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In those 306 adult trials, serious suicidal behaviour (completed suicide, suicide attempt, intentional self-harm or intentional overdose) affected 46 of 40,564 participants on antidepressants and 19 of 31,079 on placebo (Mantel-Haenszel risk ratio 1.86, 95% CI 1.06 to 3.27; p = 0.030), and any serious suicidality 82 against 43 (1.48, 1.01 to 2.18; p = 0.045), but neither difference is significant after the registered Holm correction across these two co-primary endpoints (adjusted p = 0.060 for both), and under random effects both shrink toward 1 (1.22, 0.78 to 1.90; 1.10, 0.78 to 1.55). · sciencejournal.ai