982 }, "discovery_q": 0.629158, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 1, "glp1_at_risk": 46377, "hi": 1.22069, "lo": 0.0205292, "log_rr": -1.84324, "p": 0.0769575, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.158303, "se": 1.04219, "strata_with_events": 3, "z": -1.76862 } }, "Dizziness": { "all": { "glp1_affected": 70, "glp1_at_risk": 93765, "hi": 1.83077, "lo": 0.88121, "log_rr": 0.239138, "p": 0.199836, "placebo_affected": 51, "placebo_at_risk": 67544, "rr": 1.27015, "se": 0.186532, "strata_with_events": 24, "z": 1.28202 }, "discovered": false, "discovery": { "glp1_affected": 46, "glp1_at_risk": 47388, "hi": 2.20041, "lo": 0.878791, "log_rr": 0.329717, "p": 0.159088, "placebo_affected": 31, "placebo_at_risk": 35018, "rr": 1.39057, "se": 0.23415, "strata_with_events": 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"se": 0.762522, "strata_with_events": 5, "z": 0.479588 } }, "Dry gangrene": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 1.50069, "lo": 0.309867, "log_rr": -0.382844, "p": 0.341449, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 0.681919, "se": 0.402441, "strata_with_events": 7, "z": -0.951306 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 2.41231, "lo": 0.317475, "log_rr": -0.133386, "p": 0.796538, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.875127, "se": 0.517342, "strata_with_events": 3, "z": -0.25783 }, "discovery_q": 0.924777, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 1.64769, "lo": 0.122978, "log_rr": -0.798186, "p": 0.22795, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.450145, "se": 0.662034, "strata_with_events": 4, "z": -1.20566 } }, "Duodenal ulcer": { "all": { "glp1_affected": 27, "glp1_at_risk": 93765, "hi": 1.37845, 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0.305569, "strata_with_events": 12, "z": -0.452807 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 1.29509, "lo": 0.28918, "log_rr": -0.491062, "p": 0.199178, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 0.611976, "se": 0.382478, "strata_with_events": 7, "z": -1.2839 }, "discovery_q": 0.680634, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 5.37505, "lo": 0.604389, "log_rr": 0.589115, "p": 0.290632, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.80239, "se": 0.557486, "strata_with_events": 5, "z": 1.05674 } }, "Duodenitis": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 1.26312, "lo": 0.276019, "log_rr": -0.526851, "p": 0.174489, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.590461, "se": 0.387983, "strata_with_events": 11, "z": -1.35792 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 2.51869, "lo": 0.397092, "log_rr": 7.49958e-05, "p": 0.999873, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 1.00007, "se": 0.471265, "strata_with_events": 5, "z": 0.000159137 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 1, "glp1_at_risk": 46377, "hi": 0.847929, "lo": 0.0187748, "log_rr": -2.0701, "p": 0.0331989, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.126173, "se": 0.972028, "strata_with_events": 6, "z": -2.12967 } }, "Dyspepsia": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 2.61948, "lo": 0.64334, "log_rr": 0.260948, "p": 0.46629, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.29816, "se": 0.358185, "strata_with_events": 10, "z": 0.728528 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 3.28804, "lo": 0.586818, "log_rr": 0.328626, "p": 0.454762, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 1.38906, "se": 0.439634, "strata_with_events": 6, 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"strata_with_events": 13, "z": -0.260791 } }, "Dyspnoea exertional": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 0.801669, "lo": 0.219654, "log_rr": -0.86838, "p": 0.00855638, "placebo_affected": 31, "placebo_at_risk": 67544, "rr": 0.419631, "se": 0.330272, "strata_with_events": 8, "z": -2.62929 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 0.816783, "lo": 0.162025, "log_rr": -1.01119, "p": 0.0142702, "placebo_affected": 22, "placebo_at_risk": 35018, "rr": 0.363785, "se": 0.412666, "strata_with_events": 4, "z": -2.45039 }, "discovery_q": 0.27974, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 1.65884, "lo": 0.186473, "log_rr": -0.586678, "p": 0.292695, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.556172, "se": 0.557558, "strata_with_events": 4, "z": -1.05223 } }, "Electrolyte imbalance": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 2.47533, "lo": 0.481959, "log_rr": 0.0882388, "p": 0.832584, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 1.09225, "se": 0.417424, "strata_with_events": 8, "z": 0.211389 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 5.97596, "lo": 0.51254, "log_rr": 0.559684, "p": 0.371725, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 1.75012, "se": 0.626573, "strata_with_events": 4, "z": 0.893247 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 2.25556, "lo": 0.227165, "log_rr": -0.33434, "p": 0.568037, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.71581, "se": 0.585592, "strata_with_events": 4, "z": -0.570945 } }, "Embolic stroke": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 2.69341, "lo": 0.635553, "log_rr": 0.268774, "p": 0.465641, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 1.30836, "se": 0.368391, 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0.598305, "log_rr": 0.17705, "p": 0.615384, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 1.19369, "se": 0.352407, "strata_with_events": 6, "z": 0.502404 }, "discovery_q": 0.882346, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 17, "glp1_at_risk": 46377, "hi": 2.81497, "lo": 0.649895, "log_rr": 0.302003, "p": 0.419331, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 1.35257, "se": 0.37396, "strata_with_events": 5, "z": 0.807582 } }, "End stage renal disease": { "all": { "glp1_affected": 50, "glp1_at_risk": 93765, "hi": 1.07598, "lo": 0.515683, "log_rr": -0.294514, "p": 0.116498, "placebo_affected": 66, "placebo_at_risk": 67544, "rr": 0.744894, "se": 0.187631, "strata_with_events": 6, "z": -1.56964 }, "discovered": false, "discovery": { "glp1_affected": 16, "glp1_at_risk": 47388, "hi": 1.20596, "lo": 0.331509, "log_rr": -0.458413, "p": 0.164074, "placebo_affected": 24, "placebo_at_risk": 35018, "rr": 0.632286, "se": 0.329438, 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"placebo_at_risk": 32526, "rr": 0.950195, "se": 0.375111, "strata_with_events": 8, "z": -0.136195 } }, "Endometrial cancer": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 3.40906, "lo": 0.561202, "log_rr": 0.324382, "p": 0.480929, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 1.38318, "se": 0.460241, "strata_with_events": 11, "z": 0.704809 }, "discovered": false, "discovery": { "glp1_affected": 4, "glp1_at_risk": 47388, "hi": 5.46129, "lo": 0.206267, "log_rr": 0.0595521, "p": 0.943197, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 1.06136, "se": 0.835798, "strata_with_events": 6, "z": 0.0712518 }, "discovery_q": 0.995276, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 4.63563, "lo": 0.527648, "log_rr": 0.447223, "p": 0.419827, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.56396, "se": 0.554372, "strata_with_events": 5, "z": 0.806721 } }, "Endometrial hyperplasia": { "all": { 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"hi": 1.82495, "lo": 0.400769, "log_rr": -0.15641, "p": 0.685881, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.855209, "se": 0.386722, "strata_with_events": 9, "z": -0.404451 }, "discovery_q": 0.907474, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 13, "glp1_at_risk": 46377, "hi": 1.75989, "lo": 0.356762, "log_rr": -0.232716, "p": 0.567597, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 0.792379, "se": 0.407135, "strata_with_events": 9, "z": -0.571594 } }, "Epistaxis": { "all": { "glp1_affected": 31, "glp1_at_risk": 93765, "hi": 1.55742, "lo": 0.58244, "log_rr": -0.0487504, "p": 0.845947, "placebo_affected": 31, "placebo_at_risk": 67544, "rr": 0.952419, "se": 0.250912, "strata_with_events": 12, "z": -0.194293 }, "discovered": false, "discovery": { "glp1_affected": 23, "glp1_at_risk": 47388, "hi": 2.362, "lo": 0.685827, "log_rr": 0.241189, "p": 0.444552, "placebo_affected": 17, "placebo_at_risk": 35018, "rr": 1.27276, "se": 0.315475, 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47388, "hi": 1.91397, "lo": 0.18724, "log_rr": -0.513092, "p": 0.386908, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.598642, "se": 0.593007, "strata_with_events": 8, "z": -0.865238 }, "discovery_q": 0.762002, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 7.99792, "lo": 0.501559, "log_rr": 0.694574, "p": 0.325511, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.00286, "se": 0.706445, "strata_with_events": 5, "z": 0.983195 } }, "Foot fracture": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 1.32618, "lo": 0.417685, "log_rr": -0.295362, "p": 0.316279, "placebo_affected": 26, "placebo_at_risk": 67544, "rr": 0.744262, "se": 0.294733, "strata_with_events": 16, "z": -1.00213 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 1.83263, "lo": 0.3793, "log_rr": -0.181838, "p": 0.650899, "placebo_affected": 14, "placebo_at_risk": 35018, "rr": 0.833737, "se": 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"placebo_at_risk": 32526, "rr": 1.61332, "se": 0.37608, "strata_with_events": 9, "z": 1.27178 } }, "Gastric polyps": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 2.03779, "lo": 0.3849, "log_rr": -0.121452, "p": 0.775143, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 0.885634, "se": 0.425171, "strata_with_events": 9, "z": -0.285654 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 2.55083, "lo": 0.288192, "log_rr": -0.153855, "p": 0.782101, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 0.857396, "se": 0.556272, "strata_with_events": 4, "z": -0.276582 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 3.36838, "lo": 0.254114, "log_rr": -0.077771, "p": 0.906099, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 0.925176, "se": 0.659299, "strata_with_events": 5, "z": -0.11796 } }, "Gastric ulcer": { "all": { "glp1_affected": 32, 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}, "Gastrooesophageal reflux disease": { "all": { "glp1_affected": 71, "glp1_at_risk": 93765, "hi": 1.7215, "lo": 0.848212, "log_rr": 0.189287, "p": 0.294514, "placebo_affected": 54, "placebo_at_risk": 67544, "rr": 1.20839, "se": 0.180571, "strata_with_events": 27, "z": 1.04827 }, "discovered": false, "discovery": { "glp1_affected": 36, "glp1_at_risk": 47388, "hi": 1.52685, "lo": 0.617454, "log_rr": -0.0294725, "p": 0.89846, "placebo_affected": 35, "placebo_at_risk": 35018, "rr": 0.970958, "se": 0.230963, "strata_with_events": 14, "z": -0.127607 }, "discovery_q": 0.971591, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 35, "glp1_at_risk": 46377, "hi": 2.97597, "lo": 0.935028, "log_rr": 0.511696, "p": 0.0831829, "placebo_affected": 19, "placebo_at_risk": 32526, "rr": 1.66812, "se": 0.29535, "strata_with_events": 13, "z": 1.73251 } }, "General physical health deterioration": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 4.00963, "lo": 0.688359, "log_rr": 0.507627, "p": 0.258802, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 1.66134, "se": 0.449535, "strata_with_events": 7, "z": 1.12923 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 3.47182, "lo": 0.39218, "log_rr": 0.154323, "p": 0.781471, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 1.16687, "se": 0.556315, "strata_with_events": 3, "z": 0.277403 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 15.7246, "lo": 0.628652, "log_rr": 1.14553, "p": 0.163081, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 3.14409, "se": 0.821292, "strata_with_events": 4, "z": 1.39478 } }, "Generalised oedema": { "all": { "glp1_affected": 8, "glp1_at_risk": 93765, "hi": 1.48546, "lo": 0.255394, "log_rr": -0.484612, "p": 0.280619, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 0.615936, "se": 0.44916, "strata_with_events": 8, 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49, "placebo_at_risk": 67544, "rr": 1.08613, "se": 0.194659, "strata_with_events": 12, "z": 0.424437 }, "discovered": false, "discovery": { "glp1_affected": 36, "glp1_at_risk": 47388, "hi": 2.21119, "lo": 0.821256, "log_rr": 0.298304, "p": 0.237759, "placebo_affected": 26, "placebo_at_risk": 35018, "rr": 1.34757, "se": 0.25267, "strata_with_events": 6, "z": 1.18061 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 19, "glp1_at_risk": 46377, "hi": 1.44978, "lo": 0.426781, "log_rr": -0.240038, "p": 0.441638, "placebo_affected": 23, "placebo_at_risk": 32526, "rr": 0.786598, "se": 0.311968, "strata_with_events": 6, "z": -0.76943 } }, "Haemoptysis": { "all": { "glp1_affected": 15, "glp1_at_risk": 93765, "hi": 2.18546, "lo": 0.502481, "log_rr": 0.0468155, "p": 0.900653, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.04793, "se": 0.375013, "strata_with_events": 9, "z": 0.124837 }, "discovered": false, "discovery": { 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28, "glp1_at_risk": 47388, "hi": 2.01327, "lo": 0.676865, "log_rr": 0.154738, "p": 0.577899, "placebo_affected": 24, "placebo_at_risk": 35018, "rr": 1.16735, "se": 0.278077, "strata_with_events": 6, "z": 0.556456 }, "discovery_q": 0.872706, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 3.19896, "lo": 0.4727, "log_rr": 0.206765, "p": 0.671656, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 1.22969, "se": 0.487794, "strata_with_events": 8, "z": 0.423877 } }, "Headache": { "all": { "glp1_affected": 32, "glp1_at_risk": 93765, "hi": 1.47291, "lo": 0.547228, "log_rr": -0.107825, "p": 0.669466, "placebo_affected": 32, "placebo_at_risk": 67544, "rr": 0.897784, "se": 0.252589, "strata_with_events": 20, "z": -0.426881 }, "discovered": false, "discovery": { "glp1_affected": 17, "glp1_at_risk": 47388, "hi": 1.39442, "lo": 0.39488, "log_rr": -0.298345, "p": 0.353952, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 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"placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.21345, "se": 0.563186, "strata_with_events": 6, "z": 0.343527 } }, "Impaired gastric emptying": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 5.26874, "lo": 0.983197, "log_rr": 0.822423, "p": 0.0548079, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 2.27601, "se": 0.428257, "strata_with_events": 13, "z": 1.9204 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 9.33525, "lo": 0.968824, "log_rr": 1.10106, "p": 0.0567591, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 3.00736, "se": 0.577937, "strata_with_events": 6, "z": 1.90516 }, "discovery_q": 0.507552, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 5.59576, "lo": 0.427191, "log_rr": 0.435742, "p": 0.506711, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.54611, "se": 0.656271, "strata_with_events": 7, "z": 0.663967 } }, "Impaired healing": { "all": { "glp1_affected": 25, "glp1_at_risk": 93765, "hi": 1.8929, "lo": 0.590335, "log_rr": 0.0555218, "p": 0.851826, "placebo_affected": 22, "placebo_at_risk": 67544, "rr": 1.05709, "se": 0.297244, "strata_with_events": 13, "z": 0.186789 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 3.23639, "lo": 0.665896, "log_rr": 0.383919, "p": 0.341179, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 1.46803, "se": 0.403345, "strata_with_events": 5, "z": 0.951838 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 1.72805, "lo": 0.289292, "log_rr": -0.346664, "p": 0.447073, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 0.707043, "se": 0.455955, "strata_with_events": 8, "z": -0.760303 } }, "Incisional hernia": { "all": { "glp1_affected": 34, "glp1_at_risk": 93765, "hi": 1.91087, "lo": 0.685008, "log_rr": 0.134618, "p": 0.606988, "placebo_affected": 27, "placebo_at_risk": 67544, "rr": 1.1441, "se": 0.26171, "strata_with_events": 17, "z": 0.514377 }, "discovered": false, "discovery": { "glp1_affected": 17, "glp1_at_risk": 47388, "hi": 2.5564, "lo": 0.597118, "log_rr": 0.211479, "p": 0.568647, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 1.2355, "se": 0.370986, "strata_with_events": 8, "z": 0.570045 }, "discovery_q": 0.868112, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 17, "glp1_at_risk": 46377, "hi": 2.18761, "lo": 0.513382, "log_rr": 0.0580364, "p": 0.875288, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 1.05975, "se": 0.369788, "strata_with_events": 9, "z": 0.156945 } }, "Infected skin ulcer": { "all": { "glp1_affected": 15, "glp1_at_risk": 93765, "hi": 1.47095, "lo": 0.401473, "log_rr": -0.263351, "p": 0.426618, "placebo_affected": 18, "placebo_at_risk": 67544, "rr": 0.768472, "se": 0.331262, "strata_with_events": 11, "z": -0.794993 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 1.7924, "lo": 0.201864, "log_rr": -0.508302, "p": 0.361539, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.601516, "se": 0.557081, "strata_with_events": 5, "z": -0.912437 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 2.00961, "lo": 0.396185, "log_rr": -0.113967, "p": 0.783224, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.892287, "se": 0.414246, "strata_with_events": 6, "z": -0.27512 } }, "Infection": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.67524, "lo": 0.281099, "log_rr": -0.376546, "p": 0.408289, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 0.686227, "se": 0.455366, "strata_with_events": 8, "z": -0.826909 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 2.16235, "lo": 0.260386, "log_rr": -0.287198, "p": 0.594835, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.750363, "se": 0.540006, "strata_with_events": 3, "z": -0.531842 }, "discovery_q": 0.872706, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 2.96615, "lo": 0.104975, "log_rr": -0.583383, "p": 0.493716, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 0.558007, "se": 0.852388, "strata_with_events": 5, "z": -0.684411 } }, "Infective exacerbation of chronic obstructive airways disease": { "all": { "glp1_affected": 16, "glp1_at_risk": 93765, "hi": 1.93049, "lo": 0.47312, "log_rr": -0.0453155, "p": 0.899476, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.955696, "se": 0.358726, "strata_with_events": 10, "z": -0.126323 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 3.97727, "lo": 0.479384, "log_rr": 0.322672, "p": 0.549974, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 1.38081, "se": 0.539767, "strata_with_events": 5, "z": 0.597798 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1.77582, "lo": 0.462113, "log_rr": -0.0988422, "p": 0.773491, "placebo_affected": 18, "placebo_at_risk": 32526, "rr": 0.905886, "se": 0.343426, "strata_with_events": 8, "z": -0.287812 } }, "Inguinal hernia": { "all": { "glp1_affected": 142, "glp1_at_risk": 93765, "hi": 1.98999, "lo": 1.17209, "log_rr": 0.42346, "p": 0.00171348, "placebo_affected": 86, "placebo_at_risk": 67544, "rr": 1.52724, "se": 0.135038, "strata_with_events": 26, "z": 3.13587 }, "discovered": false, "discovery": { "glp1_affected": 90, "glp1_at_risk": 47388, "hi": 2.15064, "lo": 1.11161, "log_rr": 0.435787, "p": 0.0096413, "placebo_affected": 58, "placebo_at_risk": 35018, "rr": 1.54618, "se": 0.168359, "strata_with_events": 9, "z": 2.58844 }, "discovery_q": 0.27584, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 52, "glp1_at_risk": 46377, "hi": 2.32396, "lo": 0.958228, "log_rr": 0.400301, "p": 0.0765327, "placebo_affected": 28, "placebo_at_risk": 32526, "rr": 1.49227, "se": 0.22601, "strata_with_events": 17, "z": 1.77117 } }, "Intermittent claudication": { "all": { "glp1_affected": 29, "glp1_at_risk": 93765, "hi": 1.75276, "lo": 0.613004, "log_rr": 0.0359033, "p": 0.893432, "placebo_affected": 27, "placebo_at_risk": 67544, "rr": 1.03656, "se": 0.268008, "strata_with_events": 9, "z": 0.133963 }, "discovered": false, "discovery": { "glp1_affected": 22, "glp1_at_risk": 47388, "hi": 2.13882, "lo": 0.626957, "log_rr": 0.146689, "p": 0.639369, "placebo_affected": 19, "placebo_at_risk": 35018, "rr": 1.15799, "se": 0.31305, "strata_with_events": 5, "z": 0.468581 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 2.13456, "lo": 0.270365, "log_rr": -0.274862, "p": 0.602054, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.759677, "se": 0.527112, "strata_with_events": 4, "z": -0.521448 } }, "Interstitial lung disease": { "all": { "glp1_affected": 23, "glp1_at_risk": 93765, "hi": 2.77341, "lo": 0.755604, "log_rr": 0.369919, "p": 0.264783, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 1.44762, "se": 0.331719, "strata_with_events": 10, "z": 1.11516 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 4.10538, "lo": 0.37228, "log_rr": 0.212094, "p": 0.729076, "placebo_affected": 5, "placebo_at_risk": 35018, "rr": 1.23626, "se": 0.61236, "strata_with_events": 6, "z": 0.346355 }, "discovery_q": 0.917569, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 3.36353, "lo": 0.714193, "log_rr": 0.438194, "p": 0.267656, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 1.54991, "se": 0.395311, "strata_with_events": 4, "z": 1.10848 } }, "Intervertebral disc degeneration": { "all": { "glp1_affected": 15, "glp1_at_risk": 93765, "hi": 1.39703, "lo": 0.351969, "log_rr": -0.354932, "p": 0.312857, "placebo_affected": 20, "placebo_at_risk": 67544, "rr": 0.701221, "se": 0.351681, "strata_with_events": 11, "z": -1.00924 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 2.21569, "lo": 0.366257, "log_rr": -0.104428, "p": 0.820097, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 0.900839, "se": 0.459187, "strata_with_events": 4, "z": -0.22742 }, "discovery_q": 0.930223, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 1.50114, "lo": 0.167512, "log_rr": -0.690239, "p": 0.217269, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.501456, "se": 0.559431, "strata_with_events": 7, "z": -1.23382 } }, "Intervertebral disc disorder": { "all": { "glp1_affected": 18, "glp1_at_risk": 93765, "hi": 4.16939, "lo": 0.799198, "log_rr": 0.601811, "p": 0.153271, "placebo_affected": 9, "placebo_at_risk": 67544, "rr": 1.82542, "se": 0.421415, "strata_with_events": 13, "z": 1.42807 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 14.3569, "lo": 0.516926, "log_rr": 1.00219, "p": 0.237274, "placebo_affected": 2, "placebo_at_risk": 35018, "rr": 2.72423, "se": 0.847997, "strata_with_events": 6, "z": 1.18183 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 4.09384, "lo": 0.600776, "log_rr": 0.449975, "p": 0.358015, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 1.56827, "se": 0.489554, "strata_with_events": 7, "z": 0.919153 } }, "Intervertebral disc protrusion": { "all": { "glp1_affected": 123, "glp1_at_risk": 93765, "hi": 1.281, "lo": 0.759392, "log_rr": -0.0137964, "p": 0.917623, "placebo_affected": 107, "placebo_at_risk": 67544, "rr": 0.986298, "se": 0.133391, "strata_with_events": 39, "z": -0.103428 }, "discovered": false, "discovery": { "glp1_affected": 70, "glp1_at_risk": 47388, "hi": 1.68119, "lo": 0.80832, "log_rr": 0.153353, "p": 0.411714, "placebo_affected": 53, "placebo_at_risk": 35018, "rr": 1.16574, "se": 0.186815, "strata_with_events": 20, "z": 0.820881 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 53, "glp1_at_risk": 46377, "hi": 1.19358, "lo": 0.562506, "log_rr": -0.1992, "p": 0.299297, "placebo_affected": 54, "placebo_at_risk": 32526, "rr": 0.819386, "se": 0.191918, "strata_with_events": 19, "z": -1.03794 } }, "Intestinal ischaemia": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 5.10005, "lo": 1.04732, "log_rr": 0.837741, "p": 0.038038, "placebo_affected": 9, "placebo_at_risk": 67544, "rr": 2.31114, "se": 0.403839, "strata_with_events": 14, "z": 2.07445 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 4.07306, "lo": 0.701352, "log_rr": 0.524824, "p": 0.242211, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 1.69016, "se": 0.448768, "strata_with_events": 9, "z": 1.16948 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { 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"placebo_at_risk": 32526, "rr": 0.933938, "se": 0.305508, "strata_with_events": 8, "z": -0.223711 } }, "Intracranial aneurysm": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 2.40758, "lo": 0.457648, "log_rr": 0.0484837, "p": 0.908865, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 1.04968, "se": 0.423548, "strata_with_events": 10, "z": 0.11447 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 3.45448, "lo": 0.289926, "log_rr": 0.00076973, "p": 0.999028, "placebo_affected": 5, "placebo_at_risk": 35018, "rr": 1.00077, "se": 0.632104, "strata_with_events": 4, "z": 0.00121773 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 3.33766, "lo": 0.356264, "log_rr": 0.0865937, "p": 0.879411, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 1.09045, "se": 0.570764, "strata_with_events": 6, "z": 0.151715 } }, "Intraductal proliferative breast lesion": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 1.29656, "lo": 0.288006, "log_rr": -0.49253, "p": 0.199393, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.611079, "se": 0.383804, "strata_with_events": 15, "z": -1.28328 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 2.1789, "lo": 0.324372, "log_rr": -0.173522, "p": 0.721005, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 0.840699, "se": 0.485897, "strata_with_events": 9, "z": -0.357116 }, "discovery_q": 0.916484, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.25782, "lo": 0.0919939, "log_rr": -1.07833, "p": 0.106056, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.340164, "se": 0.667209, "strata_with_events": 6, "z": -1.61618 } }, "Invasive ductal breast carcinoma": { "all": { "glp1_affected": 54, "glp1_at_risk": 93765, "hi": 1.71443, "lo": 0.748289, "log_rr": 0.124556, "p": 0.555906, "placebo_affected": 41, "placebo_at_risk": 67544, "rr": 1.13265, "se": 0.211495, "strata_with_events": 24, "z": 0.588933 }, "discovered": false, "discovery": { "glp1_affected": 33, "glp1_at_risk": 47388, "hi": 2.12251, "lo": 0.725272, "log_rr": 0.215696, "p": 0.431051, "placebo_affected": 23, "placebo_at_risk": 35018, "rr": 1.24072, "se": 0.273936, "strata_with_events": 11, "z": 0.787395 }, "discovery_q": 0.779523, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 21, "glp1_at_risk": 46377, "hi": 1.90837, "lo": 0.515319, "log_rr": -0.00835921, "p": 0.980032, "placebo_affected": 18, "placebo_at_risk": 32526, "rr": 0.991676, "se": 0.333991, "strata_with_events": 13, "z": -0.0250282 } }, "Iron deficiency anaemia": { "all": { "glp1_affected": 62, "glp1_at_risk": 93765, "hi": 1.48227, "lo": 0.723764, "log_rr": 0.0351412, "p": 0.847618, "placebo_affected": 58, "placebo_at_risk": 67544, "rr": 1.03577, "se": 0.182876, "strata_with_events": 14, "z": 0.192158 }, "discovered": false, "discovery": { "glp1_affected": 28, "glp1_at_risk": 47388, "hi": 1.26655, "lo": 0.470421, "log_rr": -0.258914, "p": 0.305489, "placebo_affected": 36, "placebo_at_risk": 35018, "rr": 0.771889, "se": 0.252665, "strata_with_events": 6, "z": -1.02473 }, "discovery_q": 0.739916, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 34, "glp1_at_risk": 46377, "hi": 2.48023, "lo": 0.853475, "log_rr": 0.374956, "p": 0.168272, "placebo_affected": 22, "placebo_at_risk": 32526, "rr": 1.45493, "se": 0.272145, "strata_with_events": 8, "z": 1.37778 } }, "Ischaemic cardiomyopathy": { "all": { "glp1_affected": 34, "glp1_at_risk": 93765, "hi": 1.89693, "lo": 0.709021, "log_rr": 0.148184, "p": 0.555023, "placebo_affected": 29, "placebo_at_risk": 67544, "rr": 1.15973, "se": 0.251052, "strata_with_events": 11, "z": 0.59025 }, "discovered": false, "discovery": { "glp1_affected": 22, "glp1_at_risk": 47388, "hi": 2.01533, "lo": 0.600572, "log_rr": 0.0954543, "p": 0.75727, "placebo_affected": 20, "placebo_at_risk": 35018, "rr": 1.10016, "se": 0.308846, "strata_with_events": 6, "z": 0.309068 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 3.00162, "lo": 0.552221, "log_rr": 0.252672, "p": 0.558517, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 1.28746, "se": 0.431886, "strata_with_events": 5, "z": 0.585045 } }, "Ischaemic cerebral infarction": { "all": { "glp1_affected": 7, "glp1_at_risk": 93765, "hi": 0.968657, "lo": 0.160743, "log_rr": -0.929896, "p": 0.0424111, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.394595, "se": 0.458198, "strata_with_events": 9, "z": -2.02946 }, "discovered": false, "discovery": { "glp1_affected": 4, "glp1_at_risk": 47388, "hi": 0.963688, "lo": 0.106574, "log_rr": -1.13795, "p": 0.0427843, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 0.320475, "se": 0.561727, "strata_with_events": 5, "z": -2.02581 }, "discovery_q": 0.446498, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 3.1288, "lo": 0.125224, "log_rr": -0.468501, "p": 0.568244, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 0.62594, "se": 0.821011, "strata_with_events": 4, "z": -0.57064 } }, "Ischaemic stroke": { "all": { "glp1_affected": 281, "glp1_at_risk": 93765, "hi": 1.04761, "lo": 0.75725, "log_rr": -0.115774, "p": 0.162049, "placebo_affected": 297, "placebo_at_risk": 67544, "rr": 0.890676, "se": 0.0828016, "strata_with_events": 40, "z": -1.39821 }, "discovered": false, "discovery": { "glp1_affected": 217, "glp1_at_risk": 47388, "hi": 1.1716, "lo": 0.805665, "log_rr": -0.0288572, "p": 0.762589, "placebo_affected": 215, "placebo_at_risk": 35018, "rr": 0.971555, "se": 0.0955272, "strata_with_events": 22, "z": -0.302083 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 64, "glp1_at_risk": 46377, "hi": 0.950087, "lo": 0.491814, "log_rr": -0.380428, "p": 0.0235261, "placebo_affected": 82, "placebo_at_risk": 32526, "rr": 0.683569, "se": 0.167976, "strata_with_events": 18, "z": -2.26478 } }, "Joint dislocation": { "all": { "glp1_affected": 30, "glp1_at_risk": 93765, "hi": 1.89565, "lo": 0.618577, "log_rr": 0.0796137, "p": 0.780499, "placebo_affected": 24, "placebo_at_risk": 67544, "rr": 1.08287, "se": 0.285693, "strata_with_events": 19, "z": 0.278669 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 2.15792, "lo": 0.452412, "log_rr": -0.0120072, "p": 0.975966, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 0.988065, "se": 0.398555, "strata_with_events": 8, "z": -0.0301268 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 2.66494, "lo": 0.532863, "log_rr": 0.175346, "p": 0.669373, "placebo_affected": 11, "placebo_at_risk": 32526, "rr": 1.19166, "se": 0.410638, "strata_with_events": 11, "z": 0.427008 } }, "Joint injury": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 2.80736, "lo": 0.635061, "log_rr": 0.289105, "p": 0.445768, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 1.33523, "se": 0.37916, "strata_with_events": 13, "z": 0.76249 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 10.3855, "lo": 1.09761, "log_rr": 1.21677, "p": 0.0338028, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 3.37628, "se": 0.573296, "strata_with_events": 6, "z": 2.12242 }, "discovery_q": 0.396534, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 1.18426, "lo": 0.0725851, "log_rr": -1.22694, "p": 0.0849734, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.293189, "se": 0.712288, "strata_with_events": 7, "z": -1.72253 } }, "Lactic acidosis": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 1.74419, "lo": 0.478319, "log_rr": -0.0905938, "p": 0.783711, "placebo_affected": 19, "placebo_at_risk": 67544, "rr": 0.913389, "se": 0.330049, "strata_with_events": 12, "z": -0.274486 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 4.77329, "lo": 0.758908, "log_rr": 0.64358, "p": 0.170097, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.90328, "se": 0.469119, "strata_with_events": 5, "z": 1.37189 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 1.04977, "lo": 0.117665, "log_rr": -1.04567, "p": 0.061073, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 0.351456, "se": 0.558297, "strata_with_events": 7, "z": -1.87297 } }, "Lacunar infarction": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 1.3441, "lo": 0.425967, "log_rr": -0.278833, "p": 0.341521, "placebo_affected": 26, "placebo_at_risk": 67544, "rr": 0.756666, "se": 0.293149, "strata_with_events": 13, "z": -0.951165 }, "discovered": false, "discovery": { "glp1_affected": 16, "glp1_at_risk": 47388, "hi": 1.68727, "lo": 0.42823, "log_rr": -0.162492, "p": 0.642272, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 0.850023, "se": 0.349803, "strata_with_events": 6, "z": -0.464525 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 1.64818, "lo": 0.194737, "log_rr": -0.568217, "p": 0.297001, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.566534, "se": 0.544851, "strata_with_events": 7, "z": -1.04289 } }, "Large intestine polyp": { "all": { "glp1_affected": 66, "glp1_at_risk": 93765, "hi": 1.31327, "lo": 0.651708, "log_rr": -0.0778177, "p": 0.663311, "placebo_affected": 65, "placebo_at_risk": 67544, "rr": 0.925133, "se": 0.178749, "strata_with_events": 26, "z": -0.435347 }, "discovered": false, "discovery": { "glp1_affected": 44, "glp1_at_risk": 47388, "hi": 1.72192, "lo": 0.710084, "log_rr": 0.100534, "p": 0.656401, "placebo_affected": 37, "placebo_at_risk": 35018, "rr": 1.10576, "se": 0.225977, "strata_with_events": 13, "z": 0.444888 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 22, "glp1_at_risk": 46377, "hi": 1.22915, "lo": 0.383155, "log_rr": -0.376496, "p": 0.205471, "placebo_affected": 28, "placebo_at_risk": 32526, "rr": 0.686262, "se": 0.297363, "strata_with_events": 13, "z": -1.26612 } }, "Laryngeal squamous cell carcinoma": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.78199, "lo": 0.316322, "log_rr": -0.286632, "p": 0.515728, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 0.750788, "se": 0.441009, "strata_with_events": 9, "z": -0.649945 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 3.45765, "lo": 0.289619, "log_rr": 0.000699674, "p": 0.999118, "placebo_affected": 5, "placebo_at_risk": 35018, "rr": 1.0007, "se": 0.632609, "strata_with_events": 4, "z": 0.00110601 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.95471, "lo": 0.167535, "log_rr": -0.558159, "p": 0.373163, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.572262, "se": 0.626747, "strata_with_events": 5, "z": -0.890565 } }, "Left ventricular dysfunction": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 0.967884, "lo": 0.265281, "log_rr": -0.679804, "p": 0.039511, "placebo_affected": 25, "placebo_at_risk": 67544, "rr": 0.506716, "se": 0.33019, "strata_with_events": 10, "z": -2.05883 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 0.964093, "lo": 0.203297, "log_rr": -0.814828, "p": 0.0401643, "placebo_affected": 20, "placebo_at_risk": 35018, "rr": 0.442716, "se": 0.397079, "strata_with_events": 5, "z": -2.05206 }, "discovery_q": 0.43697, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 2.35607, "lo": 0.222268, "log_rr": -0.323439, "p": 0.591246, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 0.723656, "se": 0.602273, "strata_with_events": 5, "z": -0.537031 } }, "Left ventricular failure": { "all": { "glp1_affected": 36, "glp1_at_risk": 93765, "hi": 1.23962, "lo": 0.512475, "log_rr": -0.22685, "p": 0.314074, "placebo_affected": 44, "placebo_at_risk": 67544, "rr": 0.797041, "se": 0.225338, "strata_with_events": 11, "z": -1.00671 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 0.981361, "lo": 0.2334, "log_rr": -0.736907, "p": 0.0442921, "placebo_affected": 23, "placebo_at_risk": 35018, "rr": 0.478592, "se": 0.366381, "strata_with_events": 5, "z": -2.01132 }, "discovery_q": 0.448132, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 25, "glp1_at_risk": 46377, "hi": 2.03814, "lo": 0.638028, "log_rr": 0.131331, "p": 0.657576, "placebo_affected": 21, "placebo_at_risk": 32526, "rr": 1.14035, "se": 0.296283, "strata_with_events": 6, "z": 0.443263 } }, "Limb injury": { "all": { "glp1_affected": 32, "glp1_at_risk": 93765, "hi": 1.95688, "lo": 0.667837, "log_rr": 0.13382, "p": 0.625593, "placebo_affected": 25, "placebo_at_risk": 67544, "rr": 1.14319, "se": 0.274256, "strata_with_events": 19, "z": 0.487939 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 1.86764, "lo": 0.450362, "log_rr": -0.0865143, "p": 0.811552, "placebo_affected": 16, "placebo_at_risk": 35018, "rr": 0.917122, "se": 0.362859, "strata_with_events": 9, "z": -0.238424 }, "discovery_q": 0.927658, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 17, "glp1_at_risk": 46377, "hi": 3.5304, "lo": 0.663077, "log_rr": 0.425273, "p": 0.318828, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 1.53001, "se": 0.426608, "strata_with_events": 10, "z": 0.996869 } }, "Lipase increased": { 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-0.878594 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 1.4121, "lo": 0.154135, "log_rr": -0.762425, "p": 0.177248, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 0.466534, "se": 0.565062, "strata_with_events": 6, "z": -1.34928 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 4.6685, "lo": 0.336853, "log_rr": 0.226366, "p": 0.735721, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.25403, "se": 0.670662, "strata_with_events": 2, "z": 0.337526 } }, "Liver abscess": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 4.95613, "lo": 0.807532, "log_rr": 0.693426, "p": 0.134103, "placebo_affected": 7, "placebo_at_risk": 67544, "rr": 2.00056, "se": 0.462865, "strata_with_events": 9, "z": 1.49812 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 5.97932, "lo": 0.512368, "log_rr": 0.559797, "p": 0.371804, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 1.75032, "se": 0.626802, "strata_with_events": 5, "z": 0.893099 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 9.0234, "lo": 0.603783, "log_rr": 0.847641, "p": 0.219206, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.33413, "se": 0.689901, "strata_with_events": 4, "z": 1.22864 } }, "Lobar pneumonia": { "all": { "glp1_affected": 21, "glp1_at_risk": 93765, "hi": 1.7201, "lo": 0.516285, "log_rr": -0.059356, "p": 0.846699, "placebo_affected": 20, "placebo_at_risk": 67544, "rr": 0.942371, "se": 0.307016, "strata_with_events": 9, "z": -0.193332 }, "discovered": false, "discovery": { "glp1_affected": 18, "glp1_at_risk": 47388, "hi": 1.63061, "lo": 0.467938, "log_rr": -0.135234, "p": 0.6711, "placebo_affected": 19, "placebo_at_risk": 35018, "rr": 0.873511, "se": 0.318468, "strata_with_events": 6, "z": -0.424639 }, "discovery_q": 0.897117, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 28.2649, "lo": 0.193064, "log_rr": 0.848444, "p": 0.50478, "placebo_affected": 1, "placebo_at_risk": 32526, "rr": 2.33601, "se": 1.27205, "strata_with_events": 3, "z": 0.666988 } }, "Localised infection": { "all": { "glp1_affected": 38, "glp1_at_risk": 93765, "hi": 1.21611, "lo": 0.510718, "log_rr": -0.238138, "p": 0.281953, "placebo_affected": 43, "placebo_at_risk": 67544, "rr": 0.788094, "se": 0.22133, "strata_with_events": 15, "z": -1.07594 }, "discovered": false, "discovery": { "glp1_affected": 18, "glp1_at_risk": 47388, "hi": 1.37846, "lo": 0.39861, "log_rr": -0.299403, "p": 0.34419, "placebo_affected": 22, "placebo_at_risk": 35018, "rr": 0.741261, "se": 0.31652, "strata_with_events": 9, "z": -0.945919 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 20, "glp1_at_risk": 46377, "hi": 1.53486, "lo": 0.455542, "log_rr": -0.178914, "p": 0.563691, "placebo_affected": 21, "placebo_at_risk": 32526, "rr": 0.836178, "se": 0.309879, "strata_with_events": 6, "z": -0.577367 } }, "Loss of consciousness": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 1.48745, "lo": 0.446024, "log_rr": -0.205159, "p": 0.504325, "placebo_affected": 23, "placebo_at_risk": 67544, "rr": 0.814518, "se": 0.307262, "strata_with_events": 11, "z": -0.667701 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 1.47404, "lo": 0.354072, "log_rr": -0.325123, "p": 0.371555, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 0.722438, "se": 0.36385, "strata_with_events": 4, "z": -0.893565 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 3.52721, "lo": 0.35885, "log_rr": 0.117828, "p": 0.839837, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.12505, "se": 0.583011, "strata_with_events": 7, "z": 0.202102 } }, "Lower gastrointestinal haemorrhage": { "all": { "glp1_affected": 27, "glp1_at_risk": 93765, "hi": 1.2655, "lo": 0.451349, "log_rr": -0.280022, "p": 0.287021, "placebo_affected": 34, "placebo_at_risk": 67544, "rr": 0.755767, "se": 0.263011, "strata_with_events": 14, "z": -1.06468 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 1.67689, "lo": 0.360769, "log_rr": -0.251287, "p": 0.521456, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.777799, "se": 0.391961, "strata_with_events": 7, "z": -0.641103 }, "discovery_q": 0.833037, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 15, "glp1_at_risk": 46377, "hi": 1.47996, "lo": 0.368371, "log_rr": -0.303324, "p": 0.392562, "placebo_affected": 19, "placebo_at_risk": 32526, "rr": 0.73836, "se": 0.354773, "strata_with_events": 7, "z": -0.854981 } }, "Lower limb fracture": { "all": { "glp1_affected": 23, "glp1_at_risk": 93765, "hi": 1.48318, "lo": 0.462199, "log_rr": -0.188786, "p": 0.525625, "placebo_affected": 25, "placebo_at_risk": 67544, "rr": 0.827964, "se": 0.297441, "strata_with_events": 16, "z": -0.634699 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 1.53322, "lo": 0.21332, "log_rr": -0.558795, "p": 0.266749, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 0.571898, "se": 0.503156, "strata_with_events": 7, "z": -1.11058 }, "discovery_q": 0.714845, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 2.13378, "lo": 0.491918, "log_rr": 0.0242272, "p": 0.948395, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 1.02452, "se": 0.374328, "strata_with_events": 9, "z": 0.0647218 } }, "Lower respiratory tract infection": { "all": { "glp1_affected": 47, "glp1_at_risk": 93765, "hi": 1.45092, "lo": 0.647484, "log_rr": -0.0312315, "p": 0.879399, "placebo_affected": 48, "placebo_at_risk": 67544, "rr": 0.969251, "se": 0.205835, "strata_with_events": 10, "z": -0.151731 }, "discovered": false, "discovery": { "glp1_affected": 32, "glp1_at_risk": 47388, "hi": 1.87353, "lo": 0.676092, "log_rr": 0.1182, "p": 0.649408, "placebo_affected": 28, "placebo_at_risk": 35018, "rr": 1.12547, "se": 0.260018, "strata_with_events": 6, "z": 0.454584 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 15, "glp1_at_risk": 46377, "hi": 1.46498, "lo": 0.384512, "log_rr": -0.28697, "p": 0.400365, "placebo_affected": 20, "placebo_at_risk": 32526, "rr": 0.750534, "se": 0.341237, "strata_with_events": 4, "z": -0.84097 } }, "Lumbar radiculopathy": { "all": { "glp1_affected": 18, "glp1_at_risk": 93765, "hi": 2.38344, "lo": 0.597397, "log_rr": 0.176686, "p": 0.6167, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.19326, "se": 0.352996, "strata_with_events": 9, "z": 0.500533 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 3.11431, "lo": 0.53826, "log_rr": 0.258298, "p": 0.564082, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 1.29472, "se": 0.44782, "strata_with_events": 5, "z": 0.576789 }, "discovery_q": 0.866575, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 3.24052, "lo": 0.339878, "log_rr": 0.0482824, "p": 0.933109, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 1.04947, "se": 0.575241, "strata_with_events": 4, "z": 0.0839342 } }, "Lumbar spinal stenosis": { "all": { "glp1_affected": 82, "glp1_at_risk": 93765, "hi": 1.23108, "lo": 0.666199, "log_rr": -0.0991388, "p": 0.526819, "placebo_affected": 85, "placebo_at_risk": 67544, "rr": 0.905617, "se": 0.15665, "strata_with_events": 21, "z": -0.632869 }, "discovered": false, "discovery": { "glp1_affected": 45, "glp1_at_risk": 47388, "hi": 1.48038, "lo": 0.639257, "log_rr": -0.027576, "p": 0.897576, "placebo_affected": 44, "placebo_at_risk": 35018, "rr": 0.972801, "se": 0.214225, "strata_with_events": 11, "z": -0.128724 }, "discovery_q": 0.971591, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 37, "glp1_at_risk": 46377, "hi": 1.30918, "lo": 0.531398, "log_rr": -0.181424, "p": 0.43026, "placebo_affected": 41, "placebo_at_risk": 32526, "rr": 0.834082, "se": 0.230015, "strata_with_events": 10, "z": -0.788747 } }, "Lumbar vertebral fracture": { "all": { "glp1_affected": 21, "glp1_at_risk": 93765, "hi": 2.06537, "lo": 0.566764, "log_rr": 0.0787485, "p": 0.811326, "placebo_affected": 18, "placebo_at_risk": 67544, "rr": 1.08193, "se": 0.329884, "strata_with_events": 12, "z": 0.238716 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 2.57471, "lo": 0.452503, "log_rr": 0.0763874, "p": 0.863267, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 1.07938, "se": 0.443553, "strata_with_events": 6, "z": 0.172217 }, "discovery_q": 0.953845, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 2.85448, "lo": 0.412508, "log_rr": 0.0816945, "p": 0.868512, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 1.08512, "se": 0.493476, "strata_with_events": 6, "z": 0.165549 } }, "Lung adenocarcinoma": { "all": { "glp1_affected": 44, "glp1_at_risk": 93765, "hi": 1.43813, "lo": 0.615494, "log_rr": -0.0609923, "p": 0.778162, "placebo_affected": 44, "placebo_at_risk": 67544, "rr": 0.940831, "se": 0.216503, "strata_with_events": 19, "z": -0.281715 }, "discovered": false, "discovery": { "glp1_affected": 33, "glp1_at_risk": 47388, "hi": 2.58706, "lo": 0.847265, "log_rr": 0.39239, "p": 0.168222, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 1.48051, "se": 0.284766, "strata_with_events": 11, "z": 1.37794 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 11, "glp1_at_risk": 46377, "hi": 0.937738, "lo": 0.220769, "log_rr": -0.787461, "p": 0.0328273, "placebo_affected": 23, "placebo_at_risk": 32526, "rr": 0.454999, "se": 0.368974, "strata_with_events": 8, "z": -2.13419 } }, "Lung cancer metastatic": { "all": { "glp1_affected": 30, "glp1_at_risk": 93765, "hi": 1.85657, "lo": 0.653487, "log_rr": 0.096649, "p": 0.71673, "placebo_affected": 26, "placebo_at_risk": 67544, "rr": 1.10147, "se": 0.266373, "strata_with_events": 15, "z": 0.362833 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 2.68564, "lo": 0.568915, "log_rr": 0.211948, "p": 0.592413, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 1.23608, "se": 0.395911, "strata_with_events": 9, "z": 0.535342 }, "discovery_q": 0.872706, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 2.03268, "lo": 0.493855, "log_rr": 0.00192067, "p": 0.995754, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 1.00192, "se": 0.360943, "strata_with_events": 6, "z": 0.00532126 } }, "Lung neoplasm malignant": { "all": { "glp1_affected": 48, "glp1_at_risk": 93765, "hi": 1.31557, "lo": 0.604461, "log_rr": -0.114576, "p": 0.563589, "placebo_affected": 50, "placebo_at_risk": 67544, "rr": 0.891745, "se": 0.198392, "strata_with_events": 18, "z": -0.577519 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 1.2258, "lo": 0.319175, "log_rr": -0.469213, "p": 0.171663, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 0.625494, "se": 0.343273, "strata_with_events": 7, "z": -1.36688 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 34, "glp1_at_risk": 46377, "hi": 1.74732, "lo": 0.665793, "log_rr": 0.0756539, "p": 0.758571, "placebo_affected": 29, "placebo_at_risk": 32526, "rr": 1.07859, "se": 0.246143, "strata_with_events": 11, "z": 0.307358 } }, "Major depression": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 2.73004, "lo": 0.660342, "log_rr": 0.294659, "p": 0.415758, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.34267, "se": 0.362076, "strata_with_events": 15, "z": 0.813803 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 2.25872, "lo": 0.404276, "log_rr": -0.0454305, "p": 0.917558, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 0.955586, "se": 0.4389, "strata_with_events": 9, "z": -0.10351 }, "discovery_q": 0.978223, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 10.9277, "lo": 0.69885, "log_rr": 1.01649, "p": 0.1473, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.76348, "se": 0.701447, "strata_with_events": 6, "z": 1.44914 } }, "Malignant melanoma": { "all": { "glp1_affected": 47, "glp1_at_risk": 93765, "hi": 1.72148, "lo": 0.722656, "log_rr": 0.10918, "p": 0.62197, "placebo_affected": 38, "placebo_at_risk": 67544, "rr": 1.11536, "se": 0.221434, "strata_with_events": 19, "z": 0.49306 }, "discovered": false, "discovery": { "glp1_affected": 28, "glp1_at_risk": 47388, "hi": 2.12534, "lo": 0.672359, "log_rr": 0.178485, "p": 0.543243, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 1.19541, "se": 0.293601, "strata_with_events": 10, "z": 0.607916 }, "discovery_q": 0.854614, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 19, "glp1_at_risk": 46377, "hi": 1.97027, "lo": 0.524089, "log_rr": 0.0160391, "p": 0.962133, "placebo_affected": 17, "placebo_at_risk": 32526, "rr": 1.01617, "se": 0.337829, "strata_with_events": 9, "z": 0.0474769 } }, "Mallory-Weiss syndrome": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 18.578, "lo": 1.54621, "log_rr": 1.67889, "p": 0.00811864, "placebo_affected": 3, "placebo_at_risk": 67544, "rr": 5.35961, "se": 0.634239, "strata_with_events": 10, "z": 2.6471 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 99.4546, "lo": 1.70086, "log_rr": 2.56542, "p": 0.0134476, "placebo_affected": 1, "placebo_at_risk": 35018, "rr": 13.0061, "se": 1.03792, "strata_with_events": 4, "z": 2.47169 }, "discovery_q": 0.27974, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 9.61263, "lo": 0.244547, "log_rr": 0.427365, "p": 0.648181, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 1.53321, "se": 0.936606, "strata_with_events": 6, "z": 0.456291 } }, "Melaena": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 1.79982, "lo": 0.37562, "log_rr": -0.195745, "p": 0.624341, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 0.822222, "se": 0.399718, "strata_with_events": 11, "z": -0.489707 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 2.309, "lo": 0.286571, "log_rr": -0.206477, "p": 0.698093, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.813445, "se": 0.532301, "strata_with_events": 6, "z": -0.387895 }, "discovery_q": 0.915356, 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"p": 0.485274, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 0.60084, "se": 0.73, "strata_with_events": 4, "z": -0.697846 } }, "Meniscus injury": { "all": { "glp1_affected": 43, "glp1_at_risk": 93765, "hi": 1.41002, "lo": 0.598862, "log_rr": -0.0845603, "p": 0.698694, "placebo_affected": 39, "placebo_at_risk": 67544, "rr": 0.918916, "se": 0.218455, "strata_with_events": 25, "z": -0.387084 }, "discovered": false, "discovery": { "glp1_affected": 16, "glp1_at_risk": 47388, "hi": 1.31533, "lo": 0.359082, "log_rr": -0.37506, "p": 0.257459, "placebo_affected": 19, "placebo_at_risk": 35018, "rr": 0.687248, "se": 0.331203, "strata_with_events": 12, "z": -1.13242 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 27, "glp1_at_risk": 46377, "hi": 2.04512, "lo": 0.644063, "log_rr": 0.137748, "p": 0.640261, "placebo_affected": 20, "placebo_at_risk": 32526, "rr": 1.14769, "se": 0.294754, "strata_with_events": 13, "z": 0.467334 } }, "Mental status changes": { "all": { "glp1_affected": 32, "glp1_at_risk": 93765, "hi": 2.31859, "lo": 0.784856, "log_rr": 0.299352, "p": 0.278678, "placebo_affected": 23, "placebo_at_risk": 67544, "rr": 1.34898, "se": 0.276335, "strata_with_events": 12, "z": 1.08329 }, "discovered": false, "discovery": { "glp1_affected": 20, "glp1_at_risk": 47388, "hi": 4.19387, "lo": 0.907484, "log_rr": 0.668272, "p": 0.0870154, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 1.95086, "se": 0.390493, "strata_with_events": 6, "z": 1.71136 }, "discovery_q": 0.540963, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 1.96549, "lo": 0.399405, "log_rr": -0.12102, "p": 0.765933, "placebo_affected": 13, "placebo_at_risk": 32526, "rr": 0.886016, "se": 0.406517, "strata_with_events": 6, "z": -0.297699 } }, "Metabolic acidosis": { "all": { "glp1_affected": 20, "glp1_at_risk": 93765, "hi": 1.11596, "lo": 0.349257, "log_rr": -0.471117, "p": 0.111892, "placebo_affected": 30, "placebo_at_risk": 67544, "rr": 0.624304, "se": 0.296348, "strata_with_events": 10, "z": -1.58975 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 1.75873, "lo": 0.388529, "log_rr": -0.190399, "p": 0.621109, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.826629, "se": 0.385206, "strata_with_events": 5, "z": -0.494279 }, "discovery_q": 0.882899, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 1.07815, "lo": 0.165173, "log_rr": -0.862756, "p": 0.07143, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 0.421997, "se": 0.478582, "strata_with_events": 5, "z": -1.80273 } }, "Metabolic encephalopathy": { "all": { "glp1_affected": 36, "glp1_at_risk": 93765, "hi": 2.41765, "lo": 0.876496, "log_rr": 0.375486, "p": 0.146871, "placebo_affected": 24, "placebo_at_risk": 67544, "rr": 1.4557, "se": 0.258836, "strata_with_events": 10, "z": 1.45067 }, "discovered": false, "discovery": { "glp1_affected": 17, "glp1_at_risk": 47388, "hi": 2.36541, "lo": 0.588978, "log_rr": 0.165791, "p": 0.640185, "placebo_affected": 14, "placebo_at_risk": 35018, "rr": 1.18033, "se": 0.354679, "strata_with_events": 4, "z": 0.467441 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 19, "glp1_at_risk": 46377, "hi": 3.90025, "lo": 0.867728, "log_rr": 0.609582, "p": 0.111853, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 1.83966, "se": 0.383404, "strata_with_events": 6, "z": 1.58992 } }, "Metastases to liver": { "all": { "glp1_affected": 23, "glp1_at_risk": 93765, "hi": 1.33061, "lo": 0.4521, "log_rr": -0.254108, "p": 0.356144, "placebo_affected": 29, "placebo_at_risk": 67544, "rr": 0.775608, "se": 0.275385, "strata_with_events": 12, "z": -0.922738 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 1.28509, "lo": 0.269511, "log_rr": -0.53016, "p": 0.183356, "placebo_affected": 17, "placebo_at_risk": 35018, "rr": 0.588511, "se": 0.398469, "strata_with_events": 6, "z": -1.33049 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 13, "glp1_at_risk": 46377, "hi": 2.1951, "lo": 0.480178, "log_rr": 0.0263138, "p": 0.94589, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 1.02666, "se": 0.387717, "strata_with_events": 6, "z": 0.0678686 } }, "Metastases to lung": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.327, "lo": 0.259825, "log_rr": -0.532412, "p": 0.200598, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 0.587187, "se": 0.415995, "strata_with_events": 10, "z": -1.27985 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 2.55072, "lo": 0.288212, "log_rr": -0.153842, "p": 0.782108, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 0.857407, "se": 0.556243, "strata_with_events": 5, "z": -0.276573 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 1.31278, "lo": 0.098816, "log_rr": -1.02117, "p": 0.121734, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.360172, "se": 0.659871, "strata_with_events": 5, "z": -1.54754 } }, "Migraine": { "all": { "glp1_affected": 30, "glp1_at_risk": 93765, "hi": 3.18649, "lo": 0.910704, "log_rr": 0.532691, "p": 0.0954725, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 1.70351, "se": 0.31951, "strata_with_events": 17, "z": 1.66721 }, "discovered": false, "discovery": { "glp1_affected": 17, "glp1_at_risk": 47388, "hi": 2.67978, "lo": 0.573777, "log_rr": 0.21511, "p": 0.584311, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 1.24, "se": 0.393183, "strata_with_events": 10, "z": 0.547098 }, "discovery_q": 0.872706, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 13, "glp1_at_risk": 46377, "hi": 9.65748, "lo": 0.979994, "log_rr": 1.12376, "p": 0.0541869, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 3.0764, "se": 0.583669, "strata_with_events": 7, "z": 1.92534 } }, "Mitral valve incompetence": { "all": { "glp1_affected": 28, "glp1_at_risk": 93765, "hi": 1.28705, "lo": 0.471585, "log_rr": -0.249651, "p": 0.329704, "placebo_affected": 34, "placebo_at_risk": 67544, "rr": 0.779072, "se": 0.256129, "strata_with_events": 13, "z": -0.97471 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 0.790477, "lo": 0.173142, "log_rr": -0.994381, "p": 0.0102612, "placebo_affected": 24, "placebo_at_risk": 35018, "rr": 0.369953, "se": 0.387386, "strata_with_events": 6, "z": -2.5669 }, "discovery_q": 0.27584, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 19, "glp1_at_risk": 46377, "hi": 3.75647, "lo": 0.808891, "log_rr": 0.555694, "p": 0.156031, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 1.74315, "se": 0.391734, "strata_with_events": 7, "z": 1.41855 } }, "Multiple injuries": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 2.30902, "lo": 0.426229, "log_rr": -0.00797764, "p": 0.985233, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 0.992054, "se": 0.431029, "strata_with_events": 12, "z": -0.0185084 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 2.43575, "lo": 0.264833, "log_rr": -0.2192, "p": 0.698579, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 0.803161, "se": 0.56606, "strata_with_events": 6, "z": -0.387239 }, "discovery_q": 0.915356, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 5.02978, "lo": 0.353425, "log_rr": 0.287647, "p": 0.671116, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.33329, "se": 0.677425, "strata_with_events": 6, "z": 0.424617 } }, "Multiple organ dysfunction syndrome": { "all": { "glp1_affected": 41, "glp1_at_risk": 93765, "hi": 1.16261, "lo": 0.514859, "log_rr": -0.256597, "p": 0.216876, "placebo_affected": 53, "placebo_at_risk": 67544, "rr": 0.77368, "se": 0.207792, "strata_with_events": 8, "z": -1.23488 }, "discovered": false, "discovery": { "glp1_affected": 25, "glp1_at_risk": 47388, "hi": 1.36545, "lo": 0.476497, "log_rr": -0.214905, "p": 0.423604, "placebo_affected": 31, "placebo_at_risk": 35018, "rr": 0.806618, "se": 0.26857, "strata_with_events": 4, "z": -0.800185 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 1.38386, "lo": 0.38221, "log_rr": -0.318454, "p": 0.331947, "placebo_affected": 22, "placebo_at_risk": 32526, "rr": 0.727272, "se": 0.328236, "strata_with_events": 4, "z": -0.970199 } }, "Muscular weakness": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 1.82477, "lo": 0.466737, "log_rr": -0.0802664, "p": 0.817495, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 0.92287, "se": 0.347824, "strata_with_events": 12, "z": -0.230768 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 2.66404, "lo": 0.375437, "log_rr": 8.95887e-05, "p": 0.999857, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 1.00009, "se": 0.499884, "strata_with_events": 4, "z": 0.000179219 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 2.21619, "lo": 0.331147, "log_rr": -0.154701, "p": 0.749725, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.856671, "se": 0.484954, "strata_with_events": 8, "z": -0.319002 } }, "Musculoskeletal chest pain": { "all": { "glp1_affected": 60, "glp1_at_risk": 93765, "hi": 1.39242, "lo": 0.675196, "log_rr": -0.0308546, "p": 0.867289, "placebo_affected": 59, "placebo_at_risk": 67544, "rr": 0.969617, "se": 0.184645, "strata_with_events": 20, "z": -0.167102 }, "discovered": false, "discovery": { "glp1_affected": 28, "glp1_at_risk": 47388, "hi": 1.41184, "lo": 0.511776, "log_rr": -0.162487, "p": 0.530219, "placebo_affected": 32, "placebo_at_risk": 35018, "rr": 0.850027, "se": 0.258873, "strata_with_events": 8, "z": -0.627672 }, "discovery_q": 0.839242, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 32, "glp1_at_risk": 46377, "hi": 1.86646, "lo": 0.661441, "log_rr": 0.105354, "p": 0.690555, "placebo_affected": 27, "placebo_at_risk": 32526, "rr": 1.1111, "se": 0.264642, "strata_with_events": 12, "z": 0.398102 } }, "Musculoskeletal pain": { "all": { "glp1_affected": 25, "glp1_at_risk": 93765, "hi": 2.31831, "lo": 0.658107, "log_rr": 0.211225, "p": 0.510836, "placebo_affected": 18, "placebo_at_risk": 67544, "rr": 1.23519, "se": 0.321237, "strata_with_events": 13, "z": 0.657537 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 6.14533, "lo": 0.886592, "log_rr": 0.847661, "p": 0.0861163, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 2.33418, "se": 0.493903, "strata_with_events": 6, "z": 1.71625 }, "discovery_q": 0.540963, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 1.68733, "lo": 0.279208, "log_rr": -0.376325, "p": 0.412207, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 0.686379, "se": 0.458924, "strata_with_events": 7, "z": -0.820016 } }, "Myocardial infarction": { "all": { "glp1_affected": 265, "glp1_at_risk": 93765, "hi": 1.03162, "lo": 0.732632, "log_rr": -0.139989, "p": 0.108855, "placebo_affected": 271, "placebo_at_risk": 67544, "rr": 0.869368, "se": 0.0873094, "strata_with_events": 47, "z": -1.60336 }, "discovered": false, "discovery": { "glp1_affected": 173, "glp1_at_risk": 47388, "hi": 1.13309, "lo": 0.742535, "log_rr": -0.0863664, "p": 0.423107, "placebo_affected": 178, "placebo_at_risk": 35018, "rr": 0.917258, "se": 0.107818, "strata_with_events": 20, "z": -0.801042 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 92, "glp1_at_risk": 46377, "hi": 1.04953, "lo": 0.585009, "log_rr": -0.243894, "p": 0.101889, "placebo_affected": 93, "placebo_at_risk": 32526, "rr": 0.78357, "se": 0.149101, "strata_with_events": 27, "z": -1.63576 } }, "Myocardial ischaemia": { "all": { "glp1_affected": 130, "glp1_at_risk": 93765, "hi": 0.940264, "lo": 0.592785, "log_rr": -0.292259, "p": 0.0130159, "placebo_affected": 164, "placebo_at_risk": 67544, "rr": 0.746575, "se": 0.117688, "strata_with_events": 24, "z": -2.48333 }, "discovered": false, "discovery": { "glp1_affected": 79, "glp1_at_risk": 47388, "hi": 0.860699, "lo": 0.487505, "log_rr": -0.434233, "p": 0.00274972, "placebo_affected": 119, "placebo_at_risk": 35018, "rr": 0.647761, "se": 0.145014, "strata_with_events": 10, "z": -2.99441 }, "discovery_q": 0.141886, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 51, "glp1_at_risk": 46377, "hi": 1.48981, "lo": 0.668454, "log_rr": -0.00206962, "p": 0.991923, "placebo_affected": 45, "placebo_at_risk": 32526, "rr": 0.997933, "se": 0.204452, "strata_with_events": 14, "z": -0.0101227 } }, "Nausea": { "all": { "glp1_affected": 66, "glp1_at_risk": 93765, "hi": 2.92182, "lo": 1.17027, "log_rr": 0.61472, "p": 0.00844881, "placebo_affected": 30, "placebo_at_risk": 67544, "rr": 1.84914, "se": 0.233415, "strata_with_events": 31, "z": 2.63359 }, "discovered": false, "discovery": { "glp1_affected": 39, "glp1_at_risk": 47388, "hi": 2.3246, "lo": 0.813446, "log_rr": 0.318535, "p": 0.23438, "placebo_affected": 25, "placebo_at_risk": 35018, "rr": 1.37511, "se": 0.267868, "strata_with_events": 17, "z": 1.18915 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 27, "glp1_at_risk": 46377, "hi": 11.7919, "lo": 1.50971, "log_rr": 1.43967, "p": 0.00604175, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 4.21929, "se": 0.524372, "strata_with_events": 14, "z": 2.74551 } }, "Neck pain": { "all": { "glp1_affected": 7, "glp1_at_risk": 93765, "hi": 1.01013, "lo": 0.135619, "log_rr": -0.993911, "p": 0.0523456, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 0.370126, "se": 0.512251, "strata_with_events": 10, "z": -1.94028 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 1.07518, "lo": 0.105014, "log_rr": -1.09058, "p": 0.0660909, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 0.33602, "se": 0.593416, "strata_with_events": 6, "z": -1.83781 }, "discovery_q": 0.508999, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 2, "glp1_at_risk": 46377, "hi": 3.74944, "lo": 0.0664146, "log_rr": -0.695115, "p": 0.499325, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 0.499017, "se": 1.02896, "strata_with_events": 4, "z": -0.675552 } }, "Nephrolithiasis": { "all": { "glp1_affected": 179, "glp1_at_risk": 93765, "hi": 1.45394, "lo": 0.924386, "log_rr": 0.147827, "p": 0.200738, "placebo_affected": 133, 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9, "glp1_at_risk": 47388, "hi": 1.4854, "lo": 0.278598, "log_rr": -0.44115, "p": 0.3015, "placebo_affected": 14, "placebo_at_risk": 35018, "rr": 0.643296, "se": 0.426965, "strata_with_events": 4, "z": -1.03322 }, "discovery_q": 0.739916, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 1.65656, "lo": 0.110871, "log_rr": -0.84732, "p": 0.219341, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.428562, "se": 0.689842, "strata_with_events": 4, "z": -1.22828 } }, "Neuropathy peripheral": { "all": { "glp1_affected": 15, "glp1_at_risk": 93765, "hi": 2.63127, "lo": 0.568658, "log_rr": 0.201495, "p": 0.606145, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 1.22323, "se": 0.390809, "strata_with_events": 9, "z": 0.515583 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 2.73071, "lo": 0.254448, "log_rr": -0.182049, "p": 0.763646, "placebo_affected": 6, "placebo_at_risk": 35018, 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"Obesity": { "all": { "glp1_affected": 20, "glp1_at_risk": 93765, "hi": 0.594418, "lo": 0.210705, "log_rr": -1.03873, "p": 8.6366e-05, "placebo_affected": 47, "placebo_at_risk": 67544, "rr": 0.353902, "se": 0.264578, "strata_with_events": 19, "z": -3.92601 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 0.656567, "lo": 0.162152, "log_rr": -1.11998, "p": 0.00169378, "placebo_affected": 25, "placebo_at_risk": 35018, "rr": 0.326287, "se": 0.356765, "strata_with_events": 10, "z": -3.13926 }, "discovery_q": 0.124855, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 0.841273, "lo": 0.179102, "log_rr": -0.94632, "p": 0.0164881, "placebo_affected": 22, "placebo_at_risk": 32526, "rr": 0.388167, "se": 0.39464, "strata_with_events": 9, "z": -2.39793 } }, "Obstructive pancreatitis": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 1.32743, "lo": 0.380874, "log_rr": -0.341021, "p": 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"z": 0.000772252 } }, "Orthostatic hypotension": { "all": { "glp1_affected": 64, "glp1_at_risk": 93765, "hi": 1.89255, "lo": 0.878161, "log_rr": 0.253999, "p": 0.194739, "placebo_affected": 47, "placebo_at_risk": 67544, "rr": 1.28917, "se": 0.195883, "strata_with_events": 17, "z": 1.29669 }, "discovered": false, "discovery": { "glp1_affected": 44, "glp1_at_risk": 47388, "hi": 2.08144, "lo": 0.824216, "log_rr": 0.269868, "p": 0.253482, "placebo_affected": 32, "placebo_at_risk": 35018, "rr": 1.30979, "se": 0.236326, "strata_with_events": 11, "z": 1.14193 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 20, "glp1_at_risk": 46377, "hi": 2.47363, "lo": 0.626799, "log_rr": 0.219278, "p": 0.531233, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 1.24518, "se": 0.350214, "strata_with_events": 6, "z": 0.626125 } }, "Osteoarthritis": { "all": { "glp1_affected": 518, "glp1_at_risk": 93765, "hi": 1.09685, "lo": 0.857108, "log_rr": 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0.536721, "log_rr": -0.256477, "p": 0.169377, "placebo_affected": 64, "placebo_at_risk": 35018, "rr": 0.773773, "se": 0.186636, "strata_with_events": 16, "z": -1.37421 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 39, "glp1_at_risk": 46377, "hi": 1.01854, "lo": 0.441802, "log_rr": -0.399261, "p": 0.0609664, "placebo_affected": 51, "placebo_at_risk": 32526, "rr": 0.670816, "se": 0.213082, "strata_with_events": 11, "z": -1.87374 } }, "Osteonecrosis": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 1.77825, "lo": 0.330138, "log_rr": -0.266306, "p": 0.535297, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 0.766204, "se": 0.429567, "strata_with_events": 11, "z": -0.619941 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 1.72714, "lo": 0.141434, "log_rr": -0.704727, "p": 0.269621, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.494243, "se": 0.638377, 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4.95413, "lo": 0.80742, "log_rr": 0.693155, "p": 0.134198, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 2.00002, "se": 0.462798, "strata_with_events": 4, "z": 1.49775 }, "discovery_q": 0.623841, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 1, "glp1_at_risk": 46377, "hi": 15.9748, "lo": 0.0626009, "log_rr": 2.02545e-05, "p": 0.999989, "placebo_affected": 1, "placebo_at_risk": 32526, "rr": 1.00002, "se": 1.4138, "strata_with_events": 2, "z": 1.43263e-05 } }, "Peripheral artery angioplasty": { "all": { "glp1_affected": 24, "glp1_at_risk": 93765, "hi": 1.40582, "lo": 0.474729, "log_rr": -0.202195, "p": 0.465346, "placebo_affected": 29, "placebo_at_risk": 67544, "rr": 0.816936, "se": 0.276952, "strata_with_events": 3, "z": -0.730072 }, "discovered": false, "discovery": { "glp1_affected": 20, "glp1_at_risk": 47388, "hi": 1.3199, "lo": 0.416423, "log_rr": -0.299248, "p": 0.309232, "placebo_affected": 27, "placebo_at_risk": 35018, "rr": 0.741375, "se": 0.294294, "strata_with_events": 1, "z": -1.01683 }, "discovery_q": 0.739916, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 10.6194, "lo": 0.31773, "log_rr": 0.608063, "p": 0.496994, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 1.83687, "se": 0.895228, "strata_with_events": 2, "z": 0.679227 } }, "Peripheral artery bypass": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 1.68902, "lo": 0.391488, "log_rr": -0.206826, "p": 0.579192, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.813161, "se": 0.372953, "strata_with_events": 3, "z": -0.554565 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 1.59634, "lo": 0.337447, "log_rr": -0.309316, "p": 0.435266, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.733949, "se": 0.396451, "strata_with_events": 2, "z": -0.780213 }, "discovery_q": 0.780524, "overlap_bound": 1.0, "replicated": false, "replication": { 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"placebo_at_risk": 32526, "rr": 1.02388, "se": 0.378464, "strata_with_events": 4, "z": 0.0623548 } }, "Peripheral artery stenosis": { "all": { "glp1_affected": 44, "glp1_at_risk": 93765, "hi": 1.29014, "lo": 0.572699, "log_rr": -0.151323, "p": 0.465156, "placebo_affected": 50, "placebo_at_risk": 67544, "rr": 0.85957, "se": 0.207184, "strata_with_events": 12, "z": -0.730382 }, "discovered": false, "discovery": { "glp1_affected": 37, "glp1_at_risk": 47388, "hi": 1.51699, "lo": 0.611512, "log_rr": -0.0375469, "p": 0.871309, "placebo_affected": 38, "placebo_at_risk": 35018, "rr": 0.963149, "se": 0.231777, "strata_with_events": 7, "z": -0.161996 }, "discovery_q": 0.958626, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 1.37853, "lo": 0.211885, "log_rr": -0.615346, "p": 0.197739, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 0.540454, "se": 0.477745, "strata_with_events": 5, "z": -1.28802 } }, "Peripheral artery stent 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0.333572, "strata_with_events": 11, "z": 0.463255 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 2.30663, "lo": 0.433766, "log_rr": 0.000269162, "p": 0.999496, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 1.00027, "se": 0.426293, "strata_with_events": 4, "z": 0.000631401 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 4.25564, "lo": 0.509894, "log_rr": 0.387346, "p": 0.474236, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 1.47307, "se": 0.541285, "strata_with_events": 7, "z": 0.715604 } }, "Peripheral ischaemia": { "all": { "glp1_affected": 65, "glp1_at_risk": 93765, "hi": 1.11575, "lo": 0.580068, "log_rr": -0.217541, "p": 0.192366, "placebo_affected": 78, "placebo_at_risk": 67544, "rr": 0.804495, "se": 0.166875, "strata_with_events": 14, "z": -1.30361 }, "discovered": false, "discovery": { "glp1_affected": 42, "glp1_at_risk": 47388, "hi": 1.43365, "lo": 0.619982, "log_rr": -0.0589217, "p": 0.782913, "placebo_affected": 44, "placebo_at_risk": 35018, "rr": 0.942781, "se": 0.213852, "strata_with_events": 9, "z": -0.275525 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 23, "glp1_at_risk": 46377, "hi": 1.06723, "lo": 0.370089, "log_rr": -0.464471, "p": 0.0855904, "placebo_affected": 34, "placebo_at_risk": 32526, "rr": 0.628467, "se": 0.270178, "strata_with_events": 5, "z": -1.71913 } }, "Peripheral revascularisation": { "all": { "glp1_affected": 35, "glp1_at_risk": 93765, "hi": 1.07754, "lo": 0.455468, "log_rr": -0.355875, "p": 0.105231, "placebo_affected": 50, "placebo_at_risk": 67544, "rr": 0.70056, "se": 0.219675, "strata_with_events": 2, "z": -1.62001 }, "discovered": false, "discovery": { "glp1_affected": 29, "glp1_at_risk": 47388, "hi": 1.31259, "lo": 0.49523, "log_rr": -0.215367, "p": 0.386432, "placebo_affected": 36, "placebo_at_risk": 35018, "rr": 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0.873782, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.925596, "se": 0.486711, "strata_with_events": 5, "z": -0.158856 } }, "Plasma cell myeloma": { "all": { "glp1_affected": 29, "glp1_at_risk": 93765, "hi": 1.84653, "lo": 0.648922, "log_rr": 0.0904333, "p": 0.734623, "placebo_affected": 26, "placebo_at_risk": 67544, "rr": 1.09465, "se": 0.266779, "strata_with_events": 14, "z": 0.338983 }, "discovered": false, "discovery": { "glp1_affected": 16, "glp1_at_risk": 47388, "hi": 2.22753, "lo": 0.547197, "log_rr": 0.098973, "p": 0.78227, "placebo_affected": 14, "placebo_at_risk": 35018, "rr": 1.10404, "se": 0.358129, "strata_with_events": 7, "z": 0.276362 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 13, "glp1_at_risk": 46377, "hi": 2.37188, "lo": 0.494791, "log_rr": 0.0800317, "p": 0.841352, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 1.08332, "se": 0.399829, "strata_with_events": 7, "z": 0.200165 } }, "Pleural effusion": { "all": { "glp1_affected": 78, "glp1_at_risk": 93765, "hi": 1.18542, "lo": 0.640806, "log_rr": -0.137467, "p": 0.381017, "placebo_affected": 87, "placebo_at_risk": 67544, "rr": 0.871563, "se": 0.156922, "strata_with_events": 15, "z": -0.876023 }, "discovered": false, "discovery": { "glp1_affected": 39, "glp1_at_risk": 47388, "hi": 1.13252, "lo": 0.487886, "log_rr": -0.296614, "p": 0.167373, "placebo_affected": 51, "placebo_at_risk": 35018, "rr": 0.743331, "se": 0.21483, "strata_with_events": 8, "z": -1.38069 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 39, "glp1_at_risk": 46377, "hi": 1.6558, "lo": 0.66792, "log_rr": 0.0503479, "p": 0.827906, "placebo_affected": 36, "placebo_at_risk": 32526, "rr": 1.05164, "se": 0.231603, "strata_with_events": 7, "z": 0.217388 } }, "Pneumonia": { "all": { "glp1_affected": 807, "glp1_at_risk": 93765, "hi": 0.95087, "lo": 0.786347, "log_rr": -0.145367, "p": 0.00270483, "placebo_affected": 880, "placebo_at_risk": 67544, "rr": 0.864705, "se": 0.048465, "strata_with_events": 80, "z": -2.99943 }, "discovered": false, "discovery": { "glp1_affected": 440, "glp1_at_risk": 47388, "hi": 0.960747, "lo": 0.744781, "log_rr": -0.167354, "p": 0.00998202, "placebo_affected": 501, "placebo_at_risk": 35018, "rr": 0.8459, "se": 0.0649554, "strata_with_events": 40, "z": -2.57645 }, "discovery_q": 0.27584, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 367, "glp1_at_risk": 46377, "hi": 1.02549, "lo": 0.770891, "log_rr": -0.117517, "p": 0.106488, "placebo_affected": 379, "placebo_at_risk": 32526, "rr": 0.889125, "se": 0.0728029, "strata_with_events": 40, "z": -1.61418 } }, "Pneumonia aspiration": { "all": { "glp1_affected": 42, "glp1_at_risk": 93765, "hi": 1.46494, "lo": 0.626359, "log_rr": -0.0430082, "p": 0.842714, "placebo_affected": 43, "placebo_at_risk": 67544, "rr": 0.957904, "se": 0.21675, "strata_with_events": 10, "z": -0.198423 }, "discovered": false, "discovery": { "glp1_affected": 28, "glp1_at_risk": 47388, "hi": 1.48377, "lo": 0.530765, "log_rr": -0.119424, "p": 0.648842, "placebo_affected": 31, "placebo_at_risk": 35018, "rr": 0.887432, "se": 0.262256, "strata_with_events": 5, "z": -0.455371 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 14, "glp1_at_risk": 46377, "hi": 2.42308, "lo": 0.531662, "log_rr": 0.126647, "p": 0.74344, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 1.13502, "se": 0.386943, "strata_with_events": 5, "z": 0.327301 } }, "Pneumonia bacterial": { "all": { "glp1_affected": 35, "glp1_at_risk": 93765, "hi": 1.49144, "lo": 0.578688, "log_rr": -0.0736235, "p": 0.760491, "placebo_affected": 36, "placebo_at_risk": 67544, "rr": 0.929021, "se": 0.241519, "strata_with_events": 11, "z": -0.304836 }, "discovered": false, "discovery": { "glp1_affected": 27, "glp1_at_risk": 47388, "hi": 2.12235, "lo": 0.684028, "log_rr": 0.186383, "p": 0.518762, "placebo_affected": 22, "placebo_at_risk": 35018, "rr": 1.20488, "se": 0.288852, "strata_with_events": 5, "z": 0.645255 }, "discovery_q": 0.831308, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 1.24827, "lo": 0.196771, "log_rr": -0.701979, "p": 0.136371, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 0.495604, "se": 0.471304, "strata_with_events": 6, "z": -1.48944 } }, "Pneumonia viral": { "all": { "glp1_affected": 20, "glp1_at_risk": 93765, "hi": 2.46589, "lo": 0.625267, "log_rr": 0.216489, "p": 0.536267, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 1.24171, "se": 0.35004, "strata_with_events": 11, "z": 0.618468 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 2.69301, "lo": 0.54178, "log_rr": 0.188882, "p": 0.644277, "placebo_affected": 11, "placebo_at_risk": 35018, "rr": 1.2079, "se": 0.409077, "strata_with_events": 6, "z": 0.461726 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 5.02632, "lo": 0.354418, "log_rr": 0.288705, "p": 0.669568, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.3347, "se": 0.676535, "strata_with_events": 5, "z": 0.42674 } }, "Pneumothorax": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 1.34657, "lo": 0.438764, "log_rr": -0.263117, "p": 0.357688, "placebo_affected": 27, "placebo_at_risk": 67544, "rr": 0.768652, "se": 0.286065, "strata_with_events": 13, "z": -0.91978 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 1.97676, "lo": 0.397823, "log_rr": -0.120144, "p": 0.768942, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 0.886792, "se": 0.408989, "strata_with_events": 4, "z": -0.29376 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 11, "glp1_at_risk": 46377, "hi": 1.48016, "lo": 0.306199, "log_rr": -0.395685, "p": 0.324928, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 0.673219, "se": 0.401963, "strata_with_events": 9, "z": -0.984382 } }, "Post procedural haematoma": { "all": { "glp1_affected": 11, "glp1_at_risk": 93765, "hi": 2.63082, "lo": 0.46514, "log_rr": 0.10094, "p": 0.819369, "placebo_affected": 9, "placebo_at_risk": 67544, "rr": 1.10621, "se": 0.442026, "strata_with_events": 11, "z": 0.228357 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 9.03007, "lo": 0.817252, "log_rr": 0.999376, "p": 0.102959, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 2.71659, "se": 0.61286, "strata_with_events": 7, "z": 1.63068 }, "discovery_q": 0.574134, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 1, "glp1_at_risk": 46377, "hi": 1.38563, "lo": 0.0200586, "log_rr": -1.79147, "p": 0.0972989, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.166715, "se": 1.08044, "strata_with_events": 4, "z": -1.65809 } }, "Post procedural haemorrhage": { "all": { "glp1_affected": 39, "glp1_at_risk": 93765, "hi": 2.97411, "lo": 1.00875, "log_rr": 0.549326, "p": 0.0464222, "placebo_affected": 20, "placebo_at_risk": 67544, "rr": 1.73209, "se": 0.275831, "strata_with_events": 19, "z": 1.99153 }, "discovered": false, "discovery": { "glp1_affected": 21, "glp1_at_risk": 47388, "hi": 3.25719, "lo": 0.797046, "log_rr": 0.477011, "p": 0.184081, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 1.61125, "se": 0.359116, "strata_with_events": 7, "z": 1.32829 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 18, "glp1_at_risk": 46377, "hi": 4.45307, "lo": 0.821052, "log_rr": 0.648212, "p": 0.13288, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 1.91212, "se": 0.431325, "strata_with_events": 12, "z": 1.50284 } }, "Post procedural infection": { "all": { "glp1_affected": 18, "glp1_at_risk": 93765, "hi": 1.98421, "lo": 0.51434, "log_rr": 0.0101745, "p": 0.976433, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 1.01023, "se": 0.344417, "strata_with_events": 11, "z": 0.0295413 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 2.26825, "lo": 0.453477, "log_rr": 0.0140992, "p": 0.972613, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 1.0142, "se": 0.410675, "strata_with_events": 7, "z": 0.0343318 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 3.45544, "lo": 0.289798, "log_rr": 0.0006895, "p": 0.99913, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.00069, "se": 0.632287, "strata_with_events": 4, "z": 0.00109049 } }, "Postoperative wound infection": { "all": { "glp1_affected": 60, "glp1_at_risk": 93765, "hi": 1.90411, "lo": 0.852706, "log_rr": 0.242336, "p": 0.237019, "placebo_affected": 43, "placebo_at_risk": 67544, "rr": 1.27422, "se": 0.204941, "strata_with_events": 18, "z": 1.18247 }, "discovered": false, "discovery": { "glp1_affected": 30, "glp1_at_risk": 47388, "hi": 1.66971, "lo": 0.60185, "log_rr": 0.00245271, "p": 0.992482, "placebo_affected": 29, "placebo_at_risk": 35018, "rr": 1.00246, "se": 0.260311, "strata_with_events": 8, "z": 0.00942224 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 30, "glp1_at_risk": 46377, "hi": 3.59738, "lo": 0.944674, "log_rr": 0.611645, "p": 0.0729553, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 1.84346, "se": 0.341109, "strata_with_events": 10, "z": 1.79311 } }, "Presyncope": { "all": { "glp1_affected": 49, "glp1_at_risk": 93765, "hi": 1.90055, "lo": 0.797071, "log_rr": 0.207665, "p": 0.348864, "placebo_affected": 37, "placebo_at_risk": 67544, "rr": 1.2308, "se": 0.221676, "strata_with_events": 18, "z": 0.936795 }, "discovered": false, "discovery": { "glp1_affected": 31, "glp1_at_risk": 47388, "hi": 1.8705, "lo": 0.658797, "log_rr": 0.104432, "p": 0.694847, "placebo_affected": 27, "placebo_at_risk": 35018, "rr": 1.11008, "se": 0.266215, "strata_with_events": 8, "z": 0.392286 }, "discovery_q": 0.915356, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 18, "glp1_at_risk": 46377, "hi": 3.41129, "lo": 0.700192, "log_rr": 0.435345, "p": 0.28117, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 1.5455, "se": 0.40396, "strata_with_events": 10, "z": 1.07769 } }, "Procedural pain": { "all": { "glp1_affected": 11, "glp1_at_risk": 93765, "hi": 2.23805, "lo": 0.347123, "log_rr": -0.126234, "p": 0.790616, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 0.881409, "se": 0.475438, "strata_with_events": 12, "z": -0.265511 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 2.2443, "lo": 0.265785, "log_rr": -0.258338, "p": 0.63503, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.772334, "se": 0.54426, "strata_with_events": 7, "z": -0.474659 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 9.37559, "lo": 0.185265, "log_rr": 0.276071, "p": 0.782717, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 1.31794, "se": 1.00106, "strata_with_events": 5, "z": 0.275779 } }, "Prostate cancer": { "all": { "glp1_affected": 235, "glp1_at_risk": 93765, "hi": 1.18661, "lo": 0.820891, "log_rr": -0.0131307, "p": 0.888905, "placebo_affected": 223, "placebo_at_risk": 67544, "rr": 0.986955, "se": 0.0939989, "strata_with_events": 41, "z": -0.13969 }, "discovered": false, "discovery": { "glp1_affected": 146, "glp1_at_risk": 47388, "hi": 1.31107, "lo": 0.820592, "log_rr": 0.0365558, "p": 0.759745, "placebo_affected": 134, "placebo_at_risk": 35018, "rr": 1.03723, "se": 0.119535, "strata_with_events": 19, "z": 0.305815 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 89, "glp1_at_risk": 46377, "hi": 1.22849, "lo": 0.676098, "log_rr": -0.0928144, "p": 0.542383, "placebo_affected": 89, "placebo_at_risk": 32526, "rr": 0.911363, "se": 0.152351, "strata_with_events": 22, "z": -0.609213 } }, "Prostate cancer metastatic": { "all": { "glp1_affected": 24, "glp1_at_risk": 93765, "hi": 1.22115, "lo": 0.437382, "log_rr": -0.313577, "p": 0.231236, "placebo_affected": 31, "placebo_at_risk": 67544, "rr": 0.730828, "se": 0.261929, "strata_with_events": 16, "z": -1.19718 }, "discovered": false, "discovery": { "glp1_affected": 17, "glp1_at_risk": 47388, "hi": 1.48502, "lo": 0.421485, "log_rr": -0.23427, "p": 0.465896, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 0.791148, "se": 0.321282, "strata_with_events": 7, "z": -0.729173 }, "discovery_q": 0.796034, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 1.5009, "lo": 0.253363, "log_rr": -0.483433, "p": 0.286776, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.616663, "se": 0.453834, "strata_with_events": 9, "z": -1.06522 } }, "Prostatic adenoma": { "all": { "glp1_affected": 15, "glp1_at_risk": 93765, "hi": 3.29054, "lo": 0.654579, "log_rr": 0.383643, "p": 0.351705, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 1.46762, "se": 0.41195, "strata_with_events": 8, "z": 0.931287 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 2.73303, "lo": 0.254406, "log_rr": -0.181706, "p": 0.764176, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.833847, "se": 0.605683, "strata_with_events": 4, "z": -0.300001 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 7.82555, "lo": 0.747149, "log_rr": 0.882952, "p": 0.140613, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 2.41803, "se": 0.599216, "strata_with_events": 4, "z": 1.47351 } }, "Prostatitis": { "all": { "glp1_affected": 28, "glp1_at_risk": 93765, "hi": 2.57843, "lo": 0.813758, "log_rr": 0.370544, "p": 0.207862, "placebo_affected": 19, "placebo_at_risk": 67544, "rr": 1.44852, "se": 0.294207, "strata_with_events": 10, "z": 1.25947 }, "discovered": false, "discovery": { "glp1_affected": 19, "glp1_at_risk": 47388, "hi": 4.66583, "lo": 0.955632, "log_rr": 0.747441, "p": 0.0646354, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 2.11159, "se": 0.40451, "strata_with_events": 4, "z": 1.84777 }, "discovery_q": 0.507552, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 2.10642, "lo": 0.360213, "log_rr": -0.138036, "p": 0.759311, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.871067, "se": 0.450531, "strata_with_events": 6, "z": -0.306385 } }, "Prostatomegaly": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 3.81847, "lo": 0.64041, "log_rr": 0.447102, "p": 0.326307, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 1.56377, "se": 0.455492, "strata_with_events": 8, "z": 0.981579 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 6.33161, "lo": 0.764637, "log_rr": 0.7886, "p": 0.143648, "placebo_affected": 5, "placebo_at_risk": 35018, "rr": 2.20031, "se": 0.539273, "strata_with_events": 4, "z": 1.46234 }, "discovery_q": 0.629158, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 2, "glp1_at_risk": 46377, "hi": 3.75466, "lo": 0.0671021, "log_rr": -0.689272, "p": 0.501994, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 0.501942, "se": 1.02669, "strata_with_events": 4, "z": -0.671356 } }, "Pulmonary embolism": { "all": { "glp1_affected": 144, "glp1_at_risk": 93765, "hi": 1.00738, "lo": 0.643412, "log_rr": -0.216809, "p": 0.0580037, "placebo_affected": 160, "placebo_at_risk": 67544, "rr": 0.805084, "se": 0.11437, "strata_with_events": 37, "z": -1.89567 }, "discovered": false, "discovery": { "glp1_affected": 91, "glp1_at_risk": 47388, "hi": 1.05065, "lo": 0.603024, "log_rr": -0.228197, "p": 0.107147, "placebo_affected": 106, "placebo_at_risk": 35018, "rr": 0.795967, "se": 0.141636, "strata_with_events": 18, "z": -1.61115 }, "discovery_q": 0.58166, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 53, "glp1_at_risk": 46377, "hi": 1.20277, "lo": 0.562439, "log_rr": -0.195424, "p": 0.313537, "placebo_affected": 54, "placebo_at_risk": 32526, "rr": 0.822486, "se": 0.193906, "strata_with_events": 19, "z": -1.00783 } }, "Pulmonary fibrosis": { "all": { "glp1_affected": 8, "glp1_at_risk": 93765, "hi": 1.23918, "lo": 0.208911, "log_rr": -0.675699, "p": 0.136809, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 0.508801, "se": 0.454166, "strata_with_events": 11, "z": -1.48778 }, "discovered": false, "discovery": { "glp1_affected": 4, "glp1_at_risk": 47388, "hi": 1.98194, "lo": 0.145721, "log_rr": -0.620993, "p": 0.35102, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.53741, "se": 0.665864, "strata_with_events": 5, "z": -0.932612 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.64242, "lo": 0.143909, "log_rr": -0.721202, "p": 0.245588, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.486168, "se": 0.62112, "strata_with_events": 6, "z": -1.16113 } }, "Pulmonary hypertension": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 2.61853, "lo": 0.722549, "log_rr": 0.318821, "p": 0.331737, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 1.37551, "se": 0.328471, "strata_with_events": 8, "z": 0.970622 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 2.58989, "lo": 0.467465, "log_rr": 0.0955916, "p": 0.826753, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 1.10031, "se": 0.436755, "strata_with_events": 4, "z": 0.218868 }, "discovery_q": 0.935536, "overlap_bound": 1.0, "replicated": false, "replication": { 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32526, "rr": 1.47063, "se": 0.597203, "strata_with_events": 6, "z": 0.645827 } }, "Pulmonary oedema": { "all": { "glp1_affected": 74, "glp1_at_risk": 93765, "hi": 0.90413, "lo": 0.489771, "log_rr": -0.407299, "p": 0.00920356, "placebo_affected": 103, "placebo_at_risk": 67544, "rr": 0.665445, "se": 0.156389, "strata_with_events": 21, "z": -2.6044 }, "discovered": false, "discovery": { "glp1_affected": 38, "glp1_at_risk": 47388, "hi": 1.09513, "lo": 0.472595, "log_rr": -0.329322, "p": 0.124515, "placebo_affected": 52, "placebo_at_risk": 35018, "rr": 0.719411, "se": 0.214389, "strata_with_events": 6, "z": -1.53609 }, "discovery_q": 0.600466, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 36, "glp1_at_risk": 46377, "hi": 0.956692, "lo": 0.389935, "log_rr": -0.493025, "p": 0.0312924, "placebo_affected": 51, "placebo_at_risk": 32526, "rr": 0.610776, "se": 0.228959, "strata_with_events": 15, "z": -2.15333 } }, "Pulmonary sepsis": { "all": { "glp1_affected": 11, 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"se": 0.182613, "strata_with_events": 27, "z": -0.373956 }, "discovered": false, "discovery": { "glp1_affected": 38, "glp1_at_risk": 47388, "hi": 1.75504, "lo": 0.6772, "log_rr": 0.0863505, "p": 0.722252, "placebo_affected": 33, "placebo_at_risk": 35018, "rr": 1.09019, "se": 0.242932, "strata_with_events": 13, "z": 0.355451 }, "discovery_q": 0.916484, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 28, "glp1_at_risk": 46377, "hi": 1.31474, "lo": 0.439654, "log_rr": -0.274062, "p": 0.326725, "placebo_affected": 28, "placebo_at_risk": 32526, "rr": 0.760285, "se": 0.279446, "strata_with_events": 14, "z": -0.980732 } }, "Pyelonephritis acute": { "all": { "glp1_affected": 37, "glp1_at_risk": 93765, "hi": 1.33595, "lo": 0.530407, "log_rr": -0.172234, "p": 0.464859, "placebo_affected": 38, "placebo_at_risk": 67544, "rr": 0.841782, "se": 0.235656, "strata_with_events": 23, "z": -0.730869 }, "discovered": false, "discovery": { "glp1_affected": 18, "glp1_at_risk": 47388, "hi": 1.43025, "lo": 0.403438, "log_rr": -0.274942, "p": 0.394444, "placebo_affected": 22, "placebo_at_risk": 35018, "rr": 0.759616, "se": 0.322859, "strata_with_events": 10, "z": -0.851585 }, "discovery_q": 0.770959, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 19, "glp1_at_risk": 46377, "hi": 1.86872, "lo": 0.481654, "log_rr": -0.0526384, "p": 0.879036, "placebo_affected": 16, "placebo_at_risk": 32526, "rr": 0.948723, "se": 0.345869, "strata_with_events": 13, "z": -0.152192 } }, "Pyrexia": { "all": { "glp1_affected": 46, "glp1_at_risk": 93765, "hi": 1.42712, "lo": 0.626673, "log_rr": -0.0558358, "p": 0.79028, "placebo_affected": 45, "placebo_at_risk": 67544, "rr": 0.945694, "se": 0.20995, "strata_with_events": 22, "z": -0.265947 }, "discovered": false, "discovery": { "glp1_affected": 27, "glp1_at_risk": 47388, "hi": 2.20799, "lo": 0.709078, "log_rr": 0.224146, "p": 0.439205, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 1.25125, "se": 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"placebo_at_risk": 32526, "rr": 1.40675, "se": 0.504767, "strata_with_events": 7, "z": 0.676112 } }, "Rectal cancer": { "all": { "glp1_affected": 23, "glp1_at_risk": 93765, "hi": 2.77589, "lo": 0.713337, "log_rr": 0.341586, "p": 0.324408, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.40718, "se": 0.346633, "strata_with_events": 18, "z": 0.98544 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 3.75685, "lo": 0.517738, "log_rr": 0.332648, "p": 0.510574, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.39466, "se": 0.505587, "strata_with_events": 8, "z": 0.657944 }, "discovery_q": 0.827275, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 3.60635, "lo": 0.558246, "log_rr": 0.349871, "p": 0.46227, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 1.41888, "se": 0.475941, "strata_with_events": 10, "z": 0.735115 } }, "Rectal haemorrhage": { "all": { "glp1_affected": 31, "glp1_at_risk": 93765, "hi": 1.68346, "lo": 0.621962, "log_rr": 0.022988, "p": 0.927892, "placebo_affected": 29, "placebo_at_risk": 67544, "rr": 1.02325, "se": 0.254017, "strata_with_events": 12, "z": 0.0904979 }, "discovered": false, "discovery": { "glp1_affected": 19, "glp1_at_risk": 47388, "hi": 2.03889, "lo": 0.558634, "log_rr": 0.0650727, "p": 0.843809, "placebo_affected": 17, "placebo_at_risk": 35018, "rr": 1.06724, "se": 0.330278, "strata_with_events": 7, "z": 0.197024 }, "discovery_q": 0.943906, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 2.09688, "lo": 0.441043, "log_rr": -0.0390817, "p": 0.921724, "placebo_affected": 12, "placebo_at_risk": 32526, "rr": 0.961672, "se": 0.397727, "strata_with_events": 5, "z": -0.0982627 } }, "Renal artery stenosis": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.97403, "lo": 0.339136, "log_rr": -0.200638, "p": 0.655233, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 0.818208, "se": 0.449354, "strata_with_events": 7, "z": -0.446505 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 2.73106, "lo": 0.25446, "log_rr": -0.18196, "p": 0.763766, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.833635, "se": 0.605445, "strata_with_events": 4, "z": -0.300539 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 2.97656, "lo": 0.214855, "log_rr": -0.223513, "p": 0.738892, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 0.799704, "se": 0.670564, "strata_with_events": 3, "z": -0.333322 } }, "Renal cancer": { "all": { "glp1_affected": 25, "glp1_at_risk": 93765, "hi": 2.10383, "lo": 0.665069, "log_rr": 0.167947, "p": 0.567551, "placebo_affected": 20, "placebo_at_risk": 67544, "rr": 1.18287, "se": 0.293787, "strata_with_events": 12, "z": 0.571662 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 4.19548, "lo": 0.7185, "log_rr": 0.551709, "p": 0.220356, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.73622, "se": 0.450161, "strata_with_events": 6, "z": 1.22558 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 1.90354, "lo": 0.400318, "log_rr": -0.135889, "p": 0.732628, "placebo_affected": 13, "placebo_at_risk": 32526, "rr": 0.872939, "se": 0.397765, "strata_with_events": 6, "z": -0.341632 } }, "Renal cell carcinoma": { "all": { "glp1_affected": 30, "glp1_at_risk": 93765, "hi": 1.61221, "lo": 0.562667, "log_rr": -0.0487295, "p": 0.856008, "placebo_affected": 28, "placebo_at_risk": 67544, "rr": 0.952439, "se": 0.268545, "strata_with_events": 17, "z": -0.181458 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 2.19426, "lo": 0.467564, "log_rr": 0.0128131, "p": 0.974084, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 1.0129, "se": 0.394412, "strata_with_events": 7, "z": 0.0324866 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 1.85206, "lo": 0.439538, "log_rr": -0.102867, "p": 0.779211, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 0.902247, "se": 0.366927, "strata_with_events": 10, "z": -0.280347 } }, "Renal colic": { "all": { "glp1_affected": 35, "glp1_at_risk": 93765, "hi": 2.66679, "lo": 0.883282, "log_rr": 0.428383, "p": 0.128591, "placebo_affected": 21, "placebo_at_risk": 67544, "rr": 1.53477, "se": 0.28189, "strata_with_events": 18, "z": 1.51968 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 3.96675, "lo": 0.689228, "log_rr": 0.502882, "p": 0.260017, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 1.65348, "se": 0.44647, "strata_with_events": 10, "z": 1.12635 }, "discovery_q": 0.712061, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 20, "glp1_at_risk": 46377, "hi": 2.97795, "lo": 0.71553, "log_rr": 0.378252, "p": 0.298433, "placebo_affected": 13, "placebo_at_risk": 32526, "rr": 1.45973, "se": 0.363774, "strata_with_events": 8, "z": 1.0398 } }, "Renal cyst": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 1.45039, "lo": 0.324996, "log_rr": -0.376054, "p": 0.324373, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 0.686565, "se": 0.381583, "strata_with_events": 9, "z": -0.985511 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 1.43955, "lo": 0.21444, "log_rr": -0.587697, "p": 0.226316, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 0.555606, "se": 0.485738, "strata_with_events": 4, "z": -1.2099 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 3.4588, "lo": 0.289714, "log_rr": 0.00103045, "p": 0.9987, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 1.00103, "se": 0.63261, "strata_with_events": 5, "z": 0.00162889 } }, "Renal failure": { "all": { "glp1_affected": 84, "glp1_at_risk": 93765, "hi": 1.0795, "lo": 0.603016, "log_rr": -0.214659, "p": 0.14845, "placebo_affected": 100, "placebo_at_risk": 67544, "rr": 0.806817, "se": 0.14855, "strata_with_events": 20, "z": -1.44503 }, "discovered": false, "discovery": { "glp1_affected": 43, "glp1_at_risk": 47388, "hi": 1.13451, "lo": 0.508349, "log_rr": -0.275192, "p": 0.179034, "placebo_affected": 55, "placebo_at_risk": 35018, "rr": 0.759426, "se": 0.204797, "strata_with_events": 11, "z": -1.34373 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 41, "glp1_at_risk": 46377, "hi": 1.3193, "lo": 0.565701, "log_rr": -0.146296, "p": 0.49826, "placebo_affected": 45, "placebo_at_risk": 32526, "rr": 0.863902, "se": 0.216021, "strata_with_events": 9, "z": -0.67723 } }, "Renal impairment": { 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"placebo_at_risk": 67544, "rr": 1.42329, "se": 0.374181, "strata_with_events": 11, "z": 0.943316 }, "discovered": false, "discovery": { "glp1_affected": 2, "glp1_at_risk": 47388, "hi": 2.73002, "lo": 0.0916478, "log_rr": -0.692747, "p": 0.423671, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 0.5002, "se": 0.865861, "strata_with_events": 3, "z": -0.800068 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 17, "glp1_at_risk": 46377, "hi": 4.36204, "lo": 0.798662, "log_rr": 0.624062, "p": 0.149617, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 1.86649, "se": 0.43311, "strata_with_events": 8, "z": 1.44089 } }, "Respiratory distress": { "all": { "glp1_affected": 11, "glp1_at_risk": 93765, "hi": 2.23399, "lo": 0.407763, "log_rr": -0.0466408, "p": 0.914399, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 0.95443, "se": 0.4339, "strata_with_events": 9, "z": -0.107492 }, "discovered": false, "discovery": { 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0.213759, "p": 0.622398, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 1.23832, "se": 0.434069, "strata_with_events": 12, "z": 0.492455 } }, "Rhabdomyolysis": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 2.66415, "lo": 0.682932, "log_rr": 0.299262, "p": 0.388812, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.34886, "se": 0.347263, "strata_with_events": 14, "z": 0.861774 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 1.71867, "lo": 0.321257, "log_rr": -0.296981, "p": 0.487585, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 0.743058, "se": 0.427831, "strata_with_events": 7, "z": -0.694156 }, "discovery_q": 0.801254, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 24.324, "lo": 1.08303, "log_rr": 1.63561, "p": 0.0393566, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 5.13259, "se": 0.793817, "strata_with_events": 7, "z": 2.06044 } }, "Rheumatoid arthritis": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 3.56444, "lo": 0.724975, "log_rr": 0.474694, "p": 0.242659, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 1.60752, "se": 0.406289, "strata_with_events": 10, "z": 1.16837 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 4.30484, "lo": 0.530225, "log_rr": 0.412643, "p": 0.439885, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 1.51081, "se": 0.534243, "strata_with_events": 6, "z": 0.772388 }, "discovery_q": 0.782691, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 5.98577, "lo": 0.513211, "log_rr": 0.561158, "p": 0.370532, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 1.7527, "se": 0.626658, "strata_with_events": 4, "z": 0.895478 } }, "Rib fracture": { "all": { "glp1_affected": 72, "glp1_at_risk": 93765, "hi": 1.09823, "lo": 0.576111, "log_rr": -0.228879, "p": 0.164328, "placebo_affected": 84, "placebo_at_risk": 67544, "rr": 0.795425, "se": 0.164582, "strata_with_events": 28, "z": -1.39066 }, "discovered": false, "discovery": { "glp1_affected": 37, "glp1_at_risk": 47388, "hi": 1.26791, "lo": 0.523055, "log_rr": -0.205348, "p": 0.363301, "placebo_affected": 44, "placebo_at_risk": 35018, "rr": 0.814364, "se": 0.225882, "strata_with_events": 12, "z": -0.909093 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 35, "glp1_at_risk": 46377, "hi": 1.241, "lo": 0.483783, "log_rr": -0.255103, "p": 0.288456, "placebo_affected": 40, "placebo_at_risk": 32526, "rr": 0.774837, "se": 0.240319, "strata_with_events": 16, "z": -1.06152 } }, "Road traffic accident": { "all": { "glp1_affected": 92, "glp1_at_risk": 93765, "hi": 1.47096, "lo": 0.797003, "log_rr": 0.0795089, "p": 0.61104, "placebo_affected": 76, "placebo_at_risk": 67544, "rr": 1.08276, "se": 0.156332, "strata_with_events": 27, "z": 0.508589 }, "discovered": false, "discovery": { "glp1_affected": 47, "glp1_at_risk": 47388, "hi": 1.35079, "lo": 0.611126, "log_rr": -0.0958806, "p": 0.635594, "placebo_affected": 49, "placebo_at_risk": 35018, "rr": 0.908572, "se": 0.202336, "strata_with_events": 10, "z": -0.473868 }, "discovery_q": 0.888984, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 45, "glp1_at_risk": 46377, "hi": 2.27406, "lo": 0.855207, "log_rr": 0.332578, "p": 0.18252, "placebo_affected": 27, "placebo_at_risk": 32526, "rr": 1.39456, "se": 0.249489, "strata_with_events": 17, "z": 1.33304 } }, "Rotator cuff syndrome": { "all": { "glp1_affected": 61, "glp1_at_risk": 93765, "hi": 1.6165, "lo": 0.747188, "log_rr": 0.0944125, "p": 0.631529, "placebo_affected": 49, "placebo_at_risk": 67544, "rr": 1.09901, "se": 0.196867, "strata_with_events": 21, "z": 0.479576 }, "discovered": false, "discovery": { "glp1_affected": 29, "glp1_at_risk": 47388, "hi": 2.09666, "lo": 0.68837, "log_rr": 0.183459, "p": 0.518484, "placebo_affected": 23, "placebo_at_risk": 35018, "rr": 1.20137, "se": 0.284132, "strata_with_events": 7, "z": 0.645683 }, "discovery_q": 0.831308, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 32, "glp1_at_risk": 46377, "hi": 1.72975, "lo": 0.592061, "log_rr": 0.0119157, "p": 0.96525, "placebo_affected": 26, "placebo_at_risk": 32526, "rr": 1.01199, "se": 0.273506, "strata_with_events": 14, "z": 0.0435666 } }, "Sciatica": { "all": { "glp1_affected": 32, "glp1_at_risk": 93765, "hi": 1.63851, "lo": 0.616104, "log_rr": 0.00472518, "p": 0.984892, "placebo_affected": 29, "placebo_at_risk": 67544, "rr": 1.00474, "se": 0.249527, "strata_with_events": 13, "z": 0.0189365 }, "discovered": false, "discovery": { "glp1_affected": 19, "glp1_at_risk": 47388, "hi": 1.86489, "lo": 0.527557, "log_rr": -0.00814835, "p": 0.979819, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 0.991885, "se": 0.322124, "strata_with_events": 7, "z": -0.0252957 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 13, "glp1_at_risk": 46377, "hi": 2.22058, "lo": 0.472964, "log_rr": 0.0245161, "p": 0.950451, "placebo_affected": 11, "placebo_at_risk": 32526, "rr": 1.02482, "se": 0.394523, "strata_with_events": 6, "z": 0.062141 } }, "Seizure": { "all": { "glp1_affected": 60, "glp1_at_risk": 93765, "hi": 1.67935, "lo": 0.772618, "log_rr": 0.130218, "p": 0.510879, "placebo_affected": 49, "placebo_at_risk": 67544, "rr": 1.13908, "se": 0.198059, "strata_with_events": 22, "z": 0.65747 }, "discovered": false, "discovery": { "glp1_affected": 32, "glp1_at_risk": 47388, "hi": 2.19772, "lo": 0.751458, "log_rr": 0.25084, "p": 0.35954, "placebo_affected": 24, "placebo_at_risk": 35018, "rr": 1.2851, "se": 0.273771, "strata_with_events": 10, "z": 0.916242 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 28, "glp1_at_risk": 46377, "hi": 1.75659, "lo": 0.567898, "log_rr": -0.00121809, "p": 0.996626, "placebo_affected": 25, "placebo_at_risk": 32526, "rr": 0.998783, "se": 0.288064, "strata_with_events": 12, "z": -0.00422854 } }, "Sepsis": { "all": { "glp1_affected": 255, "glp1_at_risk": 93765, "hi": 1.15131, "lo": 0.811008, "log_rr": -0.0342888, "p": 0.701264, "placebo_affected": 248, "placebo_at_risk": 67544, "rr": 0.966292, "se": 0.0893833, "strata_with_events": 35, "z": -0.383615 }, "discovered": false, "discovery": { "glp1_affected": 155, "glp1_at_risk": 47388, "hi": 1.36035, "lo": 0.861137, "log_rr": 0.0791218, "p": 0.49758, "placebo_affected": 139, "placebo_at_risk": 35018, "rr": 1.08234, "se": 0.116647, "strata_with_events": 19, "z": 0.678302 }, "discovery_q": 0.812505, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 100, "glp1_at_risk": 46377, "hi": 1.08059, "lo": 0.624462, "log_rr": -0.196678, "p": 0.159752, "placebo_affected": 109, "placebo_at_risk": 32526, "rr": 0.821455, "se": 0.139894, "strata_with_events": 16, "z": -1.40591 } }, "Septic shock": { "all": { "glp1_affected": 86, "glp1_at_risk": 93765, "hi": 0.822251, "lo": 0.475335, "log_rr": -0.469723, "p": 0.000779887, "placebo_affected": 129, "placebo_at_risk": 67544, "rr": 0.625176, "se": 0.139805, "strata_with_events": 24, "z": -3.35984 }, "discovered": false, "discovery": { "glp1_affected": 52, "glp1_at_risk": 47388, "hi": 0.963093, "lo": 0.472578, "log_rr": -0.393579, "p": 0.0302335, "placebo_affected": 74, "placebo_at_risk": 35018, "rr": 0.674638, "se": 0.181622, "strata_with_events": 14, "z": -2.16702 }, "discovery_q": 0.385856, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 34, "glp1_at_risk": 46377, "hi": 0.861262, "lo": 0.364197, "log_rr": -0.579708, "p": 0.00828606, "placebo_affected": 55, "placebo_at_risk": 32526, "rr": 0.560062, "se": 0.219571, "strata_with_events": 10, "z": -2.64019 } }, "Shock": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 2.86201, "lo": 0.527146, "log_rr": 0.205623, "p": 0.633767, "placebo_affected": 9, "placebo_at_risk": 67544, "rr": 1.22829, "se": 0.43159, "strata_with_events": 8, "z": 0.476431 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 3.64184, "lo": 0.590961, "log_rr": 0.383242, "p": 0.40874, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.46703, "se": 0.46391, "strata_with_events": 5, "z": 0.826113 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 1, "glp1_at_risk": 46377, "hi": 5.97124, "lo": 0.0185829, "log_rr": -1.09928, "p": 0.455371, "placebo_affected": 2, "placebo_at_risk": 32526, "rr": 0.333111, "se": 1.4726, "strata_with_events": 3, "z": -0.746491 } }, "Sinus bradycardia": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 0.872043, "lo": 0.19954, "log_rr": -0.874328, "p": 0.0201322, "placebo_affected": 24, "placebo_at_risk": 67544, "rr": 0.417142, "se": 0.376237, "strata_with_events": 8, "z": -2.32387 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 0.959167, "lo": 0.147015, "log_rr": -0.979455, "p": 0.0406484, "placebo_affected": 16, "placebo_at_risk": 35018, "rr": 0.375516, "se": 0.47846, "strata_with_events": 4, "z": -2.0471 }, "discovery_q": 0.43697, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.66137, "lo": 0.150715, "log_rr": -0.692364, "p": 0.258124, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.500392, "se": 0.612258, "strata_with_events": 4, "z": -1.13084 } }, "Sinus node dysfunction": { "all": { "glp1_affected": 41, "glp1_at_risk": 93765, "hi": 1.05429, "lo": 0.468013, "log_rr": -0.353194, "p": 0.0882367, "placebo_affected": 56, "placebo_at_risk": 67544, "rr": 0.702441, "se": 0.20718, "strata_with_events": 13, "z": -1.70477 }, "discovered": false, "discovery": { "glp1_affected": 25, "glp1_at_risk": 47388, "hi": 1.07153, "lo": 0.394109, "log_rr": -0.431018, "p": 0.0911821, "placebo_affected": 38, "placebo_at_risk": 35018, "rr": 0.649847, "se": 0.255162, "strata_with_events": 8, "z": -1.68919 }, "discovery_q": 0.548426, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 16, "glp1_at_risk": 46377, "hi": 1.63857, "lo": 0.405278, "log_rr": -0.204679, "p": 0.565753, "placebo_affected": 18, "placebo_at_risk": 32526, "rr": 0.814909, "se": 0.356386, "strata_with_events": 5, "z": -0.574318 } }, "Sinusitis": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 2.46639, "lo": 0.606724, "log_rr": 0.201537, "p": 0.573223, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 1.22328, "se": 0.357771, "strata_with_events": 17, "z": 0.563311 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 2.42471, "lo": 0.359081, "log_rr": -0.0692471, "p": 0.886983, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 0.933096, "se": 0.487233, "strata_with_events": 8, "z": -0.142123 }, "discovery_q": 0.969575, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 11, "glp1_at_risk": 46377, "hi": 4.59123, "lo": 0.566129, "log_rr": 0.477607, "p": 0.371073, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 1.61221, "se": 0.533959, "strata_with_events": 9, "z": 0.894464 } }, "Skin laceration": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 2.6998, "lo": 0.647469, "log_rr": 0.279246, "p": 0.443308, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 1.32213, "se": 0.364257, "strata_with_events": 9, "z": 0.766619 }, "discovered": false, "discovery": { "glp1_affected": 16, "glp1_at_risk": 47388, "hi": 6.58332, "lo": 0.986971, "log_rr": 0.935712, "p": 0.0532519, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 2.54903, "se": 0.484104, "strata_with_events": 4, "z": 1.93287 }, "discovery_q": 0.507552, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 1.38899, "lo": 0.0727997, "log_rr": -1.14573, "p": 0.127721, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.317991, "se": 0.752213, "strata_with_events": 5, "z": -1.52315 } }, "Skin ulcer": { "all": { "glp1_affected": 66, "glp1_at_risk": 93765, "hi": 0.944004, "lo": 0.496506, "log_rr": -0.378892, "p": 0.0208041, "placebo_affected": 88, "placebo_at_risk": 67544, "rr": 0.68462, "se": 0.163915, "strata_with_events": 19, "z": -2.31152 }, "discovered": false, "discovery": { "glp1_affected": 32, "glp1_at_risk": 47388, "hi": 0.90544, "lo": 0.37593, "log_rr": -0.538843, "p": 0.016264, "placebo_affected": 52, "placebo_at_risk": 35018, "rr": 0.583423, "se": 0.224243, "strata_with_events": 9, "z": -2.40294 }, "discovery_q": 0.27974, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 34, "glp1_at_risk": 46377, "hi": 1.33131, "lo": 0.515286, "log_rr": -0.188433, "p": 0.436465, "placebo_affected": 36, "placebo_at_risk": 32526, "rr": 0.828256, "se": 0.242147, "strata_with_events": 10, "z": -0.778176 } }, "Sleep apnoea syndrome": { "all": { "glp1_affected": 29, "glp1_at_risk": 93765, "hi": 1.16588, "lo": 0.42837, "log_rr": -0.347148, "p": 0.174113, "placebo_affected": 36, "placebo_at_risk": 67544, "rr": 0.706701, "se": 0.255423, "strata_with_events": 16, "z": -1.35911 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 1.2906, "lo": 0.326073, "log_rr": -0.432765, "p": 0.217543, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 0.648713, "se": 0.35096, "strata_with_events": 8, "z": -1.23309 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 14, "glp1_at_risk": 46377, "hi": 1.62667, "lo": 0.377035, "log_rr": -0.244441, "p": 0.512199, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 0.783142, "se": 0.372954, "strata_with_events": 8, "z": -0.655418 } }, "Small cell lung cancer": { "all": { "glp1_affected": 27, "glp1_at_risk": 93765, "hi": 2.7854, "lo": 0.841791, "log_rr": 0.426084, "p": 0.162779, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 1.53125, "se": 0.305264, "strata_with_events": 12, "z": 1.39579 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 5.20783, "lo": 0.856249, "log_rr": 0.747485, "p": 0.10459, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 2.11168, "se": 0.460559, "strata_with_events": 6, "z": 1.623 }, "discovery_q": 0.574134, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 2.58188, "lo": 0.507063, "log_rr": 0.134698, "p": 0.745635, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 1.14419, "se": 0.415221, "strata_with_events": 6, "z": 0.324401 } }, "Small cell lung cancer metastatic": { "all": { "glp1_affected": 13, "glp1_at_risk": 93765, "hi": 3.8546, "lo": 0.650386, "log_rr": 0.45954, "p": 0.31139, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 1.58334, "se": 0.453951, "strata_with_events": 8, "z": 1.01231 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 3.45193, "lo": 0.479022, "log_rr": 0.251463, "p": 0.617701, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.2859, "se": 0.503821, "strata_with_events": 4, "z": 0.499111 }, "discovery_q": 0.882346, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 35.2441, "lo": 0.381203, "log_rr": 1.29894, "p": 0.260666, "placebo_affected": 1, "placebo_at_risk": 32526, "rr": 3.6654, "se": 1.1548, "strata_with_events": 4, "z": 1.12482 } }, "Small intestinal obstruction": { "all": { "glp1_affected": 56, "glp1_at_risk": 93765, "hi": 1.45577, "lo": 0.678113, "log_rr": -0.0064516, "p": 0.973593, "placebo_affected": 53, "placebo_at_risk": 67544, "rr": 0.993569, "se": 0.194896, "strata_with_events": 21, "z": -0.0331027 }, "discovered": false, "discovery": { "glp1_affected": 32, "glp1_at_risk": 47388, "hi": 2.17852, "lo": 0.742277, "log_rr": 0.240307, "p": 0.381629, "placebo_affected": 24, "placebo_at_risk": 35018, "rr": 1.27164, "se": 0.274668, "strata_with_events": 11, "z": 0.874899 }, "discovery_q": 0.762002, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 24, "glp1_at_risk": 46377, "hi": 1.32985, "lo": 0.441815, "log_rr": -0.265899, "p": 0.344206, "placebo_affected": 29, "placebo_at_risk": 32526, "rr": 0.766517, "se": 0.28111, "strata_with_events": 10, "z": -0.945888 } }, "Soft tissue infection": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 2.22072, "lo": 0.351352, "log_rr": -0.124068, "p": 0.791958, "placebo_affected": 10, "placebo_at_risk": 67544, "rr": 0.88332, "se": 0.470365, "strata_with_events": 12, "z": -0.263769 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 8.01499, "lo": 0.500637, "log_rr": 0.69472, "p": 0.326103, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 2.00315, "se": 0.707459, "strata_with_events": 5, "z": 0.981993 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.68687, "lo": 0.0967301, "log_rr": -0.906477, "p": 0.213874, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.403945, "se": 0.729276, "strata_with_events": 7, "z": -1.24298 } }, "Spinal column stenosis": { "all": { "glp1_affected": 29, "glp1_at_risk": 93765, "hi": 1.34907, "lo": 0.49779, "log_rr": -0.199082, "p": 0.433777, "placebo_affected": 34, "placebo_at_risk": 67544, "rr": 0.819482, "se": 0.254339, "strata_with_events": 10, "z": -0.782745 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 1.58598, "lo": 0.29375, "log_rr": -0.38191, "p": 0.37464, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 0.682557, "se": 0.430168, "strata_with_events": 6, "z": -0.887815 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 19, "glp1_at_risk": 46377, "hi": 1.68556, "lo": 0.487514, "log_rr": -0.0981704, "p": 0.756404, "placebo_affected": 21, "placebo_at_risk": 32526, "rr": 0.906494, "se": 0.316468, "strata_with_events": 4, "z": -0.310206 } }, "Spinal compression fracture": { "all": { "glp1_affected": 37, "glp1_at_risk": 93765, "hi": 2.86641, "lo": 0.916668, "log_rr": 0.483026, "p": 0.0967546, "placebo_affected": 20, "placebo_at_risk": 67544, "rr": 1.62097, "se": 0.29084, "strata_with_events": 25, "z": 1.6608 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 2.25677, "lo": 0.48308, "log_rr": 0.0431806, "p": 0.912564, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 1.04413, "se": 0.393248, "strata_with_events": 8, "z": 0.109805 }, "discovery_q": 0.976812, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 22, "glp1_at_risk": 46377, "hi": 6.5773, "lo": 1.09746, "log_rr": 0.988309, "p": 0.0304997, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 2.68669, "se": 0.456802, "strata_with_events": 17, "z": 2.16354 } }, "Spinal fracture": { "all": { "glp1_affected": 16, "glp1_at_risk": 93765, "hi": 2.05899, "lo": 0.486693, "log_rr": 0.00104643, "p": 0.997731, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.00105, "se": 0.36795, "strata_with_events": 15, "z": 0.00284394 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 6.64558, "lo": 0.60369, "log_rr": 0.694628, "p": 0.2563, "placebo_affected": 4, "placebo_at_risk": 35018, "rr": 2.00296, "se": 0.611911, "strata_with_events": 7, "z": 1.13518 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 1.63725, "lo": 0.238895, "log_rr": -0.469356, "p": 0.339129, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.625405, "se": 0.491016, "strata_with_events": 8, "z": -0.955887 } }, "Spinal osteoarthritis": { "all": { "glp1_affected": 68, "glp1_at_risk": 93765, "hi": 1.47053, "lo": 0.732735, "log_rr": 0.0373247, "p": 0.833639, "placebo_affected": 59, "placebo_at_risk": 67544, "rr": 1.03803, "se": 0.177705, "strata_with_events": 26, "z": 0.210037 }, "discovered": false, "discovery": { "glp1_affected": 34, "glp1_at_risk": 47388, "hi": 2.73965, "lo": 0.875607, "log_rr": 0.437497, "p": 0.132719, "placebo_affected": 20, "placebo_at_risk": 35018, "rr": 1.54883, "se": 0.290992, "strata_with_events": 13, "z": 1.50346 }, "discovery_q": 0.622575, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 34, "glp1_at_risk": 46377, "hi": 1.23925, "lo": 0.505027, "log_rr": -0.234318, "p": 0.306194, "placebo_affected": 39, "placebo_at_risk": 32526, "rr": 0.79111, "se": 0.228996, "strata_with_events": 13, "z": -1.02324 } }, "Spinal pain": { "all": { "glp1_affected": 16, "glp1_at_risk": 93765, "hi": 2.1078, "lo": 0.516597, "log_rr": 0.0425765, "p": 0.90552, "placebo_affected": 14, "placebo_at_risk": 67544, "rr": 1.0435, "se": 0.358716, "strata_with_events": 11, "z": 0.118691 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 7.8785, "lo": 0.472206, "log_rr": 0.656899, "p": 0.360238, "placebo_affected": 3, "placebo_at_risk": 35018, "rr": 1.9288, "se": 0.717992, "strata_with_events": 5, "z": 0.914912 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 1.87859, "lo": 0.356805, "log_rr": -0.200023, "p": 0.636909, "placebo_affected": 11, "placebo_at_risk": 32526, "rr": 0.818712, "se": 0.423754, "strata_with_events": 6, "z": -0.472025 } }, "Spinal stenosis": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 1.86156, "lo": 0.513714, "log_rr": -0.0223381, "p": 0.945777, "placebo_affected": 18, "placebo_at_risk": 67544, "rr": 0.97791, "se": 0.32845, "strata_with_events": 8, "z": -0.0680107 }, "discovered": false, "discovery": { "glp1_affected": 16, "glp1_at_risk": 47388, "hi": 2.12008, "lo": 0.523514, "log_rr": 0.0521305, "p": 0.883839, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 1.05351, "se": 0.356803, "strata_with_events": 4, "z": 0.146104 }, "discovery_q": 0.968282, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 3.47191, "lo": 0.117815, "log_rr": -0.446967, "p": 0.60456, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 0.639565, "se": 0.863113, "strata_with_events": 4, "z": -0.517854 } }, "Spondylolisthesis": { "all": { "glp1_affected": 23, "glp1_at_risk": 93765, "hi": 2.31017, "lo": 0.669905, "log_rr": 0.21835, "p": 0.489312, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 1.24402, "se": 0.315807, "strata_with_events": 12, "z": 0.691403 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 3.74115, "lo": 0.582262, "log_rr": 0.389279, "p": 0.412044, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.47592, "se": 0.474556, "strata_with_events": 5, "z": 0.820301 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 2.49035, "lo": 0.470057, "log_rr": 0.0787622, "p": 0.853094, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 1.08195, "se": 0.425346, "strata_with_events": 7, "z": 0.185172 } }, "Squamous cell carcinoma": { "all": { "glp1_affected": 38, "glp1_at_risk": 93765, "hi": 2.51563, "lo": 0.887758, "log_rr": 0.401734, "p": 0.130559, "placebo_affected": 24, "placebo_at_risk": 67544, "rr": 1.49441, "se": 0.265714, "strata_with_events": 16, "z": 1.5119 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 3.45249, "lo": 0.630836, "log_rr": 0.389194, "p": 0.369441, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 1.47579, "se": 0.433632, "strata_with_events": 7, "z": 0.897521 }, "discovery_q": 0.761081, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 24, "glp1_at_risk": 46377, "hi": 2.91015, "lo": 0.778949, "log_rr": 0.409197, "p": 0.223604, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 1.50561, "se": 0.336234, "strata_with_events": 9, "z": 1.217 } }, "Squamous cell carcinoma of lung": { "all": { "glp1_affected": 22, "glp1_at_risk": 93765, "hi": 1.29751, "lo": 0.424182, "log_rr": -0.298572, "p": 0.295187, "placebo_affected": 29, "placebo_at_risk": 67544, "rr": 0.741877, "se": 0.28522, "strata_with_events": 11, "z": -1.04681 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 1.70893, "lo": 0.374584, "log_rr": -0.223037, "p": 0.564601, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.800086, "se": 0.387203, "strata_with_events": 5, "z": -0.57602 }, "discovery_q": 0.866575, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 1.55507, "lo": 0.29689, "log_rr": -0.386435, "p": 0.360308, "placebo_affected": 14, "placebo_at_risk": 32526, "rr": 0.679475, "se": 0.422435, "strata_with_events": 6, "z": -0.914779 } }, "Squamous cell carcinoma of skin": { "all": { "glp1_affected": 41, "glp1_at_risk": 93765, "hi": 2.07087, "lo": 0.821669, "log_rr": 0.265775, "p": 0.259726, "placebo_affected": 31, "placebo_at_risk": 67544, "rr": 1.30444, "se": 0.235817, "strata_with_events": 10, "z": 1.12704 }, "discovered": false, "discovery": { "glp1_affected": 27, "glp1_at_risk": 47388, "hi": 2.72265, "lo": 0.826529, "log_rr": 0.405542, "p": 0.182368, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 1.50012, "se": 0.304119, "strata_with_events": 4, "z": 1.3335 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 14, "glp1_at_risk": 46377, "hi": 2.18221, "lo": 0.497985, "log_rr": 0.0415771, "p": 0.912167, "placebo_affected": 13, "placebo_at_risk": 32526, "rr": 1.04245, "se": 0.376926, "strata_with_events": 6, "z": 0.110306 } }, "Staphylococcal bacteraemia": { "all": { "glp1_affected": 10, "glp1_at_risk": 93765, "hi": 1.25614, "lo": 0.257351, "log_rr": -0.564636, "p": 0.162682, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 0.568567, "se": 0.404436, "strata_with_events": 9, "z": -1.39611 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 2.41244, "lo": 0.317401, "log_rr": -0.133476, "p": 0.796433, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.875049, "se": 0.517414, "strata_with_events": 4, "z": -0.257967 }, "discovery_q": 0.924777, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 1.17653, "lo": 0.0745278, "log_rr": -1.217, "p": 0.0838098, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.296116, "se": 0.703879, "strata_with_events": 5, "z": -1.729 } }, "Staphylococcal infection": { "all": { "glp1_affected": 16, "glp1_at_risk": 93765, "hi": 1.87963, "lo": 0.476088, "log_rr": -0.0555397, "p": 0.874031, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.945974, "se": 0.350319, "strata_with_events": 11, "z": -0.15854 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 2.6649, "lo": 0.375481, "log_rr": 0.000310163, "p": 0.999505, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 1.00031, "se": 0.499936, "strata_with_events": 4, "z": 0.000620405 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 2.34406, "lo": 0.341634, "log_rr": -0.111065, "p": 0.821155, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.89488, "se": 0.49131, "strata_with_events": 7, "z": -0.22606 } }, "Staphylococcal sepsis": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 1.72675, "lo": 0.368344, "log_rr": -0.226249, "p": 0.565941, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 0.79752, "se": 0.394134, "strata_with_events": 10, "z": -0.57404 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 12.8845, "lo": 0.485357, "log_rr": 0.916576, "p": 0.27318, "placebo_affected": 2, "placebo_at_risk": 35018, "rr": 2.50071, "se": 0.836468, "strata_with_events": 3, "z": 1.09577 }, "discovery_q": 0.719187, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 1.32481, "lo": 0.199175, "log_rr": -0.666153, "p": 0.168173, "placebo_affected": 11, "placebo_at_risk": 32526, "rr": 0.513681, "se": 0.483386, "strata_with_events": 7, "z": -1.3781 } }, "Stent placement": { "all": { "glp1_affected": 18, "glp1_at_risk": 93765, "hi": 1.53331, "lo": 0.433394, "log_rr": -0.20434, "p": 0.526124, "placebo_affected": 21, "placebo_at_risk": 67544, "rr": 0.815185, "se": 0.322337, "strata_with_events": 6, "z": -0.633935 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 1.68848, "lo": 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{ "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 3.6558, "lo": 0.513902, "log_rr": 0.315297, "p": 0.528742, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 1.37067, "se": 0.500529, "strata_with_events": 4, "z": 0.629928 }, "discovery_q": 0.839242, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 2.2851, "lo": 0.275071, "log_rr": -0.232158, "p": 0.667307, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 0.792821, "se": 0.540095, "strata_with_events": 6, "z": -0.429847 } }, "Thrombocytopenia": { "all": { "glp1_affected": 18, "glp1_at_risk": 93765, "hi": 3.27243, "lo": 0.739075, "log_rr": 0.441588, "p": 0.244672, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 1.55517, "se": 0.37957, "strata_with_events": 11, "z": 1.16339 }, "discovered": false, "discovery": { "glp1_affected": 11, "glp1_at_risk": 47388, "hi": 4.95682, "lo": 0.678155, "log_rr": 0.606193, "p": 0.232244, "placebo_affected": 6, 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0.475747, "placebo_affected": 23, "placebo_at_risk": 32526, "rr": 0.8027, "se": 0.308169, "strata_with_events": 8, "z": -0.71316 } }, "Toxicity to various agents": { "all": { "glp1_affected": 17, "glp1_at_risk": 93765, "hi": 1.82856, "lo": 0.486016, "log_rr": -0.058992, "p": 0.861458, "placebo_affected": 18, "placebo_at_risk": 67544, "rr": 0.942714, "se": 0.338028, "strata_with_events": 12, "z": -0.174518 }, "discovered": false, "discovery": { "glp1_affected": 9, "glp1_at_risk": 47388, "hi": 2.52053, "lo": 0.397682, "log_rr": 0.00118238, "p": 0.997997, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 1.00118, "se": 0.471072, "strata_with_events": 6, "z": 0.00250997 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 2.29173, "lo": 0.34128, "log_rr": -0.122873, "p": 0.800329, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.884376, "se": 0.485814, "strata_with_events": 6, "z": -0.252922 } }, "Transient ischaemic attack": { "all": { "glp1_affected": 233, "glp1_at_risk": 93765, "hi": 1.04332, "lo": 0.725375, "log_rr": -0.139328, "p": 0.132943, "placebo_affected": 246, "placebo_at_risk": 67544, "rr": 0.869942, "se": 0.0927249, "strata_with_events": 48, "z": -1.5026 }, "discovered": false, "discovery": { "glp1_affected": 158, "glp1_at_risk": 47388, "hi": 1.01591, "lo": 0.660641, "log_rr": -0.199382, "p": 0.0693377, "placebo_affected": 183, "placebo_at_risk": 35018, "rr": 0.819237, "se": 0.109779, "strata_with_events": 25, "z": -1.81621 }, "discovery_q": 0.517062, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 75, "glp1_at_risk": 46377, "hi": 1.42294, "lo": 0.719669, "log_rr": 0.0118795, "p": 0.945538, "placebo_affected": 63, "placebo_at_risk": 32526, "rr": 1.01195, "se": 0.173903, "strata_with_events": 23, "z": 0.0683111 } }, "Transitional cell carcinoma": { "all": { "glp1_affected": 48, "glp1_at_risk": 93765, "hi": 2.64862, "lo": 1.0486, "log_rr": 0.510745, "p": 0.0307179, "placebo_affected": 28, "placebo_at_risk": 67544, "rr": 1.66653, "se": 0.236379, "strata_with_events": 11, "z": 2.16071 }, "discovered": false, "discovery": { "glp1_affected": 31, "glp1_at_risk": 47388, "hi": 5.00432, "lo": 1.31534, "log_rr": 0.942198, "p": 0.00570883, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 2.56561, "se": 0.340875, "strata_with_events": 5, "z": 2.76405 }, "discovery_q": 0.210411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 17, "glp1_at_risk": 46377, "hi": 1.98769, "lo": 0.51523, "log_rr": 0.0119157, "p": 0.972402, "placebo_affected": 16, "placebo_at_risk": 32526, "rr": 1.01199, "se": 0.344423, "strata_with_events": 6, "z": 0.0345961 } }, "Troponin increased": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.6033, "lo": 0.273244, "log_rr": -0.412665, "p": 0.360617, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 0.661884, "se": 0.451399, "strata_with_events": 10, "z": -0.914191 }, "discovered": false, "discovery": { "glp1_affected": 3, "glp1_at_risk": 47388, "hi": 2.5107, "lo": 0.143392, "log_rr": -0.510808, "p": 0.484273, "placebo_affected": 5, "placebo_at_risk": 35018, "rr": 0.60001, "se": 0.730303, "strata_with_events": 4, "z": -0.699447 }, "discovery_q": 0.799978, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 2.17255, "lo": 0.228167, "log_rr": -0.350887, "p": 0.541636, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.704063, "se": 0.574904, "strata_with_events": 6, "z": -0.610341 } }, "Type 2 diabetes mellitus": { "all": { "glp1_affected": 18, "glp1_at_risk": 93765, "hi": 1.10314, "lo": 0.327117, "log_rr": -0.509638, "p": 0.100295, "placebo_affected": 27, "placebo_at_risk": 67544, "rr": 0.600713, "se": 0.310107, "strata_with_events": 11, "z": -1.64343 }, "discovered": false, "discovery": { "glp1_affected": 13, "glp1_at_risk": 47388, "hi": 1.36412, "lo": 0.305629, "log_rr": -0.437438, "p": 0.251675, "placebo_affected": 18, "placebo_at_risk": 35018, "rr": 0.645689, "se": 0.381612, "strata_with_events": 7, "z": -1.14629 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 1.47117, "lo": 0.181679, "log_rr": -0.659726, "p": 0.2163, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.516993, "se": 0.533574, "strata_with_events": 4, "z": -1.23643 } }, "Ulna fracture": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 2.01396, "lo": 0.408189, "log_rr": -0.0979612, "p": 0.809879, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 0.906684, "se": 0.407183, "strata_with_events": 11, "z": -0.240583 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 2.66804, "lo": 0.273504, "log_rr": -0.157547, "p": 0.786292, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.854237, "se": 0.581078, "strata_with_events": 6, "z": -0.271128 }, "discovery_q": 0.922592, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 2.95089, "lo": 0.315408, "log_rr": -0.0358897, "p": 0.949831, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 0.964747, "se": 0.570417, "strata_with_events": 5, "z": -0.0629184 } }, "Umbilical hernia": { "all": { "glp1_affected": 43, "glp1_at_risk": 93765, "hi": 1.24393, "lo": 0.538227, "log_rr": -0.200601, "p": 0.347918, "placebo_affected": 47, "placebo_at_risk": 67544, "rr": 0.818239, "se": 0.213716, "strata_with_events": 24, "z": -0.938635 }, "discovered": false, "discovery": { "glp1_affected": 31, "glp1_at_risk": 47388, "hi": 2.44145, "lo": 0.784861, "log_rr": 0.325171, "p": 0.261355, "placebo_affected": 20, "placebo_at_risk": 35018, "rr": 1.38427, "se": 0.289505, "strata_with_events": 15, "z": 1.1232 }, "discovery_q": 0.712061, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 0.791134, "lo": 0.198238, "log_rr": -0.926287, "p": 0.00870208, "placebo_affected": 27, "placebo_at_risk": 32526, "rr": 0.396021, "se": 0.353067, "strata_with_events": 9, "z": -2.62354 } }, "Upper gastrointestinal haemorrhage": { "all": { "glp1_affected": 61, "glp1_at_risk": 93765, "hi": 1.31179, "lo": 0.646646, "log_rr": -0.0822808, "p": 0.648408, "placebo_affected": 64, "placebo_at_risk": 67544, "rr": 0.921013, "se": 0.18045, "strata_with_events": 17, "z": -0.455975 }, "discovered": false, "discovery": { "glp1_affected": 32, "glp1_at_risk": 47388, "hi": 1.4165, "lo": 0.538781, "log_rr": -0.135129, "p": 0.583705, "placebo_affected": 35, "placebo_at_risk": 35018, "rr": 0.873603, "se": 0.246595, "strata_with_events": 9, "z": -0.54798 }, "discovery_q": 0.872706, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 29, "glp1_at_risk": 46377, "hi": 1.64535, "lo": 0.582287, "log_rr": -0.0214196, "p": 0.935576, "placebo_affected": 29, "placebo_at_risk": 32526, "rr": 0.978808, "se": 0.264991, "strata_with_events": 8, "z": -0.0808316 } }, "Upper limb fracture": { "all": { "glp1_affected": 26, "glp1_at_risk": 93765, "hi": 2.63875, "lo": 0.76745, "log_rr": 0.352812, "p": 0.262778, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 1.42306, "se": 0.315054, "strata_with_events": 13, "z": 1.11985 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 2.83165, "lo": 0.316488, "log_rr": -0.0548043, "p": 0.921904, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.94667, "se": 0.559023, "strata_with_events": 4, "z": -0.0980358 }, "discovery_q": 0.98083, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 20, "glp1_at_risk": 46377, "hi": 3.63938, "lo": 0.800602, "log_rr": 0.534711, "p": 0.166284, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 1.70695, "se": 0.386283, "strata_with_events": 9, "z": 1.38424 } }, "Upper respiratory tract infection": { "all": { "glp1_affected": 24, "glp1_at_risk": 93765, "hi": 1.35902, "lo": 0.445857, "log_rr": -0.250495, "p": 0.378305, "placebo_affected": 27, "placebo_at_risk": 67544, "rr": 0.778415, "se": 0.284322, "strata_with_events": 18, "z": -0.881024 }, "discovered": false, "discovery": { "glp1_affected": 14, "glp1_at_risk": 47388, "hi": 2.31555, "lo": 0.504514, "log_rr": 0.077745, "p": 0.841484, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 1.08085, "se": 0.388734, "strata_with_events": 7, "z": 0.199995 }, "discovery_q": 0.943906, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 1.24417, "lo": 0.230096, "log_rr": -0.625396, "p": 0.146349, "placebo_affected": 15, "placebo_at_risk": 32526, "rr": 0.535049, "se": 0.430551, "strata_with_events": 11, "z": -1.45255 } }, "Ureterolithiasis": { "all": { "glp1_affected": 69, "glp1_at_risk": 93765, "hi": 1.79487, "lo": 0.853716, "log_rr": 0.213389, "p": 0.260309, "placebo_affected": 48, "placebo_at_risk": 67544, "rr": 1.23787, "se": 0.189568, "strata_with_events": 25, "z": 1.12566 }, "discovered": false, "discovery": { "glp1_affected": 38, "glp1_at_risk": 47388, "hi": 2.2469, "lo": 0.791529, "log_rr": 0.287882, "p": 0.279431, "placebo_affected": 25, "placebo_at_risk": 35018, "rr": 1.3336, "se": 0.266164, "strata_with_events": 16, "z": 1.0816 }, "discovery_q": 0.724555, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 31, "glp1_at_risk": 46377, "hi": 1.93741, "lo": 0.671749, "log_rr": 0.131742, "p": 0.625873, "placebo_affected": 23, "placebo_at_risk": 32526, "rr": 1.14081, "se": 0.270215, "strata_with_events": 9, "z": 0.487544 } }, "Urethral stenosis": { "all": { "glp1_affected": 24, "glp1_at_risk": 93765, "hi": 2.03156, "lo": 0.625932, "log_rr": 0.120145, "p": 0.689135, "placebo_affected": 21, "placebo_at_risk": 67544, "rr": 1.12766, "se": 0.300342, "strata_with_events": 11, "z": 0.400029 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 2.02302, "lo": 0.421428, "log_rr": -0.0797576, "p": 0.842027, "placebo_affected": 13, "placebo_at_risk": 35018, "rr": 0.92334, "se": 0.400185, "strata_with_events": 4, "z": -0.199302 }, "discovery_q": 0.943906, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 12, "glp1_at_risk": 46377, "hi": 3.60356, "lo": 0.591075, "log_rr": 0.378056, "p": 0.41234, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 1.45944, "se": 0.461165, "strata_with_events": 7, "z": 0.819783 } }, "Urinary incontinence": { "all": { "glp1_affected": 8, "glp1_at_risk": 93765, "hi": 1.13287, "lo": 0.212268, "log_rr": -0.712576, "p": 0.0953259, "placebo_affected": 16, "placebo_at_risk": 67544, "rr": 0.490379, "se": 0.427217, "strata_with_events": 10, "z": -1.66795 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 1.38536, "lo": 0.169269, "log_rr": -0.725156, "p": 0.176322, "placebo_affected": 10, "placebo_at_risk": 35018, "rr": 0.484249, "se": 0.536292, "strata_with_events": 6, "z": -1.35217 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 3, "glp1_at_risk": 46377, "hi": 2.00129, "lo": 0.125392, "log_rr": -0.691258, "p": 0.327981, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.500946, "se": 0.706672, "strata_with_events": 4, "z": -0.978188 } }, "Urinary retention": { "all": { "glp1_affected": 54, "glp1_at_risk": 93765, "hi": 1.54158, "lo": 0.711401, "log_rr": 0.0461439, "p": 0.815063, "placebo_affected": 49, "placebo_at_risk": 67544, "rr": 1.04723, "se": 0.197281, "strata_with_events": 18, "z": 0.2339 }, "discovered": false, "discovery": { "glp1_affected": 34, "glp1_at_risk": 47388, "hi": 1.70367, "lo": 0.638461, "log_rr": 0.0420462, "p": 0.86664, "placebo_affected": 31, "placebo_at_risk": 35018, "rr": 1.04294, "se": 0.250383, "strata_with_events": 10, "z": 0.167928 }, "discovery_q": 0.955526, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 20, "glp1_at_risk": 46377, "hi": 1.97553, "lo": 0.562786, "log_rr": 0.0529893, "p": 0.868615, "placebo_affected": 18, "placebo_at_risk": 32526, "rr": 1.05442, "se": 0.320335, "strata_with_events": 8, "z": 0.165418 } }, "Urinary tract infection": { "all": { "glp1_affected": 332, "glp1_at_risk": 93765, "hi": 1.06537, "lo": 0.786025, "log_rr": -0.088722, "p": 0.252751, "placebo_affected": 344, "placebo_at_risk": 67544, "rr": 0.9151, "se": 0.077575, "strata_with_events": 38, "z": -1.14369 }, "discovered": false, "discovery": { "glp1_affected": 189, "glp1_at_risk": 47388, "hi": 1.05874, "lo": 0.711241, "log_rr": -0.141831, "p": 0.162261, "placebo_affected": 208, "placebo_at_risk": 35018, "rr": 0.867768, "se": 0.101488, "strata_with_events": 22, "z": -1.39751 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 143, "glp1_at_risk": 46377, "hi": 1.24937, "lo": 0.779154, "log_rr": -0.0134551, "p": 0.911061, "placebo_affected": 136, "placebo_at_risk": 32526, "rr": 0.986635, "se": 0.120457, "strata_with_events": 16, "z": -0.1117 } }, "Urosepsis": { "all": { "glp1_affected": 91, "glp1_at_risk": 93765, "hi": 1.21312, "lo": 0.67856, "log_rr": -0.0972923, "p": 0.51154, "placebo_affected": 96, "placebo_at_risk": 67544, "rr": 0.907291, "se": 0.148212, "strata_with_events": 20, "z": -0.656441 }, "discovered": false, "discovery": { "glp1_affected": 51, "glp1_at_risk": 47388, "hi": 1.1593, "lo": 0.542792, "log_rr": -0.231606, "p": 0.231544, "placebo_affected": 61, "placebo_at_risk": 35018, "rr": 0.793259, "se": 0.193587, "strata_with_events": 12, "z": -1.19639 }, "discovery_q": 0.711411, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 40, "glp1_at_risk": 46377, "hi": 1.74056, "lo": 0.700417, "log_rr": 0.0990638, "p": 0.669675, "placebo_affected": 35, "placebo_at_risk": 32526, "rr": 1.10414, "se": 0.23222, "strata_with_events": 8, "z": 0.426594 } }, "Uterine cancer": { "all": { "glp1_affected": 12, "glp1_at_risk": 93765, "hi": 3.33442, "lo": 0.502512, "log_rr": 0.258082, "p": 0.592939, "placebo_affected": 8, "placebo_at_risk": 67544, "rr": 1.29444, "se": 0.482773, "strata_with_events": 8, "z": 0.534582 }, "discovered": false, "discovery": { "glp1_affected": 1, "glp1_at_risk": 47388, "hi": null, "lo": null, "p": null, "placebo_affected": 0, "placebo_at_risk": 35018, "rr": null, "strata_with_events": 1 }, "discovery_q": null, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 11, "glp1_at_risk": 46377, "hi": 3.08276, "lo": 0.443554, "log_rr": 0.156445, "p": 0.751766, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 1.16935, "se": 0.494591, "strata_with_events": 7, "z": 0.316311 } }, "Uterine leiomyoma": { "all": { "glp1_affected": 35, "glp1_at_risk": 93765, "hi": 2.47756, "lo": 0.762943, "log_rr": 0.31835, "p": 0.289379, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 1.37486, "se": 0.300476, "strata_with_events": 27, "z": 1.05949 }, "discovered": false, "discovery": { "glp1_affected": 16, "glp1_at_risk": 47388, "hi": 2.73018, "lo": 0.499767, "log_rr": 0.155377, "p": 0.719819, "placebo_affected": 9, "placebo_at_risk": 35018, "rr": 1.1681, "se": 0.433166, "strata_with_events": 13, "z": 0.358701 }, "discovery_q": 0.916484, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 19, "glp1_at_risk": 46377, "hi": 3.65086, "lo": 0.704546, "log_rr": 0.47238, "p": 0.26036, "placebo_affected": 8, "placebo_at_risk": 32526, "rr": 1.60381, "se": 0.419692, "strata_with_events": 14, "z": 1.12554 } }, "Uterine polyp": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 1.31176, "lo": 0.296649, "log_rr": -0.471917, "p": 0.213356, "placebo_affected": 18, "placebo_at_risk": 67544, "rr": 0.623805, "se": 0.379235, "strata_with_events": 16, "z": -1.24439 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 1.47937, "lo": 0.190737, 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1.79431 }, "discovery_q": 0.517062, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 8, "glp1_at_risk": 46377, "hi": 9.60269, "lo": 0.637142, "log_rr": 0.905641, "p": 0.190661, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.47352, "se": 0.692055, "strata_with_events": 6, "z": 1.30863 } }, "Varicose vein": { "all": { "glp1_affected": 15, "glp1_at_risk": 93765, "hi": 1.65929, "lo": 0.403335, "log_rr": -0.200797, "p": 0.577865, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 0.818078, "se": 0.360818, "strata_with_events": 12, "z": -0.556506 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 2.79866, "lo": 0.370174, "log_rr": 0.0176787, "p": 0.972672, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 1.01784, "se": 0.516061, "strata_with_events": 6, "z": 0.034257 }, "discovery_q": 0.999955, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 7, "glp1_at_risk": 46377, "hi": 1.81988, "lo": 0.246972, "log_rr": -0.399855, "p": 0.432583, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.670417, "se": 0.509512, "strata_with_events": 6, "z": -0.78478 } }, "Vascular dementia": { "all": { "glp1_affected": 9, "glp1_at_risk": 93765, "hi": 1.37191, "lo": 0.26278, "log_rr": -0.510116, "p": 0.226297, "placebo_affected": 15, "placebo_at_risk": 67544, "rr": 0.600426, "se": 0.4216, "strata_with_events": 7, "z": -1.20995 }, "discovered": false, "discovery": { "glp1_affected": 7, "glp1_at_risk": 47388, "hi": 3.47149, "lo": 0.392202, "log_rr": 0.154303, "p": 0.781484, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 1.16684, "se": 0.556276, "strata_with_events": 4, "z": 0.277386 }, "discovery_q": 0.922336, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 2, "glp1_at_risk": 46377, "hi": 1.02973, "lo": 0.048135, "log_rr": -1.50223, "p": 0.0545463, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.222634, "se": 0.781403, "strata_with_events": 3, "z": -1.92247 } }, "Vascular graft occlusion": { "all": { "glp1_affected": 14, "glp1_at_risk": 93765, "hi": 1.67054, "lo": 0.406121, "log_rr": -0.193977, "p": 0.590817, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 0.823677, "se": 0.360785, "strata_with_events": 6, "z": -0.537653 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 1.58513, "lo": 0.354964, "log_rr": -0.287537, "p": 0.451316, "placebo_affected": 16, "placebo_at_risk": 35018, "rr": 0.750108, "se": 0.381743, "strata_with_events": 3, "z": -0.753223 }, "discovery_q": 0.785068, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 2, "glp1_at_risk": 46377, "hi": 22.0703, "lo": 0.181421, "log_rr": 0.693648, "p": 0.571169, "placebo_affected": 1, "placebo_at_risk": 32526, "rr": 2.001, "se": 1.22481, "strata_with_events": 3, "z": 0.566331 } }, "Vascular pseudoaneurysm": { "all": { "glp1_affected": 18, "glp1_at_risk": 93765, "hi": 3.0312, "lo": 0.688312, "log_rr": 0.367723, "p": 0.330888, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 1.44444, "se": 0.378189, "strata_with_events": 12, "z": 0.972326 }, "discovered": false, "discovery": { "glp1_affected": 8, "glp1_at_risk": 47388, "hi": 2.59954, "lo": 0.353779, "log_rr": -0.0418746, "p": 0.934406, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.95899, "se": 0.508789, "strata_with_events": 6, "z": -0.0823024 }, "discovery_q": 0.990048, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 10, "glp1_at_risk": 46377, "hi": 7.80782, "lo": 0.746535, "log_rr": 0.881407, "p": 0.141065, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 2.41429, "se": 0.598847, "strata_with_events": 6, "z": 1.47184 } }, "Vascular stent stenosis": { "all": { "glp1_affected": 33, "glp1_at_risk": 93765, "hi": 1.55311, "lo": 0.594069, "log_rr": -0.0402503, "p": 0.869591, "placebo_affected": 34, "placebo_at_risk": 67544, "rr": 0.960549, "se": 0.245162, "strata_with_events": 6, "z": -0.164178 }, "discovered": false, "discovery": { "glp1_affected": 29, "glp1_at_risk": 47388, "hi": 1.60926, "lo": 0.580476, "log_rr": -0.0340673, "p": 0.895804, "placebo_affected": 30, "placebo_at_risk": 35018, "rr": 0.966506, "se": 0.260127, "strata_with_events": 2, "z": -0.130964 }, "discovery_q": 0.971591, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 3.85513, "lo": 0.217589, "log_rr": -0.0878713, "p": 0.90462, "placebo_affected": 4, "placebo_at_risk": 32526, "rr": 0.915879, "se": 0.733317, "strata_with_events": 4, "z": -0.119827 } }, "Ventricular arrhythmia": { "all": { "glp1_affected": 16, "glp1_at_risk": 93765, "hi": 2.67055, "lo": 0.60449, "log_rr": 0.239458, "p": 0.527508, "placebo_affected": 12, "placebo_at_risk": 67544, "rr": 1.27056, "se": 0.379001, "strata_with_events": 9, "z": 0.631815 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 5.23739, "lo": 0.722507, "log_rr": 0.665398, "p": 0.187918, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 1.94526, "se": 0.505328, "strata_with_events": 4, "z": 1.31676 }, "discovery_q": 0.656748, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 2.14774, "lo": 0.18567, "log_rr": -0.459685, "p": 0.461717, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.631483, "se": 0.624552, "strata_with_events": 5, "z": -0.736023 } }, "Ventricular extrasystoles": { "all": { "glp1_affected": 38, "glp1_at_risk": 93765, "hi": 2.39302, "lo": 0.851619, "log_rr": 0.35597, "p": 0.176832, "placebo_affected": 25, "placebo_at_risk": 67544, "rr": 1.42756, "se": 0.263569, "strata_with_events": 15, "z": 1.35057 }, "discovered": false, "discovery": { "glp1_affected": 28, "glp1_at_risk": 47388, "hi": 2.27181, "lo": 0.720087, "log_rr": 0.246097, "p": 0.401125, "placebo_affected": 21, "placebo_at_risk": 35018, "rr": 1.27902, "se": 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"placebo_at_risk": 32526, "rr": 1.13529, "se": 0.270117, "strata_with_events": 9, "z": 0.469767 } }, "Vertebrobasilar insufficiency": { "all": { "glp1_affected": 11, "glp1_at_risk": 93765, "hi": 1.8067, "lo": 0.349834, "log_rr": -0.229398, "p": 0.583893, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 0.795012, "se": 0.418834, "strata_with_events": 7, "z": -0.547707 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 2.51378, "lo": 0.206571, "log_rr": -0.327663, "p": 0.607257, "placebo_affected": 6, "placebo_at_risk": 35018, "rr": 0.720606, "se": 0.637486, "strata_with_events": 4, "z": -0.513993 }, "discovery_q": 0.882346, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 6, "glp1_at_risk": 46377, "hi": 2.5557, "lo": 0.288622, "log_rr": -0.152154, "p": 0.78449, "placebo_affected": 7, "placebo_at_risk": 32526, "rr": 0.858856, "se": 0.556378, "strata_with_events": 3, "z": -0.273473 } }, "Vertigo": { "all": { 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"placebo_at_risk": 67544, "rr": 1.16472, "se": 0.288842, "strata_with_events": 15, "z": 0.52789 }, "discovered": false, "discovery": { "glp1_affected": 12, "glp1_at_risk": 47388, "hi": 1.53751, "lo": 0.361261, "log_rr": -0.293995, "p": 0.4262, "placebo_affected": 15, "placebo_at_risk": 35018, "rr": 0.74528, "se": 0.369475, "strata_with_events": 7, "z": -0.79571 }, "discovery_q": 0.774364, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 14, "glp1_at_risk": 46377, "hi": 6.65854, "lo": 0.887793, "log_rr": 0.888442, "p": 0.0839124, "placebo_affected": 5, "placebo_at_risk": 32526, "rr": 2.43134, "se": 0.514019, "strata_with_events": 8, "z": 1.72842 } }, "Vestibular neuronitis": { "all": { "glp1_affected": 15, "glp1_at_risk": 93765, "hi": 2.82569, "lo": 0.573457, "log_rr": 0.24134, "p": 0.553054, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 1.27295, "se": 0.406851, "strata_with_events": 9, "z": 0.59319 }, "discovered": false, "discovery": { "glp1_affected": 6, "glp1_at_risk": 47388, "hi": 2.16163, "lo": 0.260307, "log_rr": -0.287516, "p": 0.594422, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.750124, "se": 0.539998, "strata_with_events": 4, "z": -0.53244 }, "discovery_q": 0.872706, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 9, "glp1_at_risk": 46377, "hi": 10.358, "lo": 0.687133, "log_rr": 0.981264, "p": 0.156247, "placebo_affected": 3, "placebo_at_risk": 32526, "rr": 2.66783, "se": 0.6921, "strata_with_events": 5, "z": 1.41781 } }, "Viral infection": { "all": { "glp1_affected": 20, "glp1_at_risk": 93765, "hi": 3.4768, "lo": 0.755703, "log_rr": 0.483004, "p": 0.214775, "placebo_affected": 11, "placebo_at_risk": 67544, "rr": 1.62094, "se": 0.389349, "strata_with_events": 15, "z": 1.24054 }, "discovered": false, "discovery": { "glp1_affected": 10, "glp1_at_risk": 47388, "hi": 7.97408, "lo": 0.78501, "log_rr": 0.917069, "p": 0.120981, "placebo_affected": 4, "placebo_at_risk": 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false, "replication": { "glp1_affected": 22, "glp1_at_risk": 46377, "hi": 8.56709, "lo": 1.34226, "log_rr": 1.22114, "p": 0.00980955, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 3.39106, "se": 0.472858, "strata_with_events": 9, "z": 2.58247 } }, "Vomiting": { "all": { "glp1_affected": 129, "glp1_at_risk": 93765, "hi": 3.00778, "lo": 1.51829, "log_rr": 0.759392, "p": 1.33417e-05, "placebo_affected": 50, "placebo_at_risk": 67544, "rr": 2.13698, "se": 0.174396, "strata_with_events": 48, "z": 4.35442 }, "discovered": false, "discovery": { "glp1_affected": 76, "glp1_at_risk": 47388, "hi": 3.24045, "lo": 1.37531, "log_rr": 0.747194, "p": 0.000631912, "placebo_affected": 32, "placebo_at_risk": 35018, "rr": 2.11107, "se": 0.218635, "strata_with_events": 24, "z": 3.41753 }, "discovery_q": 0.108689, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 53, "glp1_at_risk": 46377, "hi": 3.84276, "lo": 1.23782, "log_rr": 0.77977, "p": 0.00697144, "placebo_affected": 18, "placebo_at_risk": 32526, "rr": 2.18097, "se": 0.288996, "strata_with_events": 24, "z": 2.69821 } }, "Weight decreased": { "all": { "glp1_affected": 8, "glp1_at_risk": 93765, "hi": 1.18876, "lo": 0.194872, "log_rr": -0.731252, "p": 0.112932, "placebo_affected": 13, "placebo_at_risk": 67544, "rr": 0.481306, "se": 0.461314, "strata_with_events": 12, "z": -1.58515 }, "discovered": false, "discovery": { "glp1_affected": 3, "glp1_at_risk": 47388, "hi": 1.2705, "lo": 0.0770327, "log_rr": -1.16206, "p": 0.104132, "placebo_affected": 7, "placebo_at_risk": 35018, "rr": 0.312842, "se": 0.715049, "strata_with_events": 6, "z": -1.62514 }, "discovery_q": 0.574134, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 5, "glp1_at_risk": 46377, "hi": 2.32498, "lo": 0.20208, "log_rr": -0.37769, "p": 0.544466, "placebo_affected": 6, "placebo_at_risk": 32526, "rr": 0.685443, "se": 0.623175, "strata_with_events": 6, "z": -0.606074 } }, "Wound infection": { "all": { "glp1_affected": 19, "glp1_at_risk": 93765, "hi": 1.48589, "lo": 0.44228, "log_rr": -0.209898, "p": 0.497163, "placebo_affected": 22, "placebo_at_risk": 67544, "rr": 0.810667, "se": 0.309146, "strata_with_events": 12, "z": -0.67896 }, "discovered": false, "discovery": { "glp1_affected": 15, "glp1_at_risk": 47388, "hi": 2.51686, "lo": 0.572691, "log_rr": 0.182802, "p": 0.628364, "placebo_affected": 12, "placebo_at_risk": 35018, "rr": 1.20058, "se": 0.377665, "strata_with_events": 7, "z": 0.484031 }, "discovery_q": 0.888317, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 4, "glp1_at_risk": 46377, "hi": 1.12924, "lo": 0.101855, "log_rr": -1.08133, "p": 0.0780825, "placebo_affected": 10, "placebo_at_risk": 32526, "rr": 0.339145, "se": 0.613721, "strata_with_events": 5, "z": -1.76192 } }, "Wrist fracture": { "all": { "glp1_affected": 16, "glp1_at_risk": 93765, "hi": 1.6341, "lo": 0.391273, "log_rr": -0.223629, "p": 0.539709, "placebo_affected": 17, "placebo_at_risk": 67544, "rr": 0.799611, "se": 0.364661, "strata_with_events": 13, "z": -0.613254 }, "discovered": false, "discovery": { "glp1_affected": 5, "glp1_at_risk": 47388, "hi": 1.91119, "lo": 0.204907, "log_rr": -0.468737, "p": 0.41058, "placebo_affected": 8, "placebo_at_risk": 35018, "rr": 0.625792, "se": 0.569634, "strata_with_events": 4, "z": -0.822874 }, "discovery_q": 0.773686, "overlap_bound": 1.0, "replicated": false, "replication": { "glp1_affected": 11, "glp1_at_risk": 46377, "hi": 2.42567, "lo": 0.371155, "log_rr": -0.0525134, "p": 0.912683, "placebo_affected": 9, "placebo_at_risk": 32526, "rr": 0.948842, "se": 0.478897, "strata_with_events": 9, "z": -0.109655 } } }, "replicated": [ "Acute myocardial infarction", "Cellulitis" ], "tested": 518 }