{ "scope": "Independent feasibility calculations only. No compensation, RNA response, inflammation association, metabolite production or causal effect tested. Species declines are compositional relative-abundance declines, not absolute population losses. Positive entries are detections, not a validated expression limit. EC annotations remain broader than validated butyrate-specific genes.", "matching": "Known header endings removed; exact assay-specific External ID metadata lookup. Exclude _TR and duplicate _P pilot profiles using author code conventions; strict specimen site_sub_coll matching; reject ambiguous specimens and participant/week/diagnosis conflicts. Do not average pilot/techrep abundances. Do not impute weeks. 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