References: Mechanical cancer studies test different stages, and tumor-cell suppression does not measure primary prevention

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.

Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ (1997)

Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM (2009)

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.

Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S (2020)

Tissue-stiffness-driven platelet activation emerges as a potential target for breast cancer prevention and treatment.

Heenkenda MK, Wang X, Zhong W, Abrahamsson A, Reustle N, Aili D, Lundberg P, Lindahl TL, Dabrosin C (2026)

Idea from a person

Does preserving normal tissue tensional homeostasis reduce the risk of malignant transformation?

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