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Neurons spend most of their ATP on ion pumping (Attwell & Laughlin 2001) and receive oxygen by diffusion from capillaries, so energy-hungry neuron types might sit closer to capillaries. In whole-brain MERFISH atlases (Yao et al. 2023; Zhang et al. 2023) we measured each neuron's distance to the nearest endothelial cell relative to neighbouring neurons in the same local tile, and correlated each subclass's excess with an OXPHOS plus Na/K-pump expression score (preregistration). Across 239 subclasses there was no relation: rho = -0.018960304 (CI -0.14959145 to 0.11132168; p = 0.7770223), with no consistent sign across the replication brains. Every subclass sits within a few percent of its neighbours' capillary distance. Decision: refute.

• Published, Reproduced.Published, Reproduced: Across 239 transcriptomic neuron subclasses (2.07 million neurons) in a whole adult mouse brain mapped by MERFISH, a subclass's energy-metabolism gene expression (88 oxidative-phosphorylation genes plus Na+/K+-ATPase Atp1a1/Atp1a3, from independent 10x data) does not predict how close its cell bodies sit to the nearest capillary endothelial cell relative to neighbouring neurons in the same 100-um tile: Spearman rho = -0.019 (95% CI -0.150 to 0.111; permutation p = 0.78). Replication brains give rho = -0.048, +0.044, -0.003 and +0.344 (2 of 4 negative). The preregistered decision is refute: energy-hungry neuron types do not sit measurably closer to capillaries; all subclasses lie within about +/-4% of local neurons' log distance.

Evidence that small fMRI studies overstate effects comes mostly from reported peaks, which are inflated by selection whatever the sample size. We asked the question with a whole-brain measure that has no peak selection. For each published (DOI-linked), group-level, unthresholded task-fMRI T or Z map on NeuroVault (Gorgolewski et al. 2015), we estimated the root-mean-square standardized effect over a fixed grey-matter mask from the mean squared statistic. We then regressed its log on log N with map-type, smoothing, upload-year and paradigm fixed effects plus a random intercept per collection. Everything was preregistered (prereg:f7ecdaf6…) on a frozen map list. After QC and de-duplication, 1245 maps from 200 collections were analysed. The slope was β = -0.101387 (CI -0.272087 to 0.069313), so the locked decision is inconclusive. There is no significant small-study inflation, and steep slopes are excluded. The data cannot rule out a modest slope at the preregistered boundary.

• Published, Reproduced.Published, Reproduced: Across 1,245 QC-passing, de-duplicated, published (DOI-linked) group-level unthresholded task-fMRI T/Z maps from 200 NeuroVault collections (N 10–1,369), the preregistered mixed model of log whole-brain rms standardized effect (grey-matter mask) on log N gives beta = -0.101387 (95% CI -0.272087 to 0.069313): no statistically significant small-study inflation of whole-brain effect sizes; slopes steeper than about -0.27 are excluded, but the preregistered refutation bound (-0.10) is not, so the locked decision is inconclusive.

Preregistered TWFE DiD test of whether pharmacist direct-authority naloxone laws cut CDC WONDER age-adjusted opioid overdose mortality before synthetic opioids dominate a state's mix, then attenuate to null once T40.4 accounts for at least half of opioid overdose deaths. On the pinned panel (661 state-years after dropping 53 suppressed or unreliable cells, 2008–2021), ATT before dominance is -0.285902 (CI -3.772196 to 3.200392); the Law×SyntheticDominant interaction is -0.926561; ATT when dominant is -1.212463. Locked success flag false is false (decision refute). Re-run from code/analyze.py.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Under the preregistered state-year TWFE DiD on CDC WONDER age-adjusted opioid overdose rates (n=661 state-years after dropping 53 suppressed/unreliable cells, 51 jurisdictions, 2008-2021), pharmacist direct-authority naloxone laws do not show a statistically significant protective association before synthetic-opioid dominance (ATT non-dominant β1=-0.285902 per 100k, 95% CI [-3.772196, 3.200392]), so the locked attenuation claim is not supported; Law×SyntheticDominant interaction β2=-0.926561 (95% CI [-6.177517, 4.324395]) and ATT in dominant years is -1.212463 (95% CI [-8.221627, 5.796701]); event-study pre-trend joint p=0.123406.

Preregistered TWFE DiD test of whether pharmacist direct-authority naloxone laws cut crude opioid overdose mortality before synthetic opioids dominate a state's mix, then attenuate to null once T40.4 accounts for at least half of opioid overdose deaths. On the pinned panel (601 state-years, 2008–2021), ATT before dominance is -0.632217 (CI -4.144376 to 2.879942); the Law×SyntheticDominant interaction is 0.231578; ATT when dominant is -0.400639. Locked success flag false is false (decision refute). Re-run from code/analyze.py.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Under the preregistered state-year TWFE DiD (n=601 state-years, 51 jurisdictions, 2008-2021), pharmacist direct-authority naloxone laws do not show a statistically significant protective association with crude opioid overdose mortality before synthetic-opioid dominance (ATT non-dominant β1=-0.632217 per 100k, 95% CI [-4.144376, 2.879942]), so the locked attenuation claim (protection before T40.4 share ≥50% that attenuates to null afterward) is not supported; the Law×SyntheticDominant interaction is β2=0.231578 (95% CI [-5.001315, 5.464471]) and ATT in dominant years is -0.400639 (95% CI [-7.530463, 6.729184]); event-study pre-trend joint p=0.318912.

This work tests a preregistered question on open New York City data: whether a fixed lag of CDC National Wastewater Surveillance System (NWSS) SARS-CoV-2 percentile predicts rises in confirmed COVID-19 cases better than the same-day percentile. The locked primary contrast is the difference in area under the receiver operating characteristic curve (AUROC) between a seven-day lag and a zero-day lag. On the pinned public snapshots, the lag-seven AUROC is 0.449326 and the lag-zero AUROC is 0.522145, so the delta is -0.07282 and the preregistered success flag false is false. The negative result is deterministic and re-run from code/analyze.py.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Under the preregistered NYC analysis, the AUROC of a fixed 7-day lag of population-weighted CDC NWSS SARS-CoV-2 wastewater percentile for predicting a subsequent rise in NYC confirmed COVID-19 cases is 0.449326, which does not exceed the contemporaneous lag-0 AUROC of 0.522145 (delta -0.07282), so the locked success rule AUROC_lag7 > AUROC_lag0 fails.

This bundle re-computes the Collatz total stopping time (delay) for every integer from 10000000 down through one, covering the closed interval of the first ten million positive integers, and extracts the delay-record sequence: each n whose delay strictly exceeds that of every smaller positive integer. The enumeration produces 54 records, ending at n=8400511 with delay 685. These values agree with the classical delay-record table of Leavens and Vermeulen as maintained in the public Collatz record lists on this range. The computation is deterministic, uses only integer arithmetic, and is re-run by verifiers from code/compute_delays.py.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: An independent enumeration of Collatz total-stopping-time delay records for all n in 1..10000000 yields exactly 54 records, the last being n=8400511 with delay 685, matching the published Leavens–Vermeulen / Roosendaal delay-record table on this range.

Turning 35, and again turning 40, moves a pregnancy into the "advanced maternal age" category, which carries more surveillance and more advice to deliver early. Using every US singleton first birth at term from 2016 to 2024, we compared mothers just below and just above each age with a preregistered regression discontinuity, using confidence intervals that stay valid when age is recorded in whole years. Labor induction jumps by 1.19 percentage points at 35 (honest 95% CI 0.7 to 1.68). The preregistered verdict is inconclusive, because the share of first births also jumps at 35, by 0.4 points. At 40, induction jumps by 2.86 points (2.05 to 3.67), and that secondary test meets its confirm rule. Delivery at 39 weeks rises at both ages. Cesarean delivery, NICU admission, low Apgar scores, severe maternal morbidity and term stillbirth show no jump at either age. The label appears to move delivery timing without changing these measured outcomes.

• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Among singleton first births at 37-44 weeks in US natality files for 2016-2024, labor induction rises by 1.19 percentage points at maternal age 35 (honest 95% CI 0.70 to 1.68, bias bound 0.1 pp per year squared), but the preregistered decision rule classifies this primary test as inconclusive because the all-parity nulliparity share also jumps at age 35 (0.40 pp, Holm-adjusted p = 0.023).
• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: In the same population, labor induction rises by 2.86 percentage points at maternal age 40 (honest 95% CI 2.05 to 3.67), with no covariate discontinuity at 40 after Holm adjustment, so the preregistered secondary test at 40 meets its confirm rule.
• Published, Reproduced, Reviewed.Published, Reproduced, Reviewed: Delivery at 39 weeks rises by 1.00 percentage points at maternal age 35 (honest 95% CI 0.52 to 1.48) and by 3.64 percentage points at age 40 (honest 95% CI 2.85 to 4.44) among singleton first births at 37-44 weeks.

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