{
 "family_b_robust": [
  "B01",
  "B12",
  "B13"
 ],
 "family_b_significant": [
  "B01",
  "B12",
  "B13"
 ],
 "organ_systems": {
  "discovered": [
   "cardiac disorders",
   "hepatobiliary disorders",
   "infections and infestations",
   "metabolism and nutrition disorders",
   "respiratory, thoracic and mediastinal disorders"
  ],
  "discovered_count": 5,
  "items": {
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    "all": {
     "comparisons_with_events": 137,
     "glp1_affected": 6373,
     "glp1_at_risk": 93765,
     "hi": 0.89,
     "lo": 0.84,
     "p": "< 0.001",
     "placebo_affected": 6949,
     "placebo_at_risk": 67544,
     "rr": 0.87
    },
    "discovery": {
     "comparisons_with_events": 67,
     "glp1_affected": 4235,
     "glp1_at_risk": 47388,
     "hi": 0.89,
     "lo": 0.8,
     "p": "< 0.001",
     "placebo_affected": 4892,
     "placebo_at_risk": 35018,
     "rr": 0.84
    },
    "discovery_q": "< 0.001",
    "replicated": true,
    "replication": {
     "comparisons_with_events": 70,
     "glp1_affected": 2138,
     "glp1_at_risk": 46377,
     "hi": 0.99,
     "lo": 0.85,
     "p": "0.036",
     "placebo_affected": 2057,
     "placebo_at_risk": 32526,
     "rr": 0.92
    }
   },
   "hepatobiliary disorders": {
    "all": {
     "comparisons_with_events": 102,
     "glp1_affected": 1096,
     "glp1_at_risk": 93765,
     "hi": 1.44,
     "lo": 1.19,
     "p": "< 0.001",
     "placebo_affected": 711,
     "placebo_at_risk": 67544,
     "rr": 1.31
    },
    "discovery": {
     "comparisons_with_events": 48,
     "glp1_affected": 670,
     "glp1_at_risk": 47388,
     "hi": 1.62,
     "lo": 1.14,
     "p": "< 0.001",
     "placebo_affected": 430,
     "placebo_at_risk": 35018,
     "rr": 1.36
    },
    "discovery_q": "0.0063",
    "replicated": false,
    "replication": {
     "comparisons_with_events": 54,
     "glp1_affected": 426,
     "glp1_at_risk": 46377,
     "hi": 1.55,
     "lo": 0.99,
     "p": "0.057",
     "placebo_affected": 281,
     "placebo_at_risk": 32526,
     "rr": 1.24
    }
   },
   "infections and infestations": {
    "all": {
     "comparisons_with_events": 140,
     "glp1_affected": 5103,
     "glp1_at_risk": 93765,
     "hi": 0.92,
     "lo": 0.85,
     "p": "< 0.001",
     "placebo_affected": 5311,
     "placebo_at_risk": 67544,
     "rr": 0.88
    },
    "discovery": {
     "comparisons_with_events": 67,
     "glp1_affected": 3088,
     "glp1_at_risk": 47388,
     "hi": 0.94,
     "lo": 0.82,
     "p": "< 0.001",
     "placebo_affected": 3312,
     "placebo_at_risk": 35018,
     "rr": 0.88
    },
    "discovery_q": "0.0021",
    "replicated": true,
    "replication": {
     "comparisons_with_events": 73,
     "glp1_affected": 2015,
     "glp1_at_risk": 46377,
     "hi": 0.97,
     "lo": 0.82,
     "p": "0.0062",
     "placebo_affected": 1999,
     "placebo_at_risk": 32526,
     "rr": 0.89
    }
   },
   "metabolism and nutrition disorders": {
    "all": {
     "comparisons_with_events": 97,
     "glp1_affected": 1236,
     "glp1_at_risk": 93765,
     "hi": 0.85,
     "lo": 0.73,
     "p": "< 0.001",
     "placebo_affected": 1419,
     "placebo_at_risk": 67544,
     "rr": 0.79
    },
    "discovery": {
     "comparisons_with_events": 49,
     "glp1_affected": 664,
     "glp1_at_risk": 47388,
     "hi": 0.93,
     "lo": 0.69,
     "p": "0.0032",
     "placebo_affected": 765,
     "placebo_at_risk": 35018,
     "rr": 0.8
    },
    "discovery_q": "0.017",
    "replicated": true,
    "replication": {
     "comparisons_with_events": 48,
     "glp1_affected": 572,
     "glp1_at_risk": 46377,
     "hi": 0.92,
     "lo": 0.67,
     "p": "0.0029",
     "placebo_affected": 654,
     "placebo_at_risk": 32526,
     "rr": 0.78
    }
   },
   "respiratory, thoracic and mediastinal disorders": {
    "all": {
     "comparisons_with_events": 98,
     "glp1_affected": 1544,
     "glp1_at_risk": 93765,
     "hi": 0.89,
     "lo": 0.78,
     "p": "< 0.001",
     "placebo_affected": 1752,
     "placebo_at_risk": 67544,
     "rr": 0.83
    },
    "discovery": {
     "comparisons_with_events": 44,
     "glp1_affected": 867,
     "glp1_at_risk": 47388,
     "hi": 0.92,
     "lo": 0.72,
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     "placebo_affected": 1022,
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     "rr": 0.81
    },
    "discovery_q": "0.010",
    "replicated": true,
    "replication": {
     "comparisons_with_events": 54,
     "glp1_affected": 677,
     "glp1_at_risk": 46377,
     "hi": 0.99,
     "lo": 0.73,
     "p": "0.037",
     "placebo_affected": 730,
     "placebo_at_risk": 32526,
     "rr": 0.85
    }
   }
  },
  "replicated": [
   "cardiac disorders",
   "infections and infestations",
   "metabolism and nutrition disorders",
   "respiratory, thoracic and mediastinal disorders"
  ],
  "replicated_all_lower": true,
  "replicated_count": 4,
  "tested": 27
 },
 "outcomes": {
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   "affected": 48,
   "all": {
    "comparisons_with_events": 13,
    "glp1_affected": 21,
    "glp1_at_risk": 93765,
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    "p": "0.31",
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    "placebo_at_risk": 67544,
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   },
   "conservative_p": "0.47",
   "dominant_term": {
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    "glp1_at_risk": 93765,
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    "lo": 0.17,
    "p": "0.21",
    "placebo_affected": 10,
    "placebo_at_risk": 67544,
    "rr": 0.5,
    "term": "Alcohol poisoning"
   },
   "half1": {
    "comparisons_with_events": 6,
    "glp1_affected": 15,
    "glp1_at_risk": 47388,
    "hi": 2.17,
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    "p": "0.93",
    "placebo_affected": 14,
    "placebo_at_risk": 35018,
    "rr": 1.04
   },
   "half2": {
    "comparisons_with_events": 7,
    "glp1_affected": 6,
    "glp1_at_risk": 46377,
    "hi": 1.16,
    "lo": 0.16,
    "p": "0.093",
    "placebo_affected": 13,
    "placebo_at_risk": 32526,
    "rr": 0.42
   },
   "leave_one_out": {
    "p_max": "0.75",
    "p_max_left_out": "NCT01144338",
    "rr_max": 0.9,
    "rr_min": 0.55
   },
   "name": "Alcohol use disorder",
   "overlap_bound": 2.0,
   "peto": {
    "hi": 1.32,
    "lo": 0.42,
    "or": 0.74,
    "p": "0.31"
   },
   "population_interaction_p": "0.16",
   "power_for_va_hr": 0.06,
   "q": "0.58",
   "random_effects": {
    "hi": 1.4,
    "i2": 0.0,
    "lo": 0.44,
    "p": "0.41",
    "rr": 0.78
   },
   "robust": false,
   "selective_only": {
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    "glp1_affected": 21,
    "glp1_at_risk": 84870,
    "hi": 1.33,
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    "p": "0.31",
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    "rr": 0.74
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   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 11,
    "glp1_affected": 11,
    "glp1_at_risk": 62240,
    "hi": 1.11,
    "lo": 0.25,
    "p": "0.093",
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    "rr": 0.53
   },
   "va_category": "inconclusive",
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   "without_diabetes": {
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    "glp1_affected": 9,
    "glp1_at_risk": 25994,
    "hi": 3.45,
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    "p": "0.62",
    "placebo_affected": 7,
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    "rr": 1.29
   }
  },
  "A02": {
   "affected": 0,
   "all": {
    "comparisons_with_events": 0,
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    "glp1_at_risk": 93765,
    "hi": null,
    "lo": null,
    "p": null,
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    "rr": null
   },
   "name": "Cannabis use disorder",
   "power_for_va_hr": 0.0,
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  "A03": {
   "affected": 0,
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    "glp1_at_risk": 93765,
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    "lo": null,
    "p": null,
    "placebo_affected": 0,
    "placebo_at_risk": 67544,
    "rr": null
   },
   "name": "Stimulant use disorder",
   "power_for_va_hr": 0.0,
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   "va_category": "too_few_events",
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  },
  "A04": {
   "affected": 0,
   "all": {
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    "glp1_affected": 0,
    "glp1_at_risk": 93765,
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    "lo": null,
    "p": null,
    "placebo_affected": 0,
    "placebo_at_risk": 67544,
    "rr": null
   },
   "name": "Opioid use disorder",
   "power_for_va_hr": 0.0,
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   "va_category": "too_few_events",
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  "A05": {
   "affected": 121,
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    "glp1_at_risk": 93765,
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    "placebo_at_risk": 67544,
    "rr": 0.86
   },
   "conservative_p": "0.53",
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    "glp1_affected": 19,
    "glp1_at_risk": 93765,
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    "lo": 0.35,
    "p": "0.16",
    "placebo_affected": 23,
    "placebo_at_risk": 67544,
    "rr": 0.65,
    "term": "Suicide attempt"
   },
   "half1": {
    "comparisons_with_events": 16,
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    "glp1_at_risk": 47388,
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   "half2": {
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    "placebo_at_risk": 32526,
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   "leave_one_out": {
    "p_max": "0.56",
    "p_max_left_out": "NCT03819153",
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    "rr_min": 0.82
   },
   "name": "Suicidal ideation, suicide attempt, or intentional self-harm",
   "overlap_bound": 1.78,
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   "population_interaction_p": "0.98",
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   "robust": false,
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   "testable": true,
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   "va_category": "inconclusive",
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    "glp1_affected": 18,
    "glp1_at_risk": 25994,
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    "rr": 0.88
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  },
  "A06": {
   "affected": 1,
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    "comparisons_with_events": 1,
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    "lo": null,
    "p": null,
    "placebo_affected": 0,
    "placebo_at_risk": 67544,
    "rr": null
   },
   "name": "Bulimia",
   "power_for_va_hr": 0.03,
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   "va_category": "too_few_events",
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  "A07": {
   "affected": 25,
   "all": {
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   "conservative_p": "0.66",
   "dominant_term": {
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    "glp1_at_risk": 93765,
    "hi": 1.78,
    "lo": 0.08,
    "p": "0.22",
    "placebo_affected": 6,
    "placebo_at_risk": 67544,
    "rr": 0.38,
    "term": "Psychotic disorder"
   },
   "half1": {
    "comparisons_with_events": 2,
    "glp1_affected": 6,
    "glp1_at_risk": 47388,
    "hi": 3.93,
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    "rr": 1.2
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   "half2": {
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    "placebo_at_risk": 32526,
    "rr": 1.36
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   "leave_one_out": {
    "p_max": "0.96",
    "p_max_left_out": "NCT03574597",
    "rr_max": 1.68,
    "rr_min": 0.97
   },
   "name": "Schizophrenia and other psychotic disorders",
   "overlap_bound": 1.67,
   "peto": {
    "hi": 2.82,
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    "or": 1.26,
    "p": "0.57"
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   "population_interaction_p": "0.30",
   "power_for_va_hr": 0.07,
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   "random_effects": {
    "hi": 2.28,
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    "rr": 1.05
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   "robust": false,
   "selective_only": {
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    "glp1_at_risk": 84870,
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    "rr": 1.28
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   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 10,
    "glp1_affected": 9,
    "glp1_at_risk": 62240,
    "hi": 2.61,
    "lo": 0.34,
    "p": "0.90",
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   "va_category": "inconclusive",
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   "without_diabetes": {
    "comparisons_with_events": 2,
    "glp1_affected": 6,
    "glp1_at_risk": 25994,
    "hi": 13.75,
    "lo": 0.51,
    "p": "0.25",
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    "rr": 2.64
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  "A08": {
   "affected": 228,
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    "comparisons_with_events": 31,
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    "glp1_at_risk": 93765,
    "hi": 1.39,
    "lo": 0.81,
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    "placebo_at_risk": 67544,
    "rr": 1.06
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   "conservative_p": "0.74",
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    "comparisons_with_events": 22,
    "glp1_affected": 60,
    "glp1_at_risk": 93765,
    "hi": 1.68,
    "lo": 0.77,
    "p": "0.51",
    "placebo_affected": 49,
    "placebo_at_risk": 67544,
    "rr": 1.14,
    "term": "Seizure"
   },
   "half1": {
    "comparisons_with_events": 14,
    "glp1_affected": 70,
    "glp1_at_risk": 47388,
    "hi": 1.72,
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    "rr": 1.2
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   "half2": {
    "comparisons_with_events": 17,
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    "glp1_at_risk": 46377,
    "hi": 1.38,
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    "placebo_at_risk": 32526,
    "rr": 0.92
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   "leave_one_out": {
    "p_max": "0.90",
    "p_max_left_out": "NCT01179048",
    "rr_max": 1.14,
    "rr_min": 1.02
   },
   "name": "Seizures",
   "overlap_bound": 1.92,
   "peto": {
    "hi": 1.38,
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    "or": 1.06,
    "p": "0.65"
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   "population_interaction_p": "0.48",
   "power_for_va_hr": 0.12,
   "q": "0.73",
   "random_effects": {
    "hi": 1.31,
    "i2": 0.0,
    "lo": 0.77,
    "p": "0.95",
    "rr": 1.01
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   "robust": false,
   "selective_only": {
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    "glp1_affected": 118,
    "glp1_at_risk": 84870,
    "hi": 1.39,
    "lo": 0.8,
    "p": "0.70",
    "placebo_affected": 103,
    "placebo_at_risk": 63762,
    "rr": 1.06
   },
   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 19,
    "glp1_affected": 84,
    "glp1_at_risk": 62240,
    "hi": 1.33,
    "lo": 0.71,
    "p": "0.86",
    "placebo_affected": 81,
    "placebo_at_risk": 47391,
    "rr": 0.97
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   "va_category": "inconclusive",
   "va_hr": 0.9,
   "without_diabetes": {
    "comparisons_with_events": 8,
    "glp1_affected": 32,
    "glp1_at_risk": 25994,
    "hi": 2.11,
    "lo": 0.7,
    "p": "0.48",
    "placebo_affected": 23,
    "placebo_at_risk": 16933,
    "rr": 1.22
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  },
  "A09": {
   "affected": 129,
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    "glp1_at_risk": 93765,
    "hi": 1.21,
    "lo": 0.61,
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    "placebo_at_risk": 67544,
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   "conservative_p": "0.54",
   "dominant_term": {
    "comparisons_with_events": 7,
    "glp1_affected": 14,
    "glp1_at_risk": 93765,
    "hi": 1.47,
    "lo": 0.37,
    "p": "0.39",
    "placebo_affected": 19,
    "placebo_at_risk": 67544,
    "rr": 0.74,
    "term": "Dementia"
   },
   "half1": {
    "comparisons_with_events": 6,
    "glp1_affected": 31,
    "glp1_at_risk": 47388,
    "hi": 1.16,
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   "half2": {
    "comparisons_with_events": 6,
    "glp1_affected": 29,
    "glp1_at_risk": 46377,
    "hi": 1.78,
    "lo": 0.62,
    "p": "0.85",
    "placebo_affected": 27,
    "placebo_at_risk": 32526,
    "rr": 1.05
   },
   "leave_one_out": {
    "p_max": "0.64",
    "p_max_left_out": "NCT03574597",
    "rr_max": 0.91,
    "rr_min": 0.79
   },
   "name": "Neurocognitive disorders",
   "overlap_bound": 2.06,
   "peto": {
    "hi": 1.21,
    "lo": 0.61,
    "or": 0.86,
    "p": "0.38"
   },
   "population_interaction_p": "0.49",
   "power_for_va_hr": 0.05,
   "q": "0.62",
   "random_effects": {
    "hi": 1.22,
    "i2": 0.0,
    "lo": 0.61,
    "p": "0.41",
    "rr": 0.86
   },
   "robust": false,
   "selective_only": {
    "comparisons_with_events": 12,
    "glp1_affected": 60,
    "glp1_at_risk": 84870,
    "hi": 1.21,
    "lo": 0.61,
    "p": "0.38",
    "placebo_affected": 69,
    "placebo_at_risk": 63762,
    "rr": 0.86
   },
   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 10,
    "glp1_affected": 52,
    "glp1_at_risk": 62240,
    "hi": 1.31,
    "lo": 0.62,
    "p": "0.59",
    "placebo_affected": 57,
    "placebo_at_risk": 47391,
    "rr": 0.9
   },
   "va_category": "inconclusive",
   "va_hr": 0.95,
   "without_diabetes": {
    "comparisons_with_events": 2,
    "glp1_affected": 8,
    "glp1_at_risk": 25994,
    "hi": 1.59,
    "lo": 0.26,
    "p": "0.33",
    "placebo_affected": 12,
    "placebo_at_risk": 16933,
    "rr": 0.64
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  },
  "A10": {
   "affected": 91,
   "all": {
    "comparisons_with_events": 9,
    "glp1_affected": 45,
    "glp1_at_risk": 93765,
    "hi": 1.47,
    "lo": 0.64,
    "p": "0.89",
    "placebo_affected": 46,
    "placebo_at_risk": 67544,
    "rr": 0.97
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   "conservative_p": "0.92",
   "dominant_term": {
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    "glp1_affected": 14,
    "glp1_at_risk": 93765,
    "hi": 1.47,
    "lo": 0.37,
    "p": "0.39",
    "placebo_affected": 19,
    "placebo_at_risk": 67544,
    "rr": 0.74,
    "term": "Dementia"
   },
   "half1": {
    "comparisons_with_events": 4,
    "glp1_affected": 23,
    "glp1_at_risk": 47388,
    "hi": 1.62,
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    "p": "0.77",
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    "placebo_at_risk": 35018,
    "rr": 0.92
   },
   "half2": {
    "comparisons_with_events": 5,
    "glp1_affected": 22,
    "glp1_at_risk": 46377,
    "hi": 1.89,
    "lo": 0.57,
    "p": "0.91",
    "placebo_affected": 21,
    "placebo_at_risk": 32526,
    "rr": 1.03
   },
   "leave_one_out": {
    "p_max": "0.97",
    "p_max_left_out": "NCT03914326",
    "rr_max": 1.04,
    "rr_min": 0.87
   },
   "name": "Dementia",
   "overlap_bound": 2.06,
   "peto": {
    "hi": 1.47,
    "lo": 0.64,
    "or": 0.97,
    "p": "0.89"
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   "population_interaction_p": "0.69",
   "power_for_va_hr": 0.06,
   "q": "0.93",
   "random_effects": {
    "hi": 1.5,
    "i2": 0.0,
    "lo": 0.65,
    "p": "0.96",
    "rr": 0.99
   },
   "robust": false,
   "selective_only": {
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    "glp1_affected": 45,
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    "lo": 0.64,
    "p": "0.89",
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    "rr": 0.97
   },
   "testable": true,
   "type2_diabetes": {
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    "glp1_affected": 40,
    "glp1_at_risk": 62240,
    "hi": 1.46,
    "lo": 0.61,
    "p": "0.80",
    "placebo_affected": 42,
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    "rr": 0.95
   },
   "va_category": "inconclusive",
   "va_hr": 0.92,
   "without_diabetes": {
    "comparisons_with_events": 1,
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    "hi": 4.65,
    "lo": 0.34,
    "p": "0.74",
    "placebo_affected": 4,
    "placebo_at_risk": 16933,
    "rr": 1.25
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  },
  "A11": {
   "affected": 55,
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    "comparisons_with_events": 13,
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    "placebo_at_risk": 67544,
    "rr": 0.84
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   "conservative_p": "0.64",
   "dominant_term": {
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    "glp1_at_risk": 93765,
    "hi": 3.16,
    "lo": 0.49,
    "p": "0.65",
    "placebo_affected": 8,
    "placebo_at_risk": 67544,
    "rr": 1.24,
    "term": "International normalised ratio increased"
   },
   "half1": {
    "comparisons_with_events": 6,
    "glp1_affected": 15,
    "glp1_at_risk": 47388,
    "hi": 1.69,
    "lo": 0.41,
    "p": "0.60",
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    "rr": 0.83
   },
   "half2": {
    "comparisons_with_events": 7,
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    "glp1_at_risk": 46377,
    "hi": 1.95,
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    "p": "0.72",
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    "placebo_at_risk": 32526,
    "rr": 0.86
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   "leave_one_out": {
    "p_max": "0.95",
    "p_max_left_out": "NCT03574597",
    "rr_max": 1.02,
    "rr_min": 0.73
   },
   "name": "Coagulopathy and clotting disorders",
   "overlap_bound": 1.83,
   "peto": {
    "hi": 1.44,
    "lo": 0.5,
    "or": 0.84,
    "p": "0.53"
   },
   "population_interaction_p": "0.41",
   "power_for_va_hr": 0.05,
   "q": "0.68",
   "random_effects": {
    "hi": 1.4,
    "i2": 0.0,
    "lo": 0.46,
    "p": "0.44",
    "rr": 0.8
   },
   "robust": false,
   "selective_only": {
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    "glp1_affected": 26,
    "glp1_at_risk": 84870,
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    "lo": 0.49,
    "p": "0.53",
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    "rr": 0.84
   },
   "testable": true,
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    "glp1_affected": 19,
    "glp1_at_risk": 62240,
    "hi": 1.68,
    "lo": 0.47,
    "p": "0.72",
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   "va_category": "inconclusive",
   "va_hr": 0.92,
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    "comparisons_with_events": 2,
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    "glp1_at_risk": 25994,
    "hi": 1.6,
    "lo": 0.17,
    "p": "0.25",
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    "rr": 0.52
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  },
  "A12": {
   "affected": 565,
   "all": {
    "comparisons_with_events": 51,
    "glp1_affected": 299,
    "glp1_at_risk": 93765,
    "hi": 1.19,
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    "p": "0.94",
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    "placebo_at_risk": 67544,
    "rr": 1.01
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   "conservative_p": "0.96",
   "dominant_term": {
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    "glp1_affected": 144,
    "glp1_at_risk": 93765,
    "hi": 1.01,
    "lo": 0.64,
    "p": "0.058",
    "placebo_affected": 160,
    "placebo_at_risk": 67544,
    "rr": 0.81,
    "term": "Pulmonary embolism"
   },
   "half1": {
    "comparisons_with_events": 27,
    "glp1_affected": 185,
    "glp1_at_risk": 47388,
    "hi": 1.17,
    "lo": 0.78,
    "p": "0.63",
    "placebo_affected": 178,
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    "rr": 0.95
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   "half2": {
    "comparisons_with_events": 24,
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    "p": "0.45",
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    "placebo_at_risk": 32526,
    "rr": 1.11
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   "leave_one_out": {
    "p_max": "0.99",
    "p_max_left_out": "NCT03611582",
    "rr_max": 1.05,
    "rr_min": 0.94
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   "name": "Venous thromboembolism",
   "overlap_bound": 1.76,
   "peto": {
    "hi": 1.19,
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    "or": 1.01,
    "p": "0.94"
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   "population_interaction_p": "0.11",
   "power_for_va_hr": 0.42,
   "q": "0.97",
   "random_effects": {
    "hi": 1.15,
    "i2": 0.0,
    "lo": 0.82,
    "p": "0.74",
    "rr": 0.97
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   "robust": false,
   "selective_only": {
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    "glp1_affected": 294,
    "glp1_at_risk": 84870,
    "hi": 1.22,
    "lo": 0.88,
    "p": "0.67",
    "placebo_affected": 258,
    "placebo_at_risk": 63762,
    "rr": 1.04
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   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 34,
    "glp1_affected": 211,
    "glp1_at_risk": 62240,
    "hi": 1.34,
    "lo": 0.9,
    "p": "0.36",
    "placebo_affected": 179,
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    "rr": 1.1
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   "va_category": "inconclusive",
   "va_hr": 0.86,
   "without_diabetes": {
    "comparisons_with_events": 15,
    "glp1_affected": 86,
    "glp1_at_risk": 25994,
    "hi": 1.1,
    "lo": 0.61,
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    "placebo_at_risk": 16933,
    "rr": 0.82
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  },
  "A13": {
   "affected": 314,
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    "comparisons_with_events": 38,
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    "glp1_at_risk": 93765,
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    "rr": 0.82
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   "conservative_p": "0.085",
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    "glp1_at_risk": 93765,
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    "p": "0.058",
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    "rr": 0.81,
    "term": "Pulmonary embolism"
   },
   "half1": {
    "comparisons_with_events": 19,
    "glp1_affected": 95,
    "glp1_at_risk": 47388,
    "hi": 1.06,
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    "rr": 0.81
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   "half2": {
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    "hi": 1.23,
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    "placebo_at_risk": 32526,
    "rr": 0.84
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   "leave_one_out": {
    "p_max": "0.14",
    "p_max_left_out": "NCT01147250",
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    "rr_min": 0.79
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   "name": "Pulmonary embolism",
   "overlap_bound": 1.03,
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    "or": 0.82,
    "p": "0.080"
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   "population_interaction_p": "0.86",
   "power_for_va_hr": 0.2,
   "q": "0.27",
   "random_effects": {
    "hi": 0.99,
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    "lo": 0.64,
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    "rr": 0.8
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 34,
    "glp1_affected": 148,
    "glp1_at_risk": 84870,
    "hi": 1.07,
    "lo": 0.69,
    "p": "0.18",
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    "rr": 0.86
   },
   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 26,
    "glp1_affected": 96,
    "glp1_at_risk": 62240,
    "hi": 1.06,
    "lo": 0.62,
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   "va_category": "inconclusive",
   "va_hr": 0.88,
   "without_diabetes": {
    "comparisons_with_events": 12,
    "glp1_affected": 54,
    "glp1_at_risk": 25994,
    "hi": 1.23,
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    "p": "0.38",
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    "rr": 0.85
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  "A14": {
   "affected": 184,
   "all": {
    "comparisons_with_events": 29,
    "glp1_affected": 113,
    "glp1_at_risk": 93765,
    "hi": 1.94,
    "lo": 1.07,
    "p": "0.016",
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    "placebo_at_risk": 67544,
    "rr": 1.44
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   "conservative_p": "0.021",
   "dominant_term": {
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    "glp1_affected": 103,
    "glp1_at_risk": 93765,
    "hi": 1.97,
    "lo": 1.06,
    "p": "0.020",
    "placebo_affected": 64,
    "placebo_at_risk": 67544,
    "rr": 1.45,
    "term": "Deep vein thrombosis"
   },
   "half1": {
    "comparisons_with_events": 15,
    "glp1_affected": 63,
    "glp1_at_risk": 47388,
    "hi": 1.7,
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    "rr": 1.17
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   "half2": {
    "comparisons_with_events": 14,
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    "glp1_at_risk": 46377,
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    "placebo_at_risk": 32526,
    "rr": 2.07
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   "leave_one_out": {
    "p_max": "0.067",
    "p_max_left_out": "NCT01179048",
    "rr_max": 1.62,
    "rr_min": 1.35
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   "name": "Deep vein thrombosis",
   "overlap_bound": 1.1,
   "peto": {
    "hi": 1.93,
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    "p": "0.015"
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   "population_interaction_p": "0.037",
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   "q": "0.10",
   "random_effects": {
    "hi": 1.74,
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    "lo": 0.96,
    "p": "0.090",
    "rr": 1.29
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 27,
    "glp1_affected": 111,
    "glp1_at_risk": 84870,
    "hi": 1.94,
    "lo": 1.07,
    "p": "0.017",
    "placebo_affected": 70,
    "placebo_at_risk": 63762,
    "rr": 1.44
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   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 18,
    "glp1_affected": 88,
    "glp1_at_risk": 62240,
    "hi": 2.47,
    "lo": 1.22,
    "p": "0.0024",
    "placebo_affected": 48,
    "placebo_at_risk": 47391,
    "rr": 1.73
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   "va_category": "excludes_va_estimate",
   "va_hr": 0.92,
   "without_diabetes": {
    "comparisons_with_events": 9,
    "glp1_affected": 23,
    "glp1_at_risk": 25994,
    "hi": 1.5,
    "lo": 0.47,
    "p": "0.56",
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    "rr": 0.84
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  "A15": {
   "affected": 28,
   "all": {
    "comparisons_with_events": 12,
    "glp1_affected": 16,
    "glp1_at_risk": 93765,
    "hi": 2.27,
    "lo": 0.53,
    "p": "0.80",
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    "placebo_at_risk": 67544,
    "rr": 1.1
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   "conservative_p": "0.83",
   "dominant_term": {
    "comparisons_with_events": 7,
    "glp1_affected": 2,
    "glp1_at_risk": 93765,
    "hi": 0.78,
    "lo": 0.04,
    "p": "0.021",
    "placebo_affected": 10,
    "placebo_at_risk": 67544,
    "rr": 0.18,
    "term": "Thrombophlebitis"
   },
   "half1": {
    "comparisons_with_events": 8,
    "glp1_affected": 11,
    "glp1_at_risk": 47388,
    "hi": 3.01,
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    "p": "0.69",
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    "rr": 1.21
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   "half2": {
    "comparisons_with_events": 4,
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    "glp1_at_risk": 46377,
    "hi": 3.09,
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    "placebo_at_risk": 32526,
    "rr": 0.94
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   "leave_one_out": {
    "p_max": "1.00",
    "p_max_left_out": "NCT01272219",
    "rr_max": 1.32,
    "rr_min": 0.78
   },
   "name": "Phlebitis",
   "overlap_bound": 1.47,
   "peto": {
    "hi": 2.36,
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    "or": 1.1,
    "p": "0.80"
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   "population_interaction_p": "0.12",
   "power_for_va_hr": 0.06,
   "q": "0.88",
   "random_effects": {
    "hi": 1.91,
    "i2": 0.0,
    "lo": 0.42,
    "p": "0.78",
    "rr": 0.9
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 10,
    "glp1_affected": 16,
    "glp1_at_risk": 84870,
    "hi": 3.15,
    "lo": 0.64,
    "p": "0.39",
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    "rr": 1.42
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   "testable": true,
   "type2_diabetes": {
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    "glp1_affected": 12,
    "glp1_at_risk": 62240,
    "hi": 4.9,
    "lo": 0.73,
    "p": "0.19",
    "placebo_affected": 6,
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    "rr": 1.89
   },
   "va_category": "inconclusive",
   "va_hr": 0.86,
   "without_diabetes": {
    "comparisons_with_events": 6,
    "glp1_affected": 4,
    "glp1_at_risk": 25994,
    "hi": 2.07,
    "lo": 0.11,
    "p": "0.32",
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    "rr": 0.48
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  },
  "A16": {
   "affected": 47,
   "all": {
    "comparisons_with_events": 8,
    "glp1_affected": 26,
    "glp1_at_risk": 93765,
    "hi": 2.2,
    "lo": 0.7,
    "p": "0.47",
    "placebo_affected": 21,
    "placebo_at_risk": 67544,
    "rr": 1.24
   },
   "conservative_p": "0.51",
   "dominant_term": {
    "comparisons_with_events": 8,
    "glp1_affected": 22,
    "glp1_at_risk": 93765,
    "hi": 2.62,
    "lo": 0.72,
    "p": "0.33",
    "placebo_affected": 16,
    "placebo_at_risk": 67544,
    "rr": 1.38,
    "term": "Pulmonary hypertension"
   },
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   "name": "Pulmonary hypertension",
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   "population_interaction_p": "0.69",
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    "rr": 1.21
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   "robust": false,
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    "glp1_at_risk": 84870,
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   "testable": true,
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   "va_category": "inconclusive",
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   "affected": 1773,
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    "placebo_affected": 688,
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    "term": "Acute kidney injury"
   },
   "half1": {
    "comparisons_with_events": 30,
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   "half2": {
    "comparisons_with_events": 32,
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    "p_max_left_out": "NCT03574597",
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   "name": "Acute kidney injury",
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   "population_interaction_p": "0.15",
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   "robust": false,
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   "testable": true,
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   "va_category": "inconclusive",
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   "affected": 4941,
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   "conservative_p": "0.0011",
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    "placebo_affected": 344,
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    "term": "Urinary tract infection"
   },
   "half1": {
    "comparisons_with_events": 59,
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   "half2": {
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   "name": "Bacterial infections",
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   "testable": true,
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   "va_category": "confirmed",
   "va_hr": 0.88,
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   "affected": 181,
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    "term": "Pneumonia bacterial"
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   "half1": {
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   "population_interaction_p": "0.30",
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   "va_category": "inconclusive",
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   "half1": {
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   "testable": true,
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   "half1": {
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   "half2": {
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   "population_interaction_p": "0.11",
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   "va_category": "confirmed",
   "va_hr": 0.84,
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   "affected": 100,
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    "placebo_affected": 43,
    "placebo_at_risk": 67544,
    "rr": 0.96,
    "term": "Pneumonia aspiration"
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   "half1": {
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    "glp1_at_risk": 47388,
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   "half2": {
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   "leave_one_out": {
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   "name": "Aspiration",
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   "population_interaction_p": "0.63",
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   "va_category": "inconclusive",
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   "affected": 120,
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    "rr": 0.88,
    "term": "Hepatic encephalopathy"
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   "half1": {
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   "name": "Hepatic failure",
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   "population_interaction_p": "0.15",
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   "half1": {
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   "name": "Gastritis",
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   "half1": {
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   "name": "Noninfectious gastroenteritis or colitis",
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   "population_interaction_p": "0.086",
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   "half1": {
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   "va_category": "inconclusive",
   "va_hr": 1.1,
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    "comparisons_with_events": 12,
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    "glp1_at_risk": 25994,
    "hi": 1.87,
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    "p": "0.80",
    "placebo_affected": 23,
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    "rr": 1.07
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  },
  "A44": {
   "affected": 1407,
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    "comparisons_with_events": 77,
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    "glp1_at_risk": 93765,
    "hi": 1.07,
    "lo": 0.87,
    "p": "0.49",
    "placebo_affected": 687,
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    "rr": 0.96
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   "conservative_p": "0.56",
   "dominant_term": {
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    "hi": 1.1,
    "lo": 0.86,
    "p": "0.62",
    "placebo_affected": 492,
    "placebo_at_risk": 67544,
    "rr": 0.97,
    "term": "Osteoarthritis"
   },
   "half1": {
    "comparisons_with_events": 39,
    "glp1_affected": 371,
    "glp1_at_risk": 47388,
    "hi": 1.22,
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   "half2": {
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    "hi": 1.03,
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    "placebo_at_risk": 32526,
    "rr": 0.89
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   "leave_one_out": {
    "p_max": "0.70",
    "p_max_left_out": "NCT02465515",
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   },
   "name": "Arthritis",
   "overlap_bound": 1.37,
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    "p": "0.49"
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   "population_interaction_p": "0.75",
   "power_for_va_hr": 0.49,
   "q": "0.68",
   "random_effects": {
    "hi": 1.05,
    "i2": 0.0,
    "lo": 0.86,
    "p": "0.33",
    "rr": 0.95
   },
   "robust": false,
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    "comparisons_with_events": 65,
    "glp1_affected": 705,
    "glp1_at_risk": 84870,
    "hi": 1.08,
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    "rr": 0.97
   },
   "testable": true,
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    "comparisons_with_events": 49,
    "glp1_affected": 561,
    "glp1_at_risk": 62240,
    "hi": 1.09,
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    "p": "0.64",
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    "rr": 0.97
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   "va_category": "excludes_va_estimate",
   "va_hr": 1.11,
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    "glp1_affected": 149,
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    "lo": 0.74,
    "p": "0.56",
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    "rr": 0.93
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   "affected": 148,
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    "p": "0.45",
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    "rr": 0.88
   },
   "conservative_p": "0.48",
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    "lo": 0.64,
    "p": "0.63",
    "placebo_affected": 61,
    "placebo_at_risk": 67544,
    "rr": 0.92,
    "term": "Arthralgia"
   },
   "half1": {
    "comparisons_with_events": 15,
    "glp1_affected": 51,
    "glp1_at_risk": 47388,
    "hi": 1.42,
    "lo": 0.64,
    "p": "0.81",
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   "half2": {
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    "hi": 1.32,
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    "placebo_at_risk": 32526,
    "rr": 0.76
   },
   "leave_one_out": {
    "p_max": "0.85",
    "p_max_left_out": "NCT01144338",
    "rr_max": 0.97,
    "rr_min": 0.74
   },
   "name": "Arthralgia",
   "overlap_bound": 1.17,
   "peto": {
    "hi": 1.22,
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    "p": "0.44"
   },
   "population_interaction_p": "0.082",
   "power_for_va_hr": 0.09,
   "q": "0.68",
   "random_effects": {
    "hi": 1.19,
    "i2": 0.0,
    "lo": 0.62,
    "p": "0.36",
    "rr": 0.86
   },
   "robust": false,
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    "glp1_affected": 73,
    "glp1_at_risk": 84870,
    "hi": 1.21,
    "lo": 0.63,
    "p": "0.43",
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    "rr": 0.88
   },
   "testable": true,
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    "glp1_affected": 44,
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    "hi": 1.05,
    "lo": 0.48,
    "p": "0.083",
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    "rr": 0.71
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   "va_category": "inconclusive",
   "va_hr": 1.11,
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    "comparisons_with_events": 6,
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    "hi": 2.47,
    "lo": 0.73,
    "p": "0.34",
    "placebo_affected": 17,
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    "rr": 1.34
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  },
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   "affected": 267,
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    "lo": 0.94,
    "p": "0.14",
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    "rr": 1.21
   },
   "conservative_p": "0.30",
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    "glp1_at_risk": 93765,
    "hi": 1.62,
    "lo": 0.75,
    "p": "0.63",
    "placebo_affected": 49,
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    "rr": 1.1,
    "term": "Rotator cuff syndrome"
   },
   "half1": {
    "comparisons_with_events": 18,
    "glp1_affected": 79,
    "glp1_at_risk": 47388,
    "hi": 1.63,
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   "half2": {
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    "hi": 1.82,
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   "leave_one_out": {
    "p_max": "0.25",
    "p_max_left_out": "NCT02465515",
    "rr_max": 1.33,
    "rr_min": 1.16
   },
   "name": "Tendinitis and synovitis",
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    "p": "0.14"
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   "population_interaction_p": "0.74",
   "power_for_va_hr": 0.12,
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    "rr": 1.11
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   "robust": false,
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   "testable": true,
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    "hi": 1.65,
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    "p": "0.13",
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   "va_category": "inconclusive",
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  },
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   "affected": 9,
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    "p": "0.28",
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   "name": "Interstitial nephritis",
   "power_for_va_hr": 0.03,
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   "affected": 600,
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   "conservative_p": "0.081",
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    "lo": 0.92,
    "p": "0.20",
    "placebo_affected": 133,
    "placebo_at_risk": 67544,
    "rr": 1.16,
    "term": "Nephrolithiasis"
   },
   "half1": {
    "comparisons_with_events": 39,
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    "p": "0.032",
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   "half2": {
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    "hi": 1.46,
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   "leave_one_out": {
    "p_max": "0.11",
    "p_max_left_out": "NCT03574597",
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   "name": "Kidney stones",
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   "population_interaction_p": "0.074",
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    "rr": 1.14
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   "robust": false,
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    "glp1_at_risk": 84870,
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    "p": "0.030",
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    "rr": 1.2
   },
   "testable": true,
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    "glp1_affected": 239,
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    "hi": 1.32,
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    "p": "0.35",
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   "va_category": "inconclusive",
   "va_hr": 1.15,
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    "glp1_affected": 92,
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  "A49": {
   "affected": 402,
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    "lo": 0.92,
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    "rr": 1.13
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   "conservative_p": "0.33",
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    "glp1_at_risk": 93765,
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    "lo": 0.76,
    "p": "0.85",
    "placebo_affected": 84,
    "placebo_at_risk": 67544,
    "rr": 1.03,
    "term": "Pancreatitis acute"
   },
   "half1": {
    "comparisons_with_events": 27,
    "glp1_affected": 118,
    "glp1_at_risk": 47388,
    "hi": 1.35,
    "lo": 0.78,
    "p": "0.84",
    "placebo_affected": 98,
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   "half2": {
    "comparisons_with_events": 27,
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   "leave_one_out": {
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    "p_max_left_out": "NCT01144338",
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   "name": "Acute pancreatitis",
   "overlap_bound": 1.47,
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   "population_interaction_p": "0.71",
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   "q": "0.55",
   "random_effects": {
    "hi": 1.27,
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    "lo": 0.85,
    "p": "0.69",
    "rr": 1.04
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   "robust": false,
   "selective_only": {
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    "glp1_affected": 210,
    "glp1_at_risk": 84870,
    "hi": 1.36,
    "lo": 0.9,
    "p": "0.34",
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    "rr": 1.1
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   "testable": true,
   "type2_diabetes": {
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    "glp1_affected": 174,
    "glp1_at_risk": 62240,
    "hi": 1.44,
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    "p": "0.22",
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    "rr": 1.15
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   "va_category": "excludes_va_estimate",
   "va_hr": 2.46,
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    "glp1_at_risk": 25994,
    "hi": 1.67,
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    "rr": 1.04
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   "affected": 1556,
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    "glp1_affected": 967,
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    "hi": 1.53,
    "lo": 1.24,
    "p": "< 0.001",
    "placebo_affected": 589,
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    "rr": 1.38
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   "conservative_p": "< 0.001",
   "dominant_term": {
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    "glp1_at_risk": 93765,
    "hi": 1.67,
    "lo": 1.17,
    "p": "< 0.001",
    "placebo_affected": 205,
    "placebo_at_risk": 67544,
    "rr": 1.4,
    "term": "Cholelithiasis"
   },
   "half1": {
    "comparisons_with_events": 50,
    "glp1_affected": 599,
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    "hi": 1.61,
    "lo": 1.23,
    "p": "< 0.001",
    "placebo_affected": 366,
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    "rr": 1.41
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   "half2": {
    "comparisons_with_events": 50,
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    "hi": 1.58,
    "lo": 1.12,
    "p": "< 0.001",
    "placebo_affected": 223,
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    "rr": 1.33
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   "leave_one_out": {
    "p_max": "< 0.001",
    "p_max_left_out": "NCT01179048",
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    "rr_min": 1.34
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   "name": "Gallbladder and biliary disease",
   "overlap_bound": 2.06,
   "peto": {
    "hi": 1.52,
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    "p": "< 0.001"
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   "population_interaction_p": "0.0067",
   "q": "< 0.001",
   "random_effects": {
    "hi": 1.42,
    "i2": 0.0,
    "lo": 1.16,
    "p": "< 0.001",
    "rr": 1.28
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   "robust": true,
   "selective_only": {
    "comparisons_with_events": 81,
    "glp1_affected": 897,
    "glp1_at_risk": 84870,
    "hi": 1.53,
    "lo": 1.23,
    "p": "< 0.001",
    "placebo_affected": 568,
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    "rr": 1.37
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   "testable": true,
   "type2_diabetes": {
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    "glp1_affected": 588,
    "glp1_at_risk": 62240,
    "hi": 1.41,
    "lo": 1.1,
    "p": "< 0.001",
    "placebo_affected": 435,
    "placebo_at_risk": 47391,
    "rr": 1.25
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   "without_diabetes": {
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    "glp1_at_risk": 25994,
    "hi": 2.14,
    "lo": 1.42,
    "p": "< 0.001",
    "placebo_affected": 140,
    "placebo_at_risk": 16933,
    "rr": 1.74
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  "B02": {
   "affected": 324,
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    "glp1_affected": 171,
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    "hi": 1.28,
    "lo": 0.82,
    "p": "0.81",
    "placebo_affected": 153,
    "placebo_at_risk": 67544,
    "rr": 1.03
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   "conservative_p": "0.86",
   "dominant_term": {
    "comparisons_with_events": 21,
    "glp1_affected": 56,
    "glp1_at_risk": 93765,
    "hi": 1.46,
    "lo": 0.68,
    "p": "0.97",
    "placebo_affected": 53,
    "placebo_at_risk": 67544,
    "rr": 0.99,
    "term": "Small intestinal obstruction"
   },
   "half1": {
    "comparisons_with_events": 23,
    "glp1_affected": 94,
    "glp1_at_risk": 47388,
    "hi": 1.46,
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    "rr": 1.08
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   "half2": {
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    "hi": 1.34,
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   "leave_one_out": {
    "p_max": "0.94",
    "p_max_left_out": "NCT01147250",
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   "name": "Intestinal obstruction or ileus",
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    "p": "0.81"
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   "population_interaction_p": "0.31",
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   "random_effects": {
    "hi": 1.2,
    "i2": 0.0,
    "lo": 0.78,
    "p": "0.77",
    "rr": 0.97
   },
   "robust": false,
   "selective_only": {
    "comparisons_with_events": 35,
    "glp1_affected": 163,
    "glp1_at_risk": 84870,
    "hi": 1.26,
    "lo": 0.81,
    "p": "0.92",
    "placebo_affected": 150,
    "placebo_at_risk": 63762,
    "rr": 1.01
   },
   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 25,
    "glp1_affected": 128,
    "glp1_at_risk": 62240,
    "hi": 1.41,
    "lo": 0.84,
    "p": "0.51",
    "placebo_affected": 110,
    "placebo_at_risk": 47391,
    "rr": 1.09
   },
   "without_diabetes": {
    "comparisons_with_events": 11,
    "glp1_affected": 39,
    "glp1_at_risk": 25994,
    "hi": 1.3,
    "lo": 0.54,
    "p": "0.43",
    "placebo_affected": 41,
    "placebo_at_risk": 16933,
    "rr": 0.84
   }
  },
  "B03": {
   "affected": 15,
   "all": {
    "comparisons_with_events": 7,
    "glp1_affected": 10,
    "glp1_at_risk": 93765,
    "hi": 5.14,
    "lo": 0.51,
    "p": "0.41",
    "placebo_affected": 5,
    "placebo_at_risk": 67544,
    "rr": 1.62
   },
   "conservative_p": "0.43",
   "dominant_term": {
    "comparisons_with_events": 7,
    "glp1_affected": 10,
    "glp1_at_risk": 93765,
    "hi": 7.02,
    "lo": 0.59,
    "p": "0.26",
    "placebo_affected": 4,
    "placebo_at_risk": 67544,
    "rr": 2.03,
    "term": "Optic ischaemic neuropathy"
   },
   "half1": {
    "comparisons_with_events": 3,
    "glp1_affected": 4,
    "glp1_at_risk": 47388,
    "hi": 2.8,
    "lo": 0.17,
    "p": "0.61",
    "placebo_affected": 5,
    "placebo_at_risk": 35018,
    "rr": 0.7
   },
   "half2": {
    "comparisons_with_events": 4,
    "glp1_affected": 6,
    "glp1_at_risk": 46377,
    "hi": null,
    "lo": null,
    "p": null,
    "placebo_affected": 0,
    "placebo_at_risk": 32526,
    "rr": null
   },
   "leave_one_out": {
    "p_max": "0.75",
    "p_max_left_out": "NCT01720446",
    "rr_max": 7.12,
    "rr_min": 1.22
   },
   "name": "Ischaemic optic neuropathy",
   "overlap_bound": 1.07,
   "peto": {
    "hi": 4.45,
    "lo": 0.55,
    "or": 1.56,
    "p": "0.40"
   },
   "population_interaction_p": "0.40",
   "q": "0.48",
   "random_effects": {
    "hi": 3.39,
    "i2": 0.0,
    "lo": 0.41,
    "p": "0.76",
    "rr": 1.18
   },
   "robust": false,
   "selective_only": {
    "comparisons_with_events": 6,
    "glp1_affected": 9,
    "glp1_at_risk": 84870,
    "hi": 4.85,
    "lo": 0.48,
    "p": "0.47",
    "placebo_affected": 5,
    "placebo_at_risk": 63762,
    "rr": 1.53
   },
   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 4,
    "glp1_affected": 5,
    "glp1_at_risk": 62240,
    "hi": 4.41,
    "lo": 0.29,
    "p": "0.87",
    "placebo_affected": 4,
    "placebo_at_risk": 47391,
    "rr": 1.12
   },
   "without_diabetes": {
    "comparisons_with_events": 3,
    "glp1_affected": 5,
    "glp1_at_risk": 25994,
    "hi": 38.51,
    "lo": 0.34,
    "p": "0.29",
    "placebo_affected": 1,
    "placebo_at_risk": 16933,
    "rr": 3.62
   }
  },
  "B04": {
   "affected": 231,
   "all": {
    "comparisons_with_events": 19,
    "glp1_affected": 131,
    "glp1_at_risk": 93765,
    "hi": 1.64,
    "lo": 0.97,
    "p": "0.086",
    "placebo_affected": 100,
    "placebo_at_risk": 67544,
    "rr": 1.26
   },
   "conservative_p": "0.19",
   "dominant_term": {
    "comparisons_with_events": 9,
    "glp1_affected": 60,
    "glp1_at_risk": 93765,
    "hi": 1.62,
    "lo": 0.77,
    "p": "0.56",
    "placebo_affected": 53,
    "placebo_at_risk": 67544,
    "rr": 1.12,
    "term": "Diabetic retinopathy"
   },
   "half1": {
    "comparisons_with_events": 9,
    "glp1_affected": 76,
    "glp1_at_risk": 47388,
    "hi": 1.53,
    "lo": 0.79,
    "p": "0.59",
    "placebo_affected": 67,
    "placebo_at_risk": 35018,
    "rr": 1.1
   },
   "half2": {
    "comparisons_with_events": 10,
    "glp1_affected": 55,
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    "hi": 2.47,
    "lo": 1.03,
    "p": "0.038",
    "placebo_affected": 33,
    "placebo_at_risk": 32526,
    "rr": 1.59
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   "leave_one_out": {
    "p_max": "0.29",
    "p_max_left_out": "NCT03914326",
    "rr_max": 1.44,
    "rr_min": 1.18
   },
   "name": "Diabetic retinopathy complications",
   "overlap_bound": 1.71,
   "peto": {
    "hi": 1.63,
    "lo": 0.97,
    "or": 1.26,
    "p": "0.085"
   },
   "population_interaction_p": "0.82",
   "q": "0.16",
   "random_effects": {
    "hi": 1.57,
    "i2": 0.0,
    "lo": 0.93,
    "p": "0.16",
    "rr": 1.21
   },
   "robust": false,
   "selective_only": {
    "comparisons_with_events": 18,
    "glp1_affected": 129,
    "glp1_at_risk": 84870,
    "hi": 1.63,
    "lo": 0.96,
    "p": "0.098",
    "placebo_affected": 100,
    "placebo_at_risk": 63762,
    "rr": 1.25
   },
   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 17,
    "glp1_affected": 127,
    "glp1_at_risk": 62240,
    "hi": 1.64,
    "lo": 0.96,
    "p": "0.095",
    "placebo_affected": 98,
    "placebo_at_risk": 47391,
    "rr": 1.25
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   "without_diabetes": {
    "comparisons_with_events": 1,
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    "glp1_at_risk": 25994,
    "hi": 7.1,
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    "p": "1.00",
    "placebo_affected": 2,
    "placebo_at_risk": 16933,
    "rr": 1.0
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  },
  "B05": {
   "affected": 99,
   "all": {
    "comparisons_with_events": 38,
    "glp1_affected": 67,
    "glp1_at_risk": 93765,
    "hi": 2.43,
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    "p": "0.023",
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    "placebo_at_risk": 67544,
    "rr": 1.61
   },
   "conservative_p": "0.039",
   "dominant_term": {
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    "glp1_affected": 36,
    "glp1_at_risk": 93765,
    "hi": 2.58,
    "lo": 0.85,
    "p": "0.17",
    "placebo_affected": 17,
    "placebo_at_risk": 67544,
    "rr": 1.48,
    "term": "Papillary thyroid cancer"
   },
   "half1": {
    "comparisons_with_events": 24,
    "glp1_affected": 33,
    "glp1_at_risk": 47388,
    "hi": 1.97,
    "lo": 0.68,
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    "rr": 1.16
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   "half2": {
    "comparisons_with_events": 14,
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    "placebo_at_risk": 32526,
    "rr": 2.55
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   "leave_one_out": {
    "p_max": "0.11",
    "p_max_left_out": "NCT01394952",
    "rr_max": 1.75,
    "rr_min": 1.42
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   "name": "Thyroid cancer",
   "overlap_bound": 1.21,
   "peto": {
    "hi": 2.41,
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    "or": 1.61,
    "p": "0.022"
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   "population_interaction_p": "0.37",
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   "random_effects": {
    "hi": 1.72,
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    "lo": 0.78,
    "p": "0.46",
    "rr": 1.16
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 34,
    "glp1_affected": 64,
    "glp1_at_risk": 84870,
    "hi": 2.47,
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    "p": "0.025",
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    "rr": 1.62
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   "testable": true,
   "type2_diabetes": {
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    "hi": 3.12,
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   "without_diabetes": {
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  "B06": {
   "affected": 4520,
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    "comparisons_with_events": 122,
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   "conservative_p": "0.50",
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    "glp1_affected": 235,
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    "lo": 0.82,
    "p": "0.89",
    "placebo_affected": 223,
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    "rr": 0.99,
    "term": "Prostate cancer"
   },
   "half1": {
    "comparisons_with_events": 62,
    "glp1_affected": 1284,
    "glp1_at_risk": 47388,
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   "half2": {
    "comparisons_with_events": 60,
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   "leave_one_out": {
    "p_max": "0.81",
    "p_max_left_out": "NCT03914326",
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    "rr_min": 1.01
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   "name": "Any malignant neoplasm",
   "overlap_bound": 2.06,
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    "p": "0.34"
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   "population_interaction_p": "0.62",
   "q": "0.48",
   "random_effects": {
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    "rr": 1.01
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 102,
    "glp1_affected": 2327,
    "glp1_at_risk": 84870,
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    "p": "0.23",
    "placebo_affected": 2104,
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    "rr": 1.04
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   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 76,
    "glp1_affected": 1832,
    "glp1_at_risk": 62240,
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   "without_diabetes": {
    "comparisons_with_events": 31,
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    "p": "0.35",
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  },
  "B07": {
   "affected": 1781,
   "all": {
    "comparisons_with_events": 98,
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    "lo": 0.99,
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    "rr": 1.09
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   "conservative_p": "0.23",
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    "comparisons_with_events": 23,
    "glp1_affected": 99,
    "glp1_at_risk": 93765,
    "hi": 1.46,
    "lo": 0.82,
    "p": "0.55",
    "placebo_affected": 86,
    "placebo_at_risk": 67544,
    "rr": 1.09,
    "term": "Adenocarcinoma of colon"
   },
   "half1": {
    "comparisons_with_events": 52,
    "glp1_affected": 501,
    "glp1_at_risk": 47388,
    "hi": 1.28,
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    "p": "0.089",
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    "rr": 1.12
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   "half2": {
    "comparisons_with_events": 46,
    "glp1_affected": 472,
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    "hi": 1.2,
    "lo": 0.92,
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    "placebo_at_risk": 32526,
    "rr": 1.05
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   "leave_one_out": {
    "p_max": "0.21",
    "p_max_left_out": "NCT01144338",
    "rr_max": 1.1,
    "rr_min": 1.07
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   "name": "Obesity-associated cancers",
   "overlap_bound": 2.06,
   "peto": {
    "hi": 1.19,
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    "p": "0.087"
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   "population_interaction_p": "0.32",
   "q": "0.16",
   "random_effects": {
    "hi": 1.16,
    "i2": 0.0,
    "lo": 0.96,
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    "rr": 1.05
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 85,
    "glp1_affected": 948,
    "glp1_at_risk": 84870,
    "hi": 1.2,
    "lo": 0.99,
    "p": "0.067",
    "placebo_affected": 792,
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    "rr": 1.09
   },
   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 60,
    "glp1_affected": 765,
    "glp1_at_risk": 62240,
    "hi": 1.18,
    "lo": 0.96,
    "p": "0.23",
    "placebo_affected": 665,
    "placebo_at_risk": 47391,
    "rr": 1.06
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   "without_diabetes": {
    "comparisons_with_events": 27,
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    "glp1_at_risk": 25994,
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    "p": "0.098",
    "placebo_affected": 130,
    "placebo_at_risk": 16933,
    "rr": 1.21
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  },
  "B08": {
   "affected": 173,
   "all": {
    "comparisons_with_events": 41,
    "glp1_affected": 85,
    "glp1_at_risk": 93765,
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    "lo": 0.62,
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    "placebo_affected": 88,
    "placebo_at_risk": 67544,
    "rr": 0.84
   },
   "conservative_p": "0.33",
   "dominant_term": {
    "comparisons_with_events": 29,
    "glp1_affected": 56,
    "glp1_at_risk": 93765,
    "hi": 1.13,
    "lo": 0.56,
    "p": "0.20",
    "placebo_affected": 64,
    "placebo_at_risk": 67544,
    "rr": 0.79,
    "term": "Depression"
   },
   "half1": {
    "comparisons_with_events": 19,
    "glp1_affected": 47,
    "glp1_at_risk": 47388,
    "hi": 1.41,
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    "placebo_at_risk": 35018,
    "rr": 0.94
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   "half2": {
    "comparisons_with_events": 22,
    "glp1_affected": 38,
    "glp1_at_risk": 46377,
    "hi": 1.16,
    "lo": 0.48,
    "p": "0.20",
    "placebo_affected": 43,
    "placebo_at_risk": 32526,
    "rr": 0.75
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   "leave_one_out": {
    "p_max": "0.42",
    "p_max_left_out": "NCT01144338",
    "rr_max": 0.88,
    "rr_min": 0.78
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   "name": "Depression",
   "overlap_bound": 1.31,
   "peto": {
    "hi": 1.14,
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    "or": 0.84,
    "p": "0.27"
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   "population_interaction_p": "0.68",
   "q": "0.43",
   "random_effects": {
    "hi": 1.07,
    "i2": 0.0,
    "lo": 0.59,
    "p": "0.13",
    "rr": 0.8
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 39,
    "glp1_affected": 83,
    "glp1_at_risk": 84870,
    "hi": 1.14,
    "lo": 0.62,
    "p": "0.26",
    "placebo_affected": 87,
    "placebo_at_risk": 63762,
    "rr": 0.84
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   "testable": true,
   "type2_diabetes": {
    "comparisons_with_events": 22,
    "glp1_affected": 56,
    "glp1_at_risk": 62240,
    "hi": 1.26,
    "lo": 0.61,
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    "placebo_at_risk": 47391,
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   "without_diabetes": {
    "comparisons_with_events": 12,
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    "glp1_at_risk": 25994,
    "hi": 1.36,
    "lo": 0.42,
    "p": "0.36",
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    "placebo_at_risk": 16933,
    "rr": 0.76
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  "B09": {
   "affected": 1706,
   "all": {
    "comparisons_with_events": 96,
    "glp1_affected": 852,
    "glp1_at_risk": 93765,
    "hi": 1.0,
    "lo": 0.82,
    "p": "0.044",
    "placebo_affected": 854,
    "placebo_at_risk": 67544,
    "rr": 0.91
   },
   "conservative_p": "0.16",
   "dominant_term": {
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    "glp1_affected": 79,
    "glp1_at_risk": 93765,
    "hi": 1.19,
    "lo": 0.64,
    "p": "0.40",
    "placebo_affected": 86,
    "placebo_at_risk": 67544,
    "rr": 0.87,
    "term": "Femur fracture"
   },
   "half1": {
    "comparisons_with_events": 47,
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    "glp1_at_risk": 47388,
    "hi": 0.88,
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    "p": "< 0.001",
    "placebo_affected": 451,
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    "rr": 0.77
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   "half2": {
    "comparisons_with_events": 49,
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    "placebo_at_risk": 32526,
    "rr": 1.06
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   "leave_one_out": {
    "p_max": "0.36",
    "p_max_left_out": "NCT03914326",
    "rr_max": 0.95,
    "rr_min": 0.86
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   "name": "Fractures",
   "overlap_bound": 2.06,
   "peto": {
    "hi": 1.0,
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    "or": 0.91,
    "p": "0.044"
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   "population_interaction_p": "0.52",
   "q": "0.11",
   "random_effects": {
    "hi": 0.96,
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    "lo": 0.8,
    "p": "0.0068",
    "rr": 0.88
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   "robust": false,
   "selective_only": {
    "comparisons_with_events": 81,
    "glp1_affected": 824,
    "glp1_at_risk": 84870,
    "hi": 0.99,
    "lo": 0.82,
    "p": "0.030",
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   "affected": 729,
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    "rr": 0.94,
    "term": "Fall"
   },
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    "placebo_at_risk": 32526,
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   "leave_one_out": {
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    "p_max_left_out": "NCT03914326",
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   "name": "Falls",
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   "population_interaction_p": "0.083",
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   "robust": false,
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   "testable": true,
   "type2_diabetes": {
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  },
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   "affected": 198,
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   "conservative_p": "0.96",
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    "placebo_affected": 43,
    "placebo_at_risk": 67544,
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   },
   "half1": {
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    "glp1_at_risk": 47388,
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   "leave_one_out": {
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    "p_max_left_out": "NCT01144338",
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   "name": "Pancreatic cancer",
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   "population_interaction_p": "0.69",
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   },
   "testable": true,
   "type2_diabetes": {
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  },
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   "affected": 5404,
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   "conservative_p": "< 0.001",
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   "leave_one_out": {
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   "name": "Death from any cause",
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   "population_interaction_p": "0.29",
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   "robust": true,
   "selective_only": {
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   "testable": true,
   "type2_diabetes": {
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   "without_diabetes": {
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   "affected": 35031,
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   },
   "conservative_p": "< 0.001",
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   "half2": {
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   "leave_one_out": {
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   "name": "Any serious adverse event",
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   "robust": true,
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 },
 "preferred_terms": {
  "discovered": [
   "Acute myocardial infarction",
   "Cellulitis"
  ],
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    },
    "discovery": {
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     "placebo_affected": 761,
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     "rr": 0.76
    },
    "discovery_q": "< 0.001",
    "replicated": true,
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     "glp1_at_risk": 46377,
     "hi": 0.93,
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     "placebo_affected": 185,
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    }
   },
   "Cellulitis": {
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     "glp1_affected": 246,
     "glp1_at_risk": 93765,
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     "rr": 0.68
    },
    "discovery": {
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     "glp1_affected": 142,
     "glp1_at_risk": 47388,
     "hi": 0.8,
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     "p": "< 0.001",
     "placebo_affected": 206,
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     "rr": 0.64
    },
    "discovery_q": "0.016",
    "replicated": true,
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     "glp1_affected": 104,
     "glp1_at_risk": 46377,
     "hi": 0.98,
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     "p": "0.037",
     "placebo_affected": 120,
     "placebo_at_risk": 32526,
     "rr": 0.75
    }
   }
  },
  "replicated": [
   "Acute myocardial infarction",
   "Cellulitis"
  ],
  "replicated_all_lower": true,
  "replicated_count": 2,
  "tested": 518
 },
 "trials": {
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  "eligible": 234,
  "found": 539,
  "glp1": 93765,
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  "half2": 117,
  "overcount_factor": 2.06,
  "participants": 161309,
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  "type2_diabetes": 109631,
  "without_diabetes": 42927
 },
 "va": {
  "counts": {
   "confirmed": 3,
   "excludes_va_estimate": 4,
   "inconclusive": 37,
   "opposite": 0,
   "too_few_events": 5
  },
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   "confirmed": 2,
   "excludes_va_estimate": 1,
   "inconclusive": 2,
   "opposite": 0,
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  },
  "informative_list": [
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   "A20",
   "A21",
   "A27",
   "A49"
  ],
  "lists": {
   "confirmed": [
    "A18",
    "A21",
    "A34"
   ],
   "excludes_va_estimate": [
    "A14",
    "A36",
    "A44",
    "A49"
   ],
   "inconclusive": [
    "A01",
    "A05",
    "A07",
    "A08",
    "A09",
    "A10",
    "A11",
    "A12",
    "A13",
    "A15",
    "A16",
    "A17",
    "A19",
    "A20",
    "A22",
    "A23",
    "A24",
    "A25",
    "A26",
    "A27",
    "A28",
    "A29",
    "A30",
    "A31",
    "A32",
    "A33",
    "A35",
    "A37",
    "A38",
    "A39",
    "A40",
    "A41",
    "A42",
    "A43",
    "A45",
    "A46",
    "A48"
   ],
   "too_few_events": [
    "A02",
    "A03",
    "A04",
    "A06",
    "A47"
   ]
  },
  "outcomes": 49,
  "robust": [
   "A18",
   "A21",
   "A34"
  ],
  "testable": 44
 }
}