[
  {
    "local_id": "C1",
    "type": "negative_result",
    "core": true,
    "statement": "In 14722 NHANES 2005-2010 adults, limitation in load-bearing tasks is associated with the PHQ-9 psychomotor item more than slow bowel transit is (age-, sex- and cycle-adjusted partial Spearman 0.2038 vs 0.0296), but also with the sleep, energy and appetite items more than slow transit is (0.2946 vs 0.0404; difference -0.2542, 95% CI -0.2762 to -0.2312), so the predicted double dissociation between a structural and a transport system does not appear.",
    "evidence": [
      {
        "result": "R1.adults_with_phq9",
        "produced_by": "code/analyze.py"
      },
      {
        "result": "R1.H1.struct_psychomotor",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H1.transit_psychomotor",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H1.struct_vegetative",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H1.transit_vegetative",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H1.H1b_difference",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H1.H1b_ci95.0",
        "produced_by": "code/analyze.py",
        "tolerance": 0.005
      },
      {
        "result": "R1.H1.H1b_ci95.1",
        "produced_by": "code/analyze.py",
        "tolerance": 0.005
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives an H1b difference whose 95% CI includes or exceeds zero.",
    "confidence": 0.85
  },
  {
    "local_id": "C2",
    "type": "empirical",
    "core": true,
    "statement": "In the same adults, load-bearing limitation, body mass index and a nine-marker allostatic load index are each associated with somatic depressive symptoms after adjusting for cognitive-affective symptoms (partial Spearman 0.1916, 0.0558, 0.08) and more strongly than with cognitive-affective symptoms after adjusting for somatic ones (differences 0.0711, 0.0399, 0.0646; Holm-adjusted p 0.002, 0.016, 0.002), whereas slow bowel transit shows no such specificity (difference 0.0074, 95% CI -0.0209 to 0.0347).",
    "evidence": [
      {
        "result": "R1.H2.struct.somatic_adj_cognitive",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2.struct.difference",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2.bmi.somatic_adj_cognitive",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2.bmi.difference",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2.allostatic.somatic_adj_cognitive",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2.allostatic.difference",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2.slow_transit.difference",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H2.slow_transit.difference_ci95.0",
        "produced_by": "code/analyze.py",
        "tolerance": 0.005
      },
      {
        "result": "R1.H2.slow_transit.difference_ci95.1",
        "produced_by": "code/analyze.py",
        "tolerance": 0.005
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives a specificity difference CI including zero for load-bearing limitation, BMI or allostatic load, or excluding zero for slow transit.",
    "confidence": 0.85
  },
  {
    "local_id": "C3",
    "type": "negative_result",
    "core": false,
    "statement": "Lower family income relates more to cognitive-affective than to somatic depressive symptoms in these adults (partial Spearman 0.1275 vs 0.0279; difference -0.0996, 95% CI -0.1299 to -0.0695), opposite to the prediction that socially distributed load expresses itself somatically.",
    "evidence": [
      {
        "result": "R1.H3.cognitive_adj_somatic",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H3.somatic_adj_cognitive",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H3.difference",
        "produced_by": "code/analyze.py",
        "tolerance": 0.002
      },
      {
        "result": "R1.H3.difference_ci95.0",
        "produced_by": "code/analyze.py",
        "tolerance": 0.005
      },
      {
        "result": "R1.H3.difference_ci95.1",
        "produced_by": "code/analyze.py",
        "tolerance": 0.005
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives a difference CI including zero or positive.",
    "confidence": 0.85
  }
]