{
  "map": {
    "papers": 4,
    "endpoint_classes": 4,
    "clinical_incident_cancer_papers": 0,
    "primary_cell_reprogramming_papers": 1,
    "classes": {
      "existing_malignant_cell_tumorigenicity": [
        "weaver1997"
      ],
      "human_biomarkers_and_cell_response": [
        "heenkenda2026"
      ],
      "oncogene_predisposed_tumor_emergence_and_progression": [
        "levental2009"
      ],
      "primary_cell_oncogenic_reprogramming_and_tumor_emergence": [
        "panciera2020"
      ]
    }
  },
  "arms": {
    "untreated": {
      "id": "untreated",
      "tumors": 15,
      "total": 16,
      "risk": 0.9375,
      "simultaneous_risk_interval": [
        0.6424006141112442,
        0.9994771211444122
      ]
    },
    "control_antibody": {
      "id": "control_antibody",
      "tumors": 14,
      "total": 16,
      "risk": 0.875,
      "simultaneous_risk_interval": [
        0.5607682714804563,
        0.9913229592285608
      ]
    },
    "blocking_antibody": {
      "id": "blocking_antibody",
      "tumors": 7,
      "total": 16,
      "risk": 0.4375,
      "simultaneous_risk_interval": [
        0.1610666185216995,
        0.7460614879917127
      ]
    }
  },
  "comparisons": {
    "blocking_antibody_vs_untreated": {
      "treated": "blocking_antibody",
      "control": "untreated",
      "risk_ratio": 0.4666666666666667,
      "risk_difference": -0.5,
      "risk_ratio_interval": [
        0.16115088090988663,
        1.1613648424416319
      ],
      "risk_difference_interval": [
        -0.8384105026227127,
        0.10366087388046852
      ],
      "fisher_p": 0.005922845029098354,
      "fisher_p_fraction": "1837/310155",
      "holm_p": 0.011845690058196709,
      "holm_p_fraction": "3674/310155"
    },
    "blocking_antibody_vs_control_antibody": {
      "treated": "blocking_antibody",
      "control": "control_antibody",
      "risk_ratio": 0.5,
      "risk_difference": -0.4375,
      "risk_ratio_interval": [
        0.16247643315659732,
        1.3304274259705762
      ],
      "risk_difference_interval": [
        -0.8302563407068613,
        0.1852932165112564
      ],
      "fisher_p": 0.023333494543051055,
      "fisher_p_fraction": "7237/310155",
      "holm_p": 0.023333494543051055,
      "holm_p_fraction": "7237/310155"
    }
  },
  "validation": {
    "fisher_exhaustive_tables": 196,
    "interval_method": "Three Bonferroni-adjusted Clopper-Pearson risk intervals transformed monotonically; at least 95% joint coverage under independent binomial arms.",
    "interval_coverage_percent": 95,
    "p_method": "Two-sided probability-ordering Fisher exact; Holm adjustment across the two prespecified-for-this-reanalysis comparisons."
  }
}