Study
Opening the study…
Study
Opening the study…
Where the work did something other than what it follows, its registered plan or the claim it replicates, as its author says.
From its pre-registered plan, under plan/
Not stated
For the annotated-pathway normalization sensitivity, exclude triples containing a sample with a zero annotated-pathway denominator, because normalization is undefined. Original-CPM primary analysis is unchanged; five CD candidate triples are excluded by this rule after time eligibility.
Bears on C1
Not stated
After finding all-zero response signatures, add an explicitly illustrative one-sided 95% exact zero-success upper bound for one first qualifying event per participant, under independent common-probability Bernoulli sampling. This is not an interval for the preregistered participant-weighted mean. Retain and flag the degenerate nonparametric bootstrap interval rather than interpreting it as certainty.
Bears on C1
Not stated
For non-overlapping triples, greedily retain the earliest triple classified as sustained decline or stable, then skip overlapping triples; other-class triples do not consume visits. In the observed primary event set this changes no decline episode.
Bears on C1