[
 {
  "id": "P1",
  "role": "primary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult trials randomized from the start",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "P2",
  "role": "primary",
  "outcome": "S3",
  "name": "Any serious suicidality (behaviour or ideation), adult trials randomized from the start",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  },
  "compare": [
   "stone_2009_suicidality_25_64",
   "kaminski_2020_attempts"
  ]
 },
 {
  "id": "A10",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials completed after 2017",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "completed_after": "2017-12"
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A11",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of SSRIs",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "classes": [
    "ssri"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A12",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of SNRIs",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "classes": [
    "snri"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A13",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of bupropion",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "classes": [
    "bupropion"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A14",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of novel-mechanism antidepressants",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "classes": [
    "novel_mechanism"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A15",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of tricyclic, MAOI and other monoaminergic antidepressants",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "classes": [
    "tricyclic",
    "maoi",
    "other_monoaminergic"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A16",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials, with combination products included",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "combinations": true
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A17",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult randomized-withdrawal trials",
  "select": {
   "design": [
    "randomized_withdrawal"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A18",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, pediatric acute trials",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "pediatric"
   ]
  },
  "compare": [
   "stone_2009_behaviour_under_25"
  ]
 },
 {
  "id": "A19",
  "role": "secondary",
  "outcome": "S3",
  "name": "Any serious suicidality, pediatric acute trials",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "pediatric"
   ]
  },
  "compare": [
   "hammad_2006_pediatric_suicidality",
   "stone_2009_suicidality_under_25"
  ]
 },
 {
  "id": "A2",
  "role": "secondary",
  "outcome": "S2",
  "name": "Serious suicidal ideation, adult acute trials",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  },
  "compare": [
   "stone_2009_suicidality_25_64"
  ]
 },
 {
  "id": "A20",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, acute trials spanning adolescents and adults",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "mixed"
   ]
  },
  "compare": [
   "stone_2009_behaviour_under_25"
  ]
 },
 {
  "id": "A4",
  "role": "secondary",
  "outcome": "S4",
  "name": "Completed suicide, adult acute trials",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A5",
  "role": "secondary",
  "outcome": "S15",
  "name": "Serious suicidal behaviour or overdose of unstated intent, adult acute trials",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A6",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of depressive disorders",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "indication": [
    "depressive"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A7",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of other psychiatric disorders",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "indication": [
    "other_psychiatric"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A8",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, adult acute trials of non-psychiatric conditions",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ],
   "indication": [
    "non_psychiatric"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "A9",
  "role": "secondary",
  "outcome": "S1",
  "name": "Serious suicidal behaviour, acute trials enrolling only people aged 60 or over",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "older"
   ]
  },
  "compare": [
   "hengartner_2019_attempts",
   "kaminski_2020_attempts",
   "stone_2009_behaviour_25_64"
  ]
 },
 {
  "id": "G1",
  "role": "age",
  "outcome": "S1",
  "name": "Serious suicidal behaviour by trial mean age, all acute trials",
  "select": {
   "design": [
    "acute"
   ]
  }
 },
 {
  "id": "G2",
  "role": "age",
  "outcome": "S3",
  "name": "Any serious suicidality by trial mean age, all acute trials",
  "select": {
   "design": [
    "acute"
   ]
  }
 },
 {
  "id": "K1",
  "role": "check",
  "outcome": "C1",
  "name": "Nausea, adult acute trials (positive control)",
  "expected": "higher",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  }
 },
 {
  "id": "K2",
  "role": "check",
  "outcome": "death",
  "name": "Death from any cause, adult acute trials",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  }
 },
 {
  "id": "K3",
  "role": "check",
  "outcome": "any_serious",
  "name": "Any serious adverse event, adult acute trials",
  "select": {
   "design": [
    "acute"
   ],
   "age_group": [
    "adult",
    "older"
   ]
  }
 }
]