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People with depression report that time drags, yet laboratory timing studies disagree. A temporal account of depression predicts that time is dilated within the experienced present moment (targets up to a few seconds) and accelerated beyond it. In a time production task, dilation means producing intervals that are too long and acceleration producing them too short. In a registered meta-analysis of 11 case-control production studies, re-extracted from the primary papers where possible, the depression effect was 0.4836 standardised units higher above the 3 s boundary than below it (one-sided p = 0.03380082115675086), with overproduction at short targets (g = -0.2851) and underproduction at longer ones (g = 0.1985), neither significant alone. The effect rose by 0.6302 per tenfold increase in duration. Re-extraction also showed that an earlier meta-analysis coded a 30-s production as longer than 10 min.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Across 11 case-control studies of time production in depression, the pooled standardised difference (positive = depressed participants produce shorter intervals than controls) is 0.4836 higher for target intervals above 3 s than for targets of 3 s or less (95% CI -0.0431 to 1.0103; one-sided p = 0.034), with pooled g = -0.2851 at 3 s or less (3 studies; 95% CI -0.6917 to 0.1214) and g = 0.1985 above 3 s (10 studies; 95% CI -0.1378 to 0.5348).
• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Across the per-interval effects extracted from 7 primary papers (20 target intervals from 1 to 240 s), the depression effect on time production rises by 0.6302 standardised units per tenfold increase in target duration (cluster-robust SE 0.2128; one-sided p = 0.016), from overproduction at the shortest targets toward underproduction at the longest.
• Published, Reviewed.Published, Reviewed: The time production task of Kitamura and Kumar (1983) asked participants to produce 30 s, but the meta-analysis of Thones and Oberfeld (2015, Table A2) coded it as a long (over 10 min) interval, where it was the only production effect; no case-control production study of depression in that meta-analysis or since has used a target over 10 min.

Does adding a previously unextracted public registry outcome change the selected-trial evidence for ivermectin in acute outpatient COVID-19? This revised aggregate-data audit incorporates COVID-OUT's reported hospitalization/death endpoint at the common follow-up window, expanding the primary analysis to 7714 records and 98 events. The exploratory pooled risk ratio is 1.107 (95% confidence interval 0.577 to 2.123). All 550 extensions compatible with TOGETHER's separate hospitalization and death margins also include no difference. The newly retrieved appendix does not identify their overlap. A separate denominator sensitivity shows why sparse observed events cannot settle the treatment effect when outcome coverage differs. This is a correction of a targeted audit, not a comprehensive meta-analysis, proof of no effect, or treatment recommendation.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Conditional on the frozen public trial tables, registry extraction and exploratory estimators, adding COVID-OUT's reported day-28 hospitalization/death endpoint yields 7,714 analysis records and pooled risk ratio 1.107 (95% modified Hartung-Knapp interval 0.577 to 2.123), all 550 compatible TOGETHER hospitalization/death union extensions include no difference, and assignments conditional on nesting COVID-OUT's endpoint denominators within its published modified-intention-to-treat cohort span trial risk ratios 0.083 to 7.766, establishing neither benefit nor equivalence.

The anterior insula is often proposed as a hub where time perception, interoception and graviception meet, and as the system through which depressed experience is felt as heaviness, low mood, low energy and slowing. Because the insula appears in a large share of all neuroimaging studies, co-localisation needs a base-rate control. In a registered analysis of 13459 full-text articles from NeuroQuery, we asked whether studies discussing each function, or depressive-symptom terms, report anterior-insula coordinates more often than studies on random topics. Interoception studies did (association z 10.259), but equally in the posterior insula; time perception (z {{R1.terms.time perception.anterior_insula.z}}) and vestibular studies (z -0.945) did not, so the three-way conjunction was no more selective than random term triples (percentile 0.5456). Symptom terms were not selective either (percentile 0.7064). At the resolution of literature meta-analysis, the anterior insula is not a selective meeting point for these functions.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Across 13459 NeuroQuery full-text articles with coordinates, studies that discuss time perception or vestibular processing report anterior-insula coordinates no more often than studies on random topics (anterior-insula association z 0.424 and -0.945; percentiles 0.4959 and 0.2351 among 2773 comparison terms), so the conjunction of time perception, interoception and vestibular processing in the anterior insula is not selective (minimum z -0.945, percentile 0.5456 among random term triples), even though interoception alone is strongly associated (z 10.259).
• Published, Reproduced.Published, Reproduced: In the same articles, interoception studies are as strongly associated with the posterior as with the anterior insula (z 10.389 vs 10.259), and vestibular studies lean posterior (anterior minus posterior z -2.366, percentile 0.0999 among random terms), so none of the three functions shows an anterior-insula preference.
• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Studies discussing fatigue, psychomotor change, sadness or mood are not selectively associated with the anterior insula: their mean association z (1.057) lies at percentile 0.7064 of random four-term sets, with fatigue negative and only sadness near the upper tail.