[
  {
    "local_id": "C1",
    "type": "negative_result",
    "core": true,
    "statement": "In 14722 NHANES 2005-2010 adults, limitation in load-bearing tasks, a nine-marker allostatic load index and BMI rise linearly with PHQ-9 depressive-symptom severity across its full range, with no steeper slope above any threshold between 8 and 22 points (wild-bootstrap sup-t tests, Holm-adjusted p = 1.0, 1.0 and 1.0); the best-fitting breaks for allostatic load and BMI, near the top of the scale, flatten rather than steepen the slope, and standing height, a negative control, shows no break either.",
    "evidence": [
      {
        "result": "R1.H1.allostatic.p_holm",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.allostatic.slope_change_per_point_sd",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.allostatic.linear_slope_per_point_sd",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.bmi.p_holm",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.bmi.slope_change_per_point_sd",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.bmi.linear_slope_per_point_sd",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.struct.p_holm",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.struct.slope_change_per_point_sd",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H1.struct.linear_slope_per_point_sd",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.control_height.p_one_sided",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.n_adults",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives a Holm-adjusted p below 0.05 for any load measure.",
    "confidence": 0.8
  },
  {
    "local_id": "C2",
    "type": "negative_result",
    "core": false,
    "statement": "The partial association of load-bearing limitation with somatic depressive symptoms, adjusting for cognitive-affective symptoms, is no stronger in adults whose symptoms make functioning very or extremely difficult (partial Spearman 0.1607, n = 454) than in other adults with symptoms (0.1746; difference -0.0139, 95% CI -0.1036 to 0.0773).",
    "evidence": [
      {
        "result": "R1.H2_difficulty_strata.pcor_high",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H2_difficulty_strata.pcor_lower",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H2_difficulty_strata.difference",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H2_difficulty_strata.ci95.0",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      },
      {
        "result": "R1.H2_difficulty_strata.ci95.1",
        "produced_by": "code/breakpoint.py",
        "tolerance": 1e-06
      }
    ],
    "depends_on": [],
    "falsified_if": "A re-run gives a difference whose one-sided bootstrap p is below 0.05.",
    "confidence": 0.7
  }
]