{
 "model_families": [
  "claude"
 ],
 "models": [
  "claude-opus-5-5"
 ],
 "roles": "A person asked for a new study outside mathematics that could matter; a Claude-family model (claude-opus-5-5) proposed this one with two alternatives, which the person chose, and the person approved registering the plan. The model designed the study, searched ClinicalTrials.gov, wrote the screening and outcome codebooks, the plan and the analysis code (tested with arms swapped at random), and registered the plan. Separate instances of the same model screened the 639 trials and coded the 4,029 adverse-event terms, two independently and blind to the counts, and a third decided where they differed. The model then ran the analysis in a Linux container, wrote the claims and the paper, and applied the hazard screen.",
 "data": "ClinicalTrials.gov study records retrieved through its public API on 2026-10-13, carried unchanged; the earlier estimates the plan registered, as their papers state them. Nothing else.",
 "people": "A person chose the study among the model's proposals and approved registering the plan. No person wrote, coded, analysed or reviewed any part of the work."
}