[
  {
    "local_id": "C1",
    "type": "empirical",
    "core": true,
    "statement": "In 27 adults from the PhysioNet Cerebral Vasoregulation in Diabetes sit-to-stand recordings, standing with eyes open raised the lag-1 autocorrelation of linearly detrended beat-to-beat systolic blood pressure relative to the preceding 240 s of sitting, by a Hodges-Lehmann shift of 0.043 (bootstrap 95% CI 0.007 to 0.076), with 19 of 27 participants rising (one-sided Wilcoxon signed-rank p = 0.012; Holm-adjusted across two primary tests p = 0.025).",
    "evidence": [
      {
        "result": "R1.H1_sbp_ar1_stand_minus_sit.hodges_lehmann",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H1_sbp_ar1_stand_minus_sit.hl_ci95.0",
        "produced_by": "code/analyze.py",
        "tolerance": 0.003
      },
      {
        "result": "R1.H1_sbp_ar1_stand_minus_sit.hl_ci95.1",
        "produced_by": "code/analyze.py",
        "tolerance": 0.003
      },
      {
        "result": "R1.H1_sbp_ar1_stand_minus_sit.n",
        "produced_by": "code/analyze.py"
      },
      {
        "result": "R1.H1_sbp_ar1_stand_minus_sit.n_positive",
        "produced_by": "code/analyze.py",
        "tolerance": 1
      },
      {
        "result": "R1.H1_sbp_ar1_stand_minus_sit.p_one_sided",
        "produced_by": "code/analyze.py",
        "tolerance": 0.003
      },
      {
        "result": "R1.holm_adjusted_p.H1",
        "produced_by": "code/analyze.py",
        "tolerance": 0.006
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run of the registered pipeline on the same files gives a Hodges-Lehmann shift whose bootstrap 95% CI includes zero, or an independent beat detection on the same windows gives a shift of the opposite sign.",
    "confidence": 0.8
  },
  {
    "local_id": "C2",
    "type": "negative_result",
    "core": true,
    "statement": "In the same recordings, the standing-induced rise in systolic-pressure lag-1 autocorrelation was not larger in 13 adults with type 2 diabetes than in 14 controls: the probability that a diabetic participant's rise exceeds a control's was 0.505 (bootstrap 95% CI 0.28 to 0.73; one-sided Mann-Whitney p = 0.49), which rules out only differences larger than that interval's upper end, since the test had 80% power only at a standardised difference of about 1.0.",
    "evidence": [
      {
        "result": "R1.H2_sbp_ar1_rise_dm_vs_control.auc_dm_gt_control",
        "produced_by": "code/analyze.py",
        "tolerance": 0.01
      },
      {
        "result": "R1.H2_sbp_ar1_rise_dm_vs_control.auc_ci95.0",
        "produced_by": "code/analyze.py",
        "tolerance": 0.02
      },
      {
        "result": "R1.H2_sbp_ar1_rise_dm_vs_control.auc_ci95.1",
        "produced_by": "code/analyze.py",
        "tolerance": 0.02
      },
      {
        "result": "R1.H2_sbp_ar1_rise_dm_vs_control.n_dm",
        "produced_by": "code/analyze.py"
      },
      {
        "result": "R1.H2_sbp_ar1_rise_dm_vs_control.n_control",
        "produced_by": "code/analyze.py"
      },
      {
        "result": "R1.H2_sbp_ar1_rise_dm_vs_control.p",
        "produced_by": "code/analyze.py",
        "tolerance": 0.02
      }
    ],
    "depends_on": [
      "C1"
    ],
    "falsified_if": "A re-run gives a group AUC whose bootstrap 95% CI excludes 0.5, or a larger cohort shows a standardised group difference above 1.0 under the same protocol.",
    "confidence": 0.75
  },
  {
    "local_id": "C3",
    "type": "negative_result",
    "core": false,
    "statement": "During eyes-open standing, magnitude-squared coherence in 0.05-0.15 Hz between anteroposterior whole-body sway acceleration (horizontal ground-reaction force over body weight) and beat-to-beat systolic pressure did not exceed phase-randomised surrogates: median surrogate z-score -0.03 across 26 participants, 2 of whom exceeded 1.645 (one-sided Wilcoxon signed-rank p = 0.54).",
    "evidence": [
      {
        "result": "R1.H3_sway_sbp_coherence_z.median_z",
        "produced_by": "code/analyze.py",
        "tolerance": 0.05
      },
      {
        "result": "R1.H3_sway_sbp_coherence_z.n",
        "produced_by": "code/analyze.py"
      },
      {
        "result": "R1.H3_sway_sbp_coherence_z.n_z_above_1_645",
        "produced_by": "code/analyze.py",
        "tolerance": 1
      },
      {
        "result": "R1.H3_sway_sbp_coherence_z.p_one_sided",
        "produced_by": "code/analyze.py",
        "tolerance": 0.05
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run on the same files, or an analysis of the same recordings with calibrated centre-of-pressure data, finds a median surrogate z-score whose one-sided test is significant at 0.05.",
    "confidence": 0.7
  }
]