{
 "note": "Computed blind to arm (code/analyze.py --blind): participants with each outcome, both arms together; the power of a two-sided 5% test to detect each registered earlier estimate; and the trials, comparisons and participants each analysis covers. None of these depends on which arm is which.",
 "pool": {
  "found": 932,
  "screened": 639,
  "eligible_trials": 393,
  "structural_exclusions": {
   "design_crossover": 68,
   "design_sequential": 9,
   "design_single_group": 10,
   "fewer_than_two_adverse_event_groups": 3,
   "not_randomized": 203
  },
  "exclusions": {
   "active_comparator_only": 33,
   "antidepressant_is_background": 78,
   "combined_with_other_active": 6,
   "groups_not_randomized_arms": 12,
   "no_antidepressant_group": 40,
   "no_placebo_group": 71,
   "other": 1
  },
  "all": {
   "by_age_group": {
    "adult": 87670,
    "mixed": 1950,
    "older": 2737,
    "pediatric": 7373
   },
   "by_class": {
    "bupropion": 25597,
    "maoi": 797,
    "novel_mechanism": 6394,
    "other_monoaminergic": 19193,
    "snri": 31858,
    "ssri": 25051,
    "tricyclic": 2768
   },
   "by_design": {
    "acute": 95567,
    "other": 376,
    "randomized_withdrawal": 3787
   },
   "by_indication": {
    "depressive": 43657,
    "non_psychiatric": 35718,
    "other_psychiatric": 20355
   },
   "comparisons": 413,
   "drug_participants": 50169,
   "participants": 99730,
   "placebo_participants": 49561,
   "trials": 393,
   "with_mean_age": 365
  }
 },
 "analyses": {
  "P1": {
   "name": "Serious suicidal behaviour, adult trials randomized from the start",
   "outcome": "S1",
   "participants_affected": 65,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.938,
    "kaminski_2020_attempts": 0.504,
    "stone_2009_behaviour_25_64": 0.081
   },
   "trials": 306,
   "comparisons": 322,
   "participants": 71643
  },
  "P2": {
   "name": "Any serious suicidality (behaviour or ideation), adult trials randomized from the start",
   "outcome": "S3",
   "participants_affected": 125,
   "testable": true,
   "power": {
    "kaminski_2020_attempts": 0.779,
    "stone_2009_suicidality_25_64": 0.26
   },
   "trials": 306,
   "comparisons": 322,
   "participants": 71643
  },
  "A10": {
   "name": "Serious suicidal behaviour, adult acute trials completed after 2017",
   "outcome": "S1",
   "participants_affected": 13,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.345,
    "kaminski_2020_attempts": 0.14,
    "stone_2009_behaviour_25_64": 0.044
   },
   "trials": 68,
   "comparisons": 75,
   "participants": 14283
  },
  "A11": {
   "name": "Serious suicidal behaviour, adult acute trials of SSRIs",
   "outcome": "S1",
   "participants_affected": 13,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.345,
    "kaminski_2020_attempts": 0.14,
    "stone_2009_behaviour_25_64": 0.044
   },
   "trials": 102,
   "comparisons": 109,
   "participants": 15653
  },
  "A12": {
   "name": "Serious suicidal behaviour, adult acute trials of SNRIs",
   "outcome": "S1",
   "participants_affected": 17,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.431,
    "kaminski_2020_attempts": 0.17,
    "stone_2009_behaviour_25_64": 0.047
   },
   "trials": 76,
   "comparisons": 78,
   "participants": 20674
  },
  "A13": {
   "name": "Serious suicidal behaviour, adult acute trials of bupropion",
   "outcome": "S1",
   "participants_affected": 6,
   "testable": false,
   "power": {
    "hengartner_2019_attempts": 0.185,
    "kaminski_2020_attempts": 0.087,
    "stone_2009_behaviour_25_64": 0.037
   },
   "trials": 36,
   "comparisons": 41,
   "participants": 10957
  },
  "A14": {
   "name": "Serious suicidal behaviour, adult acute trials of novel-mechanism antidepressants",
   "outcome": "S1",
   "participants_affected": 13,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.346,
    "kaminski_2020_attempts": 0.14,
    "stone_2009_behaviour_25_64": 0.044
   },
   "trials": 26,
   "comparisons": 27,
   "participants": 5591
  },
  "A15": {
   "name": "Serious suicidal behaviour, adult acute trials of tricyclic, MAOI and other monoaminergic antidepressants",
   "outcome": "S1",
   "participants_affected": 8,
   "testable": false,
   "power": {
    "hengartner_2019_attempts": 0.231,
    "kaminski_2020_attempts": 0.102,
    "stone_2009_behaviour_25_64": 0.039
   },
   "trials": 48,
   "comparisons": 49,
   "participants": 10721
  },
  "A16": {
   "name": "Serious suicidal behaviour, adult acute trials, with combination products included",
   "outcome": "S1",
   "participants_affected": 65,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.938,
    "kaminski_2020_attempts": 0.504,
    "stone_2009_behaviour_25_64": 0.081
   },
   "trials": 322,
   "comparisons": 340,
   "participants": 86606
  },
  "A17": {
   "name": "Serious suicidal behaviour, adult randomized-withdrawal trials",
   "outcome": "S1",
   "participants_affected": 1,
   "testable": false,
   "power": {
    "hengartner_2019_attempts": 0.063,
    "kaminski_2020_attempts": 0.043,
    "stone_2009_behaviour_25_64": 0.029
   },
   "trials": 13,
   "comparisons": 13,
   "participants": 3425
  },
  "A18": {
   "name": "Serious suicidal behaviour, pediatric acute trials",
   "outcome": "S1",
   "participants_affected": 19,
   "testable": true,
   "power": {
    "stone_2009_behaviour_under_25": 0.439
   },
   "trials": 30,
   "comparisons": 30,
   "participants": 7094
  },
  "A19": {
   "name": "Any serious suicidality, pediatric acute trials",
   "outcome": "S3",
   "participants_affected": 46,
   "testable": true,
   "power": {
    "hammad_2006_pediatric_suicidality": 0.615,
    "stone_2009_suicidality_under_25": 0.37
   },
   "trials": 30,
   "comparisons": 30,
   "participants": 7094
  },
  "A2": {
   "name": "Serious suicidal ideation, adult acute trials",
   "outcome": "S2",
   "participants_affected": 60,
   "testable": true,
   "power": {
    "stone_2009_suicidality_25_64": 0.147
   },
   "trials": 306,
   "comparisons": 322,
   "participants": 71643
  },
  "A20": {
   "name": "Serious suicidal behaviour, acute trials spanning adolescents and adults",
   "outcome": "S1",
   "participants_affected": 1,
   "testable": false,
   "power": {
    "stone_2009_behaviour_under_25": 0.061
   },
   "trials": 18,
   "comparisons": 19,
   "participants": 1612
  },
  "A4": {
   "name": "Completed suicide, adult acute trials",
   "outcome": "S4",
   "participants_affected": 7,
   "testable": false,
   "power": {
    "hengartner_2019_attempts": 0.208,
    "kaminski_2020_attempts": 0.094,
    "stone_2009_behaviour_25_64": 0.038
   },
   "trials": 306,
   "comparisons": 322,
   "participants": 71643
  },
  "A5": {
   "name": "Serious suicidal behaviour or overdose of unstated intent, adult acute trials",
   "outcome": "S15",
   "participants_affected": 70,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.952,
    "kaminski_2020_attempts": 0.533,
    "stone_2009_behaviour_25_64": 0.084
   },
   "trials": 306,
   "comparisons": 322,
   "participants": 71643
  },
  "A6": {
   "name": "Serious suicidal behaviour, adult acute trials of depressive disorders",
   "outcome": "S1",
   "participants_affected": 49,
   "testable": true,
   "power": {
    "hengartner_2019_attempts": 0.859,
    "kaminski_2020_attempts": 0.401,
    "stone_2009_behaviour_25_64": 0.07
   },
   "trials": 131,
   "comparisons": 134,
   "participants": 34345
  },
  "A7": {
   "name": "Serious suicidal behaviour, adult acute trials of other psychiatric disorders",
   "outcome": "S1",
   "participants_affected": 9,
   "testable": false,
   "power": {
    "hengartner_2019_attempts": 0.254,
    "kaminski_2020_attempts": 0.11,
    "stone_2009_behaviour_25_64": 0.04
   },
   "trials": 88,
   "comparisons": 97,
   "participants": 17743
  },
  "A8": {
   "name": "Serious suicidal behaviour, adult acute trials of non-psychiatric conditions",
   "outcome": "S1",
   "participants_affected": 7,
   "testable": false,
   "power": {
    "hengartner_2019_attempts": 0.208,
    "kaminski_2020_attempts": 0.094,
    "stone_2009_behaviour_25_64": 0.038
   },
   "trials": 87,
   "comparisons": 91,
   "participants": 19555
  },
  "A9": {
   "name": "Serious suicidal behaviour, acute trials enrolling only people aged 60 or over",
   "outcome": "S1",
   "participants_affected": 0,
   "testable": false,
   "power": {
    "hengartner_2019_attempts": 0.0,
    "kaminski_2020_attempts": 0.0,
    "stone_2009_behaviour_25_64": 0.0
   },
   "trials": 15,
   "comparisons": 15,
   "participants": 2737
  },
  "G1": {
   "name": "Serious suicidal behaviour by trial mean age, all acute trials",
   "comparisons_with_events_and_age": 51,
   "age_min": 9.3,
   "age_max": 60.8
  },
  "G2": {
   "name": "Any serious suicidality by trial mean age, all acute trials",
   "comparisons_with_events_and_age": 73,
   "age_min": 9.3,
   "age_max": 60.8
  },
  "K1": {
   "name": "Nausea, adult acute trials (positive control)",
   "participants_affected": 8157,
   "comparisons": 207
  },
  "K2": {
   "name": "Death from any cause, adult acute trials",
   "participants_affected": 295,
   "comparisons": 121
  },
  "K3": {
   "name": "Any serious adverse event, adult acute trials",
   "participants_affected": 1656,
   "comparisons": 322
  }
 }
}