[
  {
    "local_id": "C1",
    "type": "negative_result",
    "core": true,
    "statement": "Across 13459 NeuroQuery full-text articles with coordinates, studies that discuss time perception or vestibular processing report anterior-insula coordinates no more often than studies on random topics (anterior-insula association z 0.424 and -0.945; percentiles 0.4959 and 0.2351 among 2773 comparison terms), so the conjunction of time perception, interoception and vestibular processing in the anterior insula is not selective (minimum z -0.945, percentile 0.5456 among random term triples), even though interoception alone is strongly associated (z 10.259).",
    "evidence": [
      {
        "result": "R1.H1_conjunction.observed_min_z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H1_conjunction.percentile",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.pool_terms",
        "produced_by": "code/convergence.py",
        "tolerance": 0
      },
      {
        "result": "R1.studies_with_coordinates",
        "produced_by": "code/convergence.py",
        "tolerance": 0
      },
      {
        "result": "R1.terms.time perception.anterior_insula.z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.terms.vestibular.anterior_insula.z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.terms.time perception.anterior_insula.percentile_vs_random_terms",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.terms.vestibular.anterior_insula.percentile_vs_random_terms",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.terms.interoception.anterior_insula.z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives a conjunction percentile of 0.95 or more, or an equivalent analysis of another coordinate database finds selective anterior-insula association for time perception and vestibular studies.",
    "confidence": 0.75
  },
  {
    "local_id": "C2",
    "type": "negative_result",
    "core": false,
    "statement": "In the same articles, interoception studies are as strongly associated with the posterior as with the anterior insula (z 10.389 vs 10.259), and vestibular studies lean posterior (anterior minus posterior z -2.366, percentile 0.0999 among random terms), so none of the three functions shows an anterior-insula preference.",
    "evidence": [
      {
        "result": "R1.H2_anterior_minus_posterior.interoception.difference_z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2_anterior_minus_posterior.vestibular.difference_z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2_anterior_minus_posterior.vestibular.percentile_vs_random_terms",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2_anterior_minus_posterior.interoception.percentile_vs_random_terms",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.terms.interoception.posterior_insula.z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.terms.interoception.anterior_insula.z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives a positive anterior-minus-posterior difference above the 95th random-term percentile for any of the three functions.",
    "confidence": 0.7
  },
  {
    "local_id": "C3",
    "type": "negative_result",
    "core": true,
    "statement": "Studies discussing fatigue, psychomotor change, sadness or mood are not selectively associated with the anterior insula: their mean association z (1.057) lies at percentile 0.7064 of random four-term sets, with fatigue negative and only sadness near the upper tail.",
    "evidence": [
      {
        "result": "R1.H3_symptoms_mean.observed_mean_z",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H3_symptoms_mean.percentile",
        "produced_by": "code/convergence.py",
        "tolerance": 0.002
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives a percentile of 0.95 or more.",
    "confidence": 0.7
  }
]