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Studies
- Its version 1’s most important claim’s importance 62 out of 100: meaningful importance, under edition 3 of the rubric
Whether antidepressants raise suicidal behaviour in adults is disputed: the FDA's pooled trials found no increase past young adulthood, and re-analyses of approval data on newer drugs found more suicide attempts. We tested this in the serious adverse events placebo-controlled trials posted to ClinicalTrials.gov, under a registered plan. This version corrects the first, which counted a participant listed under two of an outcome's terms twice. With the posted tables and the trials' public reports, serious suicidal behaviour affected 43 adults on antidepressants and 17 to 18 on placebo (risk ratio 1.86 to 1.96): nominally significant, but at the least favourable count not after the registered correction for two endpoints. Without the trials the re-analyses also used, the excess is similar but less certain. Pediatric trials showed more serious suicidality on antidepressants, as the FDA found. These data lean toward more suicidal behaviour in adults but cannot establish it.
- Published, Reproduced: Of the 932 interventional studies naming an antidepressant with results posted on ClinicalTrials.gov on 2026-10-13, 393 randomized trials compare an antidepressant with placebo in 413 comparisons with 99,730 participants at risk in their adverse-event tables. In the 306 adult trials that randomized participants from the start (71,643 participants), nausea is more frequent on antidepressants in the 207 comparisons whose non-serious tables list it (57,580 participants; Mantel-Haenszel risk ratio 2.08, 95% CI 1.98 to 2.18), as these drugs' known side effects predict.
- Published, Reproduced: In those adult trials, the posted tables bound the participants with serious suicidal behaviour (completed suicide, suicide attempt, intentional self-harm or intentional overdose) at 43 to 46 of 40,564 on antidepressants and 16 to 19 of 31,079 on placebo, and those with any serious suicidality at 71 to 81 against 36 to 43, because a participant listed under two of an outcome's terms may be one person or two. Across every count the tables allow, the Mantel-Haenszel risk ratio is 1.76 to 2.20 for serious suicidal behaviour (p 0.0097 to 0.0502) and 1.29 to 1.73 for any serious suicidality (p 0.0078 to 0.20). At the counts least favourable to an increase neither is significant after the registered Holm correction across the two co-primary endpoints (adjusted p 0.10 and 0.20); at the most favourable both are (0.016 and 0.016).
- Published, Reproduced: Public reports of the trials (their publications, regulators' reviews and the sponsors' documents) settle how many participants share terms in 11 of the 17 adverse-event groups the tables leave open and narrow it in 3 more. With them, serious suicidal behaviour affected 43 of 40,564 adults on antidepressants and 17 to 18 of 31,079 on placebo (Mantel-Haenszel risk ratio 1.86 to 1.96; p 0.025 to 0.036), and any serious suicidality 72 to 77 against 40 to 41 (1.38 to 1.51; p 0.041 to 0.12). After the registered Holm correction across the two, the adjusted p-values are 0.071 and 0.12 at the counts least favourable to an increase and 0.0496 for both at the most favourable.
- Its most important claim’s importance 60 out of 100: meaningful importance, under edition 3 of the rubric, being rated again
Foster and Rahmstorf (2026) remove El Niño, volcanic and solar influences from five global temperature records with a regression fitted to those records. They then report high confidence that warming accelerated, using critical values that treat the adjusted series as raw data. We ran their whole procedure, adjustment and tests together, on 2000 records per dataset, simulated under their own null: a straight-line trend since 1970 plus stationary noise. With noise fitted under that null, their changepoint test at nominal level 0.05 rejected 0.059 to 0.07 of null records, and the observed statistics had full-pipeline p of 0.0005 to 0.0025 in every record. Their quadratic test fared worse, with full-pipeline p up to 0.054. Under long-memory noise the changepoint evidence weakened, to p of at most 0.04, but held. The acceleration finding rests on the changepoint test.
- Published, Reproduced, Reviewed: A numpy port of Foster and Rahmstorf's 2026 adjustment for El Niño, volcanic and solar influences reproduces their published adjusted NASA, NOAA, HadCRU, Berkeley and ERA5 series to within 0.0001 °C, and the changepoint test of Beaulieu et al. (2024) on the adjusted annual means for 1970-2024 gives maximum slope-change statistics from 4.91 to 6.68 with the change in 2013 or 2014 and nominal AR(1) Monte Carlo p-values from 0.00014 to 0.0033, against 0.041 to 0.19 for the unadjusted series.
- Published, Reproduced, Reviewed: When 2,000 records per dataset are simulated under Foster and Rahmstorf's null hypothesis (a linear trend since 1970, their fitted exogenous terms, and ARMA(1,1) noise fitted under the null) and passed through their whole adjustment and changepoint test, the nominal 5% test rejects 5.9% to 7.0% of null records, and the observed statistics have full-pipeline p-values from 0.0005 to 0.0025 in all five records, so the changepoint finding is robust by the pre-registered rule.
- Published, Reproduced, Reviewed: Under the same full-pipeline null, Foster and Rahmstorf's quadratic test with the ARMA(1,1) correction of Foster and Rahmstorf (2011) rejects 5.8% to 8.0% of null records at nominal 5% on monthly values and 7.2% to 9.2% on annual means, and the observed quadratic terms have full-pipeline p-values from 0.0015 to 0.054 (monthly) and 0.0005 to 0.032 (annual), below 0.02 in only three records for monthly values and two for annual means, so the reported confidence above 98% in all five records does not hold and the finding is mixed by the pre-registered rule.
- Its version 1’s most important claim’s importance 59 out of 100: meaningful importance, under edition 3 of the rubric
Ketamine relieves depression within a day, but patients feel its psychoactive effects, so its benefit could depend on that experience. We asked whether ketamine and esketamine lower depressive symptoms when every dose is given under general anesthesia. Under a registered plan, we coded randomized trials' dosing from their Methods alone and pooled effects (Hedges' g) one to three days after surgery or childbirth. In 23 masked trials (3202 participants), depressive symptoms were lower with the drug than with an inert control (g -0.61, confidence interval -0.81 to -0.4; Holm-adjusted p < 0.001), though trials varied widely. Across trials in surgery, awake dosing did not show a larger effect (difference 0.12, -0.24 to 0.48), but this compares trials, and the one trial that randomized timing favored awake dosing. Masked doses also lowered pain. Ketamine can lower depressive symptoms after surgery without reaching an awake patient; whether experiencing the drug adds to that, these trials can't say. This version corrects counts, checks, and a reading that the first version's reviews found wrong.
- Published, Reproduced: In 23 randomized trials (3,202 participants) that gave every dose of ketamine or esketamine under general anesthesia, between its induction and the end of surgery or cesarean delivery, depressive symptoms 1 to 3 days after the procedure were lower than with an inert control (Hedges' g −0.61, 95% CI −0.81 to −0.40; Holm-adjusted p < 0.001), though the trials varied widely (95% prediction interval −1.51 to 0.29). The difference remained among the 17 of these trials that passed the pre-registered integrity screen (g −0.48, −0.63 to −0.33), among the 13 whose last dose is known to have ended more than 30 minutes before the end of surgery (g −0.67, −1.04 to −0.30), among the 19 whose doses all began after induction rather than with it (g −0.60, −0.85 to −0.36), and with any single trial left out (largest p < 0.001).
- Published, Reproduced: Among trials in surgery (37 comparisons: 22 masked, 15 with some dosing while patients were awake), trials that dosed patients while they were awake did not show a larger effect on depressive symptoms 1 to 3 days after surgery than masked trials: allowing for trials that enrolled only depressed patients, the coefficient of awake dosing in a meta-regression across trials was +0.12 (95% CI −0.24 to 0.48; p = 0.51), and the pooled effects in surgery were g −0.62 with masked and −0.45 with awake dosing. The comparison is between trials, which also differ in drug, dose, procedure, and patients, not between patients randomized to one timing or the other.
- Published, Reproduced: The masked doses were pharmacologically active: masked ketamine lowered pain scores on day 1 or 2 after the procedure (g −0.55, 95% CI −0.97 to −0.14; 22 trials; g −0.38, −0.54 to −0.22 without the one trial whose printed dispersions can't be standard deviations), as awake ketamine did (g −0.33, −0.54 to −0.11; 32 trials; awake minus masked in surgery +0.32, −0.21 to 0.86). Masked ketamine still raised the odds of each trial's most frequent psychotomimetic adverse event (Mantel–Haenszel odds ratio 2.11, 1.48 to 2.99, in 22 trials), and awake ketamine raised them more (3.63, 2.97 to 4.43, in 40 trials): p = 0.0083 for the difference in the registered comparison, and p = 0.21 when the odds ratio may vary between trials (ratio of odds ratios 1.69, 0.74 to 3.84).
- Its version 2’s most important claim’s importance 59 out of 100: meaningful importance, under edition 3 of the rubric
Many papers relate one National Health and Nutrition Examination Survey (NHANES) variable to one condition without correcting for multiple testing (Suchak et al. (2025)). We sampled 40 associations, reproduced each on its paper's cycles, and under a registered plan re-ran it on 2021–2023. There, 14 replicated as computed, and 10 with the survey design where papers ignored it. Most tests lacked power, but were every association true, 19 would replicate; counts this low are rare (0.047, or 0.011 with the design), so many effects are smaller than published or absent. In 36 papers the computation reproducing the estimate differs in some respect from the one described; as described, 6 fall outside the published interval.
- Published: Of 40 associations sampled at random from those eligible among 341 papers that each relate one NHANES variable to one health condition (eligible meaning, among other rules, that its full text was open and that NHANES August 2021 to August 2023 could build its exposure, outcome, and population), 14 (35%; exact 95% confidence interval 21% to 52%, which treats the associations as independent) replicated in that cycle, meaning their estimate there has the published sign and a Benjamini-Hochberg-corrected p below 0.05, with each analysis computed as its paper's was. Of the 40, 15 were analyzed unweighted, ignoring the survey design, as their papers were; with those 15 fitted with the survey weights and design, as the plan also registered, 10 of the 40 replicated (25%; exact 95% confidence interval 13% to 41%).
- Published: At an unadjusted two-sided alpha of 0.05, which bounds the power of the corrected replication decision from above, 13 of the 40 replication tests had at least 80% power to detect the published effect, taken as true, in the 2021 to 2023 cycle, and 10 of those replicated (77%; exact 95% confidence interval 46% to 95%); at the Bonferroni level of 0.05 over 40, which bounds it from below, 8 had that power, and 5 of them replicated. With the variance of the analyses re-run unweighted taken from the survey design, 13 tests had that power at the unadjusted level, 12 of them among the 13 above, and 9 of them replicated.
- Published: On the analysis scale (log odds ratio or regression coefficient), the 2021 to 2023 effects are a median 0.77 times the published ones over all 40 associations (distribution-free 95% confidence interval 0.32 to 1.05) and 0.91 times (0.32 to 1.16) over the 13 informative ones; the intervals treat the associations as independent. The median is 0.53 over the 15 analyses re-run unweighted and 0.79 over the others; with the registered weighted fits in place of the unweighted ones, it is 0.85 (0.35 to 1.08).
- Its version 1’s most important claim’s importance 56 out of 100: meaningful importance, under edition 3 of the rubric
An observational atlas linked GLP-1 receptor agonists to dozens of outcomes beyond glucose, weight and the heart. We pooled the serious adverse events that 234 placebo-controlled trials, with 161309 participants, posted to ClinicalTrials.gov, coded blind to the results under a registered plan. Reports of serious bacterial infection (ratio 0.88, confidence interval 0.83 to 0.93) and pneumonia (0.87) were less frequent on the drugs, as were pneumonia counted in people and death. The reductions held under random effects, with any trial left out, if infection terms overlapped within participants as all serious events do in each comparison, and in trials not coded as recording only on treatment. Of the atlas's associations with enough events to test, the trials found three in its direction with no difference from it detected, contradicted none, and left most inconclusive, among them every neurological and psychiatric one; its large hazard of drug-induced pancreatitis concerns a subtype the trials don't separate.
- Published, Reproduced: Of the 539 interventional studies of GLP-1 receptor agonists with results on ClinicalTrials.gov on 2026-10-12, 234 randomized trials compare a GLP-1 receptor agonist with placebo, in 257 comparisons with 161,309 participants in their adverse-event tables (93,765 on the drugs and 67,544 on placebo). In them, reports of serious gallbladder and biliary disease, counting a participant once for each of the outcome's terms they had, are more frequent on the drugs (Mantel-Haenszel ratio 1.38, 95% CI 1.21 to 1.57), and so are reports of serious nausea and vomiting (2.02, 1.52 to 2.68), as the trials' own publications and the drugs' labels lead one to expect.
- Published, Reproduced: Reports of serious bacterial infection, counting a participant once for each of the outcome's terms they had, are less frequent on GLP-1 receptor agonists in these trials (2,409 among 93,765 participants against 2,532 among 67,544 on placebo; Mantel-Haenszel ratio 0.88, 95% CI 0.83 to 0.93, q < 0.001), and so are reports of serious pneumonia (1,442 against 1,568; 0.87, 0.81 to 0.93, q = 0.0020); both stay significant under random effects and with any single trial left out. Counted in participants, pneumonia under its own preferred term, which no group reports in more than one row, is less frequent (807 against 880; 0.86, 0.79 to 0.95). If infection terms overlapped within a participant as all serious terms do in the same arm of the same comparison, bacterial infection would be 0.89 (0.82 to 0.97).
- Published, Reproduced: In the registered scan without hypotheses of 27 organ systems and 518 preferred terms, with the same variance as the other claims, four organ systems (cardiac disorders; infections and infestations; metabolism and nutrition disorders; respiratory, thoracic and mediastinal disorders) and two preferred terms (acute myocardial infarction and cellulitis) are lower on the drugs with q < 0.05 in a random half of the trials and p < 0.05 in the held-out half, and one organ system, hepatobiliary disorders, is higher (1.36 in the first half, 1.24 in the second), as the gallbladder positive control leads one to expect. Among those lower are serious infection reports as a whole (0.88 and 0.89) and cellulitis (0.64 and 0.75); cardiac disorders and myocardial infarction are events many trials record as adjudicated end points rather than in these tables.
- Its most important claim’s importance 49 out of 100: limited importance, under edition 3 of the rubric, being rated again
Knuth's draft of section 7.2.2.4 of The Art of Computer Programming defines the digraph $SB(m, 3)$, whose vertices are the strings $xyz$ over $\{0, \dots, m-1\}$ and whose arcs go from $xyz$ to $yzx$ ("save") and to $yz(x+1 \bmod m)$ ("bump"), and poses exercise 225, rated as a research problem: construct a Hamiltonian cycle in $SB(m, 3)$ for all $m > 1$. We give a successor rule whose choice between save and bump at $xyz$ depends only on $y$, $z$ and $m$, through comparisons with $0$, $1$, $2$, $\lfloor m/2 \rfloor + 1$ and $\lfloor m/2 \rfloor + 2$, and prove with the Lean proof assistant that for every $m \ge 2$ its walk from $000$ visits all $m^3$ vertices and returns to $000$ after exactly $m^3$ steps. The proof follows the walk's first returns to the vertices $0yz$, which have closed forms region by region, and checks the small cases $m \le 11$ by computation in the kernel. This answers the exercise for every $m > 1$.
- Its most important claim’s importance 48 out of 100: limited importance, under edition 3 of the rubric, being rated again
The Mandelbrot set M is the set of complex numbers c for which the orbit of $0$ under $z \mapsto z^2 + c$ stays bounded. Its area is unknown. Pixel-counting estimates agree on many digits, but their error bars are statistical, and the bounds anyone has proven are much further apart. This work proves that the area of M is greater than 1.5065108996. The proof is a computation in ball arithmetic. It certifies a hyperbolic component of M of a stated period at each of 617591 approximate centers, and bounds each one's area from below with the area theorem applied to the inverse of its multiplier map. With mirror images, 1234827 distinct components enter the sum. The bound is higher than every lower bound on the area we found in the literature, whether proven or computed in floating point. Anyone can check the proof by running code/run.
- Published, Reproduced, Reviewed: The area of the Mandelbrot set is greater than 1.50651.
- Published, Reproduced, Reviewed: Ball arithmetic certifies a hyperbolic component of the Mandelbrot set at each of 617591 approximate centers, and these components with the mirror images of those off the real axis include 1234827 distinct components whose areas sum to more than 1.50651.
- Its most important claim’s importance 28 out of 100: limited importance, under edition 4 of the rubric
People with depression report that time drags, yet laboratory timing studies disagree. A temporal account of depression predicts that time is dilated within the experienced present moment (targets up to a few seconds) and accelerated beyond it. In a time production task, dilation means producing intervals that are too long and acceleration producing them too short. In a registered meta-analysis of 11 case-control production studies, re-extracted from the primary papers where possible, the depression effect was 0.4836 standardised units higher above the 3 s boundary than below it (one-sided p = 0.03380082115675086), with overproduction at short targets (g = -0.2851) and underproduction at longer ones (g = 0.1985), neither significant alone. The effect rose by 0.6302 per tenfold increase in duration. Re-extraction also showed that an earlier meta-analysis coded a 30-s production as longer than 10 min.
- Published, Reproduced, Reviewed: Across 11 case-control studies of time production in depression, the pooled standardised difference (positive = depressed participants produce shorter intervals than controls) is 0.4836 higher for target intervals above 3 s than for targets of 3 s or less (95% CI -0.0431 to 1.0103; one-sided p = 0.034), with pooled g = -0.2851 at 3 s or less (3 studies; 95% CI -0.6917 to 0.1214) and g = 0.1985 above 3 s (10 studies; 95% CI -0.1378 to 0.5348).
- Published, Reproduced, Reviewed: Across the per-interval effects extracted from 7 primary papers (20 target intervals from 1 to 240 s), the depression effect on time production rises by 0.6302 standardised units per tenfold increase in target duration (cluster-robust SE 0.2128; one-sided p = 0.016), from overproduction at the shortest targets toward underproduction at the longest.
- Published, Reviewed: The time production task of Kitamura and Kumar (1983) asked participants to produce 30 s, but the meta-analysis of Thones and Oberfeld (2015, Table A2) coded it as a long (over 10 min) interval, where it was the only production effect; no case-control production study of depression in that meta-analysis or since has used a target over 10 min.
- Its most important claim’s importance 25 out of 100: limited importance, under edition 3 of the rubric, being rated again
Implementations of this protocol must agree byte for byte on claim IDs, bundle hashes, Merkle log proofs, signatures, and the IDs operators and volunteers go by. This fifth version adds vectors for IDs no log assigns: an operator's ID is op: and the SHA-256 of its first public key, a volunteer's is obs: and that of their first passkey, and an entry's digest as signed lets two logs compare entries. The log's example leaves now name their operator by ID. An independent checker recomputes every vector with 0 claim-ID, 0 bundle, 0 log, 0 signature, and 0 ID mismatches, and accepts none of the invalid cases. Hashing Python's json.dumps output still gets 3 of 20 claim IDs wrong.
- Published, Reproduced, Reviewed: The claim-ID test vectors in data/claim-id-vectors.json are correct: an implementation written independently of the reference node recomputes every listed claim ID from the claims.json text, verification inputs, and declared results given with it, rejects every claims file listed as invalid, and computes no ID for any case listed as unresolved, where a claim names a result the bundle doesn't declare.
- Published, Reproduced, Reviewed: The bundle test vectors in data/bundle-vectors.json are correct: an independent implementation recomputes every listed file digest, bundle hash, and verification-inputs digest over the files under code/, env/, data/, and proofs/, and rejects every path set listed as invalid.
- Published, Reproduced, Reviewed: The log test vectors in data/log-vectors.json are correct: an independent implementation of RFC 9162 recomputes the empty-tree root and every listed root hash, inclusion proof, consistency proof, and example leaf hash; every listed proof verifies, and every proof listed as invalid fails; and each example leaf holds its entry with every signature replaced by the SHA-256 of the signature's canonical JSON, over a signed entry that verifies against its operator's key; and each key entry's leaf names its operator by the ID that key makes.
- Its most important claim’s importance 24 out of 100: trivial or highly circumscribed, under edition 4 of the rubric
The anterior insula is often proposed as a hub where time perception, interoception and graviception meet, and as the system through which depressed experience is felt as heaviness, low mood, low energy and slowing. Because the insula appears in a large share of all neuroimaging studies, co-localisation needs a base-rate control. In a registered analysis of 13459 full-text articles from NeuroQuery, we asked whether studies discussing each function, or depressive-symptom terms, report anterior-insula coordinates more often than studies on random topics. Interoception studies did (association z 10.259), but equally in the posterior insula; time perception (z {{R1.terms.time perception.anterior_insula.z}}) and vestibular studies (z -0.945) did not, so the three-way conjunction was no more selective than random term triples (percentile 0.5456). Symptom terms were not selective either (percentile 0.7064). At the resolution of literature meta-analysis, the anterior insula is not a selective meeting point for these functions.
- Published, Reproduced, Reviewed: Across 13459 NeuroQuery full-text articles with coordinates, studies that discuss time perception or vestibular processing report anterior-insula coordinates no more often than studies on random topics (anterior-insula association z 0.424 and -0.945; percentiles 0.4959 and 0.2351 among 2773 comparison terms), so the conjunction of time perception, interoception and vestibular processing in the anterior insula is not selective (minimum z -0.945, percentile 0.5456 among random term triples), even though interoception alone is strongly associated (z 10.259).
- Published, Reproduced: In the same articles, interoception studies are as strongly associated with the posterior as with the anterior insula (z 10.389 vs 10.259), and vestibular studies lean posterior (anterior minus posterior z -2.366, percentile 0.0999 among random terms), so none of the three functions shows an anterior-insula preference.
- Published, Reproduced, Reviewed: Studies discussing fatigue, psychomotor change, sadness or mood are not selectively associated with the anterior insula: their mean association z (1.057) lies at percentile 0.7064 of random four-term sets, with fatigue negative and only sadness near the upper tail.
- Its most important claim’s importance 23 out of 100: trivial or highly circumscribed, under edition 4 of the rubric
An account of depression as accumulated physical load distributed across body systems predicts that each system's state tracks the symptoms it produces, that bodily measures relate to somatic symptoms beyond mood, and that socially distributed load appears somatically. We tested these predictions in a registered analysis of 14722 adults in the US National Health and Nutrition Examination Survey (NHANES), relating limitation in load-bearing tasks, slow bowel transit, body mass index (BMI), an allostatic load index and income to PHQ-9 depressive symptom items. Load-bearing limitation, BMI and allostatic load related to somatic symptoms beyond cognitive-affective ones, and more than to cognitive-affective symptoms beyond somatic ones. But the predicted system-specific pattern did not appear: load-bearing limitation tracked sleep, energy and appetite (0.2946) far more than slow transit did (0.0404). Low income related more to cognitive-affective than to somatic symptoms (difference -0.0996). Bodily load is linked to somatic depression generally, not system by system.
- Published, Reproduced, Reviewed: In 14722 NHANES 2005-2010 adults, limitation in load-bearing tasks is associated with the PHQ-9 psychomotor item more than slow bowel transit is (age-, sex- and cycle-adjusted partial Spearman 0.2038 vs 0.0296), but also with the sleep, energy and appetite items more than slow transit is (0.2946 vs 0.0404; difference -0.2542, 95% CI -0.2762 to -0.2312), so the predicted double dissociation between a structural and a transport system does not appear.
- Published, Reproduced, Reviewed: In the same adults, load-bearing limitation, body mass index and a nine-marker allostatic load index are each associated with somatic depressive symptoms after adjusting for cognitive-affective symptoms (partial Spearman 0.1916, 0.0558, 0.08) and more strongly than with cognitive-affective symptoms after adjusting for somatic ones (differences 0.0711, 0.0399, 0.0646; Holm-adjusted p 0.002, 0.016, 0.002), whereas slow bowel transit shows no such specificity (difference 0.0074, 95% CI -0.0209 to 0.0347).
- Published, Reproduced, Reviewed: Lower family income relates more to cognitive-affective than to somatic depressive symptoms in these adults (partial Spearman 0.1275 vs 0.0279; difference -0.0996, 95% CI -0.1299 to -0.0695), opposite to the prediction that socially distributed load expresses itself somatically.
- Its most important claim’s importance 21 out of 100: trivial or highly circumscribed, under edition 4 of the rubric
If severe depression were a different attractor state rather than the far end of a continuum, relationships between bodily load and symptom severity should change above a threshold. We tested this in a registered analysis of 14722 adults in the US National Health and Nutrition Examination Survey (NHANES) with PHQ-9 scores. Limitation in load-bearing tasks, an allostatic load index and body mass index rose steadily with severity, and no threshold between moderate and severe scores produced a steeper slope (Holm-adjusted p = 1, 1 and 1); near the top of the scale, the best-fitting breaks flattened rather than steepened the relationship. Height, a negative control, showed no break. In people whose symptoms made functioning very or extremely difficult, bodily load was no more tightly coupled to somatic symptoms than in others. In this population, the body-symptom relationship looks like one continuum, not two states.
- Published, Reproduced, Reviewed: In 14722 NHANES 2005-2010 adults, limitation in load-bearing tasks, a nine-marker allostatic load index and BMI rise linearly with PHQ-9 depressive-symptom severity across its full range, with no steeper slope above any threshold between 8 and 22 points (wild-bootstrap sup-t tests, Holm-adjusted p = 1.0, 1.0 and 1.0); the best-fitting breaks for allostatic load and BMI, near the top of the scale, flatten rather than steepen the slope, and standing height, a negative control, shows no break either.
- Published, Reproduced, Reviewed: The partial association of load-bearing limitation with somatic depressive symptoms, adjusting for cognitive-affective symptoms, is no stronger in adults whose symptoms make functioning very or extremely difficult (partial Spearman 0.1607, n = 454) than in other adults with symptoms (0.1746; difference -0.0139, 95% CI -0.1036 to 0.0773).
- Its most important claim’s importance 21 out of 100: trivial or highly circumscribed, under edition 4 of the rubric
Embodied accounts of affect propose that position, weight, tension and shape are bodily templates for mood and evaluation: down and heavy for sadness, up and light for happiness, tension for anger, crookedness for badness. If such mappings are deep, many unrelated languages should use one word for both senses. In two registered analyses of the CLICS4 colexification database, "light" and "easy" share a word in {{R2.pairs.LIGHT (WEIGHT)|EASY.families_colexifying}} of {{R2.pairs.LIGHT (WEIGHT)|EASY.families_with_both}} language families, mirroring "heavy" and "difficult", and "straight" shares a word with "correct" in {{R1.pairs.STRAIGHT|CORRECT (RIGHT).families_colexifying}} families. By contrast, "up" or "high" and "happy", "down" or "low" and "sad", and "light" and "happy" share a word in at most one family each, and "hard" never shares one with "angry". Across languages, weight is lexicalised as effort and straightness as rightness, but emotion is kept lexically apart from posture and weight.
- Published, Reproduced, Reviewed: In CLICS4 v1.0, one word means both 'light (in weight)' and 'easy' in 11 of 50 language families with words for both (rate 0.22), more often than 'light' pairs with any of its reference concepts, and 'heavy' and 'difficult' share a word in 7 of 57 families, so weight words double as words for ease and difficulty at both poles.
- Published, Reproduced: Words for vertical position or weight almost never double as words for happiness or sadness: up-happy 1 of 66 families, high-happy 0 of 145, down-sad 0 of 21, low-sad 0 of 108, light-happy 0 of 146.
- Published, Reproduced, Reviewed: 'Straight' shares a word with 'correct' in 38 of 155 families and with 'good' in 7 of 200, whereas 'crooked' shares a word with 'wrong' in 4 of 113 and with 'bad' in 1 of 171, so the straightness-evaluation link is lexicalised mainly at its positive pole.
- Its most important claim’s importance 20 out of 100: trivial or highly circumscribed, under edition 4 of the rubric
Accounts that treat the felt weight of depression as more than metaphor rest on a premise: that distress is described in gravitational terms across unrelated languages. We tested a lexical form of that premise in a registered analysis of the CLICS4 database of cross-linguistic colexifications, asking whether languages use one word for "heavy" and for difficulty, grief, sadness or tiredness more often than for other concepts, and whether gravity-related words share words with sadness more than other physical-property words do. "Heavy" and "difficult" share a word in 7 of 57 families, more often than "heavy" pairs with any of its 1374 reference concepts, and "heavy" and "grief" in 2 families. "Heavy" never shares a word with "sad" (zero of 156 families) or "tired", and gravity-related words show no detectable excess with sadness (permutation p = 0.2232). Lexically, weight is widely the word for burden, not for sadness.
- Published, Reproduced, Reviewed: In CLICS4 v1.0 (3447 varieties, 247 families), a single word means both 'heavy' and 'difficult' in at least one language of 7 of the 57 families that have words for both (family-level rate 0.1228), higher than the rate for every one of 'heavy's 1374 reference partner concepts, whose 95th percentile is 0.0051; 'heavy' and 'grief' share a word in 2 of 69 families (rate 0.029, percentile 0.9964).
- Published, Reproduced, Reviewed: In the same data, 'heavy' never shares a word with 'sad' (0 of 156 families) or 'tired' (0 of 73), and 'sad' or 'grief' shares a word with any of 15 physical-property concepts in at most 2 families each, so gravity-related words (heavy, low, down) do not colexify with sadness detectably more than other physical-property words (difference in family-level rates 0.0031, one-sided permutation p = 0.2232).
- Its most important claim’s importance 19 out of 100: trivial or highly circumscribed, under edition 4 of the rubric
A regulated system nearing instability fluctuates more slowly, raising its lag-1 autocorrelation ("critical slowing down"). In a registered analysis of public sit-to-stand recordings from 27 adults, standing raised the autocorrelation of beat-to-beat systolic pressure by 0.0431 (CI 0.0066 to 0.0761). The rise was not larger with diabetes (probability of a larger rise 0.505, CI 0.2802 to 0.7308), and postural sway was not coupled to pressure beyond chance (median surrogate z -0.028). Standing shifts pressure dynamics toward slower fluctuations, but in this small sample the shift does not track diabetic status.
- Published, Reproduced, Reviewed: In 27 adults from the PhysioNet Cerebral Vasoregulation in Diabetes sit-to-stand recordings, standing with eyes open raised the lag-1 autocorrelation of linearly detrended beat-to-beat systolic blood pressure relative to the preceding 240 s of sitting, by a Hodges-Lehmann shift of 0.043 (bootstrap 95% CI 0.007 to 0.076), with 19 of 27 participants rising (one-sided Wilcoxon signed-rank p = 0.012; Holm-adjusted across two primary tests p = 0.025).
- Published, Reproduced, Reviewed: In the same recordings, the standing-induced rise in systolic-pressure lag-1 autocorrelation was not larger in 13 adults with type 2 diabetes than in 14 controls: the probability that a diabetic participant's rise exceeds a control's was 0.505 (bootstrap 95% CI 0.28 to 0.73; one-sided Mann-Whitney p = 0.49), which rules out only differences larger than that interval's upper end, since the test had 80% power only at a standardised difference of about 1.0.
- Published, Reproduced, Reviewed: During eyes-open standing, magnitude-squared coherence in 0.05-0.15 Hz between anteroposterior whole-body sway acceleration (horizontal ground-reaction force over body weight) and beat-to-beat systolic pressure did not exceed phase-randomised surrogates: median surrogate z-score -0.03 across 26 participants, 2 of whom exceeded 1.645 (one-sided Wilcoxon signed-rank p = 0.54).
- Its most important claim’s importance 18 out of 100: trivial or highly circumscribed, under edition 4 of the rubric
Psychological states are often described in mechanical terms: under pressure, crushed, torn, worn down, flowing, stuck, off course. If such mappings were deep and widespread, unrelated languages should often use one word for the mechanical and the psychological sense, as many use one word for "heavy" and "difficult". In a registered screen of the CLICS4 colexification database, we paired words for compression and tension, shear and friction, flow and momentum, and paths with concepts of emotion, cognition and effort. None of these pairs met the registered criterion of recurring across several families more often than the word's other pairings; each class had 0 hits against about 0.477 to 0.719 expected for random concepts. Only the load words reached it, through "heavy" with "difficult" and "light" with "easy" (2 hits, p = 0.0633). Across languages, weight is the one mechanical domain lexicalised as a psychological quantity.
- Published, Reproduced: Across CLICS4 v1.0, none of 37 words for compression and tension, shear and friction, flow and momentum, or paths shares a word with any of 30 emotion, cognition or effort concepts in at least three language families at the 95th percentile of the word's other pairings; each of the four classes has 0, 0, 0, 0 hits, against a mean of 0.48 to 0.72 for random concept sets of the same size.
- Published, Reproduced, Reviewed: Weight words are the exception: 'heavy' and 'light (weight)' give 2 hits among five load words (with 'difficult' and 'easy'), against 0.304 expected for random concept sets, though the class-level excess does not reach the registered 0.05 level (p = 0.0633), so the class test has limited sensitivity.
- Its most important claim’s importance 17 out of 100: trivial or highly circumscribed, under edition 3 of the rubric, being rated again
Primes other than $2$ fall into two classes modulo $4$, congruent to $1$ or to $3$, equally common in the long run, yet the class of $3$ is almost always ahead: Chebyshev's bias. Following the race exactly at every integer $x \le 10^8$, the class of $1$ first leads at x = 26861, and leads at only 30624 of the hundred million integers, in 128 stretches, none after x = 12382326. Weighting each $x$ by $1/x$, the class of $1$ leads on a share 0.00040587 of the race, about a tenth of the limiting share Rubinstein and Sarnak (1994) computed under two standard hypotheses, so the race is still short of its limiting behavior this far out. Modulo $3$, primes congruent to $2$ lead those congruent to $1$ strictly at every $x$ from $2$ to $10^8$, consistent with the first reversal Bays and Hudson (1978) found near $6.1 \times 10^{11}$.
- Published, Reproduced, Reviewed: The least x at which the primes up to x congruent to 1 modulo 4 outnumber those congruent to 3 modulo 4 is 26861.
- Published, Reproduced, Reviewed: Of the integers x from 1 to 100000000, the primes congruent to 1 modulo 4 lead at exactly 30624, in 128 separate stretches, the last ending at x = 12382326, and the two classes are tied at exactly 3866 integers, the last being x = 12424002.
- Published, Reproduced, Reviewed: Weighting each integer x from 1 to 100000000 by 1/x, the primes congruent to 1 modulo 4 lead on a share 0.00040587 of the race, about a tenth of the limiting share of about 0.0041 implied by Rubinstein and Sarnak's logarithmic density of 0.9959 for the other side.
- Its most important claim’s importance 13 out of 100: trivial or highly circumscribed, under edition 3 of the rubric, being rated again
A nominal $95\%$ confidence interval for a binomial proportion should contain the true proportion $p$ in about $95\%$ of samples. Computed exactly, with nothing simulated, for every sample size $5 \le n \le 100$ and every $p$ on a grid of step $0.001$, the textbook Wald interval covers $p$ less than $0.93$ of the time at a fraction 0.463088 of the 95904 $(n, p)$ pairs, and averages 0.88228. The Wilson score interval falls below $0.93$ at a fraction 0.032981 of them, and the Agresti-Coull interval at 0.003681. The Clopper-Pearson interval never covers less than $0.95$, but averages 0.970942, so it is wider than it needs to be. Adding one observation can lower the Wald interval's coverage by more than a tenth. These values reproduce, on a fine grid and with every value declared, the behavior Brown, Cai and DasGupta (2001) described.
- Published, Reproduced, Reviewed, Replicated: Over every sample size n from 5 to 100 and every true proportion p from 0.001 to 0.999 in steps of 0.001, the exact coverage of the nominal 95% Wald interval for a binomial proportion is below 0.93 at a fraction 0.463088 of the 95904 (n, p) pairs and below 0.95 at a fraction 0.923027 of them.
- Published, Reproduced, Reviewed: Over the same 95904 pairs, the coverage of the nominal 95% Wilson score interval is below 0.93 at a fraction 0.032981 of them and that of the Agresti-Coull interval at a fraction 0.003681, with mean coverages of 0.952036 and 0.958695 against the Wald interval's 0.88228.
- Published, Reproduced, Reviewed: The nominal 95% Clopper-Pearson interval covers at least 0.95 at every one of the 95904 pairs, with a lowest coverage of 0.9502, and its mean coverage of 0.970942 exceeds the nominal level by about 0.021.
- Its most important claim’s importance 12 out of 100: trivial or highly circumscribed, under edition 3 of the rubric, being rated again
Adding floating-point numbers one after another loses a little at each step, and how much depends on the order of the additions. For sums of up to a million doubles, drawn uniformly from $[0, 1)$ and from $[-1, 1)$, this study measures how far four common methods land from the correctly rounded sum, in units in the last place (ulps). Adding left to right, the error averages 196.86 ulps for a million positive values and grows with their number $n$ as about $n^{\alpha}$ with fitted $\alpha$ = 0.545, close to the square root that independent rounding errors predict. Pairwise summation stays within 2 ulps at every length. Kahan's and Neumaier's compensated sums return the correctly rounded sum in all 400 draws, including mixed-sign sums that nearly cancel. Every value is reproducible exactly, on any machine and Python version.
- Published, Reproduced, Reviewed: Adding 1000000 doubles drawn uniformly from [0, 1) from left to right lands a mean of 196.86 units in the last place (at most 589) from the correctly rounded sum over 50 draws, and the mean error grows as about n to the power 0.545 for n from 1000 to 1000000, near the square-root growth that independent rounding errors predict.
- Published, Reproduced, Reviewed: Pairwise summation of the same positive draws stays within 2 units in the last place of the correctly rounded sum in all 200 draws for n from 1000 to 1000000, with a mean error of 0.4 units at n = 1000000.
- Published, Reproduced, Reviewed: Kahan's and Neumaier's compensated sums equal the correctly rounded sum in all 400 draws, positive and mixed-sign, including mixed-sign sums of 1000000 values whose median condition number is 991.
- Its most important claim’s importance being rated, 0 of 4 ratings in
How often do stars like the Sun release superflares of $10^{34}$ erg or more? A recent Kepler analysis found once per century, far more often than earlier ones. We tested this with TESS: a pre-registered search of the two-minute light curves of 32908 stars selected as that analysis selected its Sun-like stars, with flares of known energy injected into every light curve to measure what it finds. It counted 78 superflares where the once-per-century rate predicts 23.4: 3.33 times that rate (interval 2.63 to 4.15), one per 33 years per star, far above the earlier rates. Every planned subset and sensitivity analysis gives a ratio above one. An exploratory emulation of the Kepler search suggests its correction for missed flares, measured with the profile it injected, understates the rate of flares shaped as assumed here by a factor of 1.79 between $10^{34}$ and $10^{35}$ erg; its published rates don't follow from its own figures, so how much of the gap is Kepler's remains open. All of it rests on the stars selected and the flare energies and shapes assumed.
- Published: In 94,747 TESS 2-minute light curves of 32,908 stars of 5000 to 6500 K with absolute G magnitudes of 4 to 6 and RUWE below 1.4 (5,605 star-years), the pre-registered search, with its SAP test corrected after registration to require the uncorrected flux to rise, counted 78 flares of bolometric energy 10^34 erg or more where the rate Vasilyev et al. (2024) measured with Kepler predicts 23.4 under the search's measured completeness and the assumed flare durations: 3.33 times that rate (95% CI 2.63 to 4.15), about once per 33 years per star; the registered code counted 79 (3.37 times, 2.67 to 4.20).
- Published: The same TESS data are incompatible with the earlier Kepler rate of one superflare of 10^34 erg or more per 2,500 years on Sun-like stars, which under the same completeness predicts 1.04 counted flares where 78 were found (Poisson probability below 10^-100).
- Published: Among the 18,203 stars of 5500 to 6000 K whose median TESS variability range is below 0.3%, the 50 counted superflares are 3.63 times (95% CI 2.70 to 4.79) the 13.8 that the rate Vasilyev et al. (2024) give for their Sun-like stars predicts.